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Protein

Fat-like cadherin-related tumor suppressor homolog

Gene

kug

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Required for the planar polarity of actin filament orientation at the basal side of ovarian follicle cells. Required for proper egg chamber shape; elongation of the egg chamber during oogenesis.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • cell adhesion molecule binding Source: FlyBase
  • receptor activity Source: FlyBase

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • cell-cell adhesion mediated by cadherin Source: FlyBase
  • defense response to Gram-negative bacterium Source: FlyBase
  • epithelium development Source: FlyBase
  • establishment of planar polarity of follicular epithelium Source: UniProtKB
  • establishment or maintenance of actin cytoskeleton polarity Source: FlyBase
  • foregut morphogenesis Source: FlyBase
  • germarium-derived egg chamber formation Source: FlyBase
  • growth of a germarium-derived egg chamber Source: UniProtKB
  • hindgut morphogenesis Source: FlyBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
  • negative regulation of imaginal disc growth Source: FlyBase
  • oogenesis Source: FlyBase
  • open tracheal system development Source: FlyBase
  • positive regulation of innate immune response Source: FlyBase
  • salivary gland development Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Fat-like cadherin-related tumor suppressor homolog
Alternative name(s):
Protein kugelei
Gene namesi
Name:kug
Synonyms:fat2
ORF Names:CG7749
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0261574. kug.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini39 – 42854247ExtracellularSequence analysisAdd
BLAST
Transmembranei4286 – 430621HelicalSequence analysisAdd
BLAST
Topological domaini4307 – 4699393CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • basal plasma membrane Source: FlyBase
  • focal adhesion Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Defects in actin filament orientation correlate with a failure of egg chambers to elongate during oogenesis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3838Sequence analysisAdd
BLAST
Chaini39 – 46994661Fat-like cadherin-related tumor suppressor homologPRO_0000004016Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi68 – 681N-linked (GlcNAc...)Sequence analysis
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis
Glycosylationi367 – 3671N-linked (GlcNAc...)Sequence analysis
Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence analysis
Glycosylationi846 – 8461N-linked (GlcNAc...)Sequence analysis
Glycosylationi926 – 9261N-linked (GlcNAc...)Sequence analysis
Glycosylationi1109 – 11091N-linked (GlcNAc...)Sequence analysis
Glycosylationi1201 – 12011N-linked (GlcNAc...)Sequence analysis
Glycosylationi1315 – 13151N-linked (GlcNAc...)Sequence analysis
Glycosylationi1442 – 14421N-linked (GlcNAc...)Sequence analysis
Glycosylationi1476 – 14761N-linked (GlcNAc...)Sequence analysis
Glycosylationi1514 – 15141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi3807 ↔ 3819Sequence analysis
Disulfide bondi3814 ↔ 3851Sequence analysis
Disulfide bondi3853 ↔ 3862Sequence analysis
Disulfide bondi3869 ↔ 3880Sequence analysis
Disulfide bondi3874 ↔ 3891Sequence analysis
Disulfide bondi3893 ↔ 3902Sequence analysis
Disulfide bondi4071 ↔ 4105By similarity
Disulfide bondi4117 ↔ 4128Sequence analysis
Disulfide bondi4122 ↔ 4138Sequence analysis
Disulfide bondi4140 ↔ 4149Sequence analysis
Disulfide bondi4156 ↔ 4167Sequence analysis
Disulfide bondi4161 ↔ 4177Sequence analysis
Disulfide bondi4179 ↔ 4188Sequence analysis
Disulfide bondi4194 ↔ 4205By similarity
Disulfide bondi4199 ↔ 4214By similarity
Disulfide bondi4216 ↔ 4224By similarity
Disulfide bondi4231 ↔ 4242Sequence analysis
Disulfide bondi4236 ↔ 4251Sequence analysis
Disulfide bondi4253 ↔ 4262Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9VW71.
PRIDEiQ9VW71.

Expressioni

Tissue specificityi

Localizes where basal actin filaments terminate.1 Publication

Gene expression databases

BgeeiFBgn0261574.
ExpressionAtlasiQ9VW71. differential.
GenevisibleiQ9VW71. DM.

