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Protein
Submitted name:

Gigas, isoform A

Gene

gig

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • GTPase activator activity Source: FlyBase
  • kinase binding Source: FlyBase
  • transferase activity Source: UniProtKB-KW

GO - Biological processi

  • cellular response to chloroquine Source: FlyBase
  • cellular response to DNA damage stimulus Source: FlyBase
  • cellular response to hypoxia Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • larval midgut histolysis Source: FlyBase
  • lateral inhibition Source: FlyBase
  • lipid metabolic process Source: FlyBase
  • negative regulation of cell growth Source: FlyBase
  • negative regulation of cell proliferation Source: FlyBase
  • negative regulation of cell size Source: FlyBase
  • negative regulation of insulin receptor signaling pathway Source: FlyBase
  • negative regulation of organ growth Source: FlyBase
  • negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • negative regulation of TOR signaling Source: FlyBase
  • oogenesis Source: FlyBase
  • phagocytosis Source: FlyBase
  • positive regulation of autophagy Source: FlyBase
  • positive regulation of GTPase activity Source: FlyBase
  • positive regulation of protein phosphorylation Source: FlyBase
  • regulation of cell cycle Source: FlyBase
  • regulation of phosphorylation Source: FlyBase
  • regulation of small GTPase mediated signal transduction Source: InterPro
  • regulation of terminal button organization Source: FlyBase
  • response to nutrient Source: FlyBase
  • signal transduction Source: FlyBase
  • TORC1 signaling Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-165181. Inhibition of TSC complex formation by PKB.
R-DME-198323. AKT phosphorylates targets in the cytosol.
R-DME-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-DME-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Submitted name:
Gigas, isoform AImported (EC:2.7.11.-Imported)
Gene namesi
Name:gigImported
ORF Names:CG6975Imported, Dmel_CG6975Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0005198. gig.

Subcellular locationi

GO - Cellular componenti

  • TSC1-TSC2 complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ9VW83.
PRIDEiQ9VW83.

Expressioni

Gene expression databases

BgeeiQ9VW83.
GenevisibleiQ9VW83. DM.

Interactioni

GO - Molecular functioni

  • kinase binding Source: FlyBase

Protein-protein interaction databases

IntActiQ9VW83. 5 interactions.
STRINGi7227.FBpp0074588.

