Q9VXY3 (Q9VXY3_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CG5599 EMBL AAF48423.1
EC=2.3.1.- EMBL AAF48423.1
EC=2.3.1.168 EMBL AAF48423.1

Submitted name:
LD43554p EMBL AAL29017.1

Gene names

ORF Names:

CG5599 EMBL AAL29017.1 FlyBase FBgn0030612, Dmel_CG5599 EMBL AAF48423.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the 2-oxoacid dehydrogenase family. RuleBase RU003423 Contains 1 lipoyl-binding domain. RuleBase RU000447

Ontologies

Keywords
Domain	Lipoyl RuleBase RU003765
Molecular function	Acyltransferase RuleBase RU003765 EMBL AAF48423.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty-acyl-CoA biosynthetic process Inferred from electronic annotation. Source: InterPro phagocytosis, engulfment Inferred from mutant phenotype. Source: FlyBase
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VXY3 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: A773AB80A34A873C	FASTA	462	50,073
	10 20 30 40 50 60 MATHLLRNGA TCWLLRNCIS QRAALRRCLH VTSSLDKTVS FNLSDIGEGI REVTVKEWFV 70 80 90 100 110 120 KEGDTVEQFD NLCEVQSDKA SVTITSRYDG KITKIHHKID EIALVGKPLL DFDVVNEDED 130 140 150 160 170 180 EPEDSSSSSS STSSDSSASE NEEKQSAEAS ATPTEGRVII PATPSVRRLA KEHQLDLAKV 190 200 210 220 230 240 PATGKNGRVL KGDILEFLGQ VPPGTNVPHP TLLAKTPSAA PSGAASVSVP ADRVEVLKGV 250 260 270 280 290 300 RKAMLKSMTE SLKIPHFAYS DEIDMTQLMQ FRNQLQLVAK ENGVPKLTFM PFCIKAASIA 310 320 330 340 350 360 LSKYPIVNSS LDLASESLVF KGAHNISVAI DTPQGLVVPN IKNCQTKTII EIAKDLNALV 370 380 390 400 410 420 ERGRTGSLSP ADFADGTFSL SNIGVIGGTY THPCIMAPQV AIGAMGRTKA VPRFNDKDEV 430 440 450 460 VKAYVMSVSW SADHRVIDGV TMASFSNVWK QYLENPALFL LH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL29017.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF48423.1. AY061469 mRNA. Translation: AAL29017.1.
RefSeq	NP_573000.1. NM_132772.2.
UniGene	Dm.165.
3D structure databases
HSSP	HSSP built from PDB template 1K8M based on UniProtKB P11182.
ProteinModelPortal	Q9VXY3.
SMR	Q9VXY3. Positions 35-113, 158-200, 231-462.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VXY3. 1 interaction.
MINT	MINT-1656970.
STRING	Q9VXY3.
Proteomic databases
PRIDE	Q9VXY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0073964; FBpp0073781; FBgn0030612.
GeneID	32441.
KEGG	dme:Dmel_CG5599.
NMPDR	fig|7227.3.peg.17893.
UCSC	CG5599-RA. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0030612. CG5599.
Phylogenomic databases
eggNOG	inNOG06814.
GeneTree	EMGT00050000000154.
InParanoid	Q9VXY3.
OMA	SNIGPIG.
OrthoDB	EOG46HDS8.
PhylomeDB	Q9VXY3.
Gene expression databases
Bgee	Q9VXY3.
Family and domain databases
InterPro	IPR003016. 2-oxoA_DH_lipoyl-BS. IPR001078. 2-oxoacid_DH_actylTfrase. IPR000089. Biotin_lipoyl. IPR023213. CAT-like_dom. IPR004167. E3-bd. IPR015761. Lip_Acyl_TA. IPR011053. Single_hybrid_motif. [Graphical view]
Gene3D	G3DSA:3.30.559.10. CAT-like_dom. 1 hit. G3DSA:4.10.320.10. E3_bd. 1 hit.
KO	K09699.
PANTHER	PTHR23151:SF11. Lip_Acyl_TA. 1 hit.
Pfam	PF00198. 2-oxoacid_dh. 1 hit. PF00364. Biotin_lipoyl. 1 hit. PF02817. E3_binding. 1 hit. [Graphical view]
SUPFAM	SSF47005. E3_bd. 1 hit. SSF51230. Hybrid_motif. 1 hit.
PROSITE	PS50968. BIOTINYL_LIPOYL. 1 hit. PS00189. LIPOYL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	778476.

Entry information

Entry name

Q9VXY3_DROME

Accession

Primary (citable) accession number: Q9VXY3

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 99 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)