Interactioni

GO - Molecular functioni

  • cell adhesion molecule binding Source: FlyBase

Protein-protein interaction databases

BioGridi65458. 2 interactions.
DIPiDIP-24050N.
IntActiQ9VW71. 7 interactions.
MINTiMINT-931063.
STRINGi7227.FBpp0304968.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 183121Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini184 – 291108Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini288 – 400113Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini401 – 507107Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini508 – 613106Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini614 – 716103Cadherin 6PROSITE-ProRule annotationAdd
BLAST
Domaini773 – 877105Cadherin 7PROSITE-ProRule annotationAdd
BLAST
Domaini878 – 980103Cadherin 8PROSITE-ProRule annotationAdd
BLAST
Domaini981 – 1088108Cadherin 9PROSITE-ProRule annotationAdd
BLAST
Domaini1089 – 1198110Cadherin 10PROSITE-ProRule annotationAdd
BLAST
Domaini1194 – 1299106Cadherin 11PROSITE-ProRule annotationAdd
BLAST
Domaini1300 – 1405106Cadherin 12PROSITE-ProRule annotationAdd
BLAST
Domaini1408 – 150699Cadherin 13PROSITE-ProRule annotationAdd
BLAST
Domaini1507 – 1612106Cadherin 14PROSITE-ProRule annotationAdd
BLAST
Domaini1613 – 1717105Cadherin 15PROSITE-ProRule annotationAdd
BLAST
Domaini1718 – 181598Cadherin 16PROSITE-ProRule annotationAdd
BLAST
Domaini1816 – 1932117Cadherin 17PROSITE-ProRule annotationAdd
BLAST
Domaini1933 – 2033101Cadherin 18PROSITE-ProRule annotationAdd
BLAST
Domaini2034 – 2140107Cadherin 19PROSITE-ProRule annotationAdd
BLAST
Domaini2141 – 2241101Cadherin 20PROSITE-ProRule annotationAdd
BLAST
Domaini2242 – 2341100Cadherin 21PROSITE-ProRule annotationAdd
BLAST
Domaini2342 – 2449108Cadherin 22PROSITE-ProRule annotationAdd
BLAST
Domaini2450 – 2551102Cadherin 23PROSITE-ProRule annotationAdd
BLAST
Domaini2552 – 2654103Cadherin 24PROSITE-ProRule annotationAdd
BLAST
Domaini2655 – 2763109Cadherin 25PROSITE-ProRule annotationAdd
BLAST
Domaini2764 – 286097Cadherin 26PROSITE-ProRule annotationAdd
BLAST
Domaini2861 – 2967107Cadherin 27PROSITE-ProRule annotationAdd
BLAST
Domaini2968 – 3072105Cadherin 28PROSITE-ProRule annotationAdd
BLAST
Domaini3068 – 3169102Cadherin 29PROSITE-ProRule annotationAdd
BLAST
Domaini3170 – 3273104Cadherin 30PROSITE-ProRule annotationAdd
BLAST
Domaini3274 – 3378105Cadherin 31PROSITE-ProRule annotationAdd
BLAST
Domaini3379 – 3483105Cadherin 32PROSITE-ProRule annotationAdd
BLAST
Domaini3484 – 3588105Cadherin 33PROSITE-ProRule annotationAdd
BLAST
Domaini3589 – 3696108Cadherin 34PROSITE-ProRule annotationAdd
BLAST
Domaini3865 – 390339EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini3921 – 4105185Laminin G-likePROSITE-ProRule annotationAdd
BLAST
Domaini4113 – 415038EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini4152 – 418938EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini4190 – 422536EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini4227 – 426337EGF-like 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 34 cadherin domains.PROSITE-ProRule annotation
Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiQ9VW71.
KOiK16506.
OMAiCLRGECR.
OrthoDBiEOG091G00A0.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 26 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 34 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 18 hits.
PS50268. CADHERIN_2. 34 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform D (identifier: Q9VW71-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MFTMKIKKYV TPVKRKAFTI LQWISLLCSL WLIPTVQSKA DEKHTATLEY
60 70 80 90 100
RLENQLQDLY RFSHSVYNVT IPENSLGKTY AKGVLHERLA GLRVGLNAEV
110 120 130 140 150
KYRIISGDKE KLFKAEEKLV GDFAFLAIRT RTNNVVLNRE KTEEYVIRVK
160 170 180 190 200
AHVHLHDRNV SSYETEANIH IKVLDRNDLS PLFYPTQYTV VIPEDTPKYQ
210 220 230 240 250
SILKVTADDA DLGINGEIYY SLLMDSEYFA IHPTTGEITL LQQLQYAENS
260 270 280 290 300
HFELTVVAYD RGSWVNHQNH QASKTKVSIS VKQVNFYAPE IFTKTFSSVT
310 320 330 340 350
PTSNPLIYGI VRVNDKDTGI NGNIGRLEIV DGNPDGTFLL KAAETKDEYY
360 370 380 390 400
IELNQFAHLN QQHFIYNLTL LAEDLGTPRR FAYKSVPIQI KPESKNIPIF
410 420 430 440 450
TQEIYEVSIP ETAPINMPVI RLKVSDPDLG KNALVYLEIV GGNEGDEFRI
460 470 480 490 500
NPDSGMLYTA KQLDAEKKSS YTLTVSAIDQ ANVGSRKQSS AKVKISVQDM
510 520 530 540 550
NDNDPIFENV NKVISINENN LAGSFVVKLT AKDRDSGENS YISYSIANLN
560 570 580 590 600
AVPFEIDHFS GIVKTTSLLD FETMKRNYEL IIRASDWGLP YRRQTEIKLS
610 620 630 640 650
IVVKDINDNR PQFERVNCYG KVTKSAPMGT EVFVTSAIDF DAGDIISYRL
660 670 680 690 700
SDGNEDGCFN LDPTSGSLSI SCDLKKTTLT NRILKVSATD GTHFSDDLII
710 720 730 740 750
NVHLMPEDLG GDSSILHGFG SFECRETGVA RRLAETLSLA EKNNVKSASP
760 770 780 790 800
SVFSDLSLTP SRYGQNVHRP EFVNFPQELS INESVQLGET VAWIEAKDRD
810 820 830 840 850
LGYNGKLVFA ISDGDYDSVF RIDPDRGELQ IIGYLDRERQ NEYVLNITVY
860 870 880 890 900
DLGNPTKSTS KMLPITILDV NDNRPVIQKT LATFRLTESA RIGTVVHCLH
910 920 930 940 950
ATDADSGINA QVTYALSVEC SDFTVNATTG CLRLNKPLDR EKQDNYALHI
960 970 980 990 1000
TAKDGGSPVL SSEALVYVLV DDVNDNAPVF GVQEYIFKVR EDLPRGTVLA
1010 1020 1030 1040 1050
VIEAVDEDIG PNAEIQFSLK EETQDEELFR IDKHTGAIRT QGYLDYENKQ
1060 1070 1080 1090 1100
VHNLIVSAID GGDPSLTSDM SIVIMIIDVN ENRFAPEFDD FVYEGKVKEN
1110 1120 1130 1140 1150
KPKGTFVMNV TARDMDTVDL NSKITYSITG GDGLGIFAVN DQGSITSLSQ
1160 1170 1180 1190 1200
LDAETKNFYW LTLCAQDCAI VPLSNCVEVY IQVENENDNI PLTDKPVYYV
1210 1220 1230 1240 1250
NVTEASVENV EIITLKAFDP DIDPTQTITY NIVSGNLVGY FEIDSKTGVI
1260 1270 1280 1290 1300
KTTERKLDRE NQAEHILEVA ISDNGSPVLS STSRIVVSVL DINDNSPEFD
1310 1320 1330 1340 1350
QRVYKVQVPS SATVNQSIFQ VHAIDSDSGE NGRITYSIKS GKGKNKFRID
1360 1370 1380 1390 1400
