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Protein
Submitted name:

ATP7, isoform B

Gene

ATP7

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23PROSITE-ProRule annotation1
Metal bindingi26PROSITE-ProRule annotation1
Metal bindingi104PROSITE-ProRule annotation1
Metal bindingi107PROSITE-ProRule annotation1
Metal bindingi219PROSITE-ProRule annotation1
Metal bindingi222PROSITE-ProRule annotation1
Metal bindingi295PROSITE-ProRule annotation1
Metal bindingi298PROSITE-ProRule annotation1

GO - Molecular functioni

  • copper-exporting ATPase activity Source: UniProtKB-EC
  • copper ion binding Source: FlyBase
  • copper ion transmembrane transporter activity Source: FlyBase
  • nucleotide binding Source: InterPro

GO - Biological processi

  • adult chitin-containing cuticle pigmentation Source: FlyBase
  • cellular copper ion homeostasis Source: FlyBase
  • copper ion homeostasis Source: CACAO
  • developmental pigmentation Source: FlyBase
  • larval development Source: FlyBase
  • metal ion homeostasis Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationImported
LigandMetal-bindingPROSITE-ProRule annotation

Enzyme and pathway databases

BRENDAi3.6.3.4. 1994.
ReactomeiR-DME-6803544. Ion influx/efflux at host-pathogen interface.
R-DME-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.5.37. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Submitted name:
ATP7, isoform BImported (EC:3.6.3.4Imported)
Submitted name:
ATP7, isoform CImported
Gene namesi
Name:ATP7Imported
ORF Names:CG1886Imported, Dmel_CG1886Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030343. ATP7.

Subcellular locationi

  • Membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei375 – 395HelicalUniRule annotationAdd BLAST21
Transmembranei417 – 436HelicalUniRule annotationAdd BLAST20
Transmembranei448 – 474HelicalUniRule annotationAdd BLAST27
Transmembranei480 – 500HelicalUniRule annotationAdd BLAST21
Transmembranei640 – 665HelicalUniRule annotationAdd BLAST26
Transmembranei685 – 709HelicalUniRule annotationAdd BLAST25
Transmembranei1093 – 1114HelicalUniRule annotationAdd BLAST22
Transmembranei1120 – 1143HelicalUniRule annotationAdd BLAST24

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: FlyBase

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0030343.

Interactioni

Protein-protein interaction databases

MINTiMINT-324878.
STRINGi7227.FBpp0271765.

Structurei

3D structure databases

SMRiQ9VYT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 79HMAInterPro annotationAdd BLAST67
Domaini94 – 160HMAInterPro annotationAdd BLAST67
Domaini209 – 275HMAInterPro annotationAdd BLAST67
Domaini285 – 351HMAInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0207. Eukaryota.
COG2217. LUCA.
GeneTreeiENSGT00530000063773.
KOiK17686.
OMAiPHLITAE.
OrthoDBiEOG091G022E.

Family and domain databases

CDDicd00371. HMA. 4 hits.
Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 4 hits.
SUPFAMiSSF55008. SSF55008. 4 hits.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 3 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 3 hits.
PS50846. HMA_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q9VYT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSDERVEAT MSTVRLPIVG MTCQSCVRNI TEHIGQKSGI LGVRVILEEN
60 70 80 90 100
AGYFDYDPRQ TDPARIASDI DDMGFECSYP GDAADPPETP ASAWTNIRVV
110 120 130 140 150
GMTCQSCVRN IEGNIGTKPG IHSIEVQLAA KNARVQYDPA QYDPAQIAEL
160 170 180 190 200
IDDMGFEASV QEPRSPSQSP SPAPASSPKK RATPTPPPPS YAQNGSAVAI
210 220 230 240 250
PVEQELLTKC FLHIRGMTCA SCVAAIEKHC KKIYGLDSIL VALLAAKAEV
260 270 280 290 300
KFNANVVTAE NIAKSITELG FPTELIDEPD NGEAEVELEI MGMTCASCVN
310 320 330 340 350
KIESHVLKIR GVTTASVTLL TKRGKFRYIT EETGPRSICE AIEALGFEAK
360 370 380 390 400
LMTGRDKMAH NYLEHKEEIR KWRNAFLVSL IFGGPCMVAM IYFMLEMSDK
410 420 430 440 450
GHANMCCLVP GLSMENLVMF LLSTPVQFFG GFHFYVQSYR AIKHGTTNMD
460 470 480 490 500
VLISMVTTIS YVYSVAVVIA AVLLEQNSSP LTFFDTPPML LIFISLGRWL
510 520 530 540 550
EHIAKGKTSE ALSKLLSLKA ADALLVEISP DFDIISEKVI SVDYVQRGDI
560 570 580 590 600
LKVIPGAKVP VDGKVLYGHS SCDESLITGE SMPVAKRKGS VVIGGSINQN
610 620 630 640 650
GVLLVEATHT GENTTLAQIV RLVEEAQTSK APIQQLADRI AGYFVPFVVV
660 670 680 690 700
VSSITLIAWI IIGFSNPNLV PVAMEHKMHM DQNTIIVSYA FKCALSVLAI
710 720 730 740 750
ACPCALGLAT PTAVMVATGT GAINGVLVKG ATALENAHKV KTVVFDKTGT
760 770 780 790 800
ITHGTPMTSK VTLFVTAQVC SLARALTIVG AAEQNSEHPI ASAIVHFAKD
810 820 830 840 850
MLNVGATPQA GSFGKSSHFQ AVPGCGIRVT VSNYEQTLRQ ACNADRIINY
860 870 880 890 900
ENLHRTHPQG SVPVDNGASI EHLLPQRSVR KSMELNNQQL LSDLVLEPEE
910 920 930 940 950
ELLTDQKIID SPEILVLIGN REWMERNAIE VPLEISDCMT HEERKGHTAV
960 970 980 990 1000
LCALNGQLVC MFAVSDMVKP EAHLAVYTLK RMGIDVVLLT GDNKNTAASI
1010 1020 1030 1040 1050
AREVGIRTVY AEVLPSHKVA KIQRIQANGI RVAMVGDGVN DSPALAQADV
1060 1070 1080 1090 1100
GITIAAGTDV AAEASDIVLM RNDLLDVVAC LDLSRCTVRR IRYNFFFASM
1110 1120 1130 1140 1150
YNLLGIPLAS GLFAPYGFTL LPWMASVAMA ASSVSVVCSS LLLKMYRKPT
1160 1170 1180 1190 1200
AKTLRTAEYE AQLAAERASG SEDELDKLSL HRGLDDLPEK GRMPFKRSST
1210 1220 1230 1240 1250
SLISRIFMHD YGNITSPDAK YGEGLLDPEE QYDGRTKIVR SRFHANDSTE

LQKL
Length:1,254
Mass (Da):136,082
Last modified:March 3, 2009 - v3
Checksum:i15EC83DDA66EA403
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48104.3.
AE014298 Genomic DNA. Translation: AGB95309.1.
RefSeqiNP_001259466.1. NM_001272537.2.
NP_572756.3. NM_132528.3.
UniGeneiDm.18759.

Genome annotation databases

EnsemblMetazoaiFBtr0273257; FBpp0271765; FBgn0030343.
FBtr0334454; FBpp0306530; FBgn0030343.
GeneIDi32142.
KEGGidme:Dmel_CG1886.
UCSCiCG1886-RB. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VYT4_DROME
AccessioniPrimary (citable) accession number: Q9VYT4
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 3, 2009
Last modified: August 30, 2017
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported