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Protein
Submitted name:

Gigas, isoform A

Gene

gig

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: FlyBase
  • kinase binding Source: FlyBase

GO - Biological processi

  • cellular response to chloroquine Source: FlyBase
  • cellular response to hypoxia Source: FlyBase
  • cholesterol homeostasis Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • larval midgut histolysis Source: FlyBase
  • lipid homeostasis Source: FlyBase
  • negative regulation of cell growth Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of cell size Source: FlyBase
  • negative regulation of insulin receptor signaling pathway Source: FlyBase
  • negative regulation of organ growth Source: FlyBase
  • negative regulation of protein kinase B signaling Source: GO_Central
  • negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • negative regulation of TORC1 signaling Source: FlyBase
  • negative regulation of Wnt signaling pathway Source: GO_Central
  • oogenesis Source: FlyBase
  • positive regulation of autophagy Source: FlyBase
  • positive regulation of GTPase activity Source: FlyBase
  • positive regulation of protein phosphorylation Source: FlyBase
  • positive regulation of TORC2 signaling Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of phosphorylation Source: FlyBase
  • regulation of small GTPase mediated signal transduction Source: InterPro
  • regulation of terminal button organization Source: FlyBase
  • response to nutrient Source: FlyBase
  • signal transduction Source: FlyBase

Names & Taxonomyi

Protein namesi
Submitted name:
Gigas, isoform AImported
Gene namesi
Name:gigImported
Synonyms:6975Imported, C1Imported, Dmel\CG6975Imported, dTSC2Imported, dTsc2Imported, FBpp0074588Imported, GigasImported, gig|Tsc2Imported, l(3)109Imported, ME 109Imported, TSC2Imported, Tsc2Imported, tsc2Imported
ORF Names:CG6975Imported, Dmel_CG6975Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0005198 gig

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ9VW83
PRIDEiQ9VW83

Expressioni

Gene expression databases

BgeeiFBgn0005198
ExpressionAtlasiQ9VW83 baseline and differential
GenevisibleiQ9VW83 DM

Interactioni

GO - Molecular functioni

  • kinase binding Source: FlyBase

Protein-protein interaction databases

IntActiQ9VW83, 5 interactors
STRINGi7227.FBpp0074588

Structurei

3D structure databases

ProteinModelPortaliQ9VW83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1586 – 1812Rap-GAPInterPro annotationAdd BLAST227

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 136Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3687 Eukaryota
ENOG410XPFJ LUCA
GeneTreeiENSGT00760000119182
InParanoidiQ9VW83
OrthoDBiEOG091G00O2
PhylomeDBiQ9VW83

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR003913 Tuberin
IPR018515 Tuberin-type_domain
IPR027107 Tuberin/Ral-act_asu
IPR024584 Tuberin_N
PANTHERiPTHR10063 PTHR10063, 1 hit
PfamiView protein in Pfam
PF11864 DUF3384, 1 hit
PF02145 Rap_GAP, 1 hit
PF03542 Tuberin, 1 hit
PRINTSiPR01431 TUBERIN
SUPFAMiSSF111347 SSF111347, 1 hit
SSF48371 SSF48371, 4 hits
PROSITEiView protein in PROSITE
PS50085 RAPGAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VW83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKDKSKFK LFLKSLPAGY VGERTLRPEF ERELRPEQPV AQRCRMLKEL
60 70 80 90 100
GDTQLHNFNL DESAITILFN LTNDLIVPNK PAETRQIALS FYKRLIHTQY
110 120 130 140 150
KNLTIMREKF FLVIQNHEAR EDLRHLLELL DTLTDNGKDI TNFEEKIGKF
160 170 180 190 200
MLLWIPAITE ANLLTPYLDI LVNLIKFNAA HLDKDILVGI VQNACDLSCS
210 220 230 240 250
VTVNEIGLQC LTILEMVIGY TIFPSEPLPQ CITTLCRTVN HAPYCPSSFK
260 270 280 290 300
IMKNLLGTQL GYHSMKMMCS ILNDRALYDD AHLLRGAVFH LNMNIFGSNI
310 320 330 340 350
IFQVSPMTYA TNVLTAFLRA LDSRQVIVTF EVILSVRMVI TKRQLSEIIW
360 370 380 390 400
DLICDIMSSI VSNIEYYEEV NINKDRLHHL QINFHENIDC IEKLLQQDRS
410 420 430 440 450
QILGNVERIY DLIERVADRR PEASVLALIE YRSRRVTATR PDWLQVLAQF
460 470 480 490 500
VRRYYRMSNV NVRIKTIEAL VQIMDQNRAC YEEEILSRVV LVHLSHIHLE
510 520 530 540 550
SSVQVRVAVA RALSNFATHC DTKRCMDLLD ILEALINRPF EHTRHGSSSG
560 570 580 590 600
EGTLAEVTFG LVNNESEISD IIAAVDGLVK VFAIKLHRLP GIHALKIFNI
610 620 630 640 650
LMDHLELHYE RPKIFEHISV VRYKIFAWLL KARANGSYHI GYPEGSTEVV
660 670 680 690 700
KFSPYLGIDS PLLPQAHPTA ISIRRVCKLI VRCLEHDTDY QVFQLVIREL
710 720 730 740 750
PKVLQNKALV QGNDIEELAN TLLKINLVSN NKFKRPTDEF HALVLPAIAS
760 770 780 790 800
LVIYHESLQP QQHYGIITAL NSRVLTGIAS VCINTMTILI LEMPEALMRK
810 820 830 840 850
LPDVLLQMSK MSDTNALATP VLEFLSLLIH LSKHLFANFT SMHNMYVFAI
860 870 880 890 900
TLPYTKPHRY DHYTVSLAHH VIAGWFLKCK LELRRNCVNY IKSSIQSNAK
910 920 930 940 950
MLSSDIVNLN SLNEDSSNRK RSTSLTERGS RNNANAWNDL EMRPQMNNGL
960 970 980 990 1000
RNFHAELAET CFDFLARHTY SPCPSMPKRL PAAEFLLKDG VSQTWLVGNN
1010 1020 1030 1040 1050
LVTITTSGCP SAPARSGLCE RCAQLGKAPS ISLNSKSLSD AAPPLSPERE
1060 1070 1080 1090 1100
RRYTKVSLQH SSGNESAGST ELTSSSSSNS AAAGGHPHRQ ISNSSTASLD
1110 1120 1130 1140 1150
ALSRRGSNPE ALGSALGEGA HTGSNTSLLG NSLSQSSVSM SPSSGSVVQQ
1160 1170 1180 1190 1200
PVCVRACTGW AEVLVRRPTG NVSWITRIQN PITNDCFGQE LPFNNVVSLF
1210 1220 1230 1240 1250
LPTAHGGVFG PDNTIQAPPH TLADPEPEPE AEVNAATAPQ ASALRSRMVA
1260 1270 1280 1290 1300
KARALQRQEE IHSVGGNGNG NGNGNGSGNA PSTGGAAAIP IPRVPASGKR
1310 1320 1330 1340 1350
GKEAALCGSV SDGEADDDSL AFEDAQSRAR NPVRRVNSSP EMSSSWRQSF
1360 1370 1380 1390 1400
LTNKPTPLSQ EPVKTTADEP QSLLTLKKKT VQYSTKDMRV SCEAIPEEIA
1410 1420 1430 1440 1450
GSTPPSQAAA LALQPESGTL PPKQHSADDV SSHVAGGSNL QAGGSTLKLG
1460 1470 1480 1490 1500
KPPLSPGQPP LLGTGRVTSF GGTSVPQPGA LAKSSSSGSN GTNVGVITSD
1510 1520 1530 1540 1550
YDNGNNGNGD MMRGRSKTIS VVREVNNGNT RPPPASSFRN FGAAKPPINT
1560 1570 1580 1590 1600
KLCMNPSFIF MQLYTTGQLG VTDEPLKVGP ENSSAVSLID LVPPFETHKI
1610 1620 1630 1640 1650
GVLYVGQGQC NNEVEILRNS HGSARYVEFL RNIGTLVSLK EAEQNNLFIM
1660 1670 1680 1690 1700
LDRNGADGKF AYIWKDDILQ VTFHVATLMP TNLQDDPNCN EKKSHIGNDF
1710 1720 1730 1740 1750
VKIIYNESGE EYNLNTISGQ FNYACVIVEP LDLNSNRVYV KARSEISKFV
1760 1770 1780 1790 1800
CHAEYRIVSD RSAPLLARQM ALHANLASLV YQSVQKKHPY ASNWLERLRK
1810 1820 1830 1840
LKRLRSKLIE GLNSQQKSGS ASSGIGINAS AIGSDMDDQR GDFIKYT
Length:1,847
Mass (Da):204,119
Last modified:May 1, 2000 - v1
Checksum:i23D2D9E07FCC2DE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF49066.1
RefSeqiNP_524177.1, NM_079453.3
UniGeneiDm.2047

Genome annotation databases

EnsemblMetazoaiFBtr0074819; FBpp0074588; FBgn0005198
GeneIDi40201
UCSCiCG6975-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VW83_DROME
AccessioniPrimary (citable) accession number: Q9VW83
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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