SQRGHIHIAK PLDSDNEFEI HIKAEDNGIP KKSQTARVNI VVVPVNPNSQ
1410 1420 1430 1440 1450
NAPLIVRKTS ENVVDLTEND KPGFLVTQIL AVDDDNDQLW YNISNGNDDN
1460 1470 1480 1490 1500
TFYIGQDNGN ILLSKYLDYE TQQSYNLTIS VTDGTFTAFT NLLVQVIDIN
1510 1520 1530 1540 1550
DNPPQFAKDV YHVNISENIE EESVIMQLHA TDRDEDKKLF YHLHATQDPS
1560 1570 1580 1590 1600
SLALFRIDSI SGNVIVTQRL DFEKTAQHIL IVFVKDQGAP GKRNYAKIIV
1610 1620 1630 1640 1650
NVHDHNDHHP EFTAKIIQSK VPESAAIGSK LAEVRAIDRD SGHNAEIQYS
1660 1670 1680 1690 1700
IITGNVGSVF EIDPTFGIIT LAGNLNINKI QEYMLQVKAV DLGNPPLSSQ
1710 1720 1730 1740 1750
IPVHIIVTMS ENDPPKFPTN NIAIEIFENL PIGTFVTQVT ARSSSSIFFN
1760 1770 1780 1790 1800
IISGNINESF RINPSTGVIV INGNIDYESI KVFNLTVKGT NMAAESSCQN
1810 1820 1830 1840 1850
IIIHILDAND NIPYFVQNEY VGALPESAAI GSYVLKVHDS SKDHLTLQVK
1860 1870 1880 1890 1900
DADVGVNGMV EYHIVDDLAK NFFKIDSTTG AIELLRQLDY ETNAGYTFDV
1910 1920 1930 1940 1950
TVSDMGKPKL HSTTTAHVTI RVINVNDCPP VFNERELNVT LFLPTFENVF
1960 1970 1980 1990 2000
VRQVSAKDAD NDTLRFDIVD GNTNECFQIE KYTGIITTRN FEILNNENDR
2010 2020 2030 2040 2050
DYALHVRASD GIFSAILIVK IKVLSAIDSN FAFQRESYRF SAFENNTKVA
2060 2070 2080 2090 2100
TIGLVNVIGN TLDENVEYRI LNPTQLFDIG ISSGALKTTG VIFDREVKDL
2110 2120 2130 2140 2150
YRLFVEAKSM LYDGMNSNVR RAVTSIDISV LDVNDNCPLF VNMPYYATVS
2160 2170 2180 2190 2200
IDDPKGTIIM QVKAIDLDSA ENGEVRYELK KGNGELFKLD RKSGELSIKQ
2210 2220 2230 2240 2250
HVEGHNRNYE LTVAAYDGAI TPCSSEAPLQ VKVIDRSMPV FEKQFYTVSV
2260 2270 2280 2290 2300
KEDVEMYSAL SVSIEAESPL GRSLIYTISS ESQSFEIDYN TGSIFVVNEL
2310 2320 2330 2340 2350
DYEKISSHDV SIRATDSLSG VYAEVVLSVS IMDVNDCYPE IESDIYNLTI
2360 2370 2380 2390 2400
PENASFGTQI LKINATDNDS GANAKLSYYI ESINGQNNSE LFYIDVTDGN
2410 2420 2430 2440 2450
LYLKTPLDYE QIKYHHIVVN VKDHGSPSLS SRSNVFITVK DLNDNAPCFV
2460 2470 2480 2490 2500
EPSYFTKVSV AAVRGQFVAL PKAYDKDISD TDSLEYKIVY GNELQTYSID
2510 2520 2530 2540 2550
KLTGVISLQN MLNFTDKSST VLNISVSDGV HTAYARLKIS LLPENVYSPL
2560 2570 2580 2590 2600
FDQSTYEAQV PENLLHGHNI ITVKASDGDF GTYANLYYEI VSEEMKKIFL
2610 2620 2630 2640 2650
IDQTTGVITS KVTFDREKKD EYVVLLKVSD GGGKFGFASL KVIVVDVNDN
2660 2670 2680 2690 2700
VPYFLLKEYK MVVSTTVEAN QTILTVKAKD DDIVDNGSVH FQIVQKSNDK
2710 2720 2730 2740 2750
AVKDVIEINE KTGDIVFKSK AESYGVNSYQ FFVRASDRGE PQFHSEVPVS
2760 2770 2780 2790 2800
IEIIETDANI PTFEKSSVLL KIIESTPPGT VLTKLHMIGN YTFKFSIAAD
2810 2820 2830 2840 2850
QDHFMISDSG ELILQQTLDR EQQESHNLIV VAETSTVPVF FAYADVLIDV
2860 2870 2880 2890 2900
RDENDNYPKF DNTFYSASVA ENSEKVISLV KVSATDADTG PNGDIRYYLE
2910 2920 2930 2940 2950
SDTENIQNIF DIDIYSGWIT LLTSLDREVQ SEYNFKVIAA DNGHPKHDAK
2960 2970 2980 2990 3000
VPVTIKIVDY NDNAPVFKLP IEGLSVFENA LPGTVLINLL LIDPDIEKQE
3010 3020 3030 3040 3050
MDFFIVSGDK QAQFQIGKSG ELFIAKPLDR EQLMFYNLSI IATDGKFTAK
3060 3070 3080 3090 3100
ANVEIDVKDI NDNTPYCLKP RYHISTNESI SIGTTLVEVK AIDFDFQSKL
3110 3120 3130 3140 3150
