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Protein

Probable alpha-aspartyl dipeptidase

Gene

CG2200

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes dipeptides containing N-terminal aspartate residues.By similarity

Catalytic activityi

Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei125Charge relay systemBy similarity1
Active sitei140Charge relay systemBy similarity1
Active sitei162Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionDipeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS51.002

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-aspartyl dipeptidase (EC:3.4.13.21)
Alternative name(s):
Asp-specific dipeptidase
Short name:
Dipeptidase E
Gene namesi
ORF Names:CG2200
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030447 CG2200

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002099651 – 240Probable alpha-aspartyl dipeptidaseAdd BLAST240

Proteomic databases

PaxDbiQ9VYH3
PRIDEiQ9VYH3

Expressioni

Gene expression databases

BgeeiFBgn0030447
ExpressionAtlasiQ9VYH3 baseline and differential
GenevisibleiQ9VYH3 DM

Interactioni

Protein-protein interaction databases

BioGridi58644, 2 interactors
DIPiDIP-21896N
IntActiQ9VYH3, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ9VYH3
SMRiQ9VYH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S51 family.Curated

Phylogenomic databases

eggNOGiENOG410IG0E Eukaryota
COG3340 LUCA
HOGENOMiHOG000034813
InParanoidiQ9VYH3
KOiK05995
OMAiKYTATVR
OrthoDBiEOG091G0M5G
PhylomeDBiQ9VYH3

Family and domain databases

CDDicd03146 GAT1_Peptidase_E, 1 hit
Gene3Di3.40.50.880, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR005320 Peptidase_S51
PfamiView protein in Pfam
PF03575 Peptidase_S51, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VYH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASARNLLLL SSSRLHGHGY LEHARGQLED LFKSANVKTV LFVPYALRDH
60 70 80 90 100
DKYTATVRDA LQPWGFNVEG LHTKPDREQA LREAQAIFVG GGNTFVLLRS
110 120 130 140 150
LYEMKLLDPI RELVLQRGLP YVGSSAGTNV ATRSIHTTND MPVAYPPSFE
160 170 180 190 200
ALALVPFNIN PHYLDPEAGS RHKGETRDER LEEFVAYHGL PVLGLREGTS
210 220 230 240
VRVQGEKAIL LGDRNAKLFK ADGGTEELAP LADLTFLLQK
Length:240
Mass (Da):26,598
Last modified:May 1, 2000 - v1
Checksum:i3D918D9CB4F6D3E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48224.1
AY118855 mRNA Translation: AAM50715.1
RefSeqiNP_001285183.1, NM_001298254.1
NP_572852.1, NM_132624.2
UniGeneiDm.13447

Genome annotation databases

EnsemblMetazoaiFBtr0073721; FBpp0073552; FBgn0030447
FBtr0340301; FBpp0309262; FBgn0030447
GeneIDi32258
KEGGidme:Dmel_CG2200
UCSCiCG2200-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiPEPE_DROME
AccessioniPrimary (citable) accession number: Q9VYH3
Secondary accession number(s): Q540X4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health