Unreviewed, UniProtKB/TrEMBL Q9VW54 (Q9VW54_DROME)

Names and origin

Protein names

Submitted name:
    Rpn1 EMBL AAF49095.2
Submitted name:
    26S proteasome regulatory complex subunit p97 EMBL AAF08385.1
    Putative uncharacterized protein EMBL AAD34770.1

Gene names

Name:	Rpn1 EMBL AAF49095.2 FlyBase FBgn0028695
ORF Names:	CG7762 FlyBase FBgn0028695, Dmel_CG7762 EMBL AAF49095.2

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	919 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
Cellular component	Proteasome
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell proliferation Inferred from mutant phenotype. Source: FlyBase mitotic spindle elongation Inferred from mutant phenotype. Source: FlyBase proteolysis Ref.4 Inferred from direct assay. Source: FlyBase regulation of protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-KW proteasome regulatory particle Ref.4 Inferred from direct assay. Source: FlyBase
Molecular function	endopeptidase activity Ref.4 Inferred from direct assay. Source: FlyBase enzyme regulator activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VW54-1 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: 8CCBF33D2664C7D6	FASTA	919	102,278
	10 20 30 40 50 60 MTGETKLEKK PLKPAASEGD AKDPKAKKDE KKDGKDKEQQ PELSDEDQQL QEELELLVQH 70 80 90 100 110 120 LQEPDAKLYQ PTLESMAKLI RASTTSMTSV PKPLKFMRPH YETMKTVYKH MPNEQARQLC 130 140 150 160 170 180 ADIISVLSMT MGSGKDCLAY RFLCDRKQRI GDWGHEYVRH LSGEISAHYH DTTGDFRVQL 190 200 210 220 230 240 IELVKQIIPY NMEHNAEADA CDLLIEIDHL HLLSDFVDES AYPRVCLYLQ SCYPYVPDPD 250 260 270 280 290 300 NTIILETALQ LSRKFNQYTQ AMRLALMLND MDKIGEIFKE PKEPAMQKQL AFMLARQQIC 310 320 330 340 350 360 LELDELVPDY DDLMEIMSNA NLNKHFLNLA RELDIMEPKT PEDIYKSHLD NSRSRFASIQ 370 380 390 400 410 420 VDSAKQNLAA SFVNGFVNAG FGVDKLLSED GNKWLYKNKE HGMLSATASL GLILLWDVDG 430 440 450 460 470 480 GLTMIDKYLY STDDNIKSGA LLACGIVNCG IRNEVDPAHA LLSDYIDNQN SCMRVGAILG 490 500 510 520 530 540 LGIAYAGSNR SIVIDTLKTV FSFGSNNKSS ASVEILGITA LSLGLISVGS CNSEITEILL 550 560 570 580 590 600 QTIMGLTKAD LKDTYTRFLF LGLGLLYLGR QKSTEAVMMT LEVLEEPYRS MATTMVDICA 610 620 630 640 650 660 YAGTGNVLKI QQLLHICSDH YETSSADDEK EKSKKDKGKD KEKEKEKEKE KEREKDLSAT 670 680 690 700 710 720 QSIAVLGIAL IAMGEDIGAE MAYRSFGNLL RYCEPAIRRA VPLALGLISA SNPKLNIIDT 730 740 750 760 770 780 LSKFSHDSDA EVAHNAIFAM GLVGAGTNNA RLASMLRQLA QYHSKDPSNL FMVRIAQSLT 790 800 810 820 830 840 HLGKGTLSLS PYHSDRQLMN PMAVAGLMAT LVSLLDVKNL ILNRSHYLLY TLVPAMQARM 850 860 870 880 890 900 LITFDEELNQ LQVPVRVGIA IDVVGQAGKP KTITGFQTHT TPVLLAIGER AELATDEYLA 910 LTPVMEGFVI LKKNPNFVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Phosphoproteome analysis of Drosophila melanogaster embryos." Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P. J. Proteome Res. 7:1675-1682(2008) [PubMed: 18327897] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[4]	"The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme." Hoelzl H., Kapelari B., Kellermann J., Seemueller E., Suemegi M., Udvardy A., Medalia O., Sperling J., Mueller S.A., Engel A., Baumeister W. J. Cell Biol. 150:119-130(2000) [PubMed: 10893261] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	Dolenc I. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	Rubin G.M., Wan K.H., Harvey D., Lewis S.E., Brokstein P., Tsang G., Agbayani A., Arcaina T.T., Baxter E., Blazej R.G., Butenhoff C., Champe M., Chavez C., Chew M., Doyle C.M., Farfan D.E., Frise E., Galle R. , George R.A., Harris N.L., Hoskins R.A., Evans-Holm M., Houston K.A., Hummasti S.R., Kim E., Li P., Moshrefi M., Pacleb J.M., Park S., Sequeira A., Sethi H., Snir E., Svirskas R.R., Weinburg T., Celniker S.E. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF132182 mRNA. Translation: AAD34770.1. AF145304 mRNA. Translation: AAF08385.1. AE014296 Genomic DNA. Translation: AAF49095.2.
RefSeq	NP_649158.1.
UniGene	Dm.3192
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9VW54. 3 interactions.
Genome annotation databases
Ensembl	FBgn0028695. Drosophila melanogaster. [Contig view]
GeneID	40174.
KEGG	dme:Dmel_CG7762.
NMPDR	fig|7227.3.peg.10635.
Organism-specific databases
FlyBase	FBgn0028695. Rpn1.
Phylogenomic databases
HOGENOM	Q9VW54.
OMA	Q9VW54. SKFSHDS.
Enzyme and pathway databases
BRENDA	3.4.25.1. 48.
Gene expression databases
ArrayExpress	Q9VW54.
Family and domain databases
InterPro	IPR016643. 26S_Psome_Rpn1. IPR002015. APC_proteasome. [Graphical view]
Pfam	PF01851. PC_rep. 8 hits. [Graphical view]
PIRSF	PIRSF015965. 26S_Psome_Rpn1. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	817408.

Entry information

Entry name

Q9VW54_DROME

Accession

Primary (citable) accession number: Q9VW54
Secondary accession number(s): Q9XZ26

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)