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Protein

Odorant receptor 74a

Gene

Or74a

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor which mediates acceptance or avoidance behavior, depending on its substrates. The odorant receptor repertoire encodes a large collection of odor stimuli that vary widely in identity, intensity, and duration. May form a complex with Orco to form odorant-sensing units, providing sensitive and prolonged odorant signaling and calcium permeability. Involved in the behavioral responses to octanol, anisole, and 2-heptanone.2 Publications

Miscellaneous

The atypical heteromeric and topological design of the odorant receptors appears to be an insect-specific solution for odor recognition, making the OR/Orco complex an attractive target for the development of highly selective insect repellents to disrupt olfactory-mediated host-seeking behaviors of insect disease vectors. Odor-evoked OR currents are independent of known G-protein-coupled second messenger pathways.

GO - Molecular functioni

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of smell Source: FlyBase

Keywordsi

Molecular functionReceptor, Transducer
Biological processOlfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant receptor 74a
Gene namesi
Name:Or74a
ORF Names:CG13726
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036709. Or74a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38CytoplasmicSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 67ExtracellularSequence analysis8
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 141CytoplasmicSequence analysisAdd BLAST53
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini163 – 181ExtracellularSequence analysisAdd BLAST19
Transmembranei182 – 202Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini203 – 274CytoplasmicSequence analysisAdd BLAST72
Transmembranei275 – 295Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini296 – 303ExtracellularSequence analysis8
Transmembranei304 – 324Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini325 – 380CytoplasmicSequence analysisAdd BLAST56
Transmembranei381 – 401Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini402 – 404ExtracellularSequence analysis3

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742691 – 404Odorant receptor 74aAdd BLAST404

Proteomic databases

PaxDbiQ9VVF3.
PRIDEiQ9VVF3.

Expressioni

Gene expression databases

BgeeiFBgn0036709.
GenevisibleiQ9VVF3. DM.

Interactioni

Subunit structurei

Interacts with Orco. Complexes exist early in the endomembrane system in olfactory sensory neurons (OSNs), coupling these complexes to the conserved ciliary trafficking pathway (By similarity).By similarity

Protein-protein interaction databases

BioGridi65219. 1 interactor.
DIPiDIP-21424N.
IntActiQ9VVF3. 1 interactor.
MINTiMINT-901198.
STRINGi7227.FBpp0075008.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KB9X. Eukaryota.
ENOG4110NGQ. LUCA.
GeneTreeiENSGT00560000077948.
InParanoidiQ9VVF3.
KOiK08471.
OMAiCEHNEVD.
OrthoDBiEOG091G07C0.
PhylomeDBiQ9VVF3.

Family and domain databases

InterProiView protein in InterPro
IPR004117. 7tm6_olfct_rcpt.
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiView protein in Pfam
PF02949. 7tm_6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VVF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFHRYRPRL PGGELAPMPW PVSLYRVLNH VAWPLEAESG RWTVFLDRLM
60 70 80 90 100
IFLGFLVFCE HNEVDFHYLI ANRQDMDNML TGLPTYLILV EMQIRCFQLA
110 120 130 140 150
WHKDRFRALL QRFYAEIYVS EEMEPHLFAS IQRQMLATRV NSTVYLLALL
160 170 180 190 200
NFFLVPVTNV IYHRREMLYK QVYPFDNTQL HFFIPLLVLN FWVGFIITSM
210 220 230 240 250
LFGELNVMGE LMMHLNARYI QLGQDLRRSA QMLLKKSSSL NVAIAYRLNL
260 270 280 290 300
THILRRNAAL RDFGQRVEKE FTLRIFVMFA FSAGLLCALF FKAFTNPWGN
310 320 330 340 350
VAYIVWFLAK FMELLALGML GSILLKTTDE LGMMYYTADW EQVIHQSDNV
360 370 380 390 400
GENVKLMKLV TLAIQLNSRP FFITGLNYFR VSLTAVLKII QGAFSYFTFL

NSMR
Length:404
Mass (Da):47,415
Last modified:May 1, 2000 - v1
Checksum:iC61127EB0D422206
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49358.1.
RefSeqiNP_524123.1. NM_079399.3.
UniGeneiDm.27162.

Genome annotation databases

EnsemblMetazoaiFBtr0075247; FBpp0075008; FBgn0036709.
GeneIDi39929.
KEGGidme:Dmel_CG13726.

Similar proteinsi

Entry informationi

Entry nameiOR74A_DROME
AccessioniPrimary (citable) accession number: Q9VVF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families