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Protein

RNA-binding protein Musashi homolog Rbp6

Gene

Rbp6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein Musashi homolog Rbp61 PublicationBy similarity
Gene namesi
Name:Rbp61 Publication
Synonyms:RRM61 Publication
ORF Names:CG32169
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0260943. Rbp6.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003740511 – 369RNA-binding protein Musashi homolog Rbp6Add BLAST369

Proteomic databases

PaxDbiQ9VVE5.
PRIDEiQ9VVE5.

Expressioni

Gene expression databases

BgeeiFBgn0260943.
ExpressionAtlasiQ9VVE5. differential.
GenevisibleiQ9VVE5. DM.

Interactioni

Protein-protein interaction databases

BioGridi65211. 26 interactors.
DIPiDIP-19056N.
IntActiQ9VVE5. 24 interactors.
MINTiMINT-918255.
STRINGi7227.FBpp0112339.

Structurei

3D structure databases

ProteinModelPortaliQ9VVE5.
SMRiQ9VVE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 108RRM 1Add BLAST80
Domaini118 – 195RRM 2Add BLAST78

Sequence similaritiesi

Belongs to the Musashi family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205. Eukaryota.
ENOG410YA8Z. LUCA.
GeneTreeiENSGT00900000140835.
InParanoidiQ9VVE5.
KOiK14411.
OrthoDBiEOG091G1CPI.
PhylomeDBiQ9VVE5.

Family and domain databases

CDDicd12576. RRM1_MSI. 1 hit.
cd12323. RRM2_MSI. 1 hit.
InterProiView protein in InterPro
IPR034130. MSI_RRM1.
IPR034126. MSI_RRM2.
IPR035979. RBD_domain_sf.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 2 hits.
SMARTiView protein in SMART
SM00360. RRM. 2 hits.
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50102. RRM. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A1 Publication (identifier: Q9VVE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIKIEQQQQ QQQVELGPCS PSEVPNDPGK MFIGGLSWQT SPESLRDYFG
60 70 80 90 100
RYGDISEAMV MKDPTTRRSR GFGFVTFSDP NSVDKVLTQG THELDGKKVD
110 120 130 140 150
PKVAFPRRAH PKMVTRTKKI FVGGLSAPTT LEDVKSYFEQ FGPIEDAMLM
160 170 180 190 200
FDKQTNRHRG FGFVTFQSED VVDKVCEIHF HEINNKMVEC KKAQPKEVML
210 220 230 240 250
PANLAKTRAA GRSAYDNIMW GLGTLPEGFP AAAYAAYAAG RGYSGYPSFG
260 270 280 290 300
LPYPTVDLTN GQLTPNNNTP LLTQALSVMN NYQAAAAAAH SYGPSASPHA
310 320 330 340 350
AAANTATRQG FPSTNSPGPT IDMYSSAAAD NVGYVQATSP QPSGFPIAVS
360
RAPLNYSPIY SLNFAMANI
Length:369
Mass (Da):40,087
Last modified:April 26, 2005 - v3
Checksum:iADDA310C4CF993C4
GO
Isoform B1 Publication (identifier: Q9VVE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     216-369: DNIMWGLGTL...YSLNFAMANI → GELVVWGSSH...AASLYQLPGI

Show »
Length:499
Mass (Da):53,487
Checksum:i9C72B16A989F8342
GO
Isoform C1 Publication (identifier: Q9VVE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:257
Mass (Da):27,522
Checksum:i4AFA020CE3404168
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33I → V in AAM52738 (PubMed:8417324).Curated1
Sequence conflicti73G → A in AAM52738 (PubMed:8417324).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0530861 – 112Missing in isoform C. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_053087216 – 369DNIMW…AMANI → GELVVWGSSHAHSTAATSAA AAGLLPSSLAAAASVLQQQQ QQQQQQQQQQQQQQQHHQQL HHTHPQSPAHSHAHHPHTHS HSQLLGSLRYTPYPLPAHLS AAAVVVAQQQHHHQQQQQQQ QQQQQQQVVAAQQQHQQQQS LAQVVAAAAGAAPGLLPLAN PAPPATPSLLQFAAGQSNAA LANSLYADAAAVVGYKRLLA AAAVSSGLRAPTTALGALQA AAANVPAAAAAAQLQQAQLR QNAALAAAHYPLSELLAMQG GMEMGAGANSAAAAAASLYQ LPGI in isoform B. 1 PublicationAdd BLAST154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49366.3.
AE014296 Genomic DNA. Translation: ABW08559.1.
AE014296 Genomic DNA. Translation: ABW08560.1.
AY122226 mRNA. Translation: AAM52738.1.
S51715 mRNA. Translation: AAB24627.1.
PIRiF48110.
RefSeqiNP_001097631.1. NM_001104161.3. [Q9VVE5-2]
NP_001097632.1. NM_001104162.4. [Q9VVE5-3]
NP_730245.2. NM_168718.3. [Q9VVE5-1]
UniGeneiDm.22292.

Genome annotation databases

EnsemblMetazoaiFBtr0075285; FBpp0075045; FBgn0260943. [Q9VVE5-1]
FBtr0113427; FBpp0112339; FBgn0260943. [Q9VVE5-2]
FBtr0113428; FBpp0112340; FBgn0260943. [Q9VVE5-3]
GeneIDi39919.
KEGGidme:Dmel_CG32169.
UCSCiCG32169-RA. d. melanogaster. [Q9VVE5-1]
CG32169-RB. d. melanogaster.
CG32169-RC. d. melanogaster.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMSIR6_DROME
AccessioniPrimary (citable) accession number: Q9VVE5
Secondary accession number(s): A8JNU7
, A8JNU8, Q26276, Q8MQZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 26, 2005
Last modified: October 25, 2017
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families