Unreviewed, UniProtKB/TrEMBL Q9VZU7 (Q9VZU7_DROME)

Names and origin

Protein names

Recommended name:
    Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435V0
    EC=3.1.2.15

Gene names

ORF Names:

CG12082 FlyBase FBgn0035402, Dmel_CG12082 EMBL AAF47720.1

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol. RuleBase RU004435V0
Sequence similarities	Belongs to the peptidase C19 family. RuleBase RU004434V0

Ontologies

Keywords
Biological process	Ubl conjugation pathway RuleBase RU004434V0
Molecular function	Hydrolase Protease Thiol protease RuleBase RU004434V0
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VZU7-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 393E5CF5606E30BE	FASTA	827	92,092
	10 20 30 40 50 60 MEELRKHLSK VNVPCASGAG SPPIYKDECV YSYDNPETPT GLYVCLHSFL GFGEAYVREY 70 80 90 100 110 120 ADKTGNRVFL HIQRVKTIKE GADMEAECAE SEAGPERKIT RLAIGVEGGY NESDMAKKYE 130 140 150 160 170 180 IKDTYSIVVA PHLDKKLPYP DPELPMRVTQ SVEAILAADS AIAKLEKATL MGTWDGEVRQ 190 200 210 220 230 240 ASKYADNLQQ LDNGKRIPPS GWQCEKCDLT NNLWLNLTDG SIMCGRKFFD GSGGNDHAVE 250 260 270 280 290 300 HYRVTGFPLA VKLGTITADG KSDVFSYPED EMVLDPHLER HLSHFGINMA AMKKSEKSMV 310 320 330 340 350 360 ELELDINQRI GEWTALTESE SELQPVAGPG YTGMRNLGNS CYINSVMQVL FVIPDFQQRF 370 380 390 400 410 420 VGTGAERYFK EFPSDPANDF NIQMAKLGTG LQSGKYSSIA ENTLDTDHST GISPAMFKNI 430 440 450 460 470 480 VGKNHPDFST KQQQDANDFY LHLLTLLDRN SRNQTNPADA LKFLLEDRVE CLASHKVKYN 490 500 510 520 530 540 TREEYSFRLP VPLDKATNLD EVREFQERKK AARETGQRLP DRDIVRHKVP LQACLERFFG 550 560 570 580 590 600 PELIEQFYST AIGSKTNARK ITRLATMPDC LMIHVGKFTL GDDWVPKKLD VSVDMPDELD 610 620 630 640 650 660 LSNWRSAGGL QPGEEALPEP ATEEVKFAFD EAVMSELLTM GFPPEACKRA CYHTKNSGLE 670 680 690 700 710 720 AASNWLMEHI ADEDISEPFV VPNNSIGDCA ANQFVANPES LAMLMSMGFD ERQAVAALKA 730 740 750 760 770 780 TDGNVERATD WIFSHADSIG VEDAAPAANS SAAAASSTPN KTNYRDGRGK YRLVAFISHM 790 800 810 820 GTSAQVGHYV CHIRKKGEWV IFNDSKVAKS QNPPKDLGYL YLYMREQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAM52024.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014296 Genomic DNA. Translation: AAF47720.1. AY121697 mRNA. Translation: AAM52024.1.
RefSeq	NP_647773.1.
UniGene	Dm.11718
3D structure databases
SMR	Q9VZU7. Positions 174-289.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VZU7. 2 interactions.
Protein family/group databases
MEROPS	C19.001.
Proteomic databases
PRIDE	Q9VZU7.
Genome annotation databases
Ensembl	FBgn0035402. Drosophila melanogaster. [Contig view]
GeneID	38375.
KEGG	dme:Dmel_CG12082.
NMPDR	fig|7227.3.peg.7861.
Organism-specific databases
FlyBase	FBgn0035402. CG12082.
Phylogenomic databases
HOGENOM	Q9VZU7.
OMA	Q9VZU7. ERAVDWI.
Gene expression databases
ArrayExpress	Q9VZU7.
Family and domain databases
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. IPR016652. Ubiquitinyl_hydrolase. IPR001607. Znf_UBP. [Graphical view]
Pfam	PF00627. UBA. 2 hits. PF00443. UCH. 1 hit. PF02148. zf-UBP. 1 hit. [Graphical view]
PIRSF	PIRSF016308. UBP. 1 hit.
SMART	SM00165. UBA. 2 hits. SM00290. ZnF_UBP. 1 hit. [Graphical view]
PROSITE	PS50030. UBA. 2 hits. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS50271. ZF_UBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	808307.

Entry information

Entry name

Q9VZU7_DROME

Accession

Primary (citable) accession number: Q9VZU7

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)