RFYLSGKGAD DFSIGKESGI LKVASALDRE TTPKYKLVAH VQDGKDFTQE
3160 3170 3180 3190 3200
CFSEIIITVN DINDNMPIFS MAQYRVSVPE DAQLNTLITK VHAMDKDFGV
3210 3220 3230 3240 3250
NRQIKYSLMG ENHDYFKISK STGIIRLHKS LDRETISLFN LTVKAEDCGV
3260 3270 3280 3290 3300
PKLHSIATVA VNILDINDNP PEFSMRQYSC KILENATHGT EVCKVYATSI
3310 3320 3330 3340 3350
DIGVNADIHY FIMSGNEQGK FKMDSTTGDL VLNATLDYEM SKFYFLTIQA
3360 3370 3380 3390 3400
IDGGTPPLSN NAYVNISILD INDNSPTFLQ NLYRINVNED IFVGSKILDV
3410 3420 3430 3440 3450
KATDEDSDVN GLVTYNIERG DNIGQFSIDP KNGTISVSRP LDRETISHYT
3460 3470 3480 3490 3500
LEIQACDQGD PQRCNSVPIN INILDTNDNA PIFSSSNYSV VLQENRLLGY
3510 3520 3530 3540 3550
VFLTFKISDA DETPNTTPYT FDIRSGNEGG LFRLEQDGSL RTASRFNHNL
3560 3570 3580 3590 3600
QDEFVIQVRV FDNGTPPLYS DAWVVVKIIE ESQYPPIVTP LEVTINSFED
3610 3620 3630 3640 3650
DFSGAFIGKV HASDQDKYDE LNFSLVSGPD DMYQSSKLFN ISNNTGKIYA
3660 3670 3680 3690 3700
ISNLDIGLYK LNVSVSDGKF HVFSIVKINV ELVTNDMLKE SVVIRFRRIS
3710 3720 3730 3740 3750
ASEFLLSHRK TFMRSIRNIM RCRQKDVILI TLQSDYQKAS QHAVGNRRAR
3760 3770 3780 3790 3800
SIDSDLNVVF AVRKQQIIPD SDEFFTSDEI RQTLIDKKNE IENETNLVVE
3810 3820 3830 3840 3850
DVLPSTCQSN KNDCVHGECK QILQILKNNV TTTFTDVISF AAPSYIPVNT
3860 3870 3880 3890 3900
CVCRPGFDGK HCKETVNACS TDPCSPQRIC MPSGSALGYQ CVCPKGFSGT
3910 3920 3930 3940 3950
YCERKSSKCS NESCDMGLFT AVSFGGKSYA HYKINKVKAK FTLENGFSYS
3960 3970 3980 3990 4000
LQIRTVQQTG TLLYASGKVD YNILEIINGA VQYRFDLGSG EGVISVSSIN
4010 4020 4030 4040 4050
ISDGEWHQIS LERSLNSAKV MVDNKHVSHG SAPGVNGILN IQSNDIFVGA
4060 4070 4080 4090 4100
EVRPHPSIIG YEDIQRGFIG CMANIKIAKE SLPLYISGGS TIAALKRFTN
4110 4120 4130 4140 4150
VEFKCDPSNV LVRLGICGSQ PCANSGICKE LDTDVFECAC QPRYSGKHCE
4160 4170 4180 4190 4200
IDLDPCSSGP CLFGGRCDYH GPNNYSCTCP IHLSGKRCEY GKFCTPNPCK
4210 4220 4230 4240 4250
NGGICEEGDG ISHCMCRGYT GPTCEIDVDE CENQPCGNGA TCINEPGSFR
4260 4270 4280 4290 4300
CICPSYLTGA SCGDPLYSNS ISTKLKNFSI EHISGIISGV AVVLVIISCV
4310 4320 4330 4340 4350
LCCVVLKRSS SSKRRNRLEK DKNKSSYKEA NLNSLVDKDN YCKPNVKLSN
4360 4370 4380 4390 4400
LEVNQRPISY TAVPNDNLVL SNRNFVNNLD ILRSYGSAGD ELENVPFEYQ
4410 4420 4430 4440 4450
KVNRNKQHVN INSCHSTDAD NAYKQEWCEQ MHLRTFSENK LNNELKRDFG
4460 4470 4480 4490 4500
PSVSRFSTGK LIQVEMPNVC HSSSANFVDY SALANGQYHW DCSDWVRKSH
4510 4520 4530 4540 4550
NPLPDITEVP GAEIADSSSL HSNDSNESKS KKAFFVHRED GDVDPTRDIA
4560 4570 4580 4590 4600
ALNEDIGSEY LDSEAESCLE PFMLPRSSNQ PLSRLSSFNN IENEDYKSNT
4610 4620 4630 4640 4650
VPLPSKVSHS CKVYLRHPDS YLPTMHFPSE TDGESSMTEG PISRMEIKTR
4660 4670 4680 4690
RTISENSEEA YLFPCTVGEI GSNSNISVRL CEIEDSELEE FLPQQQTNN
Note: No experimental confirmation available.
Length:4,699
Mass (Da):523,781
Last modified:May 14, 2014 - v3
Checksum:i1798A54345758C36
GO
Isoform C (identifier: Q9VW71-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4601-4611: VPLPSKVSHSC → G

