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Protein

Alpha-(1,6)-fucosyltransferase

Gene

FucT6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated.1 Publication

Catalytic activityi

GDP-beta-L-fucose + N4-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine = GDP + N4-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine.1 Publication

Cofactori

Mn2+By similarity, Mg2+By similarityNote: May also use Ca2+. The enzyme has substantial activity without divalent cations.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-DME-975578 Reactions specific to the complex N-glycan synthesis pathway
UniPathwayiUPA00378

Protein family/group databases

CAZyiGT23 Glycosyltransferase Family 23

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-(1,6)-fucosyltransferase (EC:2.4.1.681 Publication)
Short name:
Alpha1-6FucT
Alternative name(s):
GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase
GDP-fucose--glycoprotein fucosyltransferase
Glycoprotein 6-alpha-L-fucosyltransferase
Gene namesi
Name:FucT6
ORF Names:CG2448
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030327 FucT6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 619LumenalSequence analysisAdd BLAST581

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805301 – 619Alpha-(1,6)-fucosyltransferaseAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi253 ↔ 315By similarity
Disulfide bondi261 ↔ 279By similarity
Disulfide bondi267 ↔ 271By similarity
Disulfide bondi511 ↔ 518By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9VYV5
PRIDEiQ9VYV5

Expressioni

Gene expression databases

BgeeiFBgn0030327
GenevisibleiQ9VYV5 DM

Interactioni

Protein-protein interaction databases

BioGridi585293 interactors.
DIPiDIP-21409N
IntActiQ9VYV5 3 interactors.
STRINGi7227.FBpp0073457

Structurei

3D structure databases

ProteinModelPortaliQ9VYV5
SMRiQ9VYV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 539GT23PROSITE-ProRule annotationAdd BLAST285
Domaini548 – 609SH3PROSITE-ProRule annotationAdd BLAST62

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni411 – 412Important for donor substrate bindingPROSITE-ProRule annotation2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi345 – 351SH3-bindingSequence analysis7

Sequence similaritiesi

Belongs to the glycosyltransferase 23 family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3705 Eukaryota
ENOG410YHM8 LUCA
GeneTreeiENSGT00530000063737
InParanoidiQ9VYV5
KOiK00717
OMAiVCKLNKG
OrthoDBiEOG091G05GD
PhylomeDBiQ9VYV5

Family and domain databases

CDDicd11792 SH3_Fut8, 1 hit
InterProiView protein in InterPro
IPR015827 Fut8
IPR035653 Fut8_SH3
IPR027350 GT23_dom
IPR036028 SH3-like_dom_sf
PIRSFiPIRSF000472 Alpha1_6FUT_euk, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51659 GT23, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VYV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLVRQLFGA SANSWARALI IFVLAWIGLV YVFVVKLTNT QGQQAAGESE
60 70 80 90 100
LNARRISQAL QMLEHTRQRN EELKQLIDEL MSDQLDKQSA MKLVQRLEND
110 120 130 140 150
ALNPKLAPEV AGPEPESMFE SAPADLRGWN NVAEGAPNDL EAGVPDHGEF
160 170 180 190 200
EPSLEYEFTR RRIQTNIGEI WNFFSSELGK VRKAVAAGHA SADLEESINQ
210 220 230 240 250
VLLQGAEHKR SLLSDMERMR QSDGYEAWRH KEARDLSDLV QRRLHHLQNP
260 270 280 290 300
SDCQNARKLV CKLNKGCGYG CQLHHVVYCF IVAYATERTL ILKSRGWRYH
310 320 330 340 350
KGGWEEVFQP VSNSCHDAGT ANTYNWPGKP NTQVLVLPII DSLMPRPPYL
360 370 380 390 400
PLAVPEDLAP RLKRLHGDPI VWWVGQFLKY LLRPQPTTRD FLTSGMRNLG
410 420 430 440 450
WERPIVGVHV RRTDKVGTEA ACHSVEEYMT YVEDYYRTLE VNGSTVARRI
460 470 480 490 500
FLASDDAQVI EEARRKYPQY QIIGDPEVAR MASVSTRYTD TALNGIILDI
510 520 530 540 550
HLLSMSDHLV CTFSSQVCRV AYEIMQTMYP DAAHRFKSLD DIYYYGGQNA
560 570 580 590 600
HNRRVVIAHK PRTHEDLQLR VGDLVSVAGN HWDGNSKGKN TRTNQGGLFP
610
SFKVEEKVDT AKLPLYAGI
Length:619
Mass (Da):70,206
Last modified:May 1, 2000 - v1
Checksum:i691BFD9B5C6557DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441264 mRNA Translation: AAN63649.1
AE014298 Genomic DNA Translation: AAF48079.1
AY051451 mRNA Translation: AAK92875.1
RefSeqiNP_572740.1, NM_132512.4
UniGeneiDm.4605

Genome annotation databases

EnsemblMetazoaiFBtr0073620; FBpp0073457; FBgn0030327
GeneIDi32122
KEGGidme:Dmel_CG2448

Similar proteinsi

Entry informationi

Entry nameiFUT8_DROME
AccessioniPrimary (citable) accession number: Q9VYV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome