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Protein

Probable 60S ribosomal protein L37-A

Gene

RpL37a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi34ZincBy similarity1
Metal bindingi37ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: GO_Central
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 60S ribosomal protein L37-A
Gene namesi
Name:RpL37a
ORF Names:CG9091
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030616. RpL37a.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397101 – 93Probable 60S ribosomal protein L37-AAdd BLAST93

Proteomic databases

PaxDbiQ9VXX8.
PRIDEiQ9VXX8.

Expressioni

Gene expression databases

BgeeiFBgn0030616.
ExpressionAtlasiQ9VXX8. differential.
GenevisibleiQ9VXX8. DM.

Interactioni

Protein-protein interaction databases

BioGridi58801. 14 interactors.
DIPiDIP-18114N.
IntActiQ9VXX8. 11 interactors.
MINTiMINT-343050.
STRINGi7227.FBpp0073844.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cj1-93[»]
ProteinModelPortaliQ9VXX8.
SMRiQ9VXX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3475. Eukaryota.
COG2126. LUCA.
GeneTreeiENSGT00390000005254.
InParanoidiQ9VXX8.
KOiK02922.
OMAiYPAAKMR.
OrthoDBiEOG091G10FG.
PhylomeDBiQ9VXX8.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e. 1 hit.
InterProiView protein in InterPro
IPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
PfamiView protein in Pfam
PF01907. Ribosomal_L37e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005132. Ribosomal_L37e. 1 hit.
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiView protein in PROSITE
PS01077. RIBOSOMAL_L37E. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VXX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGTSSFGK RHNKTHTLCR RCGRSSYHIQ KSTCAQCGYP AAKLRSYNWS
60 70 80 90
VKAKRRKTTG TGRMQHLKVV RRRFRNGFRE GTQAKPKKAV ASK
Length:93
Mass (Da):10,643
Last modified:May 1, 2000 - v1
Checksum:i12016AA606A3D717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48428.1.
BT031045 mRNA. Translation: ABV82427.1.
RefSeqiNP_001259561.1. NM_001272632.2.
NP_573005.1. NM_132777.3.
UniGeneiDm.14847.

Genome annotation databases

EnsemblMetazoaiFBtr0074027; FBpp0073844; FBgn0030616.
FBtr0330403; FBpp0303429; FBgn0030616.
GeneIDi32446.
KEGGidme:Dmel_CG9091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48428.1.
BT031045 mRNA. Translation: ABV82427.1.
RefSeqiNP_001259561.1. NM_001272632.2.
NP_573005.1. NM_132777.3.
UniGeneiDm.14847.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cj1-93[»]
ProteinModelPortaliQ9VXX8.
SMRiQ9VXX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58801. 14 interactors.
DIPiDIP-18114N.
IntActiQ9VXX8. 11 interactors.
MINTiMINT-343050.
STRINGi7227.FBpp0073844.

Proteomic databases

PaxDbiQ9VXX8.
PRIDEiQ9VXX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074027; FBpp0073844; FBgn0030616.
FBtr0330403; FBpp0303429; FBgn0030616.
GeneIDi32446.
KEGGidme:Dmel_CG9091.

Organism-specific databases

CTDi6168.
FlyBaseiFBgn0030616. RpL37a.

Phylogenomic databases

eggNOGiKOG3475. Eukaryota.
COG2126. LUCA.
GeneTreeiENSGT00390000005254.
InParanoidiQ9VXX8.
KOiK02922.
OMAiYPAAKMR.
OrthoDBiEOG091G10FG.
PhylomeDBiQ9VXX8.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL37A. fly.
GenomeRNAii32446.
PROiPR:Q9VXX8.

Gene expression databases

BgeeiFBgn0030616.
ExpressionAtlasiQ9VXX8. differential.
GenevisibleiQ9VXX8. DM.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e. 1 hit.
InterProiView protein in InterPro
IPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
PfamiView protein in Pfam
PF01907. Ribosomal_L37e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005132. Ribosomal_L37e. 1 hit.
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiView protein in PROSITE
PS01077. RIBOSOMAL_L37E. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL371_DROME
AccessioniPrimary (citable) accession number: Q9VXX8
Secondary accession number(s): A8E7A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.