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Protein

Density-regulated protein homolog

Gene

DENR

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates translation as part of a complex with MCTS1. Specifically required for translational re-initiation in mRNAs containing upstream open reading frames (uORFs). Not required for standard translational initiation. Regulates expression of a subset of gene products including mbc, InR and EcR.1 Publication

GO - Molecular functioni

  • mRNA binding Source: FlyBase
  • ribosome binding Source: GO_Central
  • translation initiation factor activity Source: GO_Central

GO - Biological processi

  • ecdysone receptor-mediated signaling pathway Source: FlyBase
  • formation of translation preinitiation complex Source: GO_Central
  • IRES-dependent translational initiation Source: GO_Central
  • positive regulation of cell proliferation Source: FlyBase
  • positive regulation of insulin receptor signaling pathway Source: FlyBase
  • positive regulation of translational initiation Source: FlyBase
  • translation reinitiation Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Density-regulated protein homolog1 Publication
Gene namesi
Name:DENRImported
ORF Names:CG9099Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030802. DENR.

Subcellular locationi

GO - Cellular componenti

  • protein complex Source: FlyBase
  • translation initiation complex Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Animals die as pharate adults with crooked legs, abnormal genitalia and a larval-like epidermis. Proliferation of histoblast cells is impaired.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004320741 – 189Density-regulated protein homologCuratedAdd BLAST189

Proteomic databases

PaxDbiQ9VX98.
PRIDEiQ9VX98.

Expressioni

Gene expression databases

BgeeiFBgn0030802.
GenevisibleiQ9VX98. DM.

Interactioni

Subunit structurei

Interacts with MCTS1.1 Publication

Protein-protein interaction databases

IntActiQ9VX98. 3 interactors.
MINTiMINT-280600.
STRINGi7227.FBpp0302657.

Structurei

3D structure databases

ProteinModelPortaliQ9VX98.
SMRiQ9VX98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 172SUI1PROSITE-ProRule annotationAdd BLAST68

Sequence similaritiesi

Belongs to the DENR family.Curated
Contains 1 SUI1 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
OMAiCKQWLER.
OrthoDBiEOG091G0R9X.
PhylomeDBiQ9VX98.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VX98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNEDVGTNS VADRLQLGPR EGVTYPIQMK YCGHCTMPIE YCEYYPEYEK
60 70 80 90 100
CKEWLELHMP DDFERLKIEE EAAAADGTDD DKKRQKRGGK GLLRVKKKED
110 120 130 140 150
VPKRICVSRA ARGKKKSVTV VTGLSTFDID LKVAAKFFGT KFACGSSVTG
160 170 180
DDEIVIQGDV KDDLFDVIPE KWAEIDEDVI EDLGDQKRT
Length:189
Mass (Da):21,349
Last modified:October 1, 2002 - v3
Checksum:i8FD869D637727C62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48679.3.
AE014298 Genomic DNA. Translation: AGB95472.1.
AY060757 mRNA. Translation: AAL28305.1.
RefSeqiNP_001259630.1. NM_001272701.1.
NP_573176.1. NM_132948.4.
UniGeneiDm.19728.

Genome annotation databases

EnsemblMetazoaiFBtr0074347; FBpp0074121; FBgn0030802.
FBtr0310520; FBpp0302657; FBgn0030802.
GeneIDi32679.
KEGGidme:Dmel_CG9099.
UCSCiCG9099-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48679.3.
AE014298 Genomic DNA. Translation: AGB95472.1.
AY060757 mRNA. Translation: AAL28305.1.
RefSeqiNP_001259630.1. NM_001272701.1.
NP_573176.1. NM_132948.4.
UniGeneiDm.19728.

3D structure databases

ProteinModelPortaliQ9VX98.
SMRiQ9VX98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VX98. 3 interactors.
MINTiMINT-280600.
STRINGi7227.FBpp0302657.

Proteomic databases

PaxDbiQ9VX98.
PRIDEiQ9VX98.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074347; FBpp0074121; FBgn0030802.
FBtr0310520; FBpp0302657; FBgn0030802.
GeneIDi32679.
KEGGidme:Dmel_CG9099.
UCSCiCG9099-RA. d. melanogaster.

Organism-specific databases

CTDi8562.
FlyBaseiFBgn0030802. DENR.

Phylogenomic databases

eggNOGiKOG3239. Eukaryota.
COG0023. LUCA.
GeneTreeiENSGT00390000014349.
OMAiCKQWLER.
OrthoDBiEOG091G0R9X.
PhylomeDBiQ9VX98.

Miscellaneous databases

GenomeRNAii32679.
PROiQ9VX98.

Gene expression databases

BgeeiFBgn0030802.
GenevisibleiQ9VX98. DM.

Family and domain databases

Gene3Di3.30.780.10. 1 hit.
InterProiIPR005873. Drp1.
IPR001950. SUI1.
[Graphical view]
PfamiPF01253. SUI1. 1 hit.
[Graphical view]
SUPFAMiSSF55159. SSF55159. 1 hit.
TIGRFAMsiTIGR01159. DRP1. 1 hit.
PROSITEiPS50296. SUI1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDENR_DROME
AccessioniPrimary (citable) accession number: Q9VX98
Secondary accession number(s): Q95SJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 4, 2015
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.