Q9VWL9 (Q9VWL9_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LD25711p EMBL AAL28880.1

Submitted name:
RhoGAP18B, isoform B EMBL AAF48919.2
Submitted name:
RhoGAP18B, isoform F EMBL ACL82951.1
Submitted name:
RhoGAP18B-PA EMBL ABF50837.1

Gene names

Name:	RhoGAP18B FlyBase FBgn0261461 FlyBase FBgn0030986 FlyBase FBgn0259169
ORF Names:	CG7481 FlyBase FBgn0030986 EMBL AAL28880.1, Dmel_CG42274 EMBL AAF48919.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin filament organization Inferred from mutant phenotype. Source: FlyBase signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTPase activator activity Inferred from direct assay Ref.2. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VWL9 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 1FCB8C2CAFF816D6	FASTA	468	52,203
	10 20 30 40 50 60 MAGDTENKRG YRTIFRSISQ VFYANAKNSS NTNSSSSNNN NNIINYNNNT IENNNEGIGQ 70 80 90 100 110 120 LTVTLTSITP PTATWTSTSP TISTCTTASA SAGSSTASLS PLASRSARSA ENISCSECGN 130 140 150 160 170 180 PDPYHGQDME LAKGQALTPE VPAVPVPAAS ADQNQKLRAS SMLDLTSNHR HQNGLRIVPV 190 200 210 220 230 240 TDILRAQQIQ EDNEVQQTQQ STILQRYKSV SIGNLLDLPG EDDKKSIKNR MRMKFAVNSN 250 260 270 280 290 300 VFRINRSPKS EKKSRSRRGQ VNSLYLDEQK YPLFAAPLSA LELNMTDHPN VPRFVVDVCA 310 320 330 340 350 360 YIEQPECIEQ DGLYRASGNK VLVDELRKKL THVYDPRWLK TDDIHTLTSL HKQFFRELTS 370 380 390 400 410 420 PLITQEAYER LGRSLNDDAA IERMSLAFDD MPEPNRSTLR FLIRHLTRVA AASASNRMPS 430 440 450 460 TNLAIVWGPC LLSANQIQLD IGRMNMLAKV LIENYDRIFH PDNERLVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms." Rothenfluh A., Threlkeld R.J., Bainton R.J., Tsai L.T., Lasek A.W., Heberlein U. Cell 127:199-211(2006) [PubMed: 17018286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL28880.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF48919.2. AY061332 mRNA. Translation: AAL28880.1. DQ486141 mRNA. Translation: ABF50837.1. AE014298 Genomic DNA. Translation: ACL82951.1.
RefSeq	NP_001138221.1. NM_001144749.1. NP_573351.1. NM_133123.1.
UniGene	Dm.3638.
3D structure databases
HSSP	HSSP built from PDB template 1F7C based on UniProtKB Q98935.
ProteinModelPortal	Q9VWL9.
SMR	Q9VWL9. Positions 274-460.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VWL9. 1 interaction.
MINT	MINT-942779.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0299622; FBpp0288897; FBgn0261461. FBtr0299625; FBpp0288900; FBgn0261461.
GeneID	32898.
KEGG	dme:Dmel_CG42274.
NMPDR	fig|7227.3.peg.18575.
UCSC	CG42274-RB. d. melanogaster.
Organism-specific databases
CTD	32898.
FlyBase	FBgn0261461. RhoGAP18B.
Phylogenomic databases
eggNOG	inNOG10890.
GeneTree	EMGT00070000025766.
InParanoid	Q9VWL9.
OMA	NISCSEC.
PhylomeDB	Q9VWL9.
Gene expression databases
ArrayExpress	Q9VWL9.
Bgee	Q9VWL9.
Family and domain databases
InterPro	IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. [Graphical view]
Gene3D	G3DSA:1.10.555.10. RhoGAP. 1 hit.
Pfam	PF00620. RhoGAP. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	780934.

Entry information

Entry name

Q9VWL9_DROME

Accession

Primary (citable) accession number: Q9VWL9
Secondary accession number(s): Q95RJ6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)