FucT6

Functionⁱ

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated.1 Publication

Catalytic activityⁱ

GDP-beta-L-fucose + N₄-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N₄-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.1 Publication

Cofactorⁱ

Mn²⁺By similarity, Mg²⁺By similarityNote: May also use Ca²⁺. The enzyme has substantial activity without divalent cations.By similarity

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functionⁱ

alpha-(1->6)-fucosyltransferase activity
Source: FlyBase
Inferred from direct assayⁱ
- 15604090
glycoprotein 6-alpha-L-fucosyltransferase activity Source: UniProtKB
metal ion binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

GDP-L-fucose metabolic process Source: UniProtKB
N-glycan fucosylation Source: GO_Central
protein glycosylation in Golgi Source: InterPro
protein N-linked glycosylation Source: GO_Central
protein N-linked glycosylation via asparagine Source: UniProtKB

Complete GO annotation...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Ligand	Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-DME-975578. Reactions specific to the complex N-glycan synthesis pathway.
UniPathwayⁱ	UPA00378.

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT23. Glycosyltransferase Family 23.

CAZyⁱ

GT23. Glycosyltransferase Family 23.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-(1,6)-fucosyltransferase (EC:2.4.1.681 Publication) Short name: Alpha1-6FucT Alternative name(s): GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase GDP-fucose--glycoprotein fucosyltransferase Glycoprotein 6-alpha-L-fucosyltransferase
Gene namesⁱ	Name:FucT6 ORF Names:CG2448
Organismⁱ	Drosophila melanogaster (Fruit fly)Imported
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome X

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0030327. FucT6.

FlyBaseⁱ

FBgn0030327. FucT6.

Subcellular locationⁱ

Golgi apparatus › Golgi stack membrane By similarity; Single-pass type II membrane protein By similarity

Note:

Membrane-bound form in trans cisternae of Golgi.By similarity

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 17	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	18 – 38	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	39 – 619	LumenalSequence analysisAdd BLAST	581

GO - Cellular componentⁱ

Golgi cisterna membrane Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080530	1 – 619	Alpha-(1,6)-fucosyltransferaseAdd BLAST		619

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	253 ↔ 315	By similarity
Disulfide bondⁱ	261 ↔ 279	By similarity
Disulfide bondⁱ	267 ↔ 271	By similarity
Disulfide bondⁱ	511 ↔ 518	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q9VYV5.
PRIDEⁱ	Q9VYV5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	FBgn0030327.
Genevisibleⁱ	Q9VYV5. DM.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	58529. 3 interactors.
Database of interacting proteins More...DIPⁱ	DIP-21409N.
IntActⁱ	Q9VYV5. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-900962.
STRINGⁱ	7227.FBpp0073457.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9VYV5.
SMRⁱ	Q9VYV5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	255 – 539	GT23PROSITE-ProRule annotationAdd BLAST		285
Domainⁱ	548 – 609	SH3By similarityAdd BLAST		62

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	411 – 412	Important for donor substrate bindingPROSITE-ProRule annotation		2

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	345 – 351	SH3-bindingSequence analysis		7

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 23 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

SH3 domain, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3705. Eukaryota. ENOG410YHM8. LUCA.
InParanoidⁱ	Q9VYV5.
KEGG Orthology (KO) More...KOⁱ	K00717.
OMAⁱ	NARKLVC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05GD.
PhylomeDBⁱ	Q9VYV5.

