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Protein

E3 ubiquitin-protein ligase UBR1

Gene

Ubr1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 178UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri1126 – 1220RING-type; atypicalAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase UBR1 (EC:6.3.2.-)
Alternative name(s):
N-recognin
Ubiquitin-protein ligase E3-alpha
Gene namesi
Name:Ubr1Imported
ORF Names:CG9086Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0030809. Ubr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000561391 – 1824E3 ubiquitin-protein ligase UBR1Add BLAST1824

Proteomic databases

PaxDbiQ9VX91.
PRIDEiQ9VX91.

Expressioni

Gene expression databases

BgeeiFBgn0030809.
ExpressionAtlasiQ9VX91. baseline.
GenevisibleiQ9VX91. DM.

Interactioni

Protein-protein interaction databases

BioGridi59018. 1 interactor.
IntActiQ9VX91. 6 interactors.
MINTiMINT-822679.
STRINGi7227.FBpp0074189.

Structurei

3D structure databases

ProteinModelPortaliQ9VX91.
SMRiQ9VX91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The RING-H2 zinc finger is an atypical RING finger with a His ligand in place of the fourth Cys of the classical motif.

Sequence similaritiesi

Belongs to the UBR1 family.Curated
Contains 1 RING-type zinc finger.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 178UBR-typePROSITE-ProRule annotationAdd BLAST72
Zinc fingeri1126 – 1220RING-type; atypicalAdd BLAST95

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1140. Eukaryota.
ENOG410XPQU. LUCA.
GeneTreeiENSGT00530000063055.
InParanoidiQ9VX91.
KOiK10626.
OMAiANCLVYD.
OrthoDBiEOG091G009K.
PhylomeDBiQ9VX91.

Family and domain databases

Gene3Di3.30.1390.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR003769. ClpS_core.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR011991. WHTH_DNA-bd_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF02617. ClpS. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54736. SSF54736. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VX91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRYDMEDVV VAPPAECSSP LKEWRLKRQA GTLDRSDIIE FLKRESPKYF
60 70 80 90 100
DYQTSATVKD TNVITLKCMF KESLAKEEII DVVVEFMLGD NPSSALEKLR
110 120 130 140 150
LEGNTATVCG KVFKNGEPTY SCRECGVDPT CVLCVNCFKR SAHRFHKYKM
160 170 180 190 200
STSGGGGCCD CGDDEAWKKD QYCELHLANR KNPLESKILT DAVLERVEIC
210 220 230 240 250
FGAILAFCVS YLEIEPNASL QCLDGNVEGG QVDGAQYCTV LYNDESHTFD
260 270 280 290 300
QVIQTLTKIA KCRAKDAMEI VAAIDREGRA VVKCDTFEEC NKLKVSIENQ
310 320 330 340 350
MILPTSLVST ARNNQSLRTS VLHIGAVACQ QFALQLLGWF QEFLVRHYLF
360 370 380 390 400
RKTFSELVQR KQETFCIRHI LEYDVKLWKT ARTCWHRLLI SGMLMEYDNK
410 420 430 440 450
MILAQEFSRR YATIVEDFIS DDHDHAFSIV SLSVQLFTVP SIAHHLIAHE
460 470 480 490 500
GIFDKLLHTF YHVAIEKFIR NKTLHFSKNI ASLTFFKRAN YILYDLRYLL
510 520 530 540 550
SLKPDVLSND LRNGFLEGCR ALMRVLNVMQ GMESMTRQTG QHMDYEPEWE
560 570 580 590 600
CAFNLHIKLA TTISQVIDWA SGDVKLLRKL YKMTMRALVS NSFIVGGEKV
610 620 630 640 650
MQPKKVADHV ANCLVYDISV QPVSIHLPLS RFFAGIYLHL GAHDLTYDGL
660 670 680 690 700
QTETEALSIK LTPREIIEPV LCTQAMIAQV GAGLWRRNGY TLLHQLYFYR
710 720 730 740 750
NVRCRVEMLD RDIACLQIGA SLMESNEFLI HVLNRFNTIP WLQENYWSLL
760 770 780 790 800
SGNEMNDDII REASIFDEFL ELLIVIIGER WMPGVSMVTE EDRLRKEIIQ
810 820 830 840 850
LLCIKPYSHS ELSRALPDGN SGNSDNVFEE VINTVAVFKK PVGADSKGVY
860 870 880 890 900
ELKEHLLKEF NMYFYHYTKE DKSKAEELQR ERRKAKKQLV CCPPPMLPKL
910 920 930 940 950
TPAFTPMANI LQCPVFLNIC SLIMERALNA YSRSFTESHL QKVLHLLGYA
960 970 980 990 1000
IQEELSEHYP FLSFYERSQE YGILEKLEEL ARCPRLEAHY DFVLWTIERF
1010 1020 1030 1040 1050
KQLQAKQAPS DGRAGPSCSQ QGTGGKLSLS AEEQAREERE NRARLAAERR
1060 1070 1080 1090 1100
AHIMAQMQKA QKSFISSNAE MFADTENETR KESASTGPMD WEDIPPEEEQ
1110 1120 1130 1140 1150
GAVALESKVA CLGPDRKFYH GTDDTFKCIL CFENCAISRG GRQLVSSAFV
1160 1170 1180 1190 1200
QTSRVIFTTP NLRNSQSALH ISCCGHVMHY SCWLEYFTNE EFKELRRPHR
1210 1220 1230 1240 1250
NRAALAQAAN VEFQCPYCRT LSNAIIPVTE TLPAFSAPPS PNESYLPLDS
1260 1270 1280 1290 1300
FVEIMSTLAI ELGNVKDHEL TTLPSVSNIL RLSGVVGGLA QFERSVQLIK
1310 1320 1330 1340 1350
NPPRLHADYI EGIEFLKKAL LNTMKIQQSH LKDHPAIESI EMVPILWDSC
1360 1370 1380 1390 1400
SYTLQALEIY LYAVEKPLKA ELSMRHQSCA RNLVRACSRS SALEWETDLP
1410 1420 1430 1440 1450
LLPPMRSQAE FSSRLLDTIF NQNDTSVLEW DCFRVLVPFQ FGVLNLMVPE
1460 1470 1480 1490 1500
KGYKTIIPSG SMFDFYIMQT MFLAQLTKAV LCFDVEKEKA KRAEKAPNSE
1510 1520 1530 1540 1550
LTQLDYIEQL PSRIRDNMID FYRRYNIPAR VLQKTKQKQL VEEESEENQG
1560 1570 1580 1590 1600
HGQTVVIPCE SHHLALLLEY VQRQMSSFLR CSCLFYRFLT DVDFPDTFPT
1610 1620 1630 1640 1650
DQPDRFDLMC QYLGLDPMLG VYFDMETVYA TMMHSFASHP HIDREVEQRC
1660 1670 1680 1690 1700
QPDARRSLQV EPCLRPLPRL KVLCDDFSDL INSVSDIFCP NNEREEMKTP
1710 1720 1730 1740 1750
TMCLICGLIL CGQSYCCQPE LGKVSVGACT HHAHACGAEV GIFLRIRDCQ
1760 1770 1780 1790 1800
VVYLGRGKGC FVPPPYLDEY GETDMGLRRG NPLRLSQAAY RKIYLQWLGH
1810 1820
GLHGEIARLN DNANVAAAAQ WHHM
Length:1,824
Mass (Da):208,361
Last modified:October 1, 2002 - v2
Checksum:i79992C11175E82A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1661E → V in AAM11168 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48687.2.
AY094815 mRNA. Translation: AAM11168.1.
BT044223 mRNA. Translation: ACH92288.1.
RefSeqiNP_001245723.1. NM_001258794.2.
NP_001285356.1. NM_001298427.1.
NP_573184.1. NM_132956.3.
UniGeneiDm.7014.

