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Q9VWE0 (DOME_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytokine receptor
Alternative name(s):
Protein domeless
Gene names
Name:dome
ORF Names:CG14226
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length1282 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Critical for epithelial morphogenesis during oogenesis; border cell migration. Required in the germarium for the polarization of follicle cells during encapsulation of germline cells. Required for embryonic segmentation and trachea specification. Essential receptor molecule for upd and JAK/STAT signaling during oogenesis. Ref.1 Ref.2

Subcellular location

Apicolateral cell membrane; Single-pass type I membrane protein. Note: Apicolateral membranes in follical cells. Ref.2

Tissue specificity

In stage 11 embryos, tracheal pits show highest expression, at stage 14 high expression is detected in the posterior spiracles, gut and head. Ref.1

Developmental stage

Expressed both maternally and zygotically in embryos. Ref.1

Sequence similarities

Belongs to the type I cytokine receptor family.

Contains 7 fibronectin type-III domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 12821259Cytokine receptor
PRO_0000010999

Regions

Topological domain24 – 889866Extracellular Potential
Transmembrane890 – 91021Helical; Potential
Topological domain911 – 1282372Cytoplasmic Potential
Domain124 – 22097Fibronectin type-III 1
Domain224 – 324101Fibronectin type-III 2
Domain328 – 42699Fibronectin type-III 3
Domain433 – 52492Fibronectin type-III 4
Domain534 – 62895Fibronectin type-III 5
Domain633 – 732100Fibronectin type-III 6
Domain733 – 83199Fibronectin type-III 7

Amino acid modifications

Modified residue9761Phosphoserine Ref.6
Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation1841N-linked (GlcNAc...) Potential
Glycosylation2301N-linked (GlcNAc...) Potential
Glycosylation2351N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3101N-linked (GlcNAc...) Potential
Glycosylation3761N-linked (GlcNAc...) Potential
Glycosylation4481N-linked (GlcNAc...) Potential
Glycosylation4661N-linked (GlcNAc...) Potential
Glycosylation5681N-linked (GlcNAc...) Potential
Glycosylation5811N-linked (GlcNAc...) Potential
Glycosylation6261N-linked (GlcNAc...) Potential
Glycosylation6761N-linked (GlcNAc...) Potential
Glycosylation7031N-linked (GlcNAc...) Potential
Glycosylation7771N-linked (GlcNAc...) Potential
Glycosylation7901N-linked (GlcNAc...) Potential
Glycosylation8621N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 106 By similarity
Disulfide bond132 ↔ 142 By similarity
Disulfide bond173 ↔ 183 By similarity
Disulfide bond472 ↔ 482 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9VWE0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 22CE960963B17011

FASTA1,282142,361
        10         20         30         40         50         60 
MVAQEQLVLL LMLLAGCRGG ANAILDPGWV IPSKVEQLIG GDFNLSCTLN EDYFNGKSAE 

        70         80         90        100        110        120 
DCPVEKLYFT GGGRVYRDSK HIRILNNTTI LFSDTNAVEQ ENDYHCMCDE YVINKSKVYV 

       130        140        150        160        170        180 
GTRPLLVRDF NCLDYDFQFM VCNFTQPPNT VITKYNISYN TNNDWRYSNT LDCNFDSAPV 

       190        200        210        220        230        240 
VTCNLTDDNY KRFSETFYFR LSISNALGHE TQPITINHFE RLVPARPGQN LTLLNRTESS 

       250        260        270        280        290        300 
VCLSWEMPRR SNYNRGLVWQ VRVTPQNFEP ITRPSWRNHT LTIKDTLCLT ELPFAGYNYT 

       310        320        330        340        350        360 
LRVRVRANQN NTLWSEPMIY AFATAPAPPR RPPRVTYGSF YVYSSEKAMR FYWEPLEEHE 

       370        380        390        400        410        420 
LNGPDFRYSI SEYRINGTAV DPGLIKVESN SAMIDHWSMS AVHHFLIRSS NSQGLSVNAT 

       430        440        450        460        470        480 
PMTIGPISNR DFKVREPRNI RSVYHPTNKS YTLSWDPPSD QRELQNYTVF WCVPKPGLQS 

       490        500        510        520        530        540 
ECEGSIRFAE VASGLHHFTT SPDQLLTLHM AVSANYQSHN TGLHWAICSS DKKDDLAKME 

