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Q9VV96

- PGSB2_DROME

UniProt

Q9VV96 - PGSB2_DROME

Protein

Peptidoglycan-recognition protein SB2

Gene

PGRP-SB2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity By similarity.By similarity

    Catalytic activityi

    Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi48 – 481ZincBy similarity
    Metal bindingi81 – 811ZincBy similarity
    Metal bindingi155 – 1551ZincBy similarity
    Metal bindingi163 – 1631ZincBy similarity

    GO - Molecular functioni

    1. N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
    2. peptidoglycan binding Source: UniProtKB
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. immune response Source: FlyBase
    2. innate immune response Source: UniProtKB
    3. peptidoglycan catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Immunity, Innate immunity

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidoglycan-recognition protein SB2 (EC:3.5.1.28)
    Gene namesi
    Name:PGRP-SB2
    ORF Names:CG9697
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0043577. PGRP-SB2.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 182165Peptidoglycan-recognition protein SB2PRO_0000023908Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 60By similarity
    Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9VV96.

    Expressioni

    Developmental stagei

    Not expressed in adults.1 Publication

    Gene expression databases

    BgeeiQ9VV96.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VV96.
    SMRiQ9VV96. Positions 40-182.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG241935.
    GeneTreeiENSGT00390000016833.
    InParanoidiQ9VV96.
    KOiK01446.
    OrthoDBiEOG757CZ5.
    PhylomeDBiQ9VV96.

    Family and domain databases

    Gene3Di3.40.80.10. 1 hit.
    InterProiIPR002502. Amidase_domain.
    IPR017331. Peptidoglycan_recognition.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view]
    PANTHERiPTHR11022. PTHR11022. 1 hit.
    PfamiPF01510. Amidase_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037945. PGRPs. 1 hit.
    SMARTiSM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view]
    SUPFAMiSSF55846. SSF55846. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9VV96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLQLALVLC GLTLALGQIV PRSSWCPVPI SPRMPRLMVP VRLIIIHHTV    50
    TAPCFNPHQC QLVLRQIRAD HMRRKFRDIG YNFLIGGDGR IYEGLGFGIR 100
    GEHAPRYNSQ SIGIAFIGNF QTGLPPSQML QAARTLIQIA VQRRQVSPNY 150
    SVVGHCQTKA TACPGIHLLN ELKKWPNWRP KP 182
    Length:182
    Mass (Da):20,459
    Last modified:May 1, 2000 - v1
    Checksum:i99AC18AD426BC308
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151A → V in strain: ZW141.
    Natural varianti51 – 511T → A in strain: Loua.
    Natural varianti62 – 621L → S in strain: ZW141.
    Natural varianti152 – 1521V → L in strain: Draveil, Loua, Monty5, P.bourg, Tahiti, Texas and ZW141.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ556575 Genomic DNA. Translation: CAD89140.1.
    AJ556576 Genomic DNA. Translation: CAD89141.1.
    AJ556577 Genomic DNA. Translation: CAD89142.1.
    AJ556578 Genomic DNA. Translation: CAD89143.1.
    AJ556579 Genomic DNA. Translation: CAD89144.1.
    AJ556580 Genomic DNA. Translation: CAD89145.1.
    AJ556581 Genomic DNA. Translation: CAD89146.1.
    AJ556582 Genomic DNA. Translation: CAD89147.1.
    AJ556583 Genomic DNA. Translation: CAD89148.1.
    AJ556584 Genomic DNA. Translation: CAD89149.1.
    AJ556585 Genomic DNA. Translation: CAD89150.1.
    AE014296 Genomic DNA. Translation: AAF49421.1.
    RefSeqiNP_648916.1. NM_140659.3.
    UniGeneiDm.24013.

    Genome annotation databases

    EnsemblMetazoaiFBtr0075320; FBpp0075079; FBgn0043577.
    GeneIDi39869.
    KEGGidme:Dmel_CG9697.
    UCSCiCG9697-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ556575 Genomic DNA. Translation: CAD89140.1 .
    AJ556576 Genomic DNA. Translation: CAD89141.1 .
    AJ556577 Genomic DNA. Translation: CAD89142.1 .
    AJ556578 Genomic DNA. Translation: CAD89143.1 .
    AJ556579 Genomic DNA. Translation: CAD89144.1 .
    AJ556580 Genomic DNA. Translation: CAD89145.1 .
    AJ556581 Genomic DNA. Translation: CAD89146.1 .
    AJ556582 Genomic DNA. Translation: CAD89147.1 .
    AJ556583 Genomic DNA. Translation: CAD89148.1 .
    AJ556584 Genomic DNA. Translation: CAD89149.1 .
    AJ556585 Genomic DNA. Translation: CAD89150.1 .
    AE014296 Genomic DNA. Translation: AAF49421.1 .
    RefSeqi NP_648916.1. NM_140659.3.
    UniGenei Dm.24013.

    3D structure databases

    ProteinModelPortali Q9VV96.
    SMRi Q9VV96. Positions 40-182.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9VV96.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0075320 ; FBpp0075079 ; FBgn0043577 .
    GeneIDi 39869.
    KEGGi dme:Dmel_CG9697.
    UCSCi CG9697-RA. d. melanogaster.

    Organism-specific databases

    CTDi 39869.
    FlyBasei FBgn0043577. PGRP-SB2.

    Phylogenomic databases

    eggNOGi NOG241935.
    GeneTreei ENSGT00390000016833.
    InParanoidi Q9VV96.
    KOi K01446.
    OrthoDBi EOG757CZ5.
    PhylomeDBi Q9VV96.

    Miscellaneous databases

    GenomeRNAii 39869.
    NextBioi 815800.

    Gene expression databases

    Bgeei Q9VV96.

    Family and domain databases

    Gene3Di 3.40.80.10. 1 hit.
    InterProi IPR002502. Amidase_domain.
    IPR017331. Peptidoglycan_recognition.
    IPR015510. PGRP.
    IPR006619. PGRP_domain_met/bac.
    [Graphical view ]
    PANTHERi PTHR11022. PTHR11022. 1 hit.
    Pfami PF01510. Amidase_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037945. PGRPs. 1 hit.
    SMARTi SM00644. Ami_2. 1 hit.
    SM00701. PGRP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55846. SSF55846. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
      Jiggins F.M., Hurst G.D.D.
      J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: DI7, Draveil, KY024, KY038, Loua, Monty5, P.bourg, S30, Tahiti, Texas and ZW141.
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. "A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster."
      Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D.
      Proc. Natl. Acad. Sci. U.S.A. 97:13772-13777(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPGSB2_DROME
    AccessioniPrimary (citable) accession number: Q9VV96
    Secondary accession number(s): Q70PX1, Q70PX3, Q70PX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3