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Protein
Submitted name:

Protein kinase C delta, isoform E

Gene

Pkcdelta

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9VYN1.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase C delta, isoform EImported (EC:2.7.11.-Imported, EC:2.7.11.13Imported)
Gene namesi
Name:PkcdeltaImported
ORF Names:CG42349Imported, Dmel_CG42349Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0259680. Pkcdelta.

PTM / Processingi

Proteomic databases

PaxDbiQ9VYN1.
PRIDEiQ9VYN1.

Expressioni

Gene expression databases

BgeeiQ9VYN1.
ExpressionAtlasiQ9VYN1. differential.
GenevisibleiQ9VYN1. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9VYN1. 8 interactions.
STRINGi7227.FBpp0289212.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1566 – 1824259Protein kinaseInterPro annotationAdd
BLAST
Domaini1825 – 189470AGC-kinase C-terminalInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili326 – 35732Sequence analysisAdd
BLAST
Coiled coili1069 – 109628Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126964.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VYN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLYSDSTNY YYSGGSSQLY SPYYSSGLGL NLGMGSSPGS SYTSSYNRSY
60 70 80 90 100
PASYMVPLSP SSPRSPSSYS SGSSGGSSSL HGLGSRYQPK LTTITETGRH
110 120 130 140 150
SGHSSLMPLT RINSPKYSSS VTTPSYGSSG ASSRYIPARP IAINTADIDV
160 170 180 190 200
SSSRYRRAVP SKSQEKEQPK EEVKQKEQKE QAEEEVKPSP KETPCESSDA
210 220 230 240 250
SAETRPNRRS TIRRNRPVVR LSTIRRRSKD RSAESPKKEQ VQEHQFRDLP
260 270 280 290 300
PATEPSLSWR QKLAEELAAF PVTSNKKSPG ELLRERFYIK DEKEELTNFN
310 320 330 340 350
RAQIQELVQP QSAHKTLTPE VEISAKKEVD DEKEDESDKQ EQELEEMQET
360 370 380 390 400
IRRLSLVQCP TFHDICEDIS SDKIDDDLNA GELRRRASII QEQEQEILNK
410 420 430 440 450
LQKSNSGSFQ LIHLERRSSH DSTTTNDEDL KERSKRRSKK SKKMRHKITA
460 470 480 490 500
IVEVENAPQA QPVEHMPSVL ELNEESLLIQ PLTSGSGSSS TPTPSPKPKF
510 520 530 540 550
TVNVETVEEH HQIHKIFKLP KKKTVPKDQD DSSLPEGFMK AAPKTTKTSP
560 570 580 590 600
LKKVNKQQHV NEAQIFTFDE AAIQQQQQVQ QQQQQPELPK TEAKVEGVAT
610 620 630 640 650
PKPIRKAIQK SESGEDFWSQ IGSRETLYMT NRKKVFNMRQ EQQEQLLEEE
660 670 680 690 700
PPKSPAMPKE TKTDLKTPTT PKLKSEILIE LKTTPSIVST SGKSETQKVP
710 720 730 740 750
STPLTPTVVK TNQVEAKKVE SMDTSSKAPA SVISKAAESP KLKSATDNNK
760 770 780 790 800
AKPTMAKKDL PKLKTAEETK LTITTKATTA TPTMDSPKTP QAKEETSQKT
810 820 830 840 850
ESATTSQIKS DTPIALQIKP QEQMKVAAPT TPQAKVETPP KDSPTRKIVA
860 870 880 890 900
PTTPQAKVET PTKDSPTRKI VTPTTPQAKV ETPTKDSPTR KIVTPTTPQA
910 920 930 940 950
KVETPTKDSP TRKIVTPTTP QAKVETPTKD SPTRKIATPT TPQAKAAAST
960 970 980 990 1000
TSPLTTPQKT PQVKAATDES KSTPAAPKTT MAKISMTTMA GTTVAEAGKT
1010 1020 1030 1040 1050
ISPKGLKQSG NAVAMPTATP TTPNTPTTAT GKSKLNETAG PKINSGQPAK
