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Protein
Submitted name:

Activated Cdc42 kinase

Gene

Ack

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  • protein tyrosine kinase activity Source: FlyBase
  • SH2 domain binding Source: FlyBase

GO - Biological processi

  • cellular protein localization Source: FlyBase
  • dorsal closure Source: FlyBase
  • negative regulation of apoptotic process Source: FlyBase
  • peptidyl-tyrosine phosphorylation Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • signal transduction Source: InterPro
  • spermatid development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Activated Cdc42 kinaseImported (EC:2.7.10.-Imported, EC:2.7.10.2Imported)
Submitted name:
BcDNA.GH10777Imported
Gene namesi
Name:AckImported
Synonyms:BcDNA.GH10777Imported
ORF Names:CG14992Imported, Dmel_CG14992Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0028484. Ack.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: FlyBase
  • clathrin-coated vesicle Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-833279.
STRINGi7227.FBpp0073067.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
Contains protein kinase domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118799.
KOiK08252.
OMAiHAKERKS.

Family and domain databases

InterProiIPR030220. Ack1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view]
PANTHERiPTHR24418:SF66. PTHR24418:SF66. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VZI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTSAVDGG LGSETAWLED LLREVQLEQF LDRIRDDLQV TRLAHFDYVL
60 70 80 90 100
PDDLERCGLG KPAIRRLMEA VRKKKAHQWR KNILSKLIGG GKQPSSKKQS
110 120 130 140 150
SAARESSQGN GTQLTCLIHE KDITMGLKLG DGSFGVVRRG EWSASPAGKV
160 170 180 190 200
IPVAVKVLKS DNLTQPGIID DFFREVQAMH ALDHANLVRL YGVVLSQPMM
210 220 230 240 250
MITELAERGS LLDTLRKQCR HTSLTIIWNW SVQIVTGMAY LEQKRFLHRD
260 270 280 290 300
LACRNVLLAA GNKIKIGDFG LMRALPQEDD CYVMSEHKKV PFPWCAPESL
310 320 330 340 350
RFRQFSHASD TWMFGVTLWE MFSFGEDPWV GLNGSQILRK IDREGERLHQ
360 370 380 390 400
PDACPPDVYA MMLQCWDKTP AERPTFAALK EYLASMSPPV MRASRSHHES
410 420 430 440 450
KGLQIEPGDT IAIIDGRHEL KLIKGQNQRT FDIGIFPRNL LEQRKVGAAG
460 470 480 490 500
DVVMRSSVGN GSSSSPFGFC WGGAAAMANG DDRQRKCASM TNQPHAKERK
510 520 530 540 550
STSSKQFAYN KLVNDSATGL QRRNAVKHKG VVVGPQRPPP PQFQQEGILI
560 570 580 590 600
DISPDMRPIA EAGTGGAKGA GDSSSLQADS SFCILDAPID VPTYAGSSGS
610 620 630 640 650
GDLNVSPTYY NEQPQFDFDP AKMTASPGRL QPPPYQMPPT YSNTMEFVQK
660 670 680 690 700
RDLHQQQLAT PVRERDPFDT TNVETTVALY SNFNQSLEAA SPPAPIYNSP
710 720 730 740 750
SVRKSLFGGS KSNKENIPAL ESAAMQLNLS NLTLERHDAT CIQPVEPVPA
760 770 780 790 800
PPGDGVLLDK SFIAELEKDM YSNGQNRAQE EYQRNSTQMY ASKDMVYKQN
810 820 830 840 850
LTPLKNGAAP GSVHSNHSSP SSTASPKQNN VEAAAAAAAT TQSVVNRIWY
860 870 880 890 900
EQVASTQSEY YAQPPTEQAE EQIYQNHRHQ QQQQQELNHS FVAISNRVVA
910 920 930 940 950
PKNNAYSSTA SLYDAVAAST AGSTYYGQVP NGSGAVLYDE VTQDDYLRPT
960 970 980 990 1000
RPAPLAPPPL SAQQIQRRME KMRLQQQQQL DGAHQLYAPV PSDYGREQEK
1010 1020 1030 1040 1050
LQQLMQELGS SAVEQDVRNA LRAASGDVGL ATRHYKIDQL ARLGVAGRPQ
1060 1070
CEQALQQTNW SLEVAAELLL NAG
Length:1,073
Mass (Da):118,418
Last modified:March 1, 2001 - v2
Checksum:iD9BF4BD87235D691
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181642 mRNA. Translation: AAD55428.1.
AE014296 Genomic DNA. Translation: AAF47839.2.
RefSeqiNP_647859.1. NM_139602.3.
UniGeneiDm.3018.

Genome annotation databases

EnsemblMetazoaiFBtr0073211; FBpp0073067; FBgn0028484.
GeneIDi38489.
KEGGidme:Dmel_CG14992.
UCSCiCG14992-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181642 mRNA. Translation: AAD55428.1.
AE014296 Genomic DNA. Translation: AAF47839.2.
RefSeqiNP_647859.1. NM_139602.3.
UniGeneiDm.3018.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-833279.
STRINGi7227.FBpp0073067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073211; FBpp0073067; FBgn0028484.
GeneIDi38489.
KEGGidme:Dmel_CG14992.
UCSCiCG14992-RA. d. melanogaster.

Organism-specific databases

CTDi107482.
FlyBaseiFBgn0028484. Ack.

Phylogenomic databases

GeneTreeiENSGT00760000118799.
KOiK08252.
OMAiHAKERKS.

Miscellaneous databases

GenomeRNAii38489.
NextBioi808907.

Family and domain databases

InterProiIPR030220. Ack1.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view]
PANTHERiPTHR24418:SF66. PTHR24418:SF66. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VZI2_DROME
AccessioniPrimary (citable) accession number: Q9VZI2
Secondary accession number(s): Q9U4G3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: June 24, 2015
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.