Structurei

3D structure databases

ProteinModelPortaliQ9VW83.
SMRiQ9VW83. Positions 1591-1749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1586 – 1812227Rap-GAPInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG3687. Eukaryota.
ENOG410XPFJ. LUCA.
GeneTreeiENSGT00760000119182.
InParanoidiQ9VW83.
OMAiSWADSAV.
PhylomeDBiQ9VW83.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR000331. Rap_GAP_dom.
IPR003913. Tuberin.
IPR018515. Tuberin-type_domain.
IPR024584. Tuberin_N.
[Graphical view]
PANTHERiPTHR10063:SF1. PTHR10063:SF1. 3 hits.
PfamiPF11864. DUF3384. 1 hit.
PF02145. Rap_GAP. 1 hit.
PF03542. Tuberin. 1 hit.
[Graphical view]
PRINTSiPR01431. TUBERIN.
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF48371. SSF48371. 4 hits.
PROSITEiPS50085. RAPGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VW83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKDKSKFK LFLKSLPAGY VGERTLRPEF ERELRPEQPV AQRCRMLKEL
60 70 80 90 100
GDTQLHNFNL DESAITILFN LTNDLIVPNK PAETRQIALS FYKRLIHTQY
110 120 130 140 150
KNLTIMREKF FLVIQNHEAR EDLRHLLELL DTLTDNGKDI TNFEEKIGKF
160 170 180 190 200
MLLWIPAITE ANLLTPYLDI LVNLIKFNAA HLDKDILVGI VQNACDLSCS
210 220 230 240 250
VTVNEIGLQC LTILEMVIGY TIFPSEPLPQ CITTLCRTVN HAPYCPSSFK
260 270 280 290 300
IMKNLLGTQL GYHSMKMMCS ILNDRALYDD AHLLRGAVFH LNMNIFGSNI
310 320 330 340 350
IFQVSPMTYA TNVLTAFLRA LDSRQVIVTF EVILSVRMVI TKRQLSEIIW
360 370 380 390 400
DLICDIMSSI VSNIEYYEEV NINKDRLHHL QINFHENIDC IEKLLQQDRS
410 420 430 440 450
QILGNVERIY DLIERVADRR PEASVLALIE YRSRRVTATR PDWLQVLAQF
460 470 480 490 500
VRRYYRMSNV NVRIKTIEAL VQIMDQNRAC YEEEILSRVV LVHLSHIHLE
510 520 530 540 550
SSVQVRVAVA RALSNFATHC DTKRCMDLLD ILEALINRPF EHTRHGSSSG
560 570 580 590 600
EGTLAEVTFG LVNNESEISD IIAAVDGLVK VFAIKLHRLP GIHALKIFNI
610 620 630 640 650
LMDHLELHYE RPKIFEHISV VRYKIFAWLL KARANGSYHI GYPEGSTEVV
660 670 680 690 700
KFSPYLGIDS PLLPQAHPTA ISIRRVCKLI VRCLEHDTDY QVFQLVIREL
710 720 730 740 750
PKVLQNKALV QGNDIEELAN TLLKINLVSN NKFKRPTDEF HALVLPAIAS
760 770 780 790 800
LVIYHESLQP QQHYGIITAL NSRVLTGIAS VCINTMTILI LEMPEALMRK
810 820 830 840 850
LPDVLLQMSK MSDTNALATP VLEFLSLLIH LSKHLFANFT SMHNMYVFAI
860 870 880 890 900
TLPYTKPHRY DHYTVSLAHH VIAGWFLKCK LELRRNCVNY IKSSIQSNAK
910 920 930 940 950
MLSSDIVNLN SLNEDSSNRK RSTSLTERGS RNNANAWNDL EMRPQMNNGL
960 970 980 990 1000
RNFHAELAET CFDFLARHTY SPCPSMPKRL PAAEFLLKDG VSQTWLVGNN
1010 1020 1030 1040 1050
LVTITTSGCP SAPARSGLCE RCAQLGKAPS ISLNSKSLSD AAPPLSPERE
1060 1070 1080 1090 1100
RRYTKVSLQH SSGNESAGST ELTSSSSSNS AAAGGHPHRQ ISNSSTASLD
1110 1120 1130 1140 1150
ALSRRGSNPE ALGSALGEGA HTGSNTSLLG NSLSQSSVSM SPSSGSVVQQ
1160 1170 1180 1190 1200
PVCVRACTGW AEVLVRRPTG NVSWITRIQN PITNDCFGQE LPFNNVVSLF
1210 1220 1230 1240 1250
LPTAHGGVFG PDNTIQAPPH TLADPEPEPE AEVNAATAPQ ASALRSRMVA
1260 1270 1280 1290 1300
KARALQRQEE IHSVGGNGNG NGNGNGSGNA PSTGGAAAIP IPRVPASGKR
1310 1320 1330 1340 1350
GKEAALCGSV SDGEADDDSL AFEDAQSRAR NPVRRVNSSP EMSSSWRQSF
1360 1370 1380 1390 1400
LTNKPTPLSQ EPVKTTADEP QSLLTLKKKT VQYSTKDMRV SCEAIPEEIA
1410 1420 1430 1440 1450
GSTPPSQAAA LALQPESGTL PPKQHSADDV SSHVAGGSNL QAGGSTLKLG
1460 1470 1480 1490 1500
KPPLSPGQPP LLGTGRVTSF GGTSVPQPGA LAKSSSSGSN GTNVGVITSD
1510 1520 1530 1540 1550
YDNGNNGNGD MMRGRSKTIS VVREVNNGNT RPPPASSFRN FGAAKPPINT
1560 1570 1580 1590 1600
KLCMNPSFIF MQLYTTGQLG VTDEPLKVGP ENSSAVSLID LVPPFETHKI
1610 1620 1630 1640 1650
GVLYVGQGQC NNEVEILRNS HGSARYVEFL RNIGTLVSLK EAEQNNLFIM
1660 1670 1680 1690 1700
LDRNGADGKF AYIWKDDILQ VTFHVATLMP TNLQDDPNCN EKKSHIGNDF
1710 1720 1730 1740 1750
VKIIYNESGE EYNLNTISGQ FNYACVIVEP LDLNSNRVYV KARSEISKFV
1760 1770 1780 1790 1800
CHAEYRIVSD RSAPLLARQM ALHANLASLV YQSVQKKHPY ASNWLERLRK
1810 1820 1830 1840
LKRLRSKLIE GLNSQQKSGS ASSGIGINAS AIGSDMDDQR GDFIKYT
Length:1,847
Mass (Da):204,119
Last modified:May 1, 2000 - v1
Checksum:i23D2D9E07FCC2DE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49066.1.
RefSeqiNP_524177.1. NM_079453.3.
UniGeneiDm.2047.

Genome annotation databases

EnsemblMetazoaiFBtr0074819; FBpp0074588; FBgn0005198.
GeneIDi40201.
UCSCiCG6975-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49066.1.
RefSeqiNP_524177.1. NM_079453.3.
UniGeneiDm.2047.

3D structure databases

ProteinModelPortaliQ9VW83.
SMRiQ9VW83. Positions 1591-1749.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VW83. 5 interactions.
STRINGi7227.FBpp0074588.

Proteomic databases

PaxDbiQ9VW83.
PRIDEiQ9VW83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0074819; FBpp0074588; FBgn0005198.
GeneIDi40201.
UCSCiCG6975-RA. d. melanogaster.

Organism-specific databases

CTDi109822.
FlyBaseiFBgn0005198. gig.

Phylogenomic databases

eggNOGiKOG3687. Eukaryota.
ENOG410XPFJ. LUCA.
GeneTreeiENSGT00760000119182.
InParanoidiQ9VW83.
OMAiSWADSAV.
PhylomeDBiQ9VW83.

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.
R-DME-165181. Inhibition of TSC complex formation by PKB.
R-DME-198323. AKT phosphorylates targets in the cytosol.
R-DME-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-DME-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

ChiTaRSigig. fly.
GenomeRNAii40201.
NextBioi817541.

Gene expression databases

BgeeiQ9VW83.
GenevisibleiQ9VW83. DM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR000331. Rap_GAP_dom.
IPR003913. Tuberin.
IPR018515. Tuberin-type_domain.
IPR024584. Tuberin_N.
[Graphical view]
PANTHERiPTHR10063:SF1. PTHR10063:SF1. 3 hits.
PfamiPF11864. DUF3384. 1 hit.
PF02145. Rap_GAP. 1 hit.
PF03542. Tuberin. 1 hit.
[Graphical view]
PRINTSiPR01431. TUBERIN.
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF48371. SSF48371. 4 hits.
PROSITEiPS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.

Entry informationi

Entry nameiQ9VW83_DROME
AccessioniPrimary (citable) accession number: Q9VW83
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.