UniProtKB - Q9VYV5 (FUT8_DROME)
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Protein
Alpha-(1,6)-fucosyltransferase
Gene
FucT6
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated.1 Publication
Catalytic activityi
GDP-beta-L-fucose + N4-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N4-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.1 Publication
Cofactori
Mn2+By similarity, Mg2+By similarityNote: May also use Ca2+. The enzyme has substantial activity without divalent cations.By similarity
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- alpha-(1->6)-fucosyltransferase activity Source: FlyBase
- glycoprotein 6-alpha-L-fucosyltransferase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- GDP-L-fucose metabolic process Source: UniProtKB
- N-glycan fucosylation Source: GO_Central
- protein glycosylation in Golgi Source: InterPro
- protein N-linked glycosylation Source: GO_Central
- protein N-linked glycosylation via asparagine Source: UniProtKB
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Ligand | Magnesium, Manganese, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DME-975578 Reactions specific to the complex N-glycan synthesis pathway |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT23 Glycosyltransferase Family 23 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-(1,6)-fucosyltransferase (EC:2.4.1.681 Publication)Short name: Alpha1-6FucT Alternative name(s): GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase GDP-fucose--glycoprotein fucosyltransferase Glycoprotein 6-alpha-L-fucosyltransferase |
Gene namesi | Name:FucT6 ORF Names:CG2448 |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0030327 FucT6 |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 39 – 619 | LumenalSequence analysisAdd BLAST | 581 |
Keywords - Cellular componenti
Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080530 | 1 – 619 | Alpha-(1,6)-fucosyltransferaseAdd BLAST | 619 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 253 ↔ 315 | By similarity | ||
Disulfide bondi | 261 ↔ 279 | By similarity | ||
Disulfide bondi | 267 ↔ 271 | By similarity | ||
Disulfide bondi | 511 ↔ 518 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q9VYV5 |
PRIDEi | Q9VYV5 |
Interactioni
Protein-protein interaction databases
BioGridi | 585293 interactors. |
DIPi | DIP-21409N |
IntActi | Q9VYV5 3 interactors. |
STRINGi | 7227.FBpp0073457 |
Structurei
3D structure databases
ProteinModelPortali | Q9VYV5 |
SMRi | Q9VYV5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 255 – 539 | GT23PROSITE-ProRule annotationAdd BLAST | 285 | |
Domaini | 548 – 609 | SH3PROSITE-ProRule annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 411 – 412 | Important for donor substrate bindingPROSITE-ProRule annotation | 2 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 345 – 351 | SH3-bindingSequence analysis | 7 |
Sequence similaritiesi
Belongs to the glycosyltransferase 23 family.PROSITE-ProRule annotation
Keywords - Domaini
SH3 domain, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3705 Eukaryota ENOG410YHM8 LUCA |
GeneTreei | ENSGT00530000063737 |
InParanoidi | Q9VYV5 |
KOi | K00717 |
OMAi | VCKLNKG |
OrthoDBi | EOG091G05GD |
PhylomeDBi | Q9VYV5 |
Family and domain databases
CDDi | cd11792 SH3_Fut8, 1 hit |
InterProi | View protein in InterPro IPR015827 Fut8 IPR035653 Fut8_SH3 IPR027350 GT23_dom IPR036028 SH3-like_dom_sf |
PIRSFi | PIRSF000472 Alpha1_6FUT_euk, 1 hit |
SUPFAMi | SSF50044 SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS51659 GT23, 1 hit PS50002 SH3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9VYV5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLVRQLFGA SANSWARALI IFVLAWIGLV YVFVVKLTNT QGQQAAGESE
60 70 80 90 100
LNARRISQAL QMLEHTRQRN EELKQLIDEL MSDQLDKQSA MKLVQRLEND
110 120 130 140 150
ALNPKLAPEV AGPEPESMFE SAPADLRGWN NVAEGAPNDL EAGVPDHGEF
160 170 180 190 200
EPSLEYEFTR RRIQTNIGEI WNFFSSELGK VRKAVAAGHA SADLEESINQ
210 220 230 240 250
VLLQGAEHKR SLLSDMERMR QSDGYEAWRH KEARDLSDLV QRRLHHLQNP
260 270 280 290 300
SDCQNARKLV CKLNKGCGYG CQLHHVVYCF IVAYATERTL ILKSRGWRYH
310 320 330 340 350
KGGWEEVFQP VSNSCHDAGT ANTYNWPGKP NTQVLVLPII DSLMPRPPYL
360 370 380 390 400
PLAVPEDLAP RLKRLHGDPI VWWVGQFLKY LLRPQPTTRD FLTSGMRNLG
410 420 430 440 450
WERPIVGVHV RRTDKVGTEA ACHSVEEYMT YVEDYYRTLE VNGSTVARRI
460 470 480 490 500
FLASDDAQVI EEARRKYPQY QIIGDPEVAR MASVSTRYTD TALNGIILDI
510 520 530 540 550
HLLSMSDHLV CTFSSQVCRV AYEIMQTMYP DAAHRFKSLD DIYYYGGQNA
560 570 580 590 600
HNRRVVIAHK PRTHEDLQLR VGDLVSVAGN HWDGNSKGKN TRTNQGGLFP
610
SFKVEEKVDT AKLPLYAGI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF441264 mRNA Translation: AAN63649.1 AE014298 Genomic DNA Translation: AAF48079.1 AY051451 mRNA Translation: AAK92875.1 |
RefSeqi | NP_572740.1, NM_132512.4 |
UniGenei | Dm.4605 |
Genome annotation databases
EnsemblMetazoai | FBtr0073620; FBpp0073457; FBgn0030327 |
GeneIDi | 32122 |
KEGGi | dme:Dmel_CG2448 |
Similar proteinsi
Entry informationi
Entry namei | FUT8_DROME | |
Accessioni | Q9VYV5Primary (citable) accession number: Q9VYV5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | May 1, 2000 | |
Last modified: | March 28, 2018 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |