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Q9VYQ8

- UBP7_DROME

UniProt

Q9VYQ8 - UBP7_DROME

Protein

Ubiquitin carboxyl-terminal hydrolase 7

Gene

Usp7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Cleaves ubiquitin fusion protein substrates.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei250 – 2501NucleophilePROSITE-ProRule annotation
    Active sitei490 – 4901Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. chromatin silencing Source: FlyBase
    2. histone deubiquitination Source: FlyBase
    3. protein deubiquitination Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    SignaLinkiQ9VYQ8.

    Protein family/group databases

    MEROPSiC19.A52.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 7 (EC:3.4.19.12)
    Alternative name(s):
    Ubiquitin thioesterase 7
    Ubiquitin-specific-processing protease 7
    Short name:
    Deubiquitinating enzyme 7
    Gene namesi
    Name:Usp7
    ORF Names:CG1490
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0030366. Usp7.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. polytene chromosome Source: FlyBase
    3. protein complex Source: FlyBase
    4. transcriptionally silent chromatin Source: FlyBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11291129Ubiquitin carboxyl-terminal hydrolase 7PRO_0000268011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1117 – 11171Phosphoserine1 Publication

    Post-translational modificationi

    Polyneddylated.By similarity
    Polyubiquitinated.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ9VYQ8.
    PRIDEiQ9VYQ8.

    Expressioni

    Gene expression databases

    BgeeiQ9VYQ8.

    Interactioni

    Protein-protein interaction databases

    BioGridi58574. 10 interactions.
    IntActiQ9VYQ8. 2 interactions.
    MINTiMINT-805769.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VYQ8.
    SMRiQ9VYQ8. Positions 98-581.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini101 – 222122MATHPROSITE-ProRule annotationAdd
    BLAST
    Domaini241 – 548308USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 MATH domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    GeneTreeiENSGT00740000115066.
    InParanoidiQ9VYQ8.
    KOiK11838.
    OMAiANHAELK.
    OrthoDBiEOG75B84G.
    PhylomeDBiQ9VYQ8.

    Family and domain databases

    InterProiIPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view]
    PfamiPF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view]
    SMARTiSM00061. MATH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49599. SSF49599. 1 hit.
    PROSITEiPS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VYQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIETDQSIE AMDTQDTQEV EILTSDLQQT QQQRNSPPQL PKFKNLIQPQ     50
    LHAVGAVTQL PSENGNMPPQ QLLADSSSTS FGDGEAMGID DESKEDQFRS 100
    ETTFSFTVEN VVQLKSQRLS PPVYVRMLPW RIMVIPNDRA LGFFLQCNGE 150
    NDSPTWSCNA IAELRLKCHK PDAQPFTRAR IKHLFYSKEN DYGYSNFITW 200
    QELKDSEKSY VHNNSITLEV HVVADAPHGV LWDSKKHTGY VGLKNQGATC 250
    YMNSLLQTLY FTNSLRLSVY RIPTEADDSS KSVGLSLQRV FHELQFGDRP 300
    VGTKKLTKSF GWETLDSFMQ HDVQEFLRVL LDKLESKMKG TILEGTIPGL 350
    FEGKMSSYIK CKNVDYNSTR YETFYDIQLN IKDKKNIYES FQDYVAPETL 400
    EGDNKYDAGV HGLQEASKGV IFTSFPPVLH LHLMRFQYDP VTDSSIKYND 450
    RFEFYEHINL DRYLAESENT LADYVLHAVL VHSGDNHGGH YVVFINPKAD 500
    GRWFKFDDDV VSSCRKQEAI EQNYGGMDDE ISFHAKCSNA YMLVYIRQSE 550
    LDRVLGDITE SEISSDLVER LDLEKRIEMA RRKERGEANT YVSVHVILEE 600
    NFEEQHKRRL FDLEKVHPRV FRIKQNQTVD ELVDLFVRGF GVSRQRMRMW 650
    NLCTAQTQKF SHFDFVAEGS RTIEQISTSQ KPWVIWLQLA WTDVPGPLPP 700
    FNPKTESLLF LKYYDPRNKR LNYIGCTQQP HTRRLIDLVP DVNSKLGFEP 750
    DTELTIYDEY ADKKLVNLNE PIESALFIPQ DHLQGHILIF ERENVDAKLD 800
    LPTVGDYFLD LVYRIEIIFS DKCNPNEPDF TLELSNRYNY DQLANAVAER 850
    LNTDPQKLQF FMCINNYKET AGNAVPYTFK GTIKDLVSYT KQSSTKRIFY 900
    QRLSLSIHEL DNKKQFKCVW VSSDLKDEKE LVLYPNKNDT VKGLLEEAAK 950
    KISFAENSRR KLRLLKISNH KIVAVCKDDI PLDTLLKSNE SITTAQGAQK 1000
    TFRIEEVPAE DMQLAENEFL IPVAHFSKEL YNSFGIPFLT KARQGEPYGA 1050
    LKQRIQRRLN VQDKEWENYK FCVISMGHNA DVNDNTPVDL EVYRSWTSGQ 1100
    LPFFGLDHIN KSRKRSSLNF SEKAIKIYN 1129
    Length:1,129
    Mass (Da):130,446
    Last modified:May 1, 2000 - v1
    Checksum:i41F7D1B654579258
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF48134.1.
    BT044531 mRNA. Translation: ACH95305.1.
    RefSeqiNP_572779.2. NM_132551.2.
    UniGeneiDm.3592.

