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Protein

Probable 60S ribosomal protein L37-A

Gene

RpL37a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi34ZincBy similarity1
Metal bindingi37ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: GO_Central
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 60S ribosomal protein L37-A
Gene namesi
Name:RpL37a
ORF Names:CG9091
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030616. RpL37a.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001397101 – 93Probable 60S ribosomal protein L37-AAdd BLAST93

Proteomic databases

PaxDbiQ9VXX8.
PRIDEiQ9VXX8.

Expressioni

Gene expression databases

BgeeiFBgn0030616.
ExpressionAtlasiQ9VXX8. differential.
GenevisibleiQ9VXX8. DM.

Interactioni

Protein-protein interaction databases

BioGridi58801. 14 interactors.
DIPiDIP-18114N.
IntActiQ9VXX8. 11 interactors.
MINTiMINT-343050.
STRINGi7227.FBpp0073844.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cj1-93[»]
ProteinModelPortaliQ9VXX8.
SMRiQ9VXX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3475. Eukaryota.
COG2126. LUCA.
InParanoidiQ9VXX8.
KOiK02922.
OMAiYPAAKMR.
OrthoDBiEOG091G10FG.
PhylomeDBiQ9VXX8.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e. 1 hit.
InterProiView protein in InterPro
IPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
PfamiView protein in Pfam
PF01907. Ribosomal_L37e. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005132. Ribosomal_L37e. 1 hit.
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiView protein in PROSITE
PS01077. RIBOSOMAL_L37E. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VXX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGTSSFGK RHNKTHTLCR RCGRSSYHIQ KSTCAQCGYP AAKLRSYNWS
60 70 80 90
VKAKRRKTTG TGRMQHLKVV RRRFRNGFRE GTQAKPKKAV ASK
Length:93
Mass (Da):10,643
Last modified:May 1, 2000 - v1
Checksum:i12016AA606A3D717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48428.1.
BT031045 mRNA. Translation: ABV82427.1.
RefSeqiNP_001259561.1. NM_001272632.2.
NP_573005.1. NM_132777.3.
UniGeneiDm.14847.

Genome annotation databases

EnsemblMetazoaiFBtr0074027; FBpp0073844; FBgn0030616.
FBtr0330403; FBpp0303429; FBgn0030616.
GeneIDi32446.
KEGGidme:Dmel_CG9091.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRL371_DROME
AccessioniPrimary (citable) accession number: Q9VXX8
Secondary accession number(s): A8E7A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families