FucT6

Functionⁱ

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated.1 Publication

Catalytic activityⁱ

GDP-beta-L-fucose + N₄-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N₄-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.1 Publication

Cofactorⁱ

Mn²⁺By similarity, Mg²⁺By similarityNote: May also use Ca²⁺. The enzyme has substantial activity without divalent cations.By similarity

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functionⁱ

alpha-(1->6)-fucosyltransferase activity
Source: FlyBase
Inferred from direct assayⁱ
- 15604090
glycoprotein 6-alpha-L-fucosyltransferase activity Source: UniProtKB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

GDP-L-fucose metabolic process Source: UniProtKB
N-glycan fucosylation Source: GO_Central
protein glycosylation in Golgi Source: InterPro
protein N-linked glycosylation Source: GO_Central
protein N-linked glycosylation via asparagine Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase
Ligand	Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-DME-975578 Reactions specific to the complex N-glycan synthesis pathway
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT23 Glycosyltransferase Family 23

CAZyⁱ

GT23 Glycosyltransferase Family 23

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Alpha-(1,6)-fucosyltransferase (EC:2.4.1.681 Publication) Short name: Alpha1-6FucT Alternative name(s): GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase GDP-fucose--glycoprotein fucosyltransferase Glycoprotein 6-alpha-L-fucosyltransferase
Gene namesⁱ	Name:FucT6 ORF Names:CG2448
Organismⁱ	Drosophila melanogaster (Fruit fly)Imported
Taxonomic identifierⁱ	7227 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › melanogaster group › melanogaster subgroup
Proteomesⁱ	UP000000803 Componentⁱ: Chromosome X

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0030327 FucT6

FlyBaseⁱ

FBgn0030327 FucT6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 17	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	18 – 38	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	39 – 619	LumenalSequence analysisAdd BLAST	581

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080530	1 – 619	Alpha-(1,6)-fucosyltransferaseAdd BLAST		619

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	253 ↔ 315	By similarity
Disulfide bondⁱ	261 ↔ 279	By similarity
Disulfide bondⁱ	267 ↔ 271	By similarity
Disulfide bondⁱ	511 ↔ 518	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q9VYV5
PRIDEⁱ	Q9VYV5

Expressionⁱ

Gene expression databases

Bgeeⁱ	FBgn0030327
Genevisibleⁱ	Q9VYV5 DM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	585293 interactors.
Database of interacting proteins More...DIPⁱ	DIP-21409N
IntActⁱ	Q9VYV5 3 interactors.
STRINGⁱ	7227.FBpp0073457

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9VYV5
SMRⁱ	Q9VYV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	255 – 539	GT23PROSITE-ProRule annotationAdd BLAST		285
Domainⁱ	548 – 609	SH3PROSITE-ProRule annotationAdd BLAST		62

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	411 – 412	Important for donor substrate bindingPROSITE-ProRule annotation		2

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	345 – 351	SH3-bindingSequence analysis		7

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 23 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

SH3 domain, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3705 Eukaryota ENOG410YHM8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063737
InParanoidⁱ	Q9VYV5
KEGG Orthology (KO) More...KOⁱ	K00717
OMAⁱ	VCKLNKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05GD
PhylomeDBⁱ	Q9VYV5

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11792 SH3_Fut8, 1 hit
InterProⁱ	View protein in InterPro IPR015827 Fut8 IPR035653 Fut8_SH3 IPR027350 GT23_dom IPR036028 SH3-like_dom_sf
PIRSFⁱ	PIRSF000472 Alpha1_6FUT_euk, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51659 GT23, 1 hit PS50002 SH3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9VYV5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLLVRQLFGA SANSWARALI IFVLAWIGLV YVFVVKLTNT QGQQAAGESE 
        60         70         80         90        100
LNARRISQAL QMLEHTRQRN EELKQLIDEL MSDQLDKQSA MKLVQRLEND 
       110        120        130        140        150
ALNPKLAPEV AGPEPESMFE SAPADLRGWN NVAEGAPNDL EAGVPDHGEF 
       160        170        180        190        200
EPSLEYEFTR RRIQTNIGEI WNFFSSELGK VRKAVAAGHA SADLEESINQ 
       210        220        230        240        250
VLLQGAEHKR SLLSDMERMR QSDGYEAWRH KEARDLSDLV QRRLHHLQNP 
       260        270        280        290        300
SDCQNARKLV CKLNKGCGYG CQLHHVVYCF IVAYATERTL ILKSRGWRYH 
       310        320        330        340        350
KGGWEEVFQP VSNSCHDAGT ANTYNWPGKP NTQVLVLPII DSLMPRPPYL 
       360        370        380        390        400
PLAVPEDLAP RLKRLHGDPI VWWVGQFLKY LLRPQPTTRD FLTSGMRNLG 
       410        420        430        440        450
WERPIVGVHV RRTDKVGTEA ACHSVEEYMT YVEDYYRTLE VNGSTVARRI 
       460        470        480        490        500
FLASDDAQVI EEARRKYPQY QIIGDPEVAR MASVSTRYTD TALNGIILDI 
       510        520        530        540        550
HLLSMSDHLV CTFSSQVCRV AYEIMQTMYP DAAHRFKSLD DIYYYGGQNA 
       560        570        580        590        600
HNRRVVIAHK PRTHEDLQLR VGDLVSVAGN HWDGNSKGKN TRTNQGGLFP 
       610 
SFKVEEKVDT AKLPLYAGI

