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Protein

Frizzled-2

Gene

fz2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Required to coordinate the cytoskeletons of epidermal cells to produce a parallel array of cuticular hairs and bristles.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: GO_Central
  • identical protein binding Source: IntAct
  • PDZ domain binding Source: FlyBase
  • transmembrane signaling receptor activity Source: FlyBase
  • Wnt-activated receptor activity Source: FlyBase
  • Wnt-protein binding Source: UniProtKB

GO - Biological processi

  • axon extension Source: FlyBase
  • axon guidance Source: FlyBase
  • canonical Wnt signaling pathway Source: FlyBase
  • cell migration Source: FlyBase
  • chitin-based larval cuticle pattern formation Source: FlyBase
  • female gonad development Source: FlyBase
  • motor neuron axon guidance Source: FlyBase
  • non-canonical Wnt signaling pathway Source: GO_Central
  • regulation of hemocyte proliferation Source: FlyBase
  • retinal ganglion cell axon guidance Source: FlyBase
  • salivary gland morphogenesis Source: FlyBase
  • segment polarity determination Source: FlyBase
  • synapse organization Source: FlyBase
  • synaptic target inhibition Source: FlyBase
  • Wnt signaling pathway Source: UniProtKB

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-DME-209387 Phosphorylation of ARR
R-DME-209440 Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM
R-DME-209472 Assembly of receptor complex
SignaLinkiQ9VVX3

Protein family/group databases

TCDBi9.A.14.16.2 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-2
Short name:
dFz2
Gene namesi
Name:fz2
ORF Names:CG9739
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0016797 fz2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 315ExtracellularSequence analysisAdd BLAST293
Transmembranei316 – 336Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini337 – 352CytoplasmicSequence analysisAdd BLAST16
Transmembranei353 – 373Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini374 – 397ExtracellularSequence analysisAdd BLAST24
Transmembranei398 – 418Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini419 – 439CytoplasmicSequence analysisAdd BLAST21
Transmembranei440 – 460Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini461 – 482ExtracellularSequence analysisAdd BLAST22
Transmembranei483 – 503Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini504 – 534CytoplasmicSequence analysisAdd BLAST31
Transmembranei535 – 555Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini556 – 584ExtracellularSequence analysisAdd BLAST29
Transmembranei585 – 605Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini606 – 694CytoplasmicSequence analysisAdd BLAST89

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001301223 – 694Frizzled-2Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 125PROSITE-ProRule annotation
Disulfide bondi72 ↔ 118PROSITE-ProRule annotation
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 147PROSITE-ProRule annotation
Disulfide bondi136 ↔ 177PROSITE-ProRule annotation
Disulfide bondi140 ↔ 164PROSITE-ProRule annotation
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9VVX3
PRIDEiQ9VVX3

Expressioni

Developmental stagei

Expression starts at stage 6 in all cells between 15 and 70 per cent of egg length, including the invaginating cells of the ventral furrow. Stripe pattern is emerging by early stage 8. From stage 9 and continuing throughout embryogenesis, expression is seen in the developing CNS. At stage 10, expressed in 15 stripes in the presumptive head and trunk regions, in the posterior midgut primordium, in a subset of cells of anterior midgut invagination and in the procephalic lobe. At stage 12, expression declines in epidermis and increases in the midgut and visceral mesoderm. At stage 17, only expressed in the CNS, hindgut and dorsal vessel.

