Unreviewed, UniProtKB/TrEMBL Q9VWL9 (Q9VWL9_DROME)

Names and origin

Protein names

Submitted name:
    RhoGAP18B, isoform B EMBL AAF48919.2
Submitted name:
    RhoGAP18B, isoform F EMBL ACL82951.1
    LD25711p EMBL AAL28880.1
    RhoGAP18B-PA EMBL ABF50837.1

Gene names

Name:	RhoGAP18B FlyBase FBgn0030986 FlyBase FBgn0259169
ORF Names:	CG7481 EMBL AAL28880.1 FlyBase FBgn0030986, Dmel_CG42274 EMBL AAF48919.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 Rho-GAP domain. Spearmint SPM000198

Ontologies

Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VWL9-1 [UniParc]. Last modified October 1, 2002. Version 2. Checksum: 1FCB8C2CAFF816D6	FASTA	468	52,203
	10 20 30 40 50 60 MAGDTENKRG YRTIFRSISQ VFYANAKNSS NTNSSSSNNN NNIINYNNNT IENNNEGIGQ 70 80 90 100 110 120 LTVTLTSITP PTATWTSTSP TISTCTTASA SAGSSTASLS PLASRSARSA ENISCSECGN 130 140 150 160 170 180 PDPYHGQDME LAKGQALTPE VPAVPVPAAS ADQNQKLRAS SMLDLTSNHR HQNGLRIVPV 190 200 210 220 230 240 TDILRAQQIQ EDNEVQQTQQ STILQRYKSV SIGNLLDLPG EDDKKSIKNR MRMKFAVNSN 250 260 270 280 290 300 VFRINRSPKS EKKSRSRRGQ VNSLYLDEQK YPLFAAPLSA LELNMTDHPN VPRFVVDVCA 310 320 330 340 350 360 YIEQPECIEQ DGLYRASGNK VLVDELRKKL THVYDPRWLK TDDIHTLTSL HKQFFRELTS 370 380 390 400 410 420 PLITQEAYER LGRSLNDDAA IERMSLAFDD MPEPNRSTLR FLIRHLTRVA AASASNRMPS 430 440 450 460 TNLAIVWGPC LLSANQIQLD IGRMNMLAKV LIENYDRIFH PDNERLVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[4]	"Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms." Rothenfluh A., Threlkeld R.J., Bainton R.J., Tsai L.T., Lasek A.W., Heberlein U. Cell 127:199-211(2006) [PubMed: 17018286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL28880.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014298 Genomic DNA. Translation: AAF48919.2. AY061332 mRNA. Translation: AAL28880.1. DQ486141 mRNA. Translation: ABF50837.1. AE014298 Genomic DNA. Translation: ACL82951.1.
RefSeq	NP_001138221.1. NP_573351.1.
UniGene	Dm.3638
3D structure databases
HSSP	HSSP built from PDB template 1F7C based on UniProtKB Q98935.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VWL9. 2 interactions.
Genome annotation databases
Ensembl	FBgn0030986. Drosophila melanogaster. [Contig view]
GeneID	32898.
KEGG	dme:Dmel_CG7481.
NMPDR	fig|7227.3.peg.18575.
Organism-specific databases
FlyBase	FBgn0259169. RhoGAP18B.
Phylogenomic databases
HOGENOM	Q9VWL9.
OMA	Q9VWL9. NSSEVED.
Gene expression databases
ArrayExpress	Q9VWL9.
Family and domain databases
InterPro	IPR000198. RhoGAP. [Graphical view]
Gene3D	G3DSA:1.10.555.10. RhoGAP. 1 hit.
Pfam	PF00620. RhoGAP. 1 hit. [Graphical view]
SMART	SM00324. RhoGAP. 1 hit. [Graphical view]
PROSITE	PS50238. RHOGAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	780934.

Entry information

Entry name

Q9VWL9_DROME

Accession

Primary (citable) accession number: Q9VWL9
Secondary accession number(s): Q95RJ6

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)