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Q9VYF3

- Q9VYF3_DROME

UniProt

Q9VYF3 - Q9VYF3_DROME

Protein
Submitted name:

FI19806p1

Gene

HDAC4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: FlyBase

    GO - Biological processi

    1. histone deacetylation Source: GOC
    2. regulation of transcription, DNA-templated Source: FlyBase

    Keywords - Molecular functioni

    HydrolaseSAAS annotationImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    FI19806p1Imported
    Submitted name:
    HDAC4, isoform DImported (EC:3.5.1.-Imported)
    Gene namesi
    Name:HDAC4Imported
    Synonyms:HDAC4-RDImported
    ORF Names:CG1770Imported, Dmel_CG1770Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0041210. HDAC4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. histone deacetylase complex Source: InterPro
    3. nucleus Source: FlyBase

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-1579842.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000062809.
    InParanoidiQ9VYF3.
    KOiK11406.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q9VYF3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPDDRIPI HDLPSEAGSD ERLLHITPAT LTLDFKPHPA VDIDQQIMEL     50
    KKSQELQKQR LINSFQEQSK QMELEHKLQL EHKYQFAVNS HGAFQELRNE 100
    SMVTAAAAAV AQEQHRQQLH QQQQQHQQQQ QQQQHQQQQQ QQQARGRDGM 150
    KLKQNCSANA SPEVKQILNC FILSRKSQAA ASNGTTTTSP YRNRGVVKSS 200
    SGESLPAGTV TSAHPYKIPQ PPPSLLKYES DFPLRKTASE PNLLKIRLKQ 250
    SVIERKARIG GPAGARRHER LLQAAQRRQQ KNSVLTNCNS TPDSGPNSPP 300
    SAAALAVGVV GSRGSPTSAP IQEENEEGSQ YQPGQRSSIN DLPLFSSPSL 350
    PNISLGRPHL PNSAQAHAQV NAQVAAQAQA QAQAQAQAHA MFAALAAAQG 400
    GCGQPGYYNP LGMAFVGRQP APLAMIPATG IAPQQPSPVV RSASATSTSS 450
    SQASLVGDVA PPQAHAASTI LPSSSSYMQQ LGSVAGSGVN LHAAAVAAAA 500
    AAAAAAGSLP PTNSHGHGHG SHAHPHPHAH GHGHGHGHGI YAGHQHNVPI 550
    TDAQVAQVHL HKQGHRPLGR TQSAPLPLGH PMLTGAVQLN VVQTHYENSE 600
    AERQAYEHQV VNQKVRQTVL TRSGAAAAAA AAAGVSVVRE AQLKEEDDDS 650
    AAEVMDLTDK KKPPKTVLTS TIATSTSQNL PEALAAAAAA AAYRAPHNAS 700
    SNSASATKSG IKLRDQEYLQ QQREQLLLLQ QEEELAKSLM RPLSRTLSSP 750
    LVPLGPHGLS QIPDTGQQPA PIATSSSADH IPPVNLSLPH RQHRQLMSTL 800
    YASQLRNHQP SASGSPPHKV TTGLAYDPLM LKHSCICGDN AQHPEHSGRL 850
    QSVWARLNET DLVKRCDRLR ARKATQEELQ TVHTEAHAML FGSNQCQLSR 900
    PKLENTLSAS FVRLSCGGLG VDLDTTWNEH HTATAARMAA GCVIDLALKT 950
    AKGDLRNGFA VVRPPGHHAE ANLAMGFCFF NSIAIAAKLL RQRMPEVRRI 1000
    LIVDWDVHHG NGTQQAFYQS PDILYLSIHR HDDGNFFPGT GGPTECGSGA 1050
    GLGFNVNISW SGALNPPLGD AEYIAAFRTV VMPIARSFNP DIVLVSSGFD 1100
    AATGHPAPLG GYHVSPACFG FMTRELLQLA NGKVVLALEG GYDLAAICDS 1150
    AQECVRALLG DPAAPIAKAE LERPPCQNAI NTLQKTIAIQ QTHWPCVRML 1200
    EHTVGLSALE TLKVEHDESE TINAMAGLSM QSMHRTLSRD DSEEPMDQDE 1250
    TK 1252
    Length:1,252
    Mass (Da):134,162
    Last modified:November 30, 2010 - v3
    Checksum:iC6FE30273DDC1EC5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF48245.3.
    BT133402 mRNA. Translation: AFH55501.1.
    RefSeqiNP_572868.3. NM_132640.5.
    UniGeneiDm.6484.

    Genome annotation databases

    EnsemblMetazoaiFBtr0301298; FBpp0290513; FBgn0041210.
    GeneIDi32278.
    KEGGidme:Dmel_CG1770.
    UCSCiCG1770-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAF48245.3 .
    BT133402 mRNA. Translation: AFH55501.1 .
    RefSeqi NP_572868.3. NM_132640.5.
    UniGenei Dm.6484.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-1579842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0301298 ; FBpp0290513 ; FBgn0041210 .
    GeneIDi 32278.
    KEGGi dme:Dmel_CG1770.
    UCSCi CG1770-RA. d. melanogaster.

    Organism-specific databases

    CTDi 9759.
    FlyBasei FBgn0041210. HDAC4.

    Phylogenomic databases

    GeneTreei ENSGT00530000062809.
    InParanoidi Q9VYF3.
    KOi K11406.

    Miscellaneous databases

    GenomeRNAii 32278.
    NextBioi 777716.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "Drosophila melanogaster release 4 sequence."
      Berkeley Drosophila Genome Project
      Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    11. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
      Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    12. FlyBase
      Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9VYF3_DROME
    AccessioniPrimary (citable) accession number: Q9VYF3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3