1060 1070 1080 1090 1100
SPEQQQATAA AVETKINKTT DKEQQQQQQQ QQQQQAQQQQ QQLIDTAATL
1110 1120 1130 1140 1150
VPQTETKTKL TEAAEPTGKS KVQSPNTTKP KSAGKTNVGK KKAATPAAAA
1160 1170 1180 1190 1200
AAAAAAAPAA ATATEAVTAL SESNVTPINA DQFITLAPTK AAKTSPNKQQ
1210 1220 1230 1240 1250
ALQLQQQHEE QQRQQQQQAT NASSPAATGD ATTTPTTITI GVAAVNVAAV
1260 1270 1280 1290 1300
AVVASAAAAA ATDAAADATT SLSSNNSCGE GVGNNLSKFA TVSNLAQCLR
1310 1320 1330 1340 1350
DVDAELDDYI PSSAENSQED DDDDDDGSGS SSDDYSSVDG CANLSASMKK
1360 1370 1380 1390 1400
KLRKEKKKQK AKAAAAAEAK RFDPHKKIKI DTTNKCYVKE EAPRYPLVAT
1410 1420 1430 1440 1450
PRPLWKREKI VYSDENTDDE SGSEEGSGGS LDEDSDDESG GEECSSTSSS
1460 1470 1480 1490 1500
ASSEDLDAVA MVTKAGSSNA TTVLDSSNSS GSNAGTLSVP SAGSGSGGGA
1510 1520 1530 1540 1550
STSSSPSIIR MSTCSNDSGF EGGTAPSSPK KMLETSYTYS QFQKSGRFTA
1560 1570 1580 1590 1600
PATVIPRFKN YSVDDFHFLA VLGKGSFGKV LLAELRDTTY YYAIKCLKKD
1610 1620 1630 1640 1650
VVLEDDDVDS TLIERKVLAL GTKHPYLCHL FCTFQTESHL FFVMEYLNGG
1660 1670 1680 1690 1700
DLMFHIQESG RFSEERARFY GAEIISGLKF LHKKGIIYRD LKLDNVLLDY
1710 1720 1730 1740 1750
EGHVRIADFG MCKLQIYLDK TADSFCGTPD YMAPEIIKGE KYNQNVDWWS
1760 1770 1780 1790 1800
FGVLLYEMLI GQSPFSGCDE DELFWSICNE IPWFPVYISA EATGILKGLL
1810 1820 1830 1840 1850
EKDYTKRIGS QYSPAGDIAD HIFFRPIDWG LLEKRQIEPP FKPQVKHPLD
1860 1870 1880 1890
TQYFDRVFTR ERVRLTPIDK EILASMDQKQ FHGFTYTNPH ITLD
Length:1,894
Mass (Da):206,645
Last modified:June 11, 2014 - v3
Checksum:i1ED2A629E2E1B9FB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48161.3.
RefSeqiNP_572797.3. NM_132569.3.
UniGeneiDm.23809.

Genome annotation databases

EnsemblMetazoaiFBtr0340086; FBpp0309085; FBgn0259680.
GeneIDi32191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48161.3.
RefSeqiNP_572797.3. NM_132569.3.
UniGeneiDm.23809.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VYN1. 8 interactions.
STRINGi7227.FBpp0289212.

Proteomic databases

PaxDbiQ9VYN1.
PRIDEiQ9VYN1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0340086; FBpp0309085; FBgn0259680.
GeneIDi32191.

Organism-specific databases

CTDi32191.
FlyBaseiFBgn0259680. Pkcdelta.

Phylogenomic databases

eggNOGiKOG0694. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126964.

Enzyme and pathway databases

SignaLinkiQ9VYN1.

Miscellaneous databases

ChiTaRSiPkcdelta. fly.
GenomeRNAii32191.
NextBioi777316.

Gene expression databases

BgeeiQ9VYN1.
ExpressionAtlasiQ9VYN1. differential.
GenevisibleiQ9VYN1. DM.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.

Entry informationi

Entry nameiQ9VYN1_DROME
AccessioniPrimary (citable) accession number: Q9VYN1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 11, 2014
Last modified: May 11, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.