    Genome annotation databases

    EnsemblMetazoaiFBtr0073641; FBpp0073474; FBgn0030366.
    GeneIDi32169.
    KEGGidme:Dmel_CG1490.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF48134.1 .
    BT044531 mRNA. Translation: ACH95305.1 .
    RefSeqi NP_572779.2. NM_132551.2.
    UniGenei Dm.3592.

    3D structure databases

    ProteinModelPortali Q9VYQ8.
    SMRi Q9VYQ8. Positions 98-581.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 58574. 10 interactions.
    IntActi Q9VYQ8. 2 interactions.
    MINTi MINT-805769.

    Protein family/group databases

    MEROPSi C19.A52.

    Proteomic databases

    PaxDbi Q9VYQ8.
    PRIDEi Q9VYQ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0073641 ; FBpp0073474 ; FBgn0030366 .
    GeneIDi 32169.
    KEGGi dme:Dmel_CG1490.

    Organism-specific databases

    CTDi 7874.
    FlyBasei FBgn0030366. Usp7.

    Phylogenomic databases

    eggNOGi COG5077.
    GeneTreei ENSGT00740000115066.
    InParanoidi Q9VYQ8.
    KOi K11838.
    OMAi ANHAELK.
    OrthoDBi EOG75B84G.
    PhylomeDBi Q9VYQ8.

    Enzyme and pathway databases

    SignaLinki Q9VYQ8.

    Miscellaneous databases

    ChiTaRSi USP7. drosophila.
    GenomeRNAii 32169.
    NextBioi 777232.
    PROi Q9VYQ8.

    Gene expression databases

    Bgeei Q9VYQ8.

    Family and domain databases

    InterProi IPR002083. MATH.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR008974. TRAF-like.
    IPR028889. UCH/PAN2.
    IPR024729. USP7_ICP0-binding_dom.
    IPR029346. USP_C.
    [Graphical view ]
    Pfami PF00917. MATH. 1 hit.
    PF00443. UCH. 1 hit.
    PF14533. USP7_C2. 1 hit.
    PF12436. USP7_ICP0_bdg. 1 hit.
    [Graphical view ]
    SMARTi SM00061. MATH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49599. SSF49599. 1 hit.
    PROSITEi PS50144. MATH. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
      Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    4. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1117, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiUBP7_DROME
    AccessioniPrimary (citable) accession number: Q9VYQ8
    Secondary accession number(s): B5RJQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3