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Protein

Annexin B11

Gene

AnxB11

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase
  • calcium-dependent phospholipid binding Source: FlyBase
  • calcium ion binding Source: InterPro

GO - Biological processi

  • cell adhesion Source: FlyBase
  • regulation of cell shape Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin B11
Gene namesi
Name:AnxB11
ORF Names:CG9968
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030749. AnxB11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511Annexin B11PRO_0000067518Add
BLAST

Proteomic databases

PaxDbiQ9VXG4.
PRIDEiQ9VXG4.

Expressioni

Gene expression databases

BgeeiQ9VXG4.
GenevisibleiQ9VXG4. DM.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi58952. 8 interactions.
IntActiQ9VXG4. 2 interactions.
MINTiMINT-338130.
STRINGi7227.FBpp0306158.

Structurei

3D structure databases

ProteinModelPortaliQ9VXG4.
SMRiQ9VXG4. Positions 197-506.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati208 – 27366Annexin 1Add
BLAST
Repeati281 – 34565Annexin 2Add
BLAST
Repeati364 – 42966Annexin 3Add
BLAST
Repeati439 – 50466Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.By similarity

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiQ9VXG4.
KOiK17095.
OMAiIFQEYEG.
OrthoDBiEOG74XS72.
PhylomeDBiQ9VXG4.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: Q9VXG4-1) [UniParc]FASTAAdd to basket

Also known as: E, G

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYPFGSGMPS HPPTSTNHHE PPRAPFGAGW VPPMQQNSPY PPPSQPHPHS
60 70 80 90 100
QPSSQMHPQQ HQQYPGGAPA PYPPMSAPYP SAAPSYPPYP TSNPYPAQYA
110 120 130 140 150
PPAHNHYQQP SVSNSPYPAD RGYTPAMTAG YDAGYGYGNG QGHGQGHGHG
160 170 180 190 200
QGHGHGHGQG HEYGHGYGQG YGHGQGHGNG QGHAHRSLPA HREGTPTVVP
210 220 230 240 250
AANFDAVKDA HDLRKAMKGF GTDEDALINI ICRRSNEQRQ EIQRQFKTHF
260 270 280 290 300
GKDLIEDIKS ETSGNFEKLL VGLLRPIVDY YCAELNDAMA GLGTDEEVLI
310 320 330 340 350
EILCTLSNME INTIKNQYLR LYGAHLESEL KSETSGNFKR LLTSLCTAAR
360 370 380 390 400
DESGRVDPVA AKNDARELLK AGELRVGTDE SMFNMILCQR NYQQLKLIFQ
410 420 430 440 450
EYEGMTGHSL EKAIKKEFSG DVMEGLIAIY RCVTNKAEYF ASRLHKAMAG
460 470 480 490 500
IGTNDTQLIR VIITRSEIDM TDIKVAFERL YGKSLKSWIK GDTSGHYKHA
510
LYALVGEQRS S
Note: No experimental confirmation available.
Length:511
Mass (Da):56,215
Last modified:February 19, 2014 - v2
Checksum:i74712A8F1C54283B
GO
Isoform A (identifier: Q9VXG4-2) [UniParc]FASTAAdd to basket

Also known as: C, F

The sequence of this isoform differs from the canonical sequence as follows:
     6-194: Missing.

Show »
Length:322
Mass (Da):36,289
Checksum:i7CCFCCF7FB9C217D
GO
Isoform D (identifier: Q9VXG4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):33,375
Checksum:iC227EE6252509AE2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 216216Missing in isoform D. CuratedVSP_053656Add
BLAST
Alternative sequencei6 – 194189Missing in isoform A. 2 PublicationsVSP_053657Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276963 mRNA. Translation: CAB86189.1.
AE014298 Genomic DNA. Translation: AAF48609.1.
AE014298 Genomic DNA. Translation: AAF48610.1.
AE014298 Genomic DNA. Translation: AGB95456.1.
AE014298 Genomic DNA. Translation: AGB95457.1.
AE014298 Genomic DNA. Translation: AGB95458.1.
AE014298 Genomic DNA. Translation: AGB95459.1.
AE014298 Genomic DNA. Translation: AGB95460.1.
AY058397 mRNA. Translation: AAL13626.1.
AY122138 mRNA. Translation: AAM52650.1.
BT125828 mRNA. Translation: ADR83713.1.
RefSeqiNP_001259614.1. NM_001272685.1. [Q9VXG4-2]
NP_001259615.1. NM_001272686.1. [Q9VXG4-3]
NP_001259616.1. NM_001272687.1. [Q9VXG4-1]
NP_001259617.1. NM_001272688.1. [Q9VXG4-2]
NP_001259618.1. NM_001272689.1. [Q9VXG4-1]
NP_523370.1. NM_078646.3. [Q9VXG4-2]
NP_727978.1. NM_167519.2. [Q9VXG4-1]
UniGeneiDm.12489.

