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Protein

Probable 60S ribosomal protein L37-A

Gene

RpL37a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi34ZincBy similarity1
Metal bindingi37ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: GO_Central
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 60S ribosomal protein L37-A
Gene namesi
Name:RpL37a
ORF Names:CG9091
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030616 RpL37a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397101 – 93Probable 60S ribosomal protein L37-AAdd BLAST93

Proteomic databases

PaxDbiQ9VXX8
PRIDEiQ9VXX8

Expressioni

Gene expression databases

BgeeiFBgn0030616
ExpressionAtlasiQ9VXX8 baseline and differential
GenevisibleiQ9VXX8 DM

Interactioni

Protein-protein interaction databases

BioGridi58801, 21 interactors
DIPiDIP-18114N
IntActiQ9VXX8, 11 interactors
STRINGi7227.FBpp0073844

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cj1-93[»]
ProteinModelPortaliQ9VXX8
SMRiQ9VXX8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3475 Eukaryota
COG2126 LUCA
GeneTreeiENSGT00390000005254
InParanoidiQ9VXX8
KOiK02922
OMAiYPAAKMR
OrthoDBiEOG091G10FG
PhylomeDBiQ9VXX8

Family and domain databases

Gene3Di2.20.25.30, 1 hit
HAMAPiMF_00547 Ribosomal_L37e, 1 hit
InterProiView protein in InterPro
IPR011331 Ribosomal_L37ae/L37e
IPR001569 Ribosomal_L37e
IPR018267 Ribosomal_L37e_CS
IPR011332 Ribosomal_zn-bd
PfamiView protein in Pfam
PF01907 Ribosomal_L37e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005132 Ribosomal_L37e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01077 RIBOSOMAL_L37E, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VXX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGTSSFGK RHNKTHTLCR RCGRSSYHIQ KSTCAQCGYP AAKLRSYNWS
60 70 80 90
VKAKRRKTTG TGRMQHLKVV RRRFRNGFRE GTQAKPKKAV ASK
Length:93
Mass (Da):10,643
Last modified:May 1, 2000 - v1
Checksum:i12016AA606A3D717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF48428.1
BT031045 mRNA Translation: ABV82427.1
RefSeqiNP_001259561.1, NM_001272632.2
NP_573005.1, NM_132777.3
UniGeneiDm.14847

Genome annotation databases

EnsemblMetazoaiFBtr0074027; FBpp0073844; FBgn0030616
FBtr0330403; FBpp0303429; FBgn0030616
GeneIDi32446
KEGGidme:Dmel_CG9091

Similar proteinsi

Entry informationi

Entry nameiRL371_DROME
AccessioniPrimary (citable) accession number: Q9VXX8
Secondary accession number(s): A8E7A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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