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Protein

Peptidoglycan-recognition protein SB2

Gene

PGRP-SB2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity).By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi48ZincBy similarity1
Metal bindingi81ZincBy similarity1
Metal bindingi155ZincBy similarity1
Metal bindingi163ZincBy similarity1

GO - Molecular functioni

  • N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
  • peptidoglycan binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • immune response Source: FlyBase
  • innate immune response Source: UniProtKB
  • peptidoglycan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DME-6803157. Antimicrobial peptides.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SB2 (EC:3.5.1.28)
Gene namesi
ORF Names:CG9697
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0043577. PGRP-SB2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002390818 – 182Peptidoglycan-recognition protein SB2Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 60By similarity
Glycosylationi149N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9VV96.
PRIDEiQ9VV96.

Expressioni

Developmental stagei

Not expressed in adults.1 Publication

Gene expression databases

BgeeiFBgn0043577.
ExpressionAtlasiQ9VV96. baseline.
GenevisibleiQ9VV96. DM.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0305802.

Structurei

3D structure databases

ProteinModelPortaliQ9VV96.
SMRiQ9VV96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000016833.
InParanoidiQ9VV96.
KOiK01446.
OrthoDBiEOG091G0O6Z.
PhylomeDBiQ9VV96.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VV96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQLALVLC GLTLALGQIV PRSSWCPVPI SPRMPRLMVP VRLIIIHHTV
60 70 80 90 100
TAPCFNPHQC QLVLRQIRAD HMRRKFRDIG YNFLIGGDGR IYEGLGFGIR
110 120 130 140 150
GEHAPRYNSQ SIGIAFIGNF QTGLPPSQML QAARTLIQIA VQRRQVSPNY
160 170 180
SVVGHCQTKA TACPGIHLLN ELKKWPNWRP KP
Length:182
Mass (Da):20,459
Last modified:May 1, 2000 - v1
Checksum:i99AC18AD426BC308
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti15A → V in strain: ZW141. 1
Natural varianti51T → A in strain: Loua. 1
Natural varianti62L → S in strain: ZW141. 1
Natural varianti152V → L in strain: Draveil, Loua, Monty5, P.bourg, Tahiti, Texas and ZW141. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556575 Genomic DNA. Translation: CAD89140.1.
AJ556576 Genomic DNA. Translation: CAD89141.1.
AJ556577 Genomic DNA. Translation: CAD89142.1.
AJ556578 Genomic DNA. Translation: CAD89143.1.
AJ556579 Genomic DNA. Translation: CAD89144.1.
AJ556580 Genomic DNA. Translation: CAD89145.1.
AJ556581 Genomic DNA. Translation: CAD89146.1.
AJ556582 Genomic DNA. Translation: CAD89147.1.
AJ556583 Genomic DNA. Translation: CAD89148.1.
AJ556584 Genomic DNA. Translation: CAD89149.1.
AJ556585 Genomic DNA. Translation: CAD89150.1.
AE014296 Genomic DNA. Translation: AAF49421.1.
RefSeqiNP_648916.1. NM_140659.3.
UniGeneiDm.24013.

Genome annotation databases

EnsemblMetazoaiFBtr0075320; FBpp0075079; FBgn0043577.
GeneIDi39869.
KEGGidme:Dmel_CG9697.
UCSCiCG9697-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556575 Genomic DNA. Translation: CAD89140.1.
AJ556576 Genomic DNA. Translation: CAD89141.1.
AJ556577 Genomic DNA. Translation: CAD89142.1.
AJ556578 Genomic DNA. Translation: CAD89143.1.
AJ556579 Genomic DNA. Translation: CAD89144.1.
AJ556580 Genomic DNA. Translation: CAD89145.1.
AJ556581 Genomic DNA. Translation: CAD89146.1.
AJ556582 Genomic DNA. Translation: CAD89147.1.
AJ556583 Genomic DNA. Translation: CAD89148.1.
AJ556584 Genomic DNA. Translation: CAD89149.1.
AJ556585 Genomic DNA. Translation: CAD89150.1.
AE014296 Genomic DNA. Translation: AAF49421.1.
RefSeqiNP_648916.1. NM_140659.3.
UniGeneiDm.24013.

3D structure databases

ProteinModelPortaliQ9VV96.
SMRiQ9VV96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0305802.

Proteomic databases

PaxDbiQ9VV96.
PRIDEiQ9VV96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075320; FBpp0075079; FBgn0043577.
GeneIDi39869.
KEGGidme:Dmel_CG9697.
UCSCiCG9697-RA. d. melanogaster.

Organism-specific databases

CTDi39869.
FlyBaseiFBgn0043577. PGRP-SB2.

Phylogenomic databases

GeneTreeiENSGT00390000016833.
InParanoidiQ9VV96.
KOiK01446.
OrthoDBiEOG091G0O6Z.
PhylomeDBiQ9VV96.

Enzyme and pathway databases

ReactomeiR-DME-6803157. Antimicrobial peptides.

Miscellaneous databases

GenomeRNAii39869.
PROiQ9VV96.

Gene expression databases

BgeeiFBgn0043577.
ExpressionAtlasiQ9VV96. baseline.
GenevisibleiQ9VV96. DM.

Family and domain databases

CDDicd06583. PGRP. 1 hit.
Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPGSB2_DROME
AccessioniPrimary (citable) accession number: Q9VV96
Secondary accession number(s): Q70PX1, Q70PX3, Q70PX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.