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Protein
Submitted name:

Cadherin 74A, isoform A

Gene

Cad74A

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium ion binding Source: FlyBase
  • protein homodimerization activity Source: FlyBase

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: FlyBase
  • cell-cell adhesion mediated by cadherin Source: FlyBase
  • dorsal appendage formation Source: FlyBase
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Cadherin 74A, isoform AImported
Submitted name:
Cadherin 74A, isoform BImported
Submitted name:
Cadherin 74A, isoform CImported
Submitted name:
FI21412p1Imported
Gene namesi
Name:Cad74AImported
Synonyms:Cad74A-RBImported
ORF Names:CG6445Imported, Dmel_CG6445Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036715. Cad74A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1753 – 177624HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: FlyBase
  • integral component of plasma membrane Source: FlyBase
  • microvillus Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: FlyBase

Protein-protein interaction databases

STRINGi7227.FBpp0075001.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 128101CadherinInterPro annotationAdd
BLAST
Domaini129 – 245117CadherinInterPro annotationAdd
BLAST
Domaini246 – 365120CadherinInterPro annotationAdd
BLAST
Domaini366 – 483118CadherinInterPro annotationAdd
BLAST
Domaini484 – 585102CadherinInterPro annotationAdd
BLAST
Domaini586 – 696111CadherinInterPro annotationAdd
BLAST
Domaini710 – 815106CadherinInterPro annotationAdd
BLAST
Domaini816 – 939124CadherinInterPro annotationAdd
BLAST
Domaini947 – 1053107CadherinInterPro annotationAdd
BLAST
Domaini1054 – 1170117CadherinInterPro annotationAdd
BLAST
Domaini1171 – 1284114CadherinInterPro annotationAdd
BLAST
Domaini1287 – 1394108CadherinInterPro annotationAdd
BLAST
Domaini1399 – 1517119CadherinInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
OMAiSRPSYIM.

Family and domain databases

Gene3Di2.60.40.60. 14 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 10 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 13 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 14 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VVG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLLLPLFL SLTAGQLVNQ PPQFVPGTGD MSRFSLSENT PVGSPVFQLK
60 70 80 90 100
GTDPEGGRLK YSISGPVFSV DRETGVVRLR QELDRETQDT VEVIISITDE
110 120 130 140 150
GIYGTEPNTV SQRRVIPVRD YNDNQPTFLG RPYTASVSES LPVGSELSVE
160 170 180 190 200
PPIVVVDRDE GINSEVQMKC LEENDICDIF EVRAVKISDG NYTARVALKQ
210 220 230 240 250
QLDFESRPSY ILTISASDSA LDNRLSSLAT ISINVIDIQD QPPIFTNAPY
260 270 280 290 300
SATVPENTPA GVSILTVKAV DGDVGIPREI FLSLEDEPFG HFELVPFGDP
310 320 330 340 350
RDGTAVLQTT SEPLDRENAE ILQNGGVYVF SIRATELIDG AIPAEHSLTR
360 370 380 390 400
VTIVVTDVDD HQPTFSGPHF NVSITENLAN GMPLPGLSIF VDDRDMGENS
410 420 430 440 450
RYELSLRDVF NAARVFEVSP TESQGRTPVV VKVLNASRLD YDVVDPDLRK
460 470 480 490 500
FEFDLVASVK GVEKAKTRVE IHLLDANDNA PVFDQGTYRF TAAENLPVDA
510 520 530 540 550
IIGHVKATDL DSGEFGHVRY VLKGFGADNF YVNPETGGVY LLKPLDYEKQ
560 570 580 590 600
SSYSLTVVAI DGGQREANAN LFVGVTDVND NHPNFESKEY SRTIREGAAL
610 620 630 640 650
FEPQFFVRAH DADGPSQGNG RVKYSIVSEN SIAGNVFRIE PDTGEIVIQK
660 670 680 690 700
AARSMDTERG EYELVVSATD FGIPPLSNTT RVLVRVGISG NQRPIFRGHF
710 720 730 740 750
QNMENLPIIG PPSYRVSIPE NAAAGSNVTS VSAHDPDGLD SLLRYRIVGA
760 770 780 790 800
NDNFEIDEIS GLITVSPQAR IDRDSNMNSF EIIVNAVDSG TPIPETATTT
810 820 830 840 850
VYVNVKDIND ERPKFEQNSY ATYVSERTAV GESVLRVKAI DKDLNSKLEY
860 870 880 890 900
SMVGPVAATT KAGVSIANRS NYRLQEAFRV DSQSGEIFVN GTLRHDVAAI
910 920 930 940 950
IIFTVGVRDL NAEVDPEGQV DTTEVTVYVQ SFQDTNPVFK NTGWTSSRPV
960 970 980 990 1000
IDVKIKEEMP IDSALFILQA EDPVTRQPIT SFELIEPKQV DYFQVAERTG
1010 1020 1030 1040 1050
EVILKKRLDY EALGDTGPEF ELQVRANSAD RQRSTVSRVN ITVENVNDNS
1060 1070 1080 1090 1100
PRFERNSYQA TIIENRPHPE RVIRVRALDK DAVLNARDER LGYHKIIYSL
1110 1120 1130 1140 1150
QGEHAMLFDI NNTTGEIIVA SGQTIDRERT PRIQLQIKAE DSPGRPTDAK
1160 1170 1180 1190 1200
QSVVELQIEV LDVNDNAPEF TQKKYSTVIP ENAQIDSFVL QLEAVDADEG
1210 1220 1230 1240 1250
LGGEVRYELV NEGEANGLFK IDTKSGLIST RRNLTGKGRA HPYVLIVRAQ
1260 1270 1280 1290 1300
DNGNQMPKQP TLSTDTDVRI YIGDVSANDG VPYFLSPRVG QMANVTENAV
1310 1320 1330 1340 1350
TGAPVFQVIA SDPDDESTPS GTITYRILPD TPDAEAFVID AHSGLITTRQ
1360 1370 1380 1390 1400
SMDRETKDMY RILLEVSDNG QPKQSATRIL QIAILDVDDH EPRFAREADA
1410 1420 1430 1440 1450
GPLSMSVREE EPAGTIVGNF SALDEDLGEN AAIDYVIIDG NNEQLFTIER
1460 1470 1480 1490 1500
NNESLAILKT KKPIDREQVE SFTLTIKCLK LGEPGYKFIG DPYDRQDLSH
1510 1520 1530 1540 1550
LRINVRVLDI DDNLPKFEQP DPTVGIRINV PIDTVVTTLK ASDADAEAPP
1560 1570 1580 1590 1600
VGLSIENVTF VPQFYKRSRS LAVGNLHNLF TLNNRTGELR TGGSFADYVD
1610 1620 1630 1640 1650
GYFLMRVMAN NSVQPKRQAH SNLKVFVIRD KSLLKFVFAR PPNEIQHNIR
1660 1670 1680 1690 1700
PFQEQLQKKL KPLGLELHVL DTQVFTRPDM SLDFTATSSC FQMFKNGAAL
1710 1720 1730 1740 1750
SFNEMQKLMN SQQLRQELID IYAAYGVSEV ESCSVRRTHA AAIFAGMLTS
1760 1770 1780 1790 1800
AGAWLVFLAA LIGLAALVSL CTACCLKKKL KRHSKRSLQA SLRTPTEHTA
1810 1820
TSYSYSMPAV LYSEPIYGPL
Length:1,820
Mass (Da):200,998
Last modified:May 1, 2000 - v1
Checksum:i8D61B907FA15C155
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49351.1.
AE014296 Genomic DNA. Translation: AAN11706.1.
AE014296 Genomic DNA. Translation: AFH04485.1.
BT150474 mRNA. Translation: AKG26251.1.
RefSeqiNP_001246814.1. NM_001259885.1.
NP_648973.1. NM_140716.2.
NP_730261.1. NM_168724.2.
UniGeneiDm.14940.