Note: No experimental confirmation available.
Show »
Length:4,689
Mass (Da):522,703
Checksum:i4C6F87D76F334666
GO

Sequence cautioni

The sequence AAL28503 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAM50035 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAM50035 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3946 – 39461G → E in AAL28503 (PubMed:12537569).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei4601 – 461111VPLPSKVSHSC → G in isoform C. 1 PublicationVSP_054450Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49078.3.
AE014296 Genomic DNA. Translation: AAZ66056.2.
AY060955 mRNA. Translation: AAL28503.1. Different initiation.
AY118666 mRNA. Translation: AAM50035.1. Sequence problems.
RefSeqiNP_001027138.2. NM_001031967.2. [Q9VW71-1]
NP_001287126.1. NM_001300197.1. [Q9VW71-2]
NP_649171.3. NM_140914.3. [Q9VW71-2]
UniGeneiDm.3778.

Genome annotation databases

EnsemblMetazoaiFBtr0332722; FBpp0304968; FBgn0261574. [Q9VW71-1]
GeneIDi40191.
KEGGidme:Dmel_CG7749.
UCSCiCG7749-RA. d. melanogaster. [Q9VW71-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49078.3.
AE014296 Genomic DNA. Translation: AAZ66056.2.
AY060955 mRNA. Translation: AAL28503.1. Different initiation.
AY118666 mRNA. Translation: AAM50035.1. Sequence problems.
RefSeqiNP_001027138.2. NM_001031967.2. [Q9VW71-1]
NP_001287126.1. NM_001300197.1. [Q9VW71-2]
NP_649171.3. NM_140914.3. [Q9VW71-2]
UniGeneiDm.3778.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi65458. 2 interactions.
DIPiDIP-24050N.
IntActiQ9VW71. 7 interactions.
MINTiMINT-931063.
STRINGi7227.FBpp0304968.

Proteomic databases

PaxDbiQ9VW71.
PRIDEiQ9VW71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0332722; FBpp0304968; FBgn0261574. [Q9VW71-1]
GeneIDi40191.
KEGGidme:Dmel_CG7749.
UCSCiCG7749-RA. d. melanogaster. [Q9VW71-1]

Organism-specific databases

CTDi40191.
FlyBaseiFBgn0261574. kug.

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
InParanoidiQ9VW71.
KOiK16506.
OMAiCLRGECR.
OrthoDBiEOG091G00A0.

Miscellaneous databases

GenomeRNAii40191.
PROiQ9VW71.

Gene expression databases

BgeeiFBgn0261574.
ExpressionAtlasiQ9VW71. differential.
GenevisibleiQ9VW71. DM.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
2.60.40.60. 33 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013320. ConA-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF00028. Cadherin. 26 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 34 hits.
SM00181. EGF. 6 hits.
SM00179. EGF_CA. 4 hits.
SM00282. LamG. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 34 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00232. CADHERIN_1. 18 hits.
PS50268. CADHERIN_2. 34 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 1 hit.
PS50025. LAM_G_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAT2_DROME
AccessioniPrimary (citable) accession number: Q9VW71
Secondary accession number(s): A4V252, Q95S51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: May 14, 2014
Last modified: September 7, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.