Family and domain databases

InterProⁱ	View protein in InterPro IPR015827. Alpha1_6FUT_euk. IPR027350. GT23_dom. IPR001452. SH3_domain.
PIRSFⁱ	PIRSF000472. Alpha1_6FUT_euk. 1 hit.
SUPFAMⁱ	SSF50044. SSF50044. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51659. GT23. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9VYV5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLVRQLFGA SANSWARALI IFVLAWIGLV YVFVVKLTNT QGQQAAGESE 
        60         70         80         90        100
LNARRISQAL QMLEHTRQRN EELKQLIDEL MSDQLDKQSA MKLVQRLEND 
       110        120        130        140        150
ALNPKLAPEV AGPEPESMFE SAPADLRGWN NVAEGAPNDL EAGVPDHGEF 
       160        170        180        190        200
EPSLEYEFTR RRIQTNIGEI WNFFSSELGK VRKAVAAGHA SADLEESINQ 
       210        220        230        240        250
VLLQGAEHKR SLLSDMERMR QSDGYEAWRH KEARDLSDLV QRRLHHLQNP 
       260        270        280        290        300
SDCQNARKLV CKLNKGCGYG CQLHHVVYCF IVAYATERTL ILKSRGWRYH 
       310        320        330        340        350
KGGWEEVFQP VSNSCHDAGT ANTYNWPGKP NTQVLVLPII DSLMPRPPYL 
       360        370        380        390        400
PLAVPEDLAP RLKRLHGDPI VWWVGQFLKY LLRPQPTTRD FLTSGMRNLG 
       410        420        430        440        450
WERPIVGVHV RRTDKVGTEA ACHSVEEYMT YVEDYYRTLE VNGSTVARRI 
       460        470        480        490        500
FLASDDAQVI EEARRKYPQY QIIGDPEVAR MASVSTRYTD TALNGIILDI 
       510        520        530        540        550
HLLSMSDHLV CTFSSQVCRV AYEIMQTMYP DAAHRFKSLD DIYYYGGQNA 
       560        570        580        590        600
HNRRVVIAHK PRTHEDLQLR VGDLVSVAGN HWDGNSKGKN TRTNQGGLFP 
       610 
SFKVEEKVDT AKLPLYAGI

Length:619

Mass (Da):70,206

Last modified:May 1, 2000 - v1

Checksum:ⁱ691BFD9B5C6557DE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441264 mRNA. Translation: AAN63649.1. AE014298 Genomic DNA. Translation: AAF48079.1. AY051451 mRNA. Translation: AAK92875.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_572740.1. NM_132512.4.
UniGeneⁱ	Dm.4605.

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0073620; FBpp0073457; FBgn0030327.
GeneIDⁱ	32122.
KEGGⁱ	dme:Dmel_CG2448.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441264 mRNA. Translation: AAN63649.1. AE014298 Genomic DNA. Translation: AAF48079.1. AY051451 mRNA. Translation: AAK92875.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_572740.1. NM_132512.4.
UniGeneⁱ	Dm.4605.

3D structure databases

ProteinModelPortalⁱ	Q9VYV5.
SMRⁱ	Q9VYV5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	58529. 3 interactors.
Database of interacting proteins More...DIPⁱ	DIP-21409N.
IntActⁱ	Q9VYV5. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-900962.
STRINGⁱ	7227.FBpp0073457.

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT23. Glycosyltransferase Family 23.

CAZyⁱ

GT23. Glycosyltransferase Family 23.

Proteomic databases

PaxDbⁱ	Q9VYV5.
PRIDEⁱ	Q9VYV5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0073620; FBpp0073457; FBgn0030327.
GeneIDⁱ	32122.
KEGGⁱ	dme:Dmel_CG2448.

Organism-specific databases

CTDⁱ	32122.
Drosophila genome database More...FlyBaseⁱ	FBgn0030327. FucT6.

Phylogenomic databases

eggNOGⁱ	KOG3705. Eukaryota. ENOG410YHM8. LUCA.
InParanoidⁱ	Q9VYV5.
KEGG Orthology (KO) More...KOⁱ	K00717.
OMAⁱ	NARKLVC.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05GD.
PhylomeDBⁱ	Q9VYV5.

Enzyme and pathway databases

UniPathwayⁱ	UPA00378.
Reactomeⁱ	R-DME-975578. Reactions specific to the complex N-glycan synthesis pathway.

Miscellaneous databases

ChiTaRSⁱ	FucT6. fly.
GenomeRNAiⁱ	32122.
Protein Ontology More...PROⁱ	PR:Q9VYV5.

Gene expression databases

Bgeeⁱ	FBgn0030327.
Genevisibleⁱ	Q9VYV5. DM.

Family and domain databases

InterProⁱ	View protein in InterPro IPR015827. Alpha1_6FUT_euk. IPR027350. GT23_dom. IPR001452. SH3_domain.
PIRSFⁱ	PIRSF000472. Alpha1_6FUT_euk. 1 hit.
SUPFAMⁱ	SSF50044. SSF50044. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51659. GT23. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FUT8_DROME
Accessionⁱ	Q9VYV5Primary (citable) accession number: Q9VYV5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
	Last sequence update:	May 1, 2000
	Last modified:	July 5, 2017
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

UniProtKB

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9VYV5 (FUT8_DROME)

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Alpha-(1,6)-fucosyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