Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9VVW1 (A76A_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Accessory gland protein Acp76A
Gene names
Name:Acp76A
ORF Names:CG3801
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for physiological and behavioral changes in mated female flies. May play a role in accessory protein regulation and/or in the coagulation of seminal fluid to form a mating plug. Ref.1

Subcellular location

Secreted Probable.

Tissue specificity

Main cells of accessory gland and seminal fluid. Ref.1

Sequence similarities

Belongs to the serpin family.

Ontologies

Keywords
   Biological processBehavior
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processbehavior

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of proteolysis

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular componentextracellular space

Inferred from direct assay. Source: FlyBase

   Molecular functionserine-type endopeptidase inhibitor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 386364Accessory gland protein Acp76A
PRO_0000032528

Sites

Site339 – 3402Reactive bond By similarity

Amino acid modifications

Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential

Natural variations

Natural variant221Q → H in strain: ZIM5C, ZIM10C, ZIM16C, ZIM18C, ZIM28C, ZIM30C, ZIM34C and ZIM53C.
Natural variant221Q → P in strain: ZIM7C and ZIM12C.
Natural variant332 – 3376EVVDDI → GKRNTR in strain: ZIM28C.
Natural variant3381D → N in strain: Canton-S and ZIM34C.
Natural variant3591I → V in strain: Canton-S, ZIM12C and ZIM16C.
Natural variant3811K → M in strain: ZIM5C and ZIM16C.

Experimental info

Sequence conflict71I → T in AAB96393. Ref.1
Sequence conflict64 – 652NN → TI in AAG38149. Ref.4
Sequence conflict64 – 652NN → TI in AAG38150. Ref.4
Sequence conflict911Y → S in AAG38149. Ref.4
Sequence conflict911Y → S in AAG38150. Ref.4
Sequence conflict911Y → S in AAG38151. Ref.4
Sequence conflict911Y → S in AAG38152. Ref.4
Sequence conflict911Y → S in AAG38153. Ref.4
Sequence conflict911Y → S in AAG38154. Ref.4
Sequence conflict911Y → S in AAG38155. Ref.4
Sequence conflict911Y → S in AAG38156. Ref.4
Sequence conflict911Y → S in AAG38157. Ref.4
Sequence conflict911Y → S in AAG38158. Ref.4
Sequence conflict1411K → T in AAG38149. Ref.4
Sequence conflict1411K → T in AAG38150. Ref.4
Sequence conflict1411K → T in AAG38151. Ref.4
Sequence conflict1411K → T in AAG38152. Ref.4
Sequence conflict1411K → T in AAG38153. Ref.4
Sequence conflict1411K → T in AAG38154. Ref.4
Sequence conflict1411K → T in AAG38155. Ref.4
Sequence conflict1411K → T in AAG38156. Ref.4
Sequence conflict1411K → T in AAG38157. Ref.4
Sequence conflict1411K → T in AAG38158. Ref.4
Sequence conflict1451E → A in AAG38149. Ref.4
Sequence conflict1451E → A in AAG38150. Ref.4
Sequence conflict1451E → A in AAG38151. Ref.4
Sequence conflict1451E → A in AAG38152. Ref.4
Sequence conflict1451E → A in AAG38153. Ref.4
Sequence conflict1451E → A in AAG38154. Ref.4
Sequence conflict1451E → A in AAG38155. Ref.4
Sequence conflict1451E → A in AAG38156. Ref.4
Sequence conflict1451E → A in AAG38157. Ref.4
Sequence conflict1451E → A in AAG38158. Ref.4
Sequence conflict165 – 1673NAG → YAA in AAG38149. Ref.4
Sequence conflict165 – 1673NAG → YAA in AAG38150. Ref.4
Sequence conflict1721A → S in AAG38149. Ref.4
Sequence conflict1721A → S in AAG38150. Ref.4
Sequence conflict1721A → S in AAG38151. Ref.4
Sequence conflict1721A → S in AAG38152. Ref.4
Sequence conflict1721A → S in AAG38153. Ref.4
Sequence conflict1721A → S in AAG38154. Ref.4
Sequence conflict1721A → S in AAG38155. Ref.4
Sequence conflict1721A → S in AAG38156. Ref.4
Sequence conflict1721A → S in AAG38157. Ref.4
Sequence conflict1721A → S in AAG38158. Ref.4
Sequence conflict1821W → C in AAG38149. Ref.4
Sequence conflict1821W → C in AAG38150. Ref.4
Sequence conflict1821W → C in AAG38151. Ref.4
Sequence conflict1821W → C in AAG38152. Ref.4
Sequence conflict1821W → C in AAG38153. Ref.4
Sequence conflict1821W → C in AAG38154. Ref.4
Sequence conflict1821W → C in AAG38155. Ref.4
Sequence conflict1821W → C in AAG38156. Ref.4
Sequence conflict1821W → C in AAG38157. Ref.4
Sequence conflict1821W → C in AAG38158. Ref.4
Sequence conflict1911N → I in AAG38149. Ref.4
Sequence conflict1911N → I in AAG38150. Ref.4
Sequence conflict1911N → I in AAG38151. Ref.4
Sequence conflict1911N → I in AAG38152. Ref.4
Sequence conflict1911N → I in AAG38153. Ref.4
Sequence conflict1911N → I in AAG38154. Ref.4
Sequence conflict1911N → I in AAG38155. Ref.4
Sequence conflict1911N → I in AAG38156. Ref.4
Sequence conflict1911N → I in AAG38157. Ref.4
Sequence conflict1911N → I in AAG38158. Ref.4
Sequence conflict2021Y → H in AAG38149. Ref.4
Sequence conflict2021Y → H in AAG38150. Ref.4
Sequence conflict2021Y → H in AAG38151. Ref.4
Sequence conflict2021Y → H in AAG38152. Ref.4
Sequence conflict2021Y → H in AAG38153. Ref.4
Sequence conflict2021Y → H in AAG38154. Ref.4
Sequence conflict2021Y → H in AAG38155. Ref.4
Sequence conflict2021Y → H in AAG38156. Ref.4
Sequence conflict2021Y → H in AAG38157. Ref.4
Sequence conflict2021Y → H in AAG38158. Ref.4
Sequence conflict2381N → Y in AAG38149. Ref.4
Sequence conflict2381N → Y in AAG38150. Ref.4
Sequence conflict2381N → Y in AAG38151. Ref.4
Sequence conflict2381N → Y in AAG38152. Ref.4
Sequence conflict2381N → Y in AAG38153. Ref.4
Sequence conflict2381N → Y in AAG38154. Ref.4
Sequence conflict2381N → Y in AAG38155. Ref.4
Sequence conflict2381N → Y in AAG38156. Ref.4
Sequence conflict2381N → Y in AAG38157. Ref.4
Sequence conflict2381N → Y in AAG38158. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9VVW1 [UniParc].

