Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

LD40846p

Gene

Ssu72

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • CTD phosphatase activity Source: FlyBase
  • phosphatase activity Source: FlyBase

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
LD40846pImported
Submitted name:
Ssu72 CTD phosphatase, isoform AImported
Submitted name:
Ssu72 CTD phosphatase, isoform CImported (EC:3.1.3.-Imported, EC:3.1.3.16Imported, EC:3.1.3.41Imported)
Gene namesi
Name:Ssu72Imported
ORF Names:CG14216Imported, Dmel_CG14216Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0031054. Ssu72.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0074516.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FDFX-ray3.20A/B/C/D1-195[»]
3FMVX-ray3.31A/B/C/D/E/F/G/H1-195[»]
3OMWX-ray2.87A/B/C/D6-195[»]
3OMXX-ray2.34A/B/C/D6-195[»]
3P9YX-ray2.10A/B/C/D1-195[»]
4IMIX-ray2.35B/D1-195[»]
4IMJX-ray2.58B/D1-195[»]
4YGXX-ray2.95B/D1-195[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2424. Eukaryota.
COG5211. LUCA.
GeneTreeiENSGT00390000010165.
OMAiITDMINL.
OrthoDBiEOG7C2R2M.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VWE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDPSKLAVA VVCSSNMNRS MEAHNFLAKK GFNVRSYGTG ERVKLPGMAF
60 70 80 90 100
DKPNVYEFGT KYEDIYRDLE SKDKEFYTQN GLLHMLDRNR RIKKCPERFQ
110 120 130 140 150
DTKEQFDIIV TVEERVYDLV VMHMESMESV DNRPVHVLNV DVVDNAEDAL
160 170 180 190
MGAFVITDMI NMMAKSTDLD NDIDELIQEF EERRKRVILH SVLFY
Length:195
Mass (Da):22,733
Last modified:May 1, 2000 - v1
Checksum:i7D1852122359BF42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48998.1.
AY060426 mRNA. Translation: AAL25465.1.
AE014298 Genomic DNA. Translation: AHN59925.1.
RefSeqiNP_001285455.1. NM_001298526.1.
NP_608342.1. NM_134498.4.
UniGeneiDm.3992.

Genome annotation databases

EnsemblMetazoaiFBtr0074747; FBpp0074516; FBgn0031054.
FBtr0344152; FBpp0310565; FBgn0031054.
GeneIDi32973.
UCSCiCG14216-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAF48998.1.
AY060426 mRNA. Translation: AAL25465.1.
AE014298 Genomic DNA. Translation: AHN59925.1.
RefSeqiNP_001285455.1. NM_001298526.1.
NP_608342.1. NM_134498.4.
UniGeneiDm.3992.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3FDFX-ray3.20A/B/C/D1-195[»]
3FMVX-ray3.31A/B/C/D/E/F/G/H1-195[»]
3OMWX-ray2.87A/B/C/D6-195[»]
3OMXX-ray2.34A/B/C/D6-195[»]
3P9YX-ray2.10A/B/C/D1-195[»]
4IMIX-ray2.35B/D1-195[»]
4IMJX-ray2.58B/D1-195[»]
4YGXX-ray2.95B/D1-195[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0074516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074747; FBpp0074516; FBgn0031054.
FBtr0344152; FBpp0310565; FBgn0031054.
GeneIDi32973.
UCSCiCG14216-RA. d. melanogaster.

Organism-specific databases

CTDi29101.
FlyBaseiFBgn0031054. Ssu72.

Phylogenomic databases

eggNOGiKOG2424. Eukaryota.
COG5211. LUCA.
GeneTreeiENSGT00390000010165.
OMAiITDMINL.
OrthoDBiEOG7C2R2M.

Miscellaneous databases

GenomeRNAii32973.
NextBioi781308.

Family and domain databases

InterProiIPR006811. RNA_pol_II_suA.
[Graphical view]
PANTHERiPTHR20383. PTHR20383. 1 hit.
PfamiPF04722. Ssu72. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BerkeleyImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  4. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  5. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  12. "Orthorombic crystal structure of serine phosphatase of rna polymerase ii ctd from fly drosofila melanogaster. northeast structural genomics consortium target fr253."
    Kuzin A.P., Chen Y., Seetharaman J., Forouhar F., Chinag Y., Fang Y., Cunningham K., Ma L.-C., Xiao R., Liu J., Baran M.C., Acton T.B., Rost B., Montelione G.T., Hunt J.F., Tong L.
    Submitted (NOV-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.20 ANGSTROMS).
  13. "Crystal structure of the serine phosphatase of RNA polymerase II CTD (SSU72 superfamily) from Drosophila melanogaster. Monoclinic crystal form. Northeast Structural Genomics Consortium target FR253."
    Kuzin A.P., Chen Y., Seetharaman J., Forouhar F., Chinag Y., Fang Y., Cunningham K., Ma L.-C., Xiao R., Liu J., Baran M.C., Acton T.B., Rost B., Montelione G.T., Hunt J.F., Tong L.
    Submitted (DEC-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.31 ANGSTROMS).
  14. "Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue."
    Zhang Y., Zhang M., Zhang Y.
    Biochem. J. 434:435-444(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.34 ANGSTROMS) OF 6-195.
  15. "cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72."
    Werner-Allen J.W., Lee C.J., Liu P., Nicely N.I., Wang S., Greenleaf A.L., Zhou P.
    J. Biol. Chem. 286:5717-5726(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
  16. "novel modifications on C-terminal domain of RNA polymerase II can fine-tune the phosphatase activity of Ssu72."
    Luo Y., Yogesha S.D., Cannon J.R., Yan W., Ellington A.D., Brodbelt J.S., Zhang Y.
    ACS Chem. Biol. 8:2042-2052(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  17. "Chemical Tools To Decipher Regulation of Phosphatases by Proline Isomerization on Eukaryotic RNA Polymerase II."
    Mayfield J.E., Fan S., Wei S., Zhang M., Li B., Ellington A.D., Etzkorn F.A., Zhang Y.J.
    ACS Chem. Biol. 10:2405-2414(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS).
  18. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VWE4_DROME
AccessioniPrimary (citable) accession number: Q9VWE4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.