Gene expression databases

BgeeiFBgn0016797
ExpressionAtlasiQ9VVX3 baseline and differential
GenevisibleiQ9VVX3 DM

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • PDZ domain binding Source: FlyBase
  • Wnt-protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi65366, 28 interactors
DIPiDIP-17196N
IntActiQ9VVX3, 60 interactors
STRINGi7227.FBpp0303228

Structurei

3D structure databases

ProteinModelPortaliQ9VVX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini59 – 180FZPROSITE-ProRule annotationAdd BLAST122

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi608 – 613Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi692 – 694PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 225Gly-richAdd BLAST39

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
InParanoidiQ9VVX3
KOiK02375
OMAiVEIHCSP
OrthoDBiEOG091G0N5M
PhylomeDBiQ9VVX3

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VVX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHNRLKVLI LGLVLLLTSC RADGPLHSAD HGMGGMGMGG HGLDASPAPG
60 70 80 90 100
YGVPVIPKDP NLRCEEITIP MCRGIGYNMT SFPNEMNHET QDEAGLEVHQ
110 120 130 140 150
FWPLVEIKCS PDLKFFLCSM YTPICLEDYH KPLPVCRSVC ERARSGCAPI
160 170 180 190 200
MQQYSFEWPE RMACEHLPLH GDPDNLCMEQ PSYTEAGSGG SSGGSGGSGS
210 220 230 240 250
GSGSGGKRKQ GGSGSGGSGA GGSSGSTSTK PCRGRNSKNC QNPQGEKASG
260 270 280 290 300
KECSCSCRSP LIFLGKEQLL QQQSQMPMMH HPHHWYMNLT VQRIAGVPNC
310 320 330 340 350
GIPCKGPFFS NDEKDFAGLW IALWSGLCFC STLMTLTTFI IDTERFKYPE
360 370 380 390 400
RPIVFLSACY FMVAVGYLSR NFLQNEEIAC DGLLLRESST GPHSCTLVFL
410 420 430 440 450
LTYFFGMASS IWWVILSFTW FLAAGLKWGN EAITKHSQYF HLAAWLIPTV
460 470 480 490 500
QSVAVLLLSA VDGDPILGIC YVGNLNPDHL KTFVLAPLFV YLVIGTTFLM
510 520 530 540 550
AGFVSLFRIR SVIKQQGGVG AGVKADKLEK LMIRIGIFSV LYTVPATIVI
560 570 580 590 600
GCYLYEAAYF EDWIKALACP CAQVKGPGKK PLYSVLMLKY FMALAVGITS
610 620 630 640 650
GVWIWSGKTL ESWRRFWRRL LGAPDRTGAN QALIKQRPPI PHPYAGSGMG
660 670 680 690
MPVGSAAGSL LATPYTQAGG ASVASTSHHH LHHHVLKQPA ASHV
Length:694
Mass (Da):75,451
Last modified:May 1, 2000 - v1
Checksum:i6C510F13CBAFB096
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55V → A in AAC47273 (PubMed:8717036).Curated1
Sequence conflicti417S → T in AAC47273 (PubMed:8717036).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65589 Genomic DNA Translation: AAC47273.1
AE014296 Genomic DNA Translation: AAF49184.1
AE014296 Genomic DNA Translation: ABW08569.1
BT023785 mRNA Translation: AAZ41794.1
PIRiS71786
RefSeqiNP_001097643.1, NM_001104173.3
NP_001137971.1, NM_001144499.3
NP_001262036.1, NM_001275107.1
NP_001262038.1, NM_001275109.1
NP_524155.1, NM_079431.2
NP_730389.1, NM_168787.3
UniGeneiDm.2524

Genome annotation databases

EnsemblMetazoaiFBtr0075028; FBpp0074795; FBgn0016797
FBtr0075029; FBpp0074796; FBgn0016797
FBtr0112890; FBpp0111803; FBgn0016797
FBtr0299586; FBpp0288861; FBgn0016797
FBtr0330194; FBpp0303227; FBgn0016797
FBtr0330195; FBpp0303228; FBgn0016797
FBtr0332735; FBpp0304981; FBgn0016797
GeneIDi40090
KEGGidme:Dmel_CG9739
UCSCiCG9739-RC d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiFRIZ2_DROME
AccessioniPrimary (citable) accession number: Q9VVX3
Secondary accession number(s): A8JNV7
, Q494J1, Q94916, Q9VVX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  3. SIMILARITY comments
    Index of protein domains and families

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