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Q9VZI2

- Q9VZI2_DROME

UniProt

Q9VZI2 - Q9VZI2_DROME

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Protein
Submitted name:

Activated Cdc42 kinase

Gene
Ack, BcDNA.GH10777, CG14992, Dmel_CG14992
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein tyrosine kinase activity Source: FlyBase
  4. SH2 domain binding Source: FlyBase

GO - Biological processi

  1. cellular protein localization Source: FlyBase
  2. dorsal closure Source: FlyBase
  3. negative regulation of apoptotic process Source: FlyBase
  4. peptidyl-tyrosine phosphorylation Source: FlyBase
  5. protein phosphorylation Source: FlyBase
  6. spermatid development Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Activated Cdc42 kinaseImported (EC:2.7.10.-Imported, EC:2.7.10.2Imported)
Submitted name:
BcDNA.GH10777Imported
Gene namesi
Name:AckImported
Synonyms:BcDNA.GH10777Imported
ORF Names:CG14992Imported, Dmel_CG14992Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0028484. Ack.

Subcellular locationi

GO - Cellular componenti

  1. cell periphery Source: FlyBase
  2. clathrin-coated vesicle Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-833279.

Family & Domainsi

Sequence similaritiesi

Contains protein kinase domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000115195.
InParanoidiQ9VZI2.
KOiK08252.
OMAiHAKERKS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VZI2-1 [UniParc]FASTAAdd to Basket

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MTSTSAVDGG LGSETAWLED LLREVQLEQF LDRIRDDLQV TRLAHFDYVL     50
PDDLERCGLG KPAIRRLMEA VRKKKAHQWR KNILSKLIGG GKQPSSKKQS 100
SAARESSQGN GTQLTCLIHE KDITMGLKLG DGSFGVVRRG EWSASPAGKV 150
IPVAVKVLKS DNLTQPGIID DFFREVQAMH ALDHANLVRL YGVVLSQPMM 200
MITELAERGS LLDTLRKQCR HTSLTIIWNW SVQIVTGMAY LEQKRFLHRD 250
LACRNVLLAA GNKIKIGDFG LMRALPQEDD CYVMSEHKKV PFPWCAPESL 300
RFRQFSHASD TWMFGVTLWE MFSFGEDPWV GLNGSQILRK IDREGERLHQ 350
PDACPPDVYA MMLQCWDKTP AERPTFAALK EYLASMSPPV MRASRSHHES 400
KGLQIEPGDT IAIIDGRHEL KLIKGQNQRT FDIGIFPRNL LEQRKVGAAG 450
DVVMRSSVGN GSSSSPFGFC WGGAAAMANG DDRQRKCASM TNQPHAKERK 500
STSSKQFAYN KLVNDSATGL QRRNAVKHKG VVVGPQRPPP PQFQQEGILI 550
DISPDMRPIA EAGTGGAKGA GDSSSLQADS SFCILDAPID VPTYAGSSGS 600
GDLNVSPTYY NEQPQFDFDP AKMTASPGRL QPPPYQMPPT YSNTMEFVQK 650
RDLHQQQLAT PVRERDPFDT TNVETTVALY SNFNQSLEAA SPPAPIYNSP 700
SVRKSLFGGS KSNKENIPAL ESAAMQLNLS NLTLERHDAT CIQPVEPVPA 750
PPGDGVLLDK SFIAELEKDM YSNGQNRAQE EYQRNSTQMY ASKDMVYKQN 800
LTPLKNGAAP GSVHSNHSSP SSTASPKQNN VEAAAAAAAT TQSVVNRIWY 850
EQVASTQSEY YAQPPTEQAE EQIYQNHRHQ QQQQQELNHS FVAISNRVVA 900
PKNNAYSSTA SLYDAVAAST AGSTYYGQVP NGSGAVLYDE VTQDDYLRPT 950
RPAPLAPPPL SAQQIQRRME KMRLQQQQQL DGAHQLYAPV PSDYGREQEK 1000
LQQLMQELGS SAVEQDVRNA LRAASGDVGL ATRHYKIDQL ARLGVAGRPQ 1050
CEQALQQTNW SLEVAAELLL NAG 1073
Length:1,073
Mass (Da):118,418
Last modified:March 1, 2001 - v2
Checksum:iD9BF4BD87235D691
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF181642 mRNA. Translation: AAD55428.1.
AE014296 Genomic DNA. Translation: AAF47839.2.
RefSeqiNP_647859.1. NM_139602.3.
UniGeneiDm.3018.

Genome annotation databases

EnsemblMetazoaiFBtr0073211; FBpp0073067; FBgn0028484.
GeneIDi38489.
KEGGidme:Dmel_CG14992.
UCSCiCG14992-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF181642 mRNA. Translation: AAD55428.1 .
AE014296 Genomic DNA. Translation: AAF47839.2 .
RefSeqi NP_647859.1. NM_139602.3.
UniGenei Dm.3018.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-833279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0073211 ; FBpp0073067 ; FBgn0028484 .
GeneIDi 38489.
KEGGi dme:Dmel_CG14992.
UCSCi CG14992-RA. d. melanogaster.

Organism-specific databases

CTDi 107482.
FlyBasei FBgn0028484. Ack.

Phylogenomic databases

GeneTreei ENSGT00740000115195.
InParanoidi Q9VZI2.
KOi K08252.
OMAi HAKERKS.

Miscellaneous databases

ChiTaRSi TNK2. drosophila.
GenomeRNAii 38489.
NextBioi 808907.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR015940. UBA/transl_elong_EF1B_N_euk.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  12. FlyBase
    Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VZI2_DROME
AccessioniPrimary (citable) accession number: Q9VZI2
Secondary accession number(s): Q9U4G3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi