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Protein

GTP-binding nuclear protein Ran

Gene

Ran

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. RanGTP modulates both spindle and nuclear envelope assembly supporting a mitotic role of Ran.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248GTPBy similarity
Nucleotide bindingi65 – 695GTPBy similarity
Nucleotide bindingi122 – 1254GTPBy similarity

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB

GO - Biological processi

  • actin filament organization Source: FlyBase
  • cell adhesion Source: FlyBase
  • cell cycle Source: UniProtKB
  • cell division Source: UniProtKB-KW
  • cellular response to starvation Source: FlyBase
  • establishment of mitotic spindle orientation Source: FlyBase
  • intracellular protein transport Source: UniProtKB
  • meiotic spindle organization Source: FlyBase
  • mitotic nuclear division Source: UniProtKB-KW
  • neuron projection morphogenesis Source: FlyBase
  • protein export from nucleus Source: FlyBase
  • regulation of cell shape Source: FlyBase
  • regulation of mitotic cell cycle Source: FlyBase
  • regulation of protein localization Source: FlyBase
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-DME-203927. MicroRNA (miRNA) biogenesis.
R-DME-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran
Alternative name(s):
Ras-related nuclear protein
Gene namesi
Name:RanImported
Synonyms:Ran10A
ORF Names:CG1404Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0020255. Ran.

Subcellular locationi

GO - Cellular componenti

  • cell cortex Source: FlyBase
  • cytoplasm Source: UniProtKB
  • lipid particle Source: FlyBase
  • microtubule associated complex Source: FlyBase
  • mitotic spindle Source: FlyBase
  • nuclear microtubule Source: UniProtKB
  • nucleus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216GTP-binding nuclear protein RanPRO_0000208710Add
BLAST

Proteomic databases

PaxDbiQ9VZ23.
PRIDEiQ9VZ23.

Expressioni

Gene expression databases

BgeeiQ9VZ23.
ExpressionAtlasiQ9VZ23. differential.
GenevisibleiQ9VZ23. DM.

Interactioni

Subunit structurei

Interacts with tamo.1 Publication

Protein-protein interaction databases

BioGridi68814. 4 interactions.
IntActiQ9VZ23. 5 interactions.
MINTiMINT-943398.
STRINGi7227.FBpp0073328.

Structurei

3D structure databases

ProteinModelPortaliQ9VZ23.
SMRiQ9VZ23. Positions 11-196.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
InParanoidiQ9VZ23.
KOiK07936.
OMAiQYQQEME.
OrthoDBiEOG7C8GJ1.
PhylomeDBiQ9VZ23.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VZ23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEGQDIPT FKCVLVGDGG TGKTTFVKRH MTGEFEKKYV ATLGVEVHPL
60 70 80 90 100
IFHTNRGAIR FNVWDTAGQE KFGGLRDGYY IQGQCAVIMF DVTSRVTYKN
110 120 130 140 150
VPNWHRDLVR VCENIPIVLC GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS
160 170 180 190 200
AKSNYNFEKP FLWLARKLVG DPNLEFVAMP ALLPPEVKMD KDWQAQIERD
210
LQEAQATALP DEDEEL
Length:216
Mass (Da):24,708
Last modified:May 1, 2000 - v1
Checksum:i95916B5D4C3413F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti90 – 934FDVT → VDGN in AAF30287 (Ref. 2) Curated
Sequence conflicti163 – 1642WL → CW in AAF30287 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233584 mRNA. Translation: AAF60289.1.
AF220950 mRNA. Translation: AAF30287.1.
AE014298 Genomic DNA. Translation: AAF48008.1.
AY061398 mRNA. Translation: AAL28946.1.
AY070533 mRNA. Translation: AAL48004.1.
BT003574 mRNA. Translation: AAO39578.1.
AF233585 mRNA. Translation: AAF60290.1.
RefSeqiNP_001285111.1. NM_001298182.1.
NP_001285112.1. NM_001298183.1.
NP_651969.1. NM_143712.4.
NP_727499.1. NM_167272.3.
UniGeneiDm.6755.

Genome annotation databases

EnsemblMetazoaiFBtr0073471; FBpp0073327; FBgn0020255.
FBtr0073472; FBpp0073328; FBgn0020255.
FBtr0340164; FBpp0309150; FBgn0020255.
FBtr0340165; FBpp0309151; FBgn0020255.
GeneIDi44072.
KEGGidme:Dmel_CG1404.
UCSCiCG1404-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233584 mRNA. Translation: AAF60289.1.
AF220950 mRNA. Translation: AAF30287.1.
AE014298 Genomic DNA. Translation: AAF48008.1.
AY061398 mRNA. Translation: AAL28946.1.
AY070533 mRNA. Translation: AAL48004.1.
BT003574 mRNA. Translation: AAO39578.1.
AF233585 mRNA. Translation: AAF60290.1.
RefSeqiNP_001285111.1. NM_001298182.1.
NP_001285112.1. NM_001298183.1.
NP_651969.1. NM_143712.4.
NP_727499.1. NM_167272.3.
UniGeneiDm.6755.

3D structure databases

ProteinModelPortaliQ9VZ23.
SMRiQ9VZ23. Positions 11-196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68814. 4 interactions.
IntActiQ9VZ23. 5 interactions.
MINTiMINT-943398.
STRINGi7227.FBpp0073328.

Proteomic databases

PaxDbiQ9VZ23.
PRIDEiQ9VZ23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073471; FBpp0073327; FBgn0020255.
FBtr0073472; FBpp0073328; FBgn0020255.
FBtr0340164; FBpp0309150; FBgn0020255.
FBtr0340165; FBpp0309151; FBgn0020255.
GeneIDi44072.
KEGGidme:Dmel_CG1404.
UCSCiCG1404-RA. d. melanogaster.

Organism-specific databases

CTDi5901.
FlyBaseiFBgn0020255. Ran.

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
InParanoidiQ9VZ23.
KOiK07936.
OMAiQYQQEME.
OrthoDBiEOG7C8GJ1.
PhylomeDBiQ9VZ23.

Enzyme and pathway databases

ReactomeiR-DME-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-DME-203927. MicroRNA (miRNA) biogenesis.
R-DME-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

ChiTaRSiran. fly.
GenomeRNAii44072.
NextBioi836708.
PROiQ9VZ23.

Gene expression databases

BgeeiQ9VZ23.
ExpressionAtlasiQ9VZ23. differential.
GenevisibleiQ9VZ23. DM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Drosophila Ran10A GTPase."
    Nguyen H.T., Frasch M.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Drosophila Ran ORF."
    Stivers C.W., Brody T., Odenwald W.F.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley1 Publication.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BerkeleyImported.
    Tissue: Embryo1 Publication and Ovary1 Publication.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BerkeleyImported.
    Tissue: Embryo.
  7. Drivas G., Frasch M.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-21.
  8. "Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos."
    Trieselmann N., Wilde A.
    Curr. Biol. 12:1124-1129(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Embryo1 Publication.
  9. "Tamo selectively modulates nuclear import in Drosophila."
    Minakhina S., Yang J., Steward R.
    Genes Cells 8:299-310(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TAMO, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRAN_DROME
AccessioniPrimary (citable) accession number: Q9VZ23
Secondary accession number(s): Q9NH14, Q9NHN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.