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Protein

Probable 6-phosphogluconolactonase

Gene

CG17333

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.By similarity

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.By similarity

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (Zw), Glucose-6-phosphate 1-dehydrogenase (Zw-RA), Glucose-6-phosphate 1-dehydrogenase (CG7140), Glucose-6-phosphate 1-dehydrogenase (Zw)
  2. Probable 6-phosphogluconolactonase (CG17333)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd), 6-phosphogluconate dehydrogenase, decarboxylating (Pgd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00409.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 6-phosphogluconolactonase (EC:3.1.1.31)
Short name:
6PGL
Gene namesi
ORF Names:CG17333
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030239. CG17333.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000900811 – 243Probable 6-phosphogluconolactonaseAdd BLAST243

Proteomic databases

PaxDbiQ9VZ64.
PRIDEiQ9VZ64.

Expressioni

Gene expression databases

BgeeiFBgn0030239.
GenevisibleiQ9VZ64. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0073235.

Structurei

3D structure databases

ProteinModelPortaliQ9VZ64.
SMRiQ9VZ64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
GeneTreeiENSGT00550000075110.
InParanoidiQ9VZ64.
KOiK01057.
OMAiCAYRTEW.
OrthoDBiEOG091G0NKD.
PhylomeDBiQ9VZ64.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VZ64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKKGALKV IPSASEEQLV QALGDLLQRC SQEALAKHDK FSVGLSGGSL
60 70 80 90 100
VQLLTKALKS CNLKTAKWVF FFCDERYVRL DDSDSTYGAY RAEWLTQLPC
110 120 130 140 150
IQESQFVRAD TSQPLDACAA DYEAKVKSQV DRFDLLLLGM GPDGHTCSLF
160 170 180 190 200
PEQPATLQET KRLVIPIRNS PKPPPERITF TLPLINKARN VAFVVTGAAK
210 220 230 240
ASVVKSVFVD LDKKFPAAWV NPTKGQLTLI VDAGAGKEIE TLK
Length:243
Mass (Da):26,672
Last modified:May 1, 2000 - v1
Checksum:i0E23EFDCF5FE042E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF47963.1.
BT012304 mRNA. Translation: AAS77429.1.
RefSeqiNP_572656.1. NM_132428.3.
UniGeneiDm.23623.

Genome annotation databases

EnsemblMetazoaiFBtr0073379; FBpp0073235; FBgn0030239.
GeneIDi32013.
KEGGidme:Dmel_CG17333.
UCSCiCG17333-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF47963.1.
BT012304 mRNA. Translation: AAS77429.1.
RefSeqiNP_572656.1. NM_132428.3.
UniGeneiDm.23623.

3D structure databases

ProteinModelPortaliQ9VZ64.
SMRiQ9VZ64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0073235.

Proteomic databases

PaxDbiQ9VZ64.
PRIDEiQ9VZ64.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073379; FBpp0073235; FBgn0030239.
GeneIDi32013.
KEGGidme:Dmel_CG17333.
UCSCiCG17333-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0030239. CG17333.

Phylogenomic databases

eggNOGiKOG3147. Eukaryota.
COG0363. LUCA.
GeneTreeiENSGT00550000075110.
InParanoidiQ9VZ64.
KOiK01057.
OMAiCAYRTEW.
OrthoDBiEOG091G0NKD.
PhylomeDBiQ9VZ64.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409.
ReactomeiR-DME-71336. Pentose phosphate pathway (hexose monophosphate shunt).

Miscellaneous databases

GenomeRNAii32013.
PROiQ9VZ64.

Gene expression databases

BgeeiFBgn0030239.
GenevisibleiQ9VZ64. DM.

Family and domain databases

CDDicd01400. 6PGL. 1 hit.
InterProiIPR005900. 6-phosphogluconolactonase_DevB.
IPR006148. Glc/Gal-6P_isomerase.
[Graphical view]
PfamiPF01182. Glucosamine_iso. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01198. pgl. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry namei6PGL_DROME
AccessioniPrimary (citable) accession number: Q9VZ64
Secondary accession number(s): Q53XD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.