       550        560        570        580        590        600 
PSIDVATSTS LTVSWSERVC AVILAGYNLT YCQRSAGRPD NCTTVTIDRY TNKHVIQNLV 

       610        620        630        640        650        660 
PYTDYSVKML MYSDSRVSKY SDELVNRTGE AAPSQPRELQ LIRVTSDSVE LAWKPPLLAN 

       670        680        690        700        710        720 
GVVRAYEGTF RSLHDNVTDT FRVSASADEL VNNEKPITYR LGNLTAFTKY EISVRARTVY 

       730        740        750        760        770        780 
PSEPSNVILF STAIGVPSPP QLYVINNPDQ SSRLDWEPPR TPAGRIDFYE ISLRDNNASC 

       790        800        810        820        830        840 
LTSTILPGRN LSYVMATPRC TSHNPFQLAV RAINVEQHPQ LNGADAAEGA VLLMSTNGKG 

       850        860        870        880        890        900 
CEARTDALGE EERLQFEAYA ANMTAYRLYR SDWGIYGFIC TPDTHSVKAM YQTIEVTVAI 

       910        920        930        940        950        960 
LVLGVIFYLV YKKYRKMSDI GLVLPQGIME TMKKPIDMGG LGLGLGPDSS VSGGIVCTRV 

       970        980        990       1000       1010       1020 
DDSPPYTPQD LPHDFSSCGS ESSKLLLRTA SSSGGGGCVD RDGYDDNHET GPISAVGPPT 

      1030       1040       1050       1060       1070       1080 
SYLAMRHGLL VQNDRERERE RDREQERERE QQQQQRESEM DREQSCTNGY IKPTQMKSWG 

      1090       1100       1110       1120       1130       1140 
GNGPSDNDHT FSVPSTAMTA PMSQPLSQIP LSGYVPVPIP QSRFNPAPVQ PFGSPAVPSA 

      1150       1160       1170       1180       1190       1200 
ATAAAASTFF PPAHLLNMDN YVQASDLHKL KPLVAAPLSQ TGGPAFAGSS PATSPPLQLP 

      1210       1220       1230       1240       1250       1260 
PVHAASPAAA TPKMADIGYT TMEQLQLTGL IKPPLAATVG SPTHAAGGAP GGGNQHSRLQ 

      1270       1280 
PQINGYVTPQ DLNAMAHNRH VL

« Hide

References

« Hide 'large scale' references
[1]"Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless."
Brown S., Hu N., Castelli-Gair Hombria J.
Curr. Biol. 11:1700-1705(2001) [PubMed: 11696329] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]"The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis."
Ghiglione C., Devergne O., Georgenthum E., Carballes F., Medioni C., Cerezo D., Noselli S.
Development 129:5437-5447(2002) [PubMed: 12403714] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
[3]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[4]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[5]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[6]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-976, MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ420377 mRNA. Translation: CAD12503.1.
AY147847 mRNA. Translation: AAN64333.1.
AE014298 Genomic DNA. Translation: AAF49002.1.
AY075427 mRNA. Translation: AAL68243.1.
RefSeqNP_523412.1. NM_078688.2.
UniGeneDm.2836.

3D structure databases

ProteinModelPortalQ9VWE0.
SMRQ9VWE0. Positions 198-336, 432-521, 536-821.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-19869N.
IntActQ9VWE0. 1 interaction.
MINTMINT-1005426.
STRINGQ9VWE0.

Proteomic databases

PRIDEQ9VWE0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0074756; FBpp0074525; FBgn0043903.
GeneID32976.
KEGGdme:Dmel_CG14226.
NMPDRfig|7227.3.peg.18684.

Organism-specific databases

CTD32976.
FlyBaseFBgn0043903. dome.

Phylogenomic databases

eggNOGinNOG08819.
GeneTreeEMGT00050000006519.
InParanoidQ9VWE0.
OMATLCLTEL.
OrthoDBEOG4S1RP4.
PhylomeDBQ9VWE0.

Gene expression databases

BgeeQ9VWE0.
GermOnlineCG14226. Drosophila melanogaster.

Family and domain databases

InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 4 hits.
PfamPF00041. fn3. 2 hits.
[Graphical view]
SMARTSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 5 hits.
PROSITEPS50853. FN3. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio781325.

Entry information

Entry nameDOME_DROME
AccessionPrimary (citable) accession number: Q9VWE0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

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