Length:619

Mass (Da):70,206

Last modified:May 1, 2000 - v1

Checksum:ⁱ691BFD9B5C6557DE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441264 mRNA Translation: AAN63649.1 AE014298 Genomic DNA Translation: AAF48079.1 AY051451 mRNA Translation: AAK92875.1
NCBI Reference Sequences More...RefSeqⁱ	NP_572740.1, NM_132512.4
UniGeneⁱ	Dm.4605

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0073620; FBpp0073457; FBgn0030327
GeneIDⁱ	32122
KEGGⁱ	dme:Dmel_CG2448

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9VYV5	UPI0007E6A87D UPI000A1CFF60 UPI0007E7AA6F UPI0007E70B22 A0A1W4WBG7 UPI0007E69C31 UPI0007E7B3E3 B3NUA1 B4IK51 B4Q1S1 +5	Drosophila kikkawai (Fruit fly) Drosophila serrata (Fruit fly) Drosophila takahashii (Fruit fly) Drosophila elegans (Fruit fly) Drosophila ficusphila (Fruit fly) Drosophila eugracilis (Fruit fly) Drosophila rhopaloa (Fruit fly) Drosophila erecta (Fruit fly) Drosophila sechellia (Fruit fly) Drosophila yakuba (Fruit fly) And more	619	UniRef90_Q9VYV5	Cluster: Alpha-(1,6)-fucosyltransferase	16

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q9VYV5	UPI0007E6A87D UPI000A1CFF60 UPI0007E7AA6F UPI0007E70B22 A0A1W4WBG7 UPI0007E69C31 UPI0007E7B3E3 B4IK51 B3NUA1 UPI00078AECEF +20	Drosophila kikkawai (Fruit fly) Drosophila serrata (Fruit fly) Drosophila takahashii (Fruit fly) Drosophila elegans (Fruit fly) Drosophila ficusphila (Fruit fly) Drosophila eugracilis (Fruit fly) Drosophila rhopaloa (Fruit fly) Drosophila sechellia (Fruit fly) Drosophila erecta (Fruit fly) Drosophila simulans (Fruit fly) And more	619	UniRef50_Q9VYV5	Cluster: Alpha-(1,6)-fucosyltransferase	31

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF441264 mRNA Translation: AAN63649.1 AE014298 Genomic DNA Translation: AAF48079.1 AY051451 mRNA Translation: AAK92875.1
NCBI Reference Sequences More...RefSeqⁱ	NP_572740.1, NM_132512.4
UniGeneⁱ	Dm.4605

3D structure databases

ProteinModelPortalⁱ	Q9VYV5
SMRⁱ	Q9VYV5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	585293 interactors.
Database of interacting proteins More...DIPⁱ	DIP-21409N
IntActⁱ	Q9VYV5 3 interactors.
STRINGⁱ	7227.FBpp0073457

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT23 Glycosyltransferase Family 23

CAZyⁱ

GT23 Glycosyltransferase Family 23

Proteomic databases

PaxDbⁱ	Q9VYV5
PRIDEⁱ	Q9VYV5

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0073620; FBpp0073457; FBgn0030327
GeneIDⁱ	32122
KEGGⁱ	dme:Dmel_CG2448

Organism-specific databases

CTDⁱ	32122
Drosophila genome database More...FlyBaseⁱ	FBgn0030327 FucT6

Phylogenomic databases

eggNOGⁱ	KOG3705 Eukaryota ENOG410YHM8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063737
InParanoidⁱ	Q9VYV5
KEGG Orthology (KO) More...KOⁱ	K00717
OMAⁱ	VCKLNKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05GD
PhylomeDBⁱ	Q9VYV5

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
Reactomeⁱ	R-DME-975578 Reactions specific to the complex N-glycan synthesis pathway

Miscellaneous databases

ChiTaRSⁱ	FucT6 fly
GenomeRNAiⁱ	32122
Protein Ontology More...PROⁱ	PR:Q9VYV5

Gene expression databases

Bgeeⁱ	FBgn0030327
Genevisibleⁱ	Q9VYV5 DM

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd11792 SH3_Fut8, 1 hit
InterProⁱ	View protein in InterPro IPR015827 Fut8 IPR035653 Fut8_SH3 IPR027350 GT23_dom IPR036028 SH3-like_dom_sf
PIRSFⁱ	PIRSF000472 Alpha1_6FUT_euk, 1 hit
SUPFAMⁱ	SSF50044 SSF50044, 1 hit
PROSITEⁱ	View protein in PROSITE PS51659 GT23, 1 hit PS50002 SH3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FUT8_DROME
Accessionⁱ	Q9VYV5Primary (citable) accession number: Q9VYV5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
	Last sequence update:	May 1, 2000
	Last modified:	March 28, 2018
	This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Drosophila annotation project

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9VYV5 (FUT8_DROME)

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Alpha-(1,6)-fucosyltransferase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Golgi apparatus

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