Genome annotation databases

EnsemblMetazoaiFBtr0074415; FBpp0074189; FBgn0030809.
FBtr0308839; FBpp0300996; FBgn0030809.
FBtr0346190; FBpp0312009; FBgn0030809.
GeneIDi32687.
KEGGidme:Dmel_CG9086.
UCSCiCG9086-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48687.2.
AY094815 mRNA. Translation: AAM11168.1.
BT044223 mRNA. Translation: ACH92288.1.
RefSeqiNP_001245723.1. NM_001258794.2.
NP_001285356.1. NM_001298427.1.
NP_573184.1. NM_132956.3.
UniGeneiDm.7014.

3D structure databases

ProteinModelPortaliQ9VX91.
SMRiQ9VX91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi59018. 1 interactor.
IntActiQ9VX91. 6 interactors.
MINTiMINT-822679.
STRINGi7227.FBpp0074189.

Proteomic databases

PaxDbiQ9VX91.
PRIDEiQ9VX91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074415; FBpp0074189; FBgn0030809.
FBtr0308839; FBpp0300996; FBgn0030809.
FBtr0346190; FBpp0312009; FBgn0030809.
GeneIDi32687.
KEGGidme:Dmel_CG9086.
UCSCiCG9086-RA. d. melanogaster.

Organism-specific databases

CTDi197131.
FlyBaseiFBgn0030809. Ubr1.

Phylogenomic databases

eggNOGiKOG1140. Eukaryota.
ENOG410XPQU. LUCA.
GeneTreeiENSGT00530000063055.
InParanoidiQ9VX91.
KOiK10626.
OMAiANCLVYD.
OrthoDBiEOG091G009K.
PhylomeDBiQ9VX91.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

GenomeRNAii32687.
PROiQ9VX91.

Gene expression databases

BgeeiFBgn0030809.
ExpressionAtlasiQ9VX91. baseline.
GenevisibleiQ9VX91. DM.

Family and domain databases

Gene3Di3.30.1390.10. 1 hit.
3.30.40.10. 2 hits.
InterProiIPR003769. ClpS_core.
IPR014719. Ribosomal_L7/12_C/ClpS-like.
IPR011991. WHTH_DNA-bd_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR003126. Znf_UBR.
[Graphical view]
PfamiPF02617. ClpS. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00396. ZnF_UBR1. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54736. SSF54736. 1 hit.
PROSITEiPS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBR1_DROME
AccessioniPrimary (citable) accession number: Q9VX91
Secondary accession number(s): B5RIU9, Q8SX71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.