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Q9VYF3

- Q9VYF3_DROME

UniProt

Q9VYF3 - Q9VYF3_DROME

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Protein
Submitted name:

FI19806p1

Gene

HDAC4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi835 – 8351ZincUniRule annotation
Metal bindingi837 – 8371ZincUniRule annotation
Metal bindingi843 – 8431ZincUniRule annotation
Metal bindingi916 – 9161ZincUniRule annotation
Active sitei968 – 9681UniRule annotation

GO - Molecular functioni

  1. histone deacetylase activity Source: FlyBase

GO - Biological processi

  1. histone deacetylation Source: GOC
  2. long-term memory Source: FlyBase
  3. memory Source: FlyBase
  4. regulation of transcription, DNA-templated Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotationImported

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
FI19806p1Imported
Submitted name:
HDAC4, isoform DImported (EC:3.5.1.-Imported)
Gene namesi
Name:HDAC4Imported
Synonyms:HDAC4-RDImported
ORF Names:CG1770Imported, Dmel_CG1770Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0041210. HDAC4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. histone deacetylase complex Source: InterPro
  3. nucleus Source: FlyBase
Complete GO annotation...

Interactioni

Protein-protein interaction databases

MINTiMINT-1579842.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
KOiK11406.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q9VYF3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPDDRIPI HDLPSEAGSD ERLLHITPAT LTLDFKPHPA VDIDQQIMEL
60 70 80 90 100
KKSQELQKQR LINSFQEQSK QMELEHKLQL EHKYQFAVNS HGAFQELRNE
110 120 130 140 150
SMVTAAAAAV AQEQHRQQLH QQQQQHQQQQ QQQQHQQQQQ QQQARGRDGM
160 170 180 190 200
KLKQNCSANA SPEVKQILNC FILSRKSQAA ASNGTTTTSP YRNRGVVKSS
210 220 230 240 250
SGESLPAGTV TSAHPYKIPQ PPPSLLKYES DFPLRKTASE PNLLKIRLKQ
260 270 280 290 300
SVIERKARIG GPAGARRHER LLQAAQRRQQ KNSVLTNCNS TPDSGPNSPP
310 320 330 340 350
SAAALAVGVV GSRGSPTSAP IQEENEEGSQ YQPGQRSSIN DLPLFSSPSL
360 370 380 390 400
PNISLGRPHL PNSAQAHAQV NAQVAAQAQA QAQAQAQAHA MFAALAAAQG
410 420 430 440 450
GCGQPGYYNP LGMAFVGRQP APLAMIPATG IAPQQPSPVV RSASATSTSS
460 470 480 490 500
SQASLVGDVA PPQAHAASTI LPSSSSYMQQ LGSVAGSGVN LHAAAVAAAA
510 520 530 540 550
AAAAAAGSLP PTNSHGHGHG SHAHPHPHAH GHGHGHGHGI YAGHQHNVPI
560 570 580 590 600
TDAQVAQVHL HKQGHRPLGR TQSAPLPLGH PMLTGAVQLN VVQTHYENSE
610 620 630 640 650
AERQAYEHQV VNQKVRQTVL TRSGAAAAAA AAAGVSVVRE AQLKEEDDDS
660 670 680 690 700
AAEVMDLTDK KKPPKTVLTS TIATSTSQNL PEALAAAAAA AAYRAPHNAS
710 720 730 740 750
SNSASATKSG IKLRDQEYLQ QQREQLLLLQ QEEELAKSLM RPLSRTLSSP
760 770 780 790 800
LVPLGPHGLS QIPDTGQQPA PIATSSSADH IPPVNLSLPH RQHRQLMSTL
810 820 830 840 850
YASQLRNHQP SASGSPPHKV TTGLAYDPLM LKHSCICGDN AQHPEHSGRL
860 870 880 890 900
QSVWARLNET DLVKRCDRLR ARKATQEELQ TVHTEAHAML FGSNQCQLSR
910 920 930 940 950
PKLENTLSAS FVRLSCGGLG VDLDTTWNEH HTATAARMAA GCVIDLALKT
960 970 980 990 1000
AKGDLRNGFA VVRPPGHHAE ANLAMGFCFF NSIAIAAKLL RQRMPEVRRI
1010 1020 1030 1040 1050
LIVDWDVHHG NGTQQAFYQS PDILYLSIHR HDDGNFFPGT GGPTECGSGA
1060 1070 1080 1090 1100
GLGFNVNISW SGALNPPLGD AEYIAAFRTV VMPIARSFNP DIVLVSSGFD
1110 1120 1130 1140 1150
AATGHPAPLG GYHVSPACFG FMTRELLQLA NGKVVLALEG GYDLAAICDS
1160 1170 1180 1190 1200
AQECVRALLG DPAAPIAKAE LERPPCQNAI NTLQKTIAIQ QTHWPCVRML
1210 1220 1230 1240 1250
EHTVGLSALE TLKVEHDESE TINAMAGLSM QSMHRTLSRD DSEEPMDQDE

TK
Length:1,252
Mass (Da):134,162
Last modified:November 30, 2010 - v3
Checksum:iC6FE30273DDC1EC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAF48245.3.
BT133402 mRNA. Translation: AFH55501.1.
RefSeqiNP_572868.3. NM_132640.6.
UniGeneiDm.6484.

Genome annotation databases

EnsemblMetazoaiFBtr0301298; FBpp0290513; FBgn0041210.
GeneIDi32278.
KEGGidme:Dmel_CG1770.
UCSCiCG1770-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAF48245.3 .
BT133402 mRNA. Translation: AFH55501.1 .
RefSeqi NP_572868.3. NM_132640.6.
UniGenei Dm.6484.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-1579842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0301298 ; FBpp0290513 ; FBgn0041210 .
GeneIDi 32278.
KEGGi dme:Dmel_CG1770.
UCSCi CG1770-RA. d. melanogaster.

Organism-specific databases

CTDi 9759.
FlyBasei FBgn0041210. HDAC4.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
KOi K11406.

Miscellaneous databases

GenomeRNAii 32278.
NextBioi 777716.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. FlyBase
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VYF3_DROME
AccessioniPrimary (citable) accession number: Q9VYF3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3