ID   DENR_DROME              Reviewed;         189 AA.
AC   Q9VX98; Q95SJ6;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 3.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Density-regulated protein homolog {ECO:0000303|PubMed:25043021};
GN   Name=DENR {ECO:0000312|FlyBase:FBgn0030802};
GN   ORFNames=CG9099 {ECO:0000312|FlyBase:FBgn0030802};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF48679.3};
RN   [1] {ECO:0000312|EMBL:AAF48679.3}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000312|EMBL:AAF48679.3}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3] {ECO:0000312|EMBL:AAL28305.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley {ECO:0000312|EMBL:AAL28305.1};
RC   TISSUE=Head {ECO:0000312|EMBL:AAL28305.1};
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH MCTS1, AND DISRUPTION PHENOTYPE.
RX   PubMed=25043021; DOI=10.1038/nature13401;
RA   Schleich S., Strassburger K., Janiesch P.C., Koledachkina T., Miller K.K.,
RA   Haneke K., Cheng Y.S., Kuchler K., Stoecklin G., Duncan K.E., Teleman A.A.;
RT   "DENR-MCT-1 promotes translation re-initiation downstream of uORFs to
RT   control tissue growth.";
RL   Nature 512:208-212(2014).
CC   -!- FUNCTION: Regulates translation as part of a complex with MCTS1.
CC       Specifically required for translational re-initiation in mRNAs
CC       containing upstream open reading frames (uORFs). Not required for
CC       standard translational initiation. Regulates expression of a subset of
CC       gene products including mbc, InR and EcR.
CC       {ECO:0000269|PubMed:25043021}.
CC   -!- SUBUNIT: Interacts with MCTS1. {ECO:0000269|PubMed:25043021}.
CC   -!- DISRUPTION PHENOTYPE: Animals die as pharate adults with crooked legs,
CC       abnormal genitalia and a larval-like epidermis. Proliferation of
CC       histoblast cells is impaired. {ECO:0000269|PubMed:25043021}.
CC   -!- SIMILARITY: Belongs to the DENR family. {ECO:0000305}.
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DR   EMBL; AE014298; AAF48679.3; -; Genomic_DNA.
DR   EMBL; AE014298; AGB95472.1; -; Genomic_DNA.
DR   EMBL; AY060757; AAL28305.1; -; mRNA.
DR   RefSeq; NP_001259630.1; NM_001272701.1.
DR   RefSeq; NP_573176.1; NM_132948.4.
DR   AlphaFoldDB; Q9VX98; -.
DR   SMR; Q9VX98; -.
DR   IntAct; Q9VX98; 3.
DR   STRING; 7227.FBpp0074121; -.
DR   PaxDb; 7227-FBpp0302657; -.
DR   DNASU; 32679; -.
DR   EnsemblMetazoa; FBtr0074347; FBpp0074121; FBgn0030802.
DR   EnsemblMetazoa; FBtr0310520; FBpp0302657; FBgn0030802.
DR   GeneID; 32679; -.
DR   KEGG; dme:Dmel_CG9099; -.
DR   UCSC; CG9099-RA; d. melanogaster.
DR   AGR; FB:FBgn0030802; -.
DR   CTD; 8562; -.
DR   FlyBase; FBgn0030802; DENR.
DR   VEuPathDB; VectorBase:FBgn0030802; -.
DR   eggNOG; KOG3239; Eukaryota.
DR   GeneTree; ENSGT00390000014349; -.
DR   HOGENOM; CLU_073511_1_0_1; -.
DR   InParanoid; Q9VX98; -.
DR   OMA; EKWPQID; -.
DR   OrthoDB; 130735at2759; -.
DR   PhylomeDB; Q9VX98; -.
DR   BioGRID-ORCS; 32679; 1 hit in 1 CRISPR screen.
DR   GenomeRNAi; 32679; -.
DR   PRO; PR:Q9VX98; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0030802; Expressed in spermathecum and 24 other cell types or tissues.
DR   GO; GO:0032991; C:protein-containing complex; IPI:FlyBase.
DR   GO; GO:0048027; F:mRNA 5'-UTR binding; IDA:FlyBase.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR   GO; GO:0001731; P:formation of translation preinitiation complex; IBA:GO_Central.
DR   GO; GO:0120142; P:positive regulation of ecdysone receptor-mediated signaling pathway; IMP:FlyBase.
DR   GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IMP:FlyBase.
DR   GO; GO:0002188; P:translation reinitiation; IDA:FlyBase.
DR   CDD; cd11607; DENR_C; 1.
DR   Gene3D; 3.30.780.10; SUI1-like domain; 1.
DR   InterPro; IPR046447; DENR_C.
DR   InterPro; IPR005873; DENR_eukaryotes.
DR   InterPro; IPR048517; DENR_N.
DR   InterPro; IPR001950; SUI1.
DR   InterPro; IPR036877; SUI1_dom_sf.
DR   NCBIfam; TIGR01159; DRP1; 1.
DR   PANTHER; PTHR12789:SF0; DENSITY-REGULATED PROTEIN; 1.
DR   PANTHER; PTHR12789; DENSITY-REGULATED PROTEIN HOMOLOG; 1.
DR   Pfam; PF21023; DENR_N; 1.
DR   Pfam; PF01253; SUI1; 1.
DR   SUPFAM; SSF55159; eIF1-like; 1.
DR   PROSITE; PS50296; SUI1; 1.
DR   Genevisible; Q9VX98; DM.
PE   1: Evidence at protein level;
KW   Reference proteome; Translation regulation.
FT   CHAIN           1..189
FT                   /note="Density-regulated protein homolog"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000432074"
FT   DOMAIN          105..172
FT                   /note="SUI1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00200"
SQ   SEQUENCE   189 AA;  21349 MW;  8FD869D637727C62 CRC64;
     MTNEDVGTNS VADRLQLGPR EGVTYPIQMK YCGHCTMPIE YCEYYPEYEK CKEWLELHMP
     DDFERLKIEE EAAAADGTDD DKKRQKRGGK GLLRVKKKED VPKRICVSRA ARGKKKSVTV
     VTGLSTFDID LKVAAKFFGT KFACGSSVTG DDEIVIQGDV KDDLFDVIPE KWAEIDEDVI
     EDLGDQKRT
//