Last modified March 1, 2001. Version 2.
Checksum: D2640A616B3F0FC8

FASTA38643,967
        10         20         30         40         50         60 
MGNHQVIFLV LCTSLLFQNT IQQNVSFQLI REIDRYTPEN FVLSVLNIEM ILFEIHAAKA 

        70         80         90        100        110        120 
VESNNDLERS LIINFGYSEA RQEVLDWGLR YKKASSAKFQ MANKVAVSQK LPLSQKLRLV 

       130        140        150        160        170        180 
NEVLMTSAKK YDVTKDVRPS KLMDEWLSSH LDGVLANFVQ EKKLNAGENI VAISGMTVTP 

       190        200        210        220        230        240 
LWASHFQSEI NRYFVNNPGT GYASKDPTCV PMMHSLSSFE TMSTDEAKGI YIPFSSANLG 

       250        260        270        280        290        300 
MLILLPRKGV TCKDILDNLN NQINVEYNDH KDVHLLLPIF KEKFDYNIAK FFNGINIEDT 

       310        320        330        340        350        360 
FKDSAFKSKA KIKINNFRVN HGIRFQPILR LEVVDDIDTG KTETFEVNRP FVFVIKDKIN 

       370        380 
VYAVGRIENL DGLTDKVNCS KKYADL

« Hide

References

« Hide 'large scale' references
[1]"New genes for male accessory gland proteins in Drosophila melanogaster."
Wolfner M.F., Harada H.A., Bertram M.J., Stelick T.J., Kraus K.W., Kalb J.M., Lung Y.O., Neubaum D.M., Park M., Tram U.K.
Insect Biochem. Mol. Biol. 27:825-834(1997) [PubMed: 9474779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY.
Strain: Canton-S.
Tissue: Male accessory gland.
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"Molecular population genetics of male accessory gland proteins in Drosophila."
Begun D.J., Whitley P., Todd B.L., Waldrip-Dail H.M., Clark A.G.
Genetics 156:1879-1888(2000) [PubMed: 11102381] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-386.
Strain: ZIM10C, ZIM12C, ZIM16C, ZIM18C, ZIM28C, ZIM30C, ZIM34C, ZIM53C, ZIM5C and ZIM7C.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U90947 Genomic DNA. Translation: AAB96393.1.
AE014296 Genomic DNA. Translation: AAF49196.1.
AY010627 Genomic DNA. Translation: AAG38149.1.
AY010628 Genomic DNA. Translation: AAG38150.1.
AY010629 Genomic DNA. Translation: AAG38151.1.
AY010630 Genomic DNA. Translation: AAG38152.1.
AY010631 Genomic DNA. Translation: AAG38153.1.
AY010632 Genomic DNA. Translation: AAG38154.1.
AY010633 Genomic DNA. Translation: AAG38155.1.
AY010634 Genomic DNA. Translation: AAG38156.1.
AY010635 Genomic DNA. Translation: AAG38157.1.
AY010636 Genomic DNA. Translation: AAG38158.1.
RefSeqNP_524153.1. NM_079429.2.

3D structure databases

ProteinModelPortalQ9VVW1.
SMRQ9VVW1. Positions 343-370.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9VVW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID40078.
KEGGdme:Dmel_CG3801.

Organism-specific databases

CTD40078.
FlyBaseFBgn0015586. Acp76A.

Phylogenomic databases

eggNOGKOG2392.
GeneTreeEMGT00050000008624.
OrthoDBEOG4MPG5P.

Gene expression databases

BgeeQ9VVW1.
GermOnlineCG3801. Drosophila melanogaster.

Family and domain databases

InterProIPR000215. Protease_inhib_I4_serpin.
IPR023795. Protease_inhib_I4_serpin_CS.
IPR023796. Sepin_dom.
[Graphical view]
PANTHERPTHR11461. Prot_inh_serpin. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. Prot_inh_serpin. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio816886.

Entry information

Entry nameA76A_DROME
AccessionPrimary (citable) accession number: Q9VVW1
Secondary accession number(s): O46224
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2001
Last modified: January 25, 2012
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents