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Protein

Probable deoxycytidylate deaminase

Gene

CG6951

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Supplies the nucleotide substrate for thymidylate synthetase.By similarity

Catalytic activityi

dCMP + H2O = dUMP + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Zinc; catalyticBy similarity1
Active sitei104Proton donorBy similarity1
Metal bindingi128Zinc; catalyticBy similarity1
Metal bindingi131Zinc; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide biosynthesis
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-499943. Interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable deoxycytidylate deaminase (EC:3.5.4.12)
Alternative name(s):
dCMP deaminase
Gene namesi
ORF Names:CG6951
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036959. CG6951.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716961 – 203Probable deoxycytidylate deaminaseAdd BLAST203

Proteomic databases

PaxDbiQ9VWA2.
PRIDEiQ9VWA2.

Expressioni

Gene expression databases

BgeeiFBgn0036959.
ExpressionAtlasiQ9VWA2. differential.
GenevisibleiQ9VWA2. DM.

Interactioni

Protein-protein interaction databases

BioGridi65486. 3 interactors.
DIPiDIP-23043N.
IntActiQ9VWA2. 1 interactor.
MINTiMINT-939888.
STRINGi7227.FBpp0074597.

Structurei

3D structure databases

ProteinModelPortaliQ9VWA2.
SMRiQ9VWA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 163CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST137

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3127. Eukaryota.
COG2131. LUCA.
GeneTreeiENSGT00390000000501.
InParanoidiQ9VWA2.
KOiK01493.
OMAiYITASPC.
OrthoDBiEOG091G0JEC.
PhylomeDBiQ9VWA2.

Family and domain databases

CDDicd01286. deoxycytidylate_deaminase. 1 hit.
InterProiView protein in InterPro
IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_dom.
IPR016193. Cytidine_deaminase-like.
IPR016473. dCMP_deaminase.
IPR015517. dCMP_deaminase-rel.
IPR035105. Deoxycytidylate_deaminase_dom.
PANTHERiPTHR11086. PTHR11086. 1 hit.
PfamiView protein in Pfam
PF00383. dCMP_cyt_deam_1. 1 hit.
PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
SUPFAMiSSF53927. SSF53927. 1 hit.
PROSITEiView protein in PROSITE
PS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VWA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVSAQDLI SQLSKSPESH KRKEYLHWDD YFMATSLLSA KRSKDPVTQV
60 70 80 90 100
GACIVDSQNR IVAIGYNGFP RNCSDDVFPW SKAKKGSQEF DPLEDKKMYV
110 120 130 140 150
VHAEANAILN SNGMSLSGTR LYTTLFPCNE CAKLIIQVGI SQVLYLSDKY
160 170 180 190 200
ADKPTYRASK RMLDAVGVEY KRHIPQKKTI TIDFDTFPEE DPNASLGLNE

LHL
Length:203
Mass (Da):22,857
Last modified:May 1, 2000 - v1
Checksum:i0E37ECB9F8A8CA5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49046.1.
AE014296 Genomic DNA. Translation: AAN11625.1.
BT011479 mRNA. Translation: AAR99137.1.
RefSeqiNP_649197.1. NM_140940.3.
NP_730502.1. NM_168838.3.
UniGeneiDm.2515.

Genome annotation databases

EnsemblMetazoaiFBtr0074828; FBpp0074597; FBgn0036959.
FBtr0074829; FBpp0074598; FBgn0036959.
GeneIDi40222.
KEGGidme:Dmel_CG6951.
UCSCiCG6951-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiDCTD_DROME
AccessioniPrimary (citable) accession number: Q9VWA2
Secondary accession number(s): Q53XF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families