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Protein

Probable 60S ribosomal protein L37-A

Gene

RpL37a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191ZincBy similarity
Metal bindingi22 – 221ZincBy similarity
Metal bindingi34 – 341ZincBy similarity
Metal bindingi37 – 371ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 3719C4-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, RNA-binding, rRNA-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 60S ribosomal protein L37-A
Gene namesi
Name:RpL37a
ORF Names:CG9091
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030616. RpL37a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Probable 60S ribosomal protein L37-APRO_0000139710Add
BLAST

Proteomic databases

PaxDbiQ9VXX8.
PRIDEiQ9VXX8.

Expressioni

Gene expression databases

BgeeiQ9VXX8.
ExpressionAtlasiQ9VXX8. differential.
GenevisibleiQ9VXX8. DM.

Interactioni

Protein-protein interaction databases

BioGridi58801. 14 interactions.
DIPiDIP-18114N.
IntActiQ9VXX8. 11 interactions.
MINTiMINT-343050.
STRINGi7227.FBpp0073844.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cj1-93[»]
ProteinModelPortaliQ9VXX8.
SMRiQ9VXX8. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L37e family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri19 – 3719C4-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3475. Eukaryota.
COG2126. LUCA.
GeneTreeiENSGT00390000005254.
InParanoidiQ9VXX8.
KOiK02922.
OMAiKKRCAGC.
OrthoDBiEOG7RJPTP.
PhylomeDBiQ9VXX8.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e.
InterProiIPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01907. Ribosomal_L37e. 1 hit.
[Graphical view]
ProDomiPD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VXX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGTSSFGK RHNKTHTLCR RCGRSSYHIQ KSTCAQCGYP AAKLRSYNWS
60 70 80 90
VKAKRRKTTG TGRMQHLKVV RRRFRNGFRE GTQAKPKKAV ASK
Length:93
Mass (Da):10,643
Last modified:May 1, 2000 - v1
Checksum:i12016AA606A3D717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48428.1.
BT031045 mRNA. Translation: ABV82427.1.
RefSeqiNP_001259561.1. NM_001272632.2.
NP_573005.1. NM_132777.3.
UniGeneiDm.14847.

Genome annotation databases

EnsemblMetazoaiFBtr0074027; FBpp0073844; FBgn0030616.
FBtr0330403; FBpp0303429; FBgn0030616.
GeneIDi32446.
KEGGidme:Dmel_CG9091.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48428.1.
BT031045 mRNA. Translation: ABV82427.1.
RefSeqiNP_001259561.1. NM_001272632.2.
NP_573005.1. NM_132777.3.
UniGeneiDm.14847.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Cj1-93[»]
ProteinModelPortaliQ9VXX8.
SMRiQ9VXX8. Positions 2-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58801. 14 interactions.
DIPiDIP-18114N.
IntActiQ9VXX8. 11 interactions.
MINTiMINT-343050.
STRINGi7227.FBpp0073844.

Proteomic databases

PaxDbiQ9VXX8.
PRIDEiQ9VXX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074027; FBpp0073844; FBgn0030616.
FBtr0330403; FBpp0303429; FBgn0030616.
GeneIDi32446.
KEGGidme:Dmel_CG9091.

Organism-specific databases

CTDi6168.
FlyBaseiFBgn0030616. RpL37a.

Phylogenomic databases

eggNOGiKOG3475. Eukaryota.
COG2126. LUCA.
GeneTreeiENSGT00390000005254.
InParanoidiQ9VXX8.
KOiK02922.
OMAiKKRCAGC.
OrthoDBiEOG7RJPTP.
PhylomeDBiQ9VXX8.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL37A. fly.
GenomeRNAii32446.
PROiQ9VXX8.

Gene expression databases

BgeeiQ9VXX8.
ExpressionAtlasiQ9VXX8. differential.
GenevisibleiQ9VXX8. DM.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e.
InterProiIPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01907. Ribosomal_L37e. 1 hit.
[Graphical view]
ProDomiPD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
  4. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.

Entry informationi

Entry nameiRL371_DROME
AccessioniPrimary (citable) accession number: Q9VXX8
Secondary accession number(s): A8E7A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.