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Q9VZI2

- Q9VZI2_DROME

UniProt

Q9VZI2 - Q9VZI2_DROME

Protein
Submitted name:

Activated Cdc42 kinase

Gene

Ack

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    3. protein tyrosine kinase activity Source: FlyBase
    4. SH2 domain binding Source: FlyBase

    GO - Biological processi

    1. cellular protein localization Source: FlyBase
    2. dorsal closure Source: FlyBase
    3. negative regulation of apoptotic process Source: FlyBase
    4. peptidyl-tyrosine phosphorylation Source: FlyBase
    5. protein phosphorylation Source: FlyBase
    6. spermatid development Source: FlyBase

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Activated Cdc42 kinaseImported (EC:2.7.10.-Imported, EC:2.7.10.2Imported)
    Submitted name:
    BcDNA.GH10777Imported
    Gene namesi
    Name:AckImported
    Synonyms:BcDNA.GH10777Imported
    ORF Names:CG14992Imported, Dmel_CG14992Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0028484. Ack.

    Subcellular locationi

    GO - Cellular componenti

    1. cell periphery Source: FlyBase
    2. clathrin-coated vesicle Source: FlyBase

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-833279.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation
    Contains protein kinase domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115195.
    InParanoidiQ9VZI2.
    KOiK08252.
    OMAiHAKERKS.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VZI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTSAVDGG LGSETAWLED LLREVQLEQF LDRIRDDLQV TRLAHFDYVL     50
    PDDLERCGLG KPAIRRLMEA VRKKKAHQWR KNILSKLIGG GKQPSSKKQS 100
    SAARESSQGN GTQLTCLIHE KDITMGLKLG DGSFGVVRRG EWSASPAGKV 150
    IPVAVKVLKS DNLTQPGIID DFFREVQAMH ALDHANLVRL YGVVLSQPMM 200
    MITELAERGS LLDTLRKQCR HTSLTIIWNW SVQIVTGMAY LEQKRFLHRD 250
    LACRNVLLAA GNKIKIGDFG LMRALPQEDD CYVMSEHKKV PFPWCAPESL 300
    RFRQFSHASD TWMFGVTLWE MFSFGEDPWV GLNGSQILRK IDREGERLHQ 350
    PDACPPDVYA MMLQCWDKTP AERPTFAALK EYLASMSPPV MRASRSHHES 400
    KGLQIEPGDT IAIIDGRHEL KLIKGQNQRT FDIGIFPRNL LEQRKVGAAG 450
    DVVMRSSVGN GSSSSPFGFC WGGAAAMANG DDRQRKCASM TNQPHAKERK 500
    STSSKQFAYN KLVNDSATGL QRRNAVKHKG VVVGPQRPPP PQFQQEGILI 550
    DISPDMRPIA EAGTGGAKGA GDSSSLQADS SFCILDAPID VPTYAGSSGS 600
    GDLNVSPTYY NEQPQFDFDP AKMTASPGRL QPPPYQMPPT YSNTMEFVQK 650
    RDLHQQQLAT PVRERDPFDT TNVETTVALY SNFNQSLEAA SPPAPIYNSP 700
    SVRKSLFGGS KSNKENIPAL ESAAMQLNLS NLTLERHDAT CIQPVEPVPA 750
    PPGDGVLLDK SFIAELEKDM YSNGQNRAQE EYQRNSTQMY ASKDMVYKQN 800
    LTPLKNGAAP GSVHSNHSSP SSTASPKQNN VEAAAAAAAT TQSVVNRIWY 850
    EQVASTQSEY YAQPPTEQAE EQIYQNHRHQ QQQQQELNHS FVAISNRVVA 900
    PKNNAYSSTA SLYDAVAAST AGSTYYGQVP NGSGAVLYDE VTQDDYLRPT 950
    RPAPLAPPPL SAQQIQRRME KMRLQQQQQL DGAHQLYAPV PSDYGREQEK 1000
    LQQLMQELGS SAVEQDVRNA LRAASGDVGL ATRHYKIDQL ARLGVAGRPQ 1050
    CEQALQQTNW SLEVAAELLL NAG 1073
    Length:1,073
    Mass (Da):118,418
    Last modified:March 1, 2001 - v2
    Checksum:iD9BF4BD87235D691
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181642 mRNA. Translation: AAD55428.1.
    AE014296 Genomic DNA. Translation: AAF47839.2.
    RefSeqiNP_647859.1. NM_139602.3.
    UniGeneiDm.3018.

    Genome annotation databases

    EnsemblMetazoaiFBtr0073211; FBpp0073067; FBgn0028484.
    GeneIDi38489.
    KEGGidme:Dmel_CG14992.
    UCSCiCG14992-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF181642 mRNA. Translation: AAD55428.1 .
    AE014296 Genomic DNA. Translation: AAF47839.2 .
    RefSeqi NP_647859.1. NM_139602.3.
    UniGenei Dm.3018.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-833279.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0073211 ; FBpp0073067 ; FBgn0028484 .
    GeneIDi 38489.
    KEGGi dme:Dmel_CG14992.
    UCSCi CG14992-RA. d. melanogaster.

    Organism-specific databases

    CTDi 107482.
    FlyBasei FBgn0028484. Ack.

    Phylogenomic databases

    GeneTreei ENSGT00740000115195.
    InParanoidi Q9VZI2.
    KOi K08252.
    OMAi HAKERKS.

    Miscellaneous databases

    ChiTaRSi TNK2. drosophila.
    GenomeRNAii 38489.
    NextBioi 808907.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR015940. UBA/transl_elong_EF1B_N_euk.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    SM00165. UBA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50030. UBA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    4. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    12. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9VZI2_DROME
    AccessioniPrimary (citable) accession number: Q9VZI2
    Secondary accession number(s): Q9U4G3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3