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Q9VWA2

- DCTD_DROME

UniProt

Q9VWA2 - DCTD_DROME

Protein

Probable deoxycytidylate deaminase

Gene

CG6951

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Supplies the nucleotide substrate for thymidylate synthetase.By similarity

    Catalytic activityi

    dCMP + H2O = dUMP + NH3.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Zinc; catalyticBy similarity
    Active sitei104 – 1041Proton donorBy similarity
    Metal bindingi128 – 1281Zinc; catalyticBy similarity
    Metal bindingi131 – 1311Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. dCMP deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. nucleotide biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_204719. Pyrimidine biosynthesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable deoxycytidylate deaminase (EC:3.5.4.12)
    Alternative name(s):
    dCMP deaminase
    Gene namesi
    ORF Names:CG6951
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0036959. CG6951.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 203203Probable deoxycytidylate deaminasePRO_0000171696Add
    BLAST

    Proteomic databases

    PaxDbiQ9VWA2.
    PRIDEiQ9VWA2.

    Expressioni

    Gene expression databases

    BgeeiQ9VWA2.

    Interactioni

    Protein-protein interaction databases

    BioGridi65486. 3 interactions.
    DIPiDIP-23043N.
    IntActiQ9VWA2. 1 interaction.
    MINTiMINT-939888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VWA2.
    SMRiQ9VWA2. Positions 25-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2131.
    GeneTreeiENSGT00390000000501.
    InParanoidiQ9VWA2.
    KOiK01493.
    OMAiKCNKIII.
    OrthoDBiEOG7JDQZR.
    PhylomeDBiQ9VWA2.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view]
    PANTHERiPTHR11086. PTHR11086. 1 hit.
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMiSSF53927. SSF53927. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VWA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEVSAQDLI SQLSKSPESH KRKEYLHWDD YFMATSLLSA KRSKDPVTQV    50
    GACIVDSQNR IVAIGYNGFP RNCSDDVFPW SKAKKGSQEF DPLEDKKMYV 100
    VHAEANAILN SNGMSLSGTR LYTTLFPCNE CAKLIIQVGI SQVLYLSDKY 150
    ADKPTYRASK RMLDAVGVEY KRHIPQKKTI TIDFDTFPEE DPNASLGLNE 200
    LHL 203
    Length:203
    Mass (Da):22,857
    Last modified:May 1, 2000 - v1
    Checksum:i0E37ECB9F8A8CA5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49046.1.
    AE014296 Genomic DNA. Translation: AAN11625.1.
    BT011479 mRNA. Translation: AAR99137.1.
    RefSeqiNP_649197.1. NM_140940.3.
    NP_730502.1. NM_168838.3.
    UniGeneiDm.2515.

    Genome annotation databases

    EnsemblMetazoaiFBtr0074828; FBpp0074597; FBgn0036959.
    FBtr0074829; FBpp0074598; FBgn0036959.
    GeneIDi40222.
    KEGGidme:Dmel_CG6951.
    UCSCiCG6951-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49046.1 .
    AE014296 Genomic DNA. Translation: AAN11625.1 .
    BT011479 mRNA. Translation: AAR99137.1 .
    RefSeqi NP_649197.1. NM_140940.3.
    NP_730502.1. NM_168838.3.
    UniGenei Dm.2515.

    3D structure databases

    ProteinModelPortali Q9VWA2.
    SMRi Q9VWA2. Positions 25-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 65486. 3 interactions.
    DIPi DIP-23043N.
    IntActi Q9VWA2. 1 interaction.
    MINTi MINT-939888.

    Proteomic databases

    PaxDbi Q9VWA2.
    PRIDEi Q9VWA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0074828 ; FBpp0074597 ; FBgn0036959 .
    FBtr0074829 ; FBpp0074598 ; FBgn0036959 .
    GeneIDi 40222.
    KEGGi dme:Dmel_CG6951.
    UCSCi CG6951-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0036959. CG6951.

    Phylogenomic databases

    eggNOGi COG2131.
    GeneTreei ENSGT00390000000501.
    InParanoidi Q9VWA2.
    KOi K01493.
    OMAi KCNKIII.
    OrthoDBi EOG7JDQZR.
    PhylomeDBi Q9VWA2.

    Enzyme and pathway databases

    Reactomei REACT_204719. Pyrimidine biosynthesis.

    Miscellaneous databases

    GenomeRNAii 40222.
    NextBioi 817648.
    PROi Q9VWA2.

    Gene expression databases

    Bgeei Q9VWA2.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR016193. Cytidine_deaminase-like.
    IPR016473. dCMP_deaminase.
    IPR015517. dCMP_deaminase-rel.
    [Graphical view ]
    PANTHERi PTHR11086. PTHR11086. 1 hit.
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006019. dCMP_deaminase. 1 hit.
    SUPFAMi SSF53927. SSF53927. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiDCTD_DROME
    AccessioniPrimary (citable) accession number: Q9VWA2
    Secondary accession number(s): Q53XF4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3