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Protein
Submitted name:

26S proteasome regulatory complex subunit p97

Gene

Rpn1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme regulator activity Source: InterPro
  • zinc ion binding Source: FlyBase

GO - Biological processi

  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
  • regulation of protein catabolic process Source: InterPro

Enzyme and pathway databases

BRENDAi3.4.25.1. 1994.
ReactomeiR-DME-1169091. Activation of NF-kappaB in B cells.
R-DME-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-DME-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-DME-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-DME-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-DME-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-DME-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-DME-195253. Degradation of beta-catenin by the destruction complex.
R-DME-202424. Downstream TCR signaling.
R-DME-2871837. FCERI mediated NF-kB activation.
R-DME-350562. Regulation of ornithine decarboxylase (ODC).
R-DME-446652. Interleukin-1 family signaling.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-DME-4608870. Asymmetric localization of PCP proteins.
R-DME-4641257. Degradation of AXIN.
R-DME-4641258. Degradation of DVL.
R-DME-5358346. Hedgehog ligand biogenesis.
R-DME-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-DME-5607764. CLEC7A (Dectin-1) signaling.
R-DME-5610780. Degradation of GLI1 by the proteasome.
R-DME-5610785. GLI3 is processed to GLI3R by the proteasome.
R-DME-5632684. Hedgehog 'on' state.
R-DME-5658442. Regulation of RAS by GAPs.
R-DME-5676590. NIK-->noncanonical NF-kB signaling.
R-DME-5689603. UCH proteinases.
R-DME-5689880. Ub-specific processing proteases.
R-DME-6798695. Neutrophil degranulation.
R-DME-68949. Orc1 removal from chromatin.
R-DME-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-DME-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-DME-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-DME-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-DME-8941858. Regulation of RUNX3 expression and activity.
R-DME-8948751. Regulation of PTEN stability and activity.
R-DME-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
26S proteasome regulatory complex subunit p97Imported
Submitted name:
Regulatory particle non-ATPase 1Imported
Gene namesi
Name:Rpn1Imported
Synonyms:BcDNA:LD21723Imported, Dmel\CG7762Imported, p97Imported, RPN1Imported, S2Imported
ORF Names:CG7762Imported, Dmel_CG7762Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0028695. Rpn1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ProteasomeImported

Expressioni

Gene expression databases

BgeeiFBgn0028695.

Interactioni

Protein-protein interaction databases

IntActiQ9VW54. 12 interactors.
MINTiMINT-294744.
STRINGi7227.FBpp0074662.

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili634 – 655Sequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2005. Eukaryota.
COG5110. LUCA.
GeneTreeiENSGT00550000074983.
KOiK03028.
OMAiMVDICAY.
OrthoDBiEOG091G04TC.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiView protein in InterPro
IPR016643. 26S_Psome_Rpn1.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002015. Proteasome/cyclosome_rpt.
PANTHERiPTHR10943:SF7. PTHR10943:SF7. 1 hit.
PfamiView protein in Pfam
PF01851. PC_rep. 3 hits.
PIRSFiPIRSF015965. 26S_Psome_Rpn1. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9VW54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGETKLEKK PLKPAASEGD AKDPKAKKDE KKDGKDKEQQ PELSDEDQQL
60 70 80 90 100
QEELELLVQH LQEPDAKLYQ PTLESMAKLI RASTTSMTSV PKPLKFMRPH
110 120 130 140 150
YETMKTVYKH MPNEQARQLC ADIISVLSMT MGSGKDCLAY RFLCDRKQRI
160 170 180 190 200
GDWGHEYVRH LSGEISAHYH DTTGDFRVQL IELVKQIIPY NMEHNAEADA
210 220 230 240 250
CDLLIEIDHL HLLSDFVDES AYPRVCLYLQ SCYPYVPDPD NTIILETALQ
260 270 280 290 300
LSRKFNQYTQ AMRLALMLND MDKIGEIFKE PKEPAMQKQL AFMLARQQIC
310 320 330 340 350
LELDELVPDY DDLMEIMSNA NLNKHFLNLA RELDIMEPKT PEDIYKSHLD
360 370 380 390 400
NSRSRFASIQ VDSAKQNLAA SFVNGFVNAG FGVDKLLSED GNKWLYKNKE
410 420 430 440 450
HGMLSATASL GLILLWDVDG GLTMIDKYLY STDDNIKSGA LLACGIVNCG
460 470 480 490 500
IRNEVDPAHA LLSDYIDNQN SCMRVGAILG LGIAYAGSNR SIVIDTLKTV
510 520 530 540 550
FSFGSNNKSS ASVEILGITA LSLGLISVGS CNSEITEILL QTIMGLTKAD
560 570 580 590 600
LKDTYTRFLF LGLGLLYLGR QKSTEAVMMT LEVLEEPYRS MATTMVDICA
610 620 630 640 650
YAGTGNVLKI QQLLHICSDH YETSSADDEK EKSKKDKGKD KEKEKEKEKE
660 670 680 690 700
KEREKDLSAT QSIAVLGIAL IAMGEDIGAE MAYRSFGNLL RYCEPAIRRA
710 720 730 740 750
VPLALGLISA SNPKLNIIDT LSKFSHDSDA EVAHNAIFAM GLVGAGTNNA
760 770 780 790 800
RLASMLRQLA QYHSKDPSNL FMVRIAQSLT HLGKGTLSLS PYHSDRQLMN
810 820 830 840 850
PMAVAGLMAT LVSLLDVKNL ILNRSHYLLY TLVPAMQARM LITFDEELNQ
860 870 880 890 900
LQVPVRVGIA IDVVGQAGKP KTITGFQTHT TPVLLAIGER AELATDEYLA
910
LTPVMEGFVI LKKNPNFVK
Length:919
Mass (Da):102,278
Last modified:March 1, 2001 - v2
Checksum:i8CCBF33D2664C7D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132182 mRNA. Translation: AAD34770.1.
AF145304 mRNA. Translation: AAF08385.1.
AE014296 Genomic DNA. Translation: AAF49095.2.
RefSeqiNP_649158.1. NM_140901.3.
UniGeneiDm.3192.

Genome annotation databases

EnsemblMetazoaiFBtr0074893; FBpp0074662; FBgn0028695.
GeneIDi40174.
KEGGidme:Dmel_CG7762.
UCSCiCG7762-RA. d. melanogaster.

Similar proteinsi

Entry informationi

Entry nameiQ9VW54_DROME
AccessioniPrimary (citable) accession number: Q9VW54
Secondary accession number(s): Q9XZ26
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: September 27, 2017
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported