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Q9VYV5

- FUT8_DROME

UniProt

Q9VYV5 - FUT8_DROME

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Protein
Alpha-(1,6)-fucosyltransferase
Gene
FucT6, CG2448
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans By similarity.By similarity

Catalytic activityi

GDP-beta-L-fucose + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.

Pathwayi

GO - Molecular functioni

  1. alpha-(1->6)-fucosyltransferase activity Source: FlyBase
  2. glycoprotein 6-alpha-L-fucosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. GDP-L-fucose metabolic process Source: UniProtKB
  2. N-glycan fucosylation Source: GOC
  3. fucosylation Source: GOC
  4. protein N-linked glycosylation via asparagine Source: UniProtKB
  5. protein glycosylation in Golgi Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_180687. Reactions specific to the complex N-glycan synthesis pathway.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT23. Glycosyltransferase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,6)-fucosyltransferase (EC:2.4.1.68)
Short name:
Alpha1-6FucT
Alternative name(s):
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
GDP-fucose--glycoprotein fucosyltransferase
Glycoprotein 6-alpha-L-fucosyltransferase
Gene namesi
Name:FucT6
ORF Names:CG2448
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030327. FucT6.

Subcellular locationi

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity
Note: Membrane-bound form in trans cisternae of Golgi By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei18 – 3821Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini39 – 619581Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi cisterna membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Alpha-(1,6)-fucosyltransferase
PRO_0000080530Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi253 ↔ 315 By similarity
Disulfide bondi261 ↔ 279 By similarity
Disulfide bondi267 ↔ 271 By similarity
Disulfide bondi511 ↔ 518 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9VYV5.
PRIDEiQ9VYV5.

Expressioni

Gene expression databases

BgeeiQ9VYV5.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CG3916Q9VGB81EBI-172309,EBI-147840
Ipk2Q9VPR61EBI-172309,EBI-83394

Protein-protein interaction databases

BioGridi58529. 3 interactions.
DIPiDIP-21409N.
IntActiQ9VYV5. 2 interactions.
MINTiMINT-900962.
STRINGi7227.FBpp0073457.

Structurei

3D structure databases

ProteinModelPortaliQ9VYV5.
SMRiQ9VYV5. Positions 155-616.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini255 – 539285GT23
Add
BLAST
Domaini548 – 60962SH3By similarity
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni411 – 4122Important for donor substrate binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi345 – 3517SH3-binding Reviewed predictionBy similarity

Sequence similaritiesi

Contains 1 GT23 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG251249.
GeneTreeiENSGT00530000063737.
InParanoidiQ9VYV5.
KOiK00717.
OMAiDPIVWWV.
OrthoDBiEOG7N37C3.
PhylomeDBiQ9VYV5.

Family and domain databases

InterProiIPR015827. Alpha1_6FUT_euk.
IPR027350. GT23_dom.
IPR001452. SH3_domain.
[Graphical view]
PIRSFiPIRSF000472. Alpha1_6FUT_euk. 1 hit.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS51659. GT23. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VYV5-1 [UniParc]FASTAAdd to Basket

« Hide

MLLVRQLFGA SANSWARALI IFVLAWIGLV YVFVVKLTNT QGQQAAGESE    50
LNARRISQAL QMLEHTRQRN EELKQLIDEL MSDQLDKQSA MKLVQRLEND 100
ALNPKLAPEV AGPEPESMFE SAPADLRGWN NVAEGAPNDL EAGVPDHGEF 150
EPSLEYEFTR RRIQTNIGEI WNFFSSELGK VRKAVAAGHA SADLEESINQ 200
VLLQGAEHKR SLLSDMERMR QSDGYEAWRH KEARDLSDLV QRRLHHLQNP 250
SDCQNARKLV CKLNKGCGYG CQLHHVVYCF IVAYATERTL ILKSRGWRYH 300
KGGWEEVFQP VSNSCHDAGT ANTYNWPGKP NTQVLVLPII DSLMPRPPYL 350
PLAVPEDLAP RLKRLHGDPI VWWVGQFLKY LLRPQPTTRD FLTSGMRNLG 400
WERPIVGVHV RRTDKVGTEA ACHSVEEYMT YVEDYYRTLE VNGSTVARRI 450
FLASDDAQVI EEARRKYPQY QIIGDPEVAR MASVSTRYTD TALNGIILDI 500
HLLSMSDHLV CTFSSQVCRV AYEIMQTMYP DAAHRFKSLD DIYYYGGQNA 550
HNRRVVIAHK PRTHEDLQLR VGDLVSVAGN HWDGNSKGKN TRTNQGGLFP 600
SFKVEEKVDT AKLPLYAGI 619
Length:619
Mass (Da):70,206
Last modified:May 1, 2000 - v1
Checksum:i691BFD9B5C6557DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF441264 mRNA. Translation: AAN63649.1.
AE014298 Genomic DNA. Translation: AAF48079.1.
AY051451 mRNA. Translation: AAK92875.1.
RefSeqiNP_572740.1. NM_132512.4.
UniGeneiDm.4605.

Genome annotation databases

EnsemblMetazoaiFBtr0073620; FBpp0073457; FBgn0030327.
GeneIDi32122.
KEGGidme:Dmel_CG2448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF441264 mRNA. Translation: AAN63649.1 .
AE014298 Genomic DNA. Translation: AAF48079.1 .
AY051451 mRNA. Translation: AAK92875.1 .
RefSeqi NP_572740.1. NM_132512.4.
UniGenei Dm.4605.

3D structure databases

ProteinModelPortali Q9VYV5.
SMRi Q9VYV5. Positions 155-616.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 58529. 3 interactions.
DIPi DIP-21409N.
IntActi Q9VYV5. 2 interactions.
MINTi MINT-900962.
STRINGi 7227.FBpp0073457.

Protein family/group databases

CAZyi GT23. Glycosyltransferase Family 23.

Proteomic databases

PaxDbi Q9VYV5.
PRIDEi Q9VYV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0073620 ; FBpp0073457 ; FBgn0030327 .
GeneIDi 32122.
KEGGi dme:Dmel_CG2448.

Organism-specific databases

CTDi 32122.
FlyBasei FBgn0030327. FucT6.

Phylogenomic databases

eggNOGi NOG251249.
GeneTreei ENSGT00530000063737.
InParanoidi Q9VYV5.
KOi K00717.
OMAi DPIVWWV.
OrthoDBi EOG7N37C3.
PhylomeDBi Q9VYV5.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_180687. Reactions specific to the complex N-glycan synthesis pathway.

Miscellaneous databases

ChiTaRSi FucT6. drosophila.
GenomeRNAii 32122.
NextBioi 776952.
PROi Q9VYV5.

Gene expression databases

Bgeei Q9VYV5.

Family and domain databases

InterProi IPR015827. Alpha1_6FUT_euk.
IPR027350. GT23_dom.
IPR001452. SH3_domain.
[Graphical view ]
PIRSFi PIRSF000472. Alpha1_6FUT_euk. 1 hit.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS51659. GT23. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Core a3- and a6-fucosyltransferases in Drosophila: characterization and origin of diversity."
    Petit D., Picaud F., Dupuy F., Germot A., Julien R., Maftah A.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Testis.
  5. "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism."
    Roos C., Kolmer M., Mattila P., Renkonen R.
    J. Biol. Chem. 277:3168-3175(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMOLOGY.

Entry informationi

Entry nameiFUT8_DROME
AccessioniPrimary (citable) accession number: Q9VYV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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