Genome annotation databases

EnsemblMetazoaiFBtr0075239; FBpp0075001; FBgn0036715.
FBtr0075240; FBpp0075002; FBgn0036715.
FBtr0309231; FBpp0301170; FBgn0036715.
GeneIDi39936.
KEGGidme:Dmel_CG6445.
UCSCiCG6445-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49351.1.
AE014296 Genomic DNA. Translation: AAN11706.1.
AE014296 Genomic DNA. Translation: AFH04485.1.
BT150474 mRNA. Translation: AKG26251.1.
RefSeqiNP_001246814.1. NM_001259885.1.
NP_648973.1. NM_140716.2.
NP_730261.1. NM_168724.2.
UniGeneiDm.14940.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0075001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075239; FBpp0075001; FBgn0036715.
FBtr0075240; FBpp0075002; FBgn0036715.
FBtr0309231; FBpp0301170; FBgn0036715.
GeneIDi39936.
KEGGidme:Dmel_CG6445.
UCSCiCG6445-RA. d. melanogaster.

Organism-specific databases

CTDi39936.
FlyBaseiFBgn0036715. Cad74A.

Phylogenomic databases

eggNOGiKOG1219. Eukaryota.
ENOG410XPEI. LUCA.
GeneTreeiENSGT00760000118805.
OMAiSRPSYIM.

Miscellaneous databases

GenomeRNAii39936.
NextBioi816164.

Family and domain databases

Gene3Di2.60.40.60. 14 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
[Graphical view]
PfamiPF00028. Cadherin. 10 hits.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 13 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 14 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  3. Cited for: GENOME REANNOTATION.
    Strain: BerkeleyImported.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  7. Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., Svirskas R., Rubin G.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Drosophila melanogaster release 4 sequence."
    Berkeley Drosophila Genome Project
    Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., Rubin G.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BerkeleyImported.
  11. Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.
    Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  12. Millard Andrew
    Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9VVG0_DROME
AccessioniPrimary (citable) accession number: Q9VVG0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.