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Protein

Phospholipid-transporting ATPase

Gene

CG9981

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: FlyBase

GO - Biological processi

  • phospholipid translocation Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
ORF Names:CG9981Imported, Dmel_CG9981Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030746. CG9981.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei52 – 68HelicalUniRule annotationAdd BLAST17
Transmembranei74 – 93HelicalUniRule annotationAdd BLAST20
Transmembranei275 – 297HelicalUniRule annotationAdd BLAST23
Transmembranei328 – 347HelicalUniRule annotationAdd BLAST20
Transmembranei832 – 856HelicalUniRule annotationAdd BLAST25
Transmembranei868 – 888HelicalUniRule annotationAdd BLAST21
Transmembranei915 – 938HelicalUniRule annotationAdd BLAST24
Transmembranei958 – 978HelicalUniRule annotationAdd BLAST21
Transmembranei985 – 1004HelicalUniRule annotationAdd BLAST20
Transmembranei1024 – 1045HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0030746.

Interactioni

Protein-protein interaction databases

IntActiQ9VXG7. 1 interactor.
STRINGi7227.FBpp0306159.

Structurei

3D structure databases

SMRiQ9VXG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 67PhoLip_ATPase_NInterPro annotationAdd BLAST44
Domaini804 – 1050PhoLip_ATPase_CInterPro annotationAdd BLAST247

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
GeneTreeiENSGT00870000136387.
KOiK01530.
OMAiLLRWPVF.
OrthoDBiEOG091G03B1.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VXG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGADKKKSAD PLRIQIGGIE SRQQKPLNRV TTTKYTWFTF LPLNFYEQFR
60 70 80 90 100
RAVYFYFLII TIVSFFVNET ISPLVSLLPL LFVMIITALK EGLEDYSRSK
110 120 130 140 150
SDKLVNTARV TVIRNGKEEI INSQFIVPGD LVVVRNDGDV PCDLVLLQSS
160 170 180 190 200
SADRKCFVNT ANLDGETNLK TICVPTNYLL AGDHELQGKD CIVCEPSSAD
210 220 230 240 250
LYTFNGRLEL RSGNDGAGSS AGDALPLTID NLLLRGVRVK STERVVGCAI
260 270 280 290 300
YTGMHTKLQL NSRYTGNKSA SSEKYINRFM VALIVGMIVV VVVLYLIERH
310 320 330 340 350
KEAKIVPTMP YQGPPTNFNS AWQIFEDFLS FLLLFNYMVP ISAYMNIEVY
360 370 380 390 400
RIFGMHFMHN DLHLYDEETD QPCRVNASNL NEELGQVNIL FSDKTGTLTK
410 420 430 440 450
NLMKFVNCYV PGTNYQLQNT HLVSEGTDEK FELEKLDADA AVLFEALAVC
460 470 480 490 500
HTVEVLQEVG DKTLESSESV SEQSHLMSRN IVDRYQASSP DEKALLEGCA
510 520 530 540 550
SLGLVYEGQE NDVLSICRYP SAEKVQFKRL HVLEFSSERQ RMSVIVRDQS
560 570 580 590 600
DTIWLYSKGA ESAIFPRCKA SPLVEQTDAQ ITKYAQNGLR TMAVGRRMLT
610 620 630 640 650
DDELFHFEEL YRKANTQLSN RNELIASCYE TVENELDLLG ATALEDALQE
660 670 680 690 700
HVGETLEALQ AAGLKIWVLT GDKVETAYNI GLACRHIPRG SKQHFIINTT
710 720 730 740 750
EPAELLARLD MIGDDEPEVL IVDGTTITAL LEHTPRQFAD LALRCRAVLC
760 770 780 790 800
CRLSPLQKSE IVTLIKRRKK YITAAIGDGA NDVSMIQEAH IGIGITGREG
810 820 830 840 850
KQAARCADFS IARFEMLRRL FLVHGHYNSQ RLAFLVLFYC YKNIIITGCM
860 870 880 890 900
ALYQVYDLYS ATNVYNSIYL WLFDIVYISF SFTVLAICDK DYSEETLLSH
910 920 930 940 950
PELYKPLAHN RQASMGVFSL WILNGFVQCF IIFFFTYAML NDANVLFNGG
960 970 980 990 1000
QTASFQTFGT MLITIIVIVG NLKLLLVAHY MTYRNFAMIL ASIAAFMLTT
1010 1020 1030 1040 1050
YLYNLYTSGE LYDVYNQFLS SLPIWLFTII CSVACLLPDF VIKVVNDMYR
1060
KVPLKSKPVV
Length:1,060
Mass (Da):119,590
Last modified:May 1, 2000 - v1
Checksum:iDFDFCECB0121AB10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48605.1.
AE014298 Genomic DNA. Translation: AGB95452.1.
AE014298 Genomic DNA. Translation: AGB95453.1.
RefSeqiNP_001259610.1. NM_001272681.1.
NP_001259611.1. NM_001272682.2.
NP_573124.1. NM_132896.2.
UniGeneiDm.17376.

Genome annotation databases

EnsemblMetazoaiFBtr0074304; FBpp0074079; FBgn0030746.
FBtr0334043; FBpp0306159; FBgn0030746.
FBtr0334044; FBpp0306160; FBgn0030746.
GeneIDi32609.
KEGGidme:Dmel_CG9981.
UCSCiCG9981-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VXG7_DROME
AccessioniPrimary (citable) accession number: Q9VXG7
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported