Q9VWD6 (OSGP2_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein CG14231

Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein CG14231

Gene names

ORF Names:

CG14231

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity.
Sequence similarities	Belongs to the KAE1 / YgjD family.
Sequence caution	The sequence AAK93306.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	tRNA processing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Probable tRNA threonylcarbamoyladenosine biosynthesis protein CG14231		PRO_0000307783

Sequences

	Sequence		Length	Mass (Da)
	Q9VWD6 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9797F66E7D155538	FASTA	409	45,329
	10 20 30 40 50 60 MHALRNFAGN GIANVFGCGI RRRLSYVLGI ETSCDDTGIA IVDTTGRVIA NVLESQQEFH 70 80 90 100 110 120 TRYGGIIPPR AQDLHRARIE SAYQRCMEAA QLKPDQLTAI AVTTRPGLPL SLLVGVRFAR 130 140 150 160 170 180 HLARRLQKPL LPVHHMEAHA LQARMEHPEQ IGYPFLCLLA SGGHCQLVVA NGPGRLTLLG 190 200 210 220 230 240 QTLDDAPGEA FDKIGRRLRL HILPEYRLWN GGRAIEHAAQ LASDPLAYEF PLPLAQQRNC 250 260 270 280 290 300 NFSFAGIKNN SFRAIRARER AERTPPDGVI SNYGDFCAGL LRSVSRHLMH RTQRAIEYCL 310 320 330 340 350 360 LPHRQLFGDT PPTLVMSGGV ANNDAIYANI EHLAAQYGCR SFRPSKRYCS DNGVMIAWHG 370 380 390 400 VEQLLQDKEA STRYDYDSID IQGSAGFAES HEEAVAAAAI KCKWIQPLV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed: 12537569] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo and Head.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014298 Genomic DNA. Translation: AAF49008.1. AY051882 mRNA. Translation: AAK93306.1. Different initiation. BT021224 mRNA. Translation: AAX33372.1.
RefSeq	NP_608347.1. NM_134503.2.
UniGene	Dm.26674.
3D structure databases
ProteinModelPortal	Q9VWD6.
SMR	Q9VWD6. Positions 23-398.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VWD6. 1 interaction.
MINT	MINT-926792.
STRING	Q9VWD6.
Proteomic databases
PRIDE	Q9VWD6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0074814; FBpp0074583; FBgn0031060.
GeneID	32982.
KEGG	dme:Dmel_CG14231.
NMPDR	fig|7227.3.peg.18691.
UCSC	CG14231-RA. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0031060. CG14231.
Phylogenomic databases
eggNOG	inNOG05057.
GeneTree	EMGT00050000016889.
InParanoid	Q9VWD6.
OMA	KDCNFSY.
OrthoDB	EOG4RJDH7.
PhylomeDB	Q9VWD6.
Gene expression databases
Bgee	Q9VWD6.
Family and domain databases
InterPro	IPR000905. Peptidase_M22. IPR017861. Peptidase_M22_subgr. [Graphical view]
KO	K01409.
Pfam	PF00814. Peptidase_M22. 1 hit. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
TIGRFAMs	TIGR00329. Gcp_kae1. 1 hit.
ProtoNet	Search...
Other
NextBio	781357.

Entry information

Entry name

OSGP2_DROME

Accession

Primary (citable) accession number: Q9VWD6
Secondary accession number(s): Q960S6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project