Genome annotation databases

EnsemblMetazoaiFBtr0074303; FBpp0074078; FBgn0030749. [Q9VXG4-1]
FBtr0334040; FBpp0306156; FBgn0030749. [Q9VXG4-1]
FBtr0334042; FBpp0306158; FBgn0030749. [Q9VXG4-1]
GeneIDi32612.
KEGGidme:Dmel_CG9968.
UCSCiCG9968-RB. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276963 mRNA. Translation: CAB86189.1.
AE014298 Genomic DNA. Translation: AAF48609.1.
AE014298 Genomic DNA. Translation: AAF48610.1.
AE014298 Genomic DNA. Translation: AGB95456.1.
AE014298 Genomic DNA. Translation: AGB95457.1.
AE014298 Genomic DNA. Translation: AGB95458.1.
AE014298 Genomic DNA. Translation: AGB95459.1.
AE014298 Genomic DNA. Translation: AGB95460.1.
AY058397 mRNA. Translation: AAL13626.1.
AY122138 mRNA. Translation: AAM52650.1.
BT125828 mRNA. Translation: ADR83713.1.
RefSeqiNP_001259614.1. NM_001272685.1. [Q9VXG4-2]
NP_001259615.1. NM_001272686.1. [Q9VXG4-3]
NP_001259616.1. NM_001272687.1. [Q9VXG4-1]
NP_001259617.1. NM_001272688.1. [Q9VXG4-2]
NP_001259618.1. NM_001272689.1. [Q9VXG4-1]
NP_523370.1. NM_078646.3. [Q9VXG4-2]
NP_727978.1. NM_167519.2. [Q9VXG4-1]
UniGeneiDm.12489.

3D structure databases

ProteinModelPortaliQ9VXG4.
SMRiQ9VXG4. Positions 197-506.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi58952. 8 interactions.
IntActiQ9VXG4. 2 interactions.
MINTiMINT-338130.
STRINGi7227.FBpp0306158.

Proteomic databases

PaxDbiQ9VXG4.
PRIDEiQ9VXG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074303; FBpp0074078; FBgn0030749. [Q9VXG4-1]
FBtr0334040; FBpp0306156; FBgn0030749. [Q9VXG4-1]
FBtr0334042; FBpp0306158; FBgn0030749. [Q9VXG4-1]
GeneIDi32612.
KEGGidme:Dmel_CG9968.
UCSCiCG9968-RB. d. melanogaster.

Organism-specific databases

CTDi32612.
FlyBaseiFBgn0030749. AnxB11.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
InParanoidiQ9VXG4.
KOiK17095.
OMAiIFQEYEG.
OrthoDBiEOG74XS72.
PhylomeDBiQ9VXG4.

Miscellaneous databases

ChiTaRSiAnxb11. fly.
GenomeRNAii32612.
PROiQ9VXG4.

Gene expression databases

BgeeiQ9VXG4.
GenevisibleiQ9VXG4. DM.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
[Graphical view]
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural comparison and molecular classification of non-vertebrate animal annexins."
    Fernandez M.-P., Morgan R.O.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "A Drosophila full-length cDNA resource."
    Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
    Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
    Tissue: Head and Ovary.
  5. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
    Strain: Berkeley.

Entry informationi

Entry nameiANX11_DROME
AccessioniPrimary (citable) accession number: Q9VXG4
Secondary accession number(s): M9PEV0, M9PHW3, Q9VXG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: February 19, 2014
Last modified: June 8, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.