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Protein

Phospholipid-transporting ATPase

Gene

CG4301

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: FlyBase

GO - Biological processi

  • phospholipid translocation Source: FlyBase

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-6798695. Neutrophil degranulation.
R-DME-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
Gene namesi
ORF Names:CG4301Imported, Dmel_CG4301Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030747. CG4301.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei99 – 117HelicalUniRule annotationAdd BLAST19
Transmembranei314 – 336HelicalUniRule annotationAdd BLAST23
Transmembranei367 – 386HelicalUniRule annotationAdd BLAST20
Transmembranei1099 – 1119HelicalUniRule annotationAdd BLAST21
Transmembranei1131 – 1151HelicalUniRule annotationAdd BLAST21
Transmembranei1179 – 1206HelicalUniRule annotationAdd BLAST28
Transmembranei1212 – 1236HelicalUniRule annotationAdd BLAST25
Transmembranei1248 – 1270HelicalUniRule annotationAdd BLAST23
Transmembranei1290 – 1309HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ9VXG6.
PRIDEiQ9VXG6.

Expressioni

Gene expression databases

BgeeiFBgn0030747.
ExpressionAtlasiQ9VXG6. differential.
GenevisibleiQ9VXG6. DM.

Interactioni

Protein-protein interaction databases

IntActiQ9VXG6. 1 interactor.
MINTiMINT-960283.
STRINGi7227.FBpp0074048.

Structurei

3D structure databases

ProteinModelPortaliQ9VXG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 122PhoLip_ATPase_NInterPro annotationAdd BLAST53
Domaini1068 – 1317PhoLip_ATPase_CInterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410ITKC. Eukaryota.
ENOG410XSS0. LUCA.
GeneTreeiENSGT00870000136387.
InParanoidiQ9VXG6.
OMAiRCSPTHV.
OrthoDBiEOG091G00LI.
PhylomeDBiQ9VXG6.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiView protein in Pfam
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 2 hits.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VXG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFFGHDHLS GFRRIDRLGA HRQTPWADQE SFHLKDAFLW NWHKGSRVST
60 70 80 90 100
INDWLQIQIG GPQDIKKKRP KGQNRIKSTK YTLITFLPQN LLEQFRRIAN
110 120 130 140 150
FYFLVMTIIS LLIDSPVSPM TSLLPLVFVI AVTAAKQGYE DILRYRTDNV
160 170 180 190 200
VNSSPVTVIR DGKEAIIKSQ DVIPGELIVV ERDCDVPCDL VLLRSTDPHG
210 220 230 240 250
KCFITTANLD GESNLKTLMV PRDLPTVDLP EMHKLGIIEC ESPTTDLYSF
260 270 280 290 300
NGKIELKGGE GRVLPLSTEN VLLRGSRVKN TECVIGCAVY TGMISKLQLN
310 320 330 340 350
SRLTRNKNAS SETYINRFLI VILVALIAIV TLLYFLKRYN ELFVIPKLTY
360 370 380 390 400
LGDATDSYSV KQFLQDYLSF LILFNYLIPI SLYVTIELQR VIGSWFMEWD
410 420 430 440 450
LELYENETDQ PCVVNTSNLN EELGQINILF SDKTGTLTKN EMNFQQCSIN
460 470 480 490 500
GNKFLFKKTR LEDEETKALL DINKFSANQR VFFQALSICH TVQVASGSLE
510 520 530 540 550
QADAGTAKRE PVTAIKSGPP EMYSISDITE ESHNASQQSE LNVGHTIDNS
560 570 580 590 600
VSAHPNGVNS TIISSDVNPL LVSDDGYGVE RRKRPVVIKR SPNFARSNRM
610 620 630 640 650
NNGAASDLNI NQTDPNTVTN GVEPTTNFRP ISLQFRRSTS EKDLQQSWEA
660 670 680 690 700
PSGQAPGHRR AHSYGAPNAY LTNPVTASTP PAGVLFRSPS TTSRESYAAP
710 720 730 740 750
TFTRQPTILV RAESQRRKNE IRDFIFTLDY QASSPDEKAL VEACANLGMV
760 770 780 790 800
YTGDDDETLR VRIVPPHMDY KRPFAKPREE TFQRLHVLEF TSDRKRMSVI
810 820 830 840 850
VRDTDGKKWI YTKGAESYVF PLCANSSAEL VTKTDAHISD FARLGLRTLA
860 870 880 890 900
IARRLISEEE YQDFLVELAQ ANSSLENRKQ LSEECYAKIE SNLDLLGATA
910 920 930 940 950
VEDALQDDVA DTLVSLQAAG IKIWVLTGDK VETALNIALS CGHIPPDAKK
960 970 980 990 1000
YFIMECKNRE EMLLHLNALD REIIFGIGQE CALLIDGKSL GVALAEASSE
1010 1020 1030 1040 1050
FRDVAVKCTA VLCCRLSPLQ KSEVVSLIKS SNENYNTASI GDGANDVSMI
1060 1070 1080 1090 1100
QEAHVGIGIM GREGRQAARC ADFAFAKFCM LKRLLLVHGH YHSVRLSLLV
1110 1120 1130 1140 1150
LYFFYKNIVF MGIMFLFQFH TLFSSSSVYD SLFLTLYNVI YTSLPILFIA
1160 1170 1180 1190 1200
ISEKPYTEEK LMRTPQLYKK NTDNKQLHWP YFLMWVLFAI YHSVIIFYFA
1210 1220 1230 1240 1250
FCFFYYNNVL LNYGQTVAFS CFGTLLMWTV VVVVNLKLWL ESMYLSFWYI
1260 1270 1280 1290 1300
FTIIISILGF VVTTVIYNVI NLDYDTDIYW AYNNLLASLP VWLWIIVTCV
1310 1320 1330 1340
ACLVPDYTIR MLQRALNIKS FSIFPGKQRK LKMREKFEST YL
Length:1,342
Mass (Da):152,046
Last modified:October 1, 2002 - v2
Checksum:i4D2F454F11C02217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48606.2.
RefSeqiNP_573125.1. NM_132897.3.

Genome annotation databases

EnsemblMetazoaiFBtr0074272; FBpp0074048; FBgn0030747.
GeneIDi32610.
UCSCiCG4301-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VXG6_DROME
AccessioniPrimary (citable) accession number: Q9VXG6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: July 5, 2017
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported