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Protein

Probable alpha-aspartyl dipeptidase

Gene

CG2200

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes dipeptides containing N-terminal aspartate residues.By similarity

Catalytic activityi

Dipeptidase E catalyzes the hydrolysis of dipeptides Asp-|-Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei125 – 1251Charge relay systemBy similarity
Active sitei140 – 1401Charge relay systemBy similarity
Active sitei162 – 1621Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS51.002.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alpha-aspartyl dipeptidase (EC:3.4.13.21)
Alternative name(s):
Asp-specific dipeptidase
Short name:
Dipeptidase E
Gene namesi
ORF Names:CG2200
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030447. CG2200.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 240240Probable alpha-aspartyl dipeptidasePRO_0000209965Add
BLAST

Proteomic databases

PaxDbiQ9VYH3.
PRIDEiQ9VYH3.

Expressioni

Gene expression databases

BgeeiFBgn0030447.
ExpressionAtlasiQ9VYH3. differential.
GenevisibleiQ9VYH3. DM.

Interactioni

Protein-protein interaction databases

BioGridi58644. 2 interactions.
DIPiDIP-21896N.
IntActiQ9VYH3. 2 interactions.
MINTiMINT-800044.

Structurei

3D structure databases

ProteinModelPortaliQ9VYH3.
SMRiQ9VYH3. Positions 7-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S51 family.Curated

Phylogenomic databases

eggNOGiENOG410IG0E. Eukaryota.
COG3340. LUCA.
HOGENOMiHOG000034813.
InParanoidiQ9VYH3.
KOiK05995.
OMAiKYTATVR.
OrthoDBiEOG091G0M5G.
PhylomeDBiQ9VYH3.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR005320. Peptidase_S51.
[Graphical view]
PfamiPF03575. Peptidase_S51. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VYH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASARNLLLL SSSRLHGHGY LEHARGQLED LFKSANVKTV LFVPYALRDH
60 70 80 90 100
DKYTATVRDA LQPWGFNVEG LHTKPDREQA LREAQAIFVG GGNTFVLLRS
110 120 130 140 150
LYEMKLLDPI RELVLQRGLP YVGSSAGTNV ATRSIHTTND MPVAYPPSFE
160 170 180 190 200
ALALVPFNIN PHYLDPEAGS RHKGETRDER LEEFVAYHGL PVLGLREGTS
210 220 230 240
VRVQGEKAIL LGDRNAKLFK ADGGTEELAP LADLTFLLQK
Length:240
Mass (Da):26,598
Last modified:May 1, 2000 - v1
Checksum:i3D918D9CB4F6D3E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48224.1.
AY118855 mRNA. Translation: AAM50715.1.
RefSeqiNP_001285183.1. NM_001298254.1.
NP_572852.1. NM_132624.2.
UniGeneiDm.13447.

Genome annotation databases

EnsemblMetazoaiFBtr0073721; FBpp0073552; FBgn0030447.
FBtr0340301; FBpp0309262; FBgn0030447.
GeneIDi32258.
KEGGidme:Dmel_CG2200.
UCSCiCG2200-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48224.1.
AY118855 mRNA. Translation: AAM50715.1.
RefSeqiNP_001285183.1. NM_001298254.1.
NP_572852.1. NM_132624.2.
UniGeneiDm.13447.

3D structure databases

ProteinModelPortaliQ9VYH3.
SMRiQ9VYH3. Positions 7-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58644. 2 interactions.
DIPiDIP-21896N.
IntActiQ9VYH3. 2 interactions.
MINTiMINT-800044.

Protein family/group databases

MEROPSiS51.002.

Proteomic databases

PaxDbiQ9VYH3.
PRIDEiQ9VYH3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0073721; FBpp0073552; FBgn0030447.
FBtr0340301; FBpp0309262; FBgn0030447.
GeneIDi32258.
KEGGidme:Dmel_CG2200.
UCSCiCG2200-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0030447. CG2200.

Phylogenomic databases

eggNOGiENOG410IG0E. Eukaryota.
COG3340. LUCA.
HOGENOMiHOG000034813.
InParanoidiQ9VYH3.
KOiK05995.
OMAiKYTATVR.
OrthoDBiEOG091G0M5G.
PhylomeDBiQ9VYH3.

Miscellaneous databases

GenomeRNAii32258.
PROiQ9VYH3.

Gene expression databases

BgeeiFBgn0030447.
ExpressionAtlasiQ9VYH3. differential.
GenevisibleiQ9VYH3. DM.

Family and domain databases

Gene3Di3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR005320. Peptidase_S51.
[Graphical view]
PfamiPF03575. Peptidase_S51. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPEPE_DROME
AccessioniPrimary (citable) accession number: Q9VYH3
Secondary accession number(s): Q540X4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.