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Q9VYQ8 (UBP7_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 7

EC=3.4.19.12
Alternative name(s):
Ubiquitin thioesterase 7
Ubiquitin-specific-processing protease 7
Short name=Deubiquitinating enzyme 7
Gene names
Name:Usp7
ORF Names:CG1490
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1129 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cleaves ubiquitin fusion protein substrates By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Post-translational modification

Polyneddylated By similarity.

Polyubiquitinated By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 MATH domain.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11291129Ubiquitin carboxyl-terminal hydrolase 7
PRO_0000268011

Regions

Domain101 – 222122MATH
Domain241 – 548308USP

Sites

Active site2501Nucleophile By similarity
Active site4901Proton acceptor By similarity

Amino acid modifications

Modified residue11171Phosphoserine Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9VYQ8 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 41F7D1B654579258

FASTA1,129130,446
        10         20         30         40         50         60 
MEIETDQSIE AMDTQDTQEV EILTSDLQQT QQQRNSPPQL PKFKNLIQPQ LHAVGAVTQL 

        70         80         90        100        110        120 
PSENGNMPPQ QLLADSSSTS FGDGEAMGID DESKEDQFRS ETTFSFTVEN VVQLKSQRLS 

       130        140        150        160        170        180 
PPVYVRMLPW RIMVIPNDRA LGFFLQCNGE NDSPTWSCNA IAELRLKCHK PDAQPFTRAR 

       190        200        210        220        230        240 
IKHLFYSKEN DYGYSNFITW QELKDSEKSY VHNNSITLEV HVVADAPHGV LWDSKKHTGY 

       250        260        270        280        290        300 
VGLKNQGATC YMNSLLQTLY FTNSLRLSVY RIPTEADDSS KSVGLSLQRV FHELQFGDRP 

       310        320        330        340        350        360 
VGTKKLTKSF GWETLDSFMQ HDVQEFLRVL LDKLESKMKG TILEGTIPGL FEGKMSSYIK 

       370        380        390        400        410        420 
CKNVDYNSTR YETFYDIQLN IKDKKNIYES FQDYVAPETL EGDNKYDAGV HGLQEASKGV 

       430        440        450        460        470        480 
IFTSFPPVLH LHLMRFQYDP VTDSSIKYND RFEFYEHINL DRYLAESENT LADYVLHAVL 

       490        500        510        520        530        540 
VHSGDNHGGH YVVFINPKAD GRWFKFDDDV VSSCRKQEAI EQNYGGMDDE ISFHAKCSNA 

       550        560        570        580        590        600 
YMLVYIRQSE LDRVLGDITE SEISSDLVER LDLEKRIEMA RRKERGEANT YVSVHVILEE 

       610        620        630        640        650        660 
NFEEQHKRRL FDLEKVHPRV FRIKQNQTVD ELVDLFVRGF GVSRQRMRMW NLCTAQTQKF 

       670        680        690        700        710        720 
SHFDFVAEGS RTIEQISTSQ KPWVIWLQLA WTDVPGPLPP FNPKTESLLF LKYYDPRNKR 

       730        740        750        760        770        780 
LNYIGCTQQP HTRRLIDLVP DVNSKLGFEP DTELTIYDEY ADKKLVNLNE PIESALFIPQ 

       790        800        810        820        830        840 
DHLQGHILIF ERENVDAKLD LPTVGDYFLD LVYRIEIIFS DKCNPNEPDF TLELSNRYNY 

       850        860        870        880        890        900 
DQLANAVAER LNTDPQKLQF FMCINNYKET AGNAVPYTFK GTIKDLVSYT KQSSTKRIFY 

       910        920        930        940        950        960 
QRLSLSIHEL DNKKQFKCVW VSSDLKDEKE LVLYPNKNDT VKGLLEEAAK KISFAENSRR 

       970        980        990       1000       1010       1020 
KLRLLKISNH KIVAVCKDDI PLDTLLKSNE SITTAQGAQK TFRIEEVPAE DMQLAENEFL 

      1030       1040       1050       1060       1070       1080 
IPVAHFSKEL YNSFGIPFLT KARQGEPYGA LKQRIQRRLN VQDKEWENYK FCVISMGHNA 

      1090       1100       1110       1120 
DVNDNTPVDL EVYRSWTSGQ LPFFGLDHIN KSRKRSSLNF SEKAIKIYN 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1117, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014298 Genomic DNA. Translation: AAF48134.1.
BT044531 mRNA. Translation: ACH95305.1.
RefSeqNP_572779.2. NM_132551.2.
UniGeneDm.3592.

3D structure databases

ProteinModelPortalQ9VYQ8.
SMRQ9VYQ8. Positions 98-581.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid58574. 10 interactions.
IntActQ9VYQ8. 2 interactions.
MINTMINT-805769.

Protein family/group databases

MEROPSC19.A52.

Proteomic databases

PaxDbQ9VYQ8.
PRIDEQ9VYQ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0073641; FBpp0073474; FBgn0030366.
GeneID32169.
KEGGdme:Dmel_CG1490.

Organism-specific databases

CTD7874.
FlyBaseFBgn0030366. Usp7.

Phylogenomic databases

eggNOGCOG5077.
GeneTreeENSGT00740000115066.
InParanoidQ9VYQ8.
KOK11838.
OMAANHAELK.
OrthoDBEOG75B84G.
PhylomeDBQ9VYQ8.

Enzyme and pathway databases

SignaLinkQ9VYQ8.

Gene expression databases

BgeeQ9VYQ8.

Family and domain databases

InterProIPR002083. MATH.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR008974. TRAF-like.
IPR028889. UCH/PAN2.
IPR024729. USP7_ICP0-binding_dom.
IPR029346. USP_C.
[Graphical view]
PfamPF00917. MATH. 1 hit.
PF00443. UCH. 1 hit.
PF14533. USP7_C2. 1 hit.
PF12436. USP7_ICP0_bdg. 1 hit.
[Graphical view]
SMARTSM00061. MATH. 1 hit.
[Graphical view]
SUPFAMSSF49599. SSF49599. 1 hit.
PROSITEPS50144. MATH. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUSP7. drosophila.
GenomeRNAi32169.
NextBio777232.
PROQ9VYQ8.

Entry information

Entry nameUBP7_DROME
AccessionPrimary (citable) accession number: Q9VYQ8
Secondary accession number(s): B5RJQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase