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Protein

Peptidoglycan-recognition protein SB2

Gene

PGRP-SB2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Probably plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity (By similarity).By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi48 – 481ZincBy similarity
Metal bindingi81 – 811ZincBy similarity
Metal bindingi155 – 1551ZincBy similarity
Metal bindingi163 – 1631ZincBy similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: FlyBase
  2. peptidoglycan binding Source: UniProtKB
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. immune response Source: FlyBase
  2. innate immune response Source: UniProtKB
  3. peptidoglycan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidoglycan-recognition protein SB2 (EC:3.5.1.28)
Gene namesi
Name:PGRP-SB2
ORF Names:CG9697
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0043577. PGRP-SB2.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 182165Peptidoglycan-recognition protein SB2PRO_0000023908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 60By similarity
Glycosylationi149 – 1491N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9VV96.

Expressioni

Developmental stagei

Not expressed in adults.1 Publication

Gene expression databases

BgeeiQ9VV96.
ExpressionAtlasiQ9VV96. differential.

Structurei

3D structure databases

ProteinModelPortaliQ9VV96.
SMRiQ9VV96. Positions 40-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG241935.
GeneTreeiENSGT00390000016833.
InParanoidiQ9VV96.
KOiK01446.
OrthoDBiEOG757CZ5.
PhylomeDBiQ9VV96.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VV96-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLQLALVLC GLTLALGQIV PRSSWCPVPI SPRMPRLMVP VRLIIIHHTV
60 70 80 90 100
TAPCFNPHQC QLVLRQIRAD HMRRKFRDIG YNFLIGGDGR IYEGLGFGIR
110 120 130 140 150
GEHAPRYNSQ SIGIAFIGNF QTGLPPSQML QAARTLIQIA VQRRQVSPNY
160 170 180
SVVGHCQTKA TACPGIHLLN ELKKWPNWRP KP
Length:182
Mass (Da):20,459
Last modified:May 1, 2000 - v1
Checksum:i99AC18AD426BC308
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151A → V in strain: ZW141.
Natural varianti51 – 511T → A in strain: Loua.
Natural varianti62 – 621L → S in strain: ZW141.
Natural varianti152 – 1521V → L in strain: Draveil, Loua, Monty5, P.bourg, Tahiti, Texas and ZW141.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556575 Genomic DNA. Translation: CAD89140.1.
AJ556576 Genomic DNA. Translation: CAD89141.1.
AJ556577 Genomic DNA. Translation: CAD89142.1.
AJ556578 Genomic DNA. Translation: CAD89143.1.
AJ556579 Genomic DNA. Translation: CAD89144.1.
AJ556580 Genomic DNA. Translation: CAD89145.1.
AJ556581 Genomic DNA. Translation: CAD89146.1.
AJ556582 Genomic DNA. Translation: CAD89147.1.
AJ556583 Genomic DNA. Translation: CAD89148.1.
AJ556584 Genomic DNA. Translation: CAD89149.1.
AJ556585 Genomic DNA. Translation: CAD89150.1.
AE014296 Genomic DNA. Translation: AAF49421.1.
RefSeqiNP_648916.1. NM_140659.3.
UniGeneiDm.24013.

Genome annotation databases

EnsemblMetazoaiFBtr0075320; FBpp0075079; FBgn0043577.
GeneIDi39869.
KEGGidme:Dmel_CG9697.
UCSCiCG9697-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ556575 Genomic DNA. Translation: CAD89140.1.
AJ556576 Genomic DNA. Translation: CAD89141.1.
AJ556577 Genomic DNA. Translation: CAD89142.1.
AJ556578 Genomic DNA. Translation: CAD89143.1.
AJ556579 Genomic DNA. Translation: CAD89144.1.
AJ556580 Genomic DNA. Translation: CAD89145.1.
AJ556581 Genomic DNA. Translation: CAD89146.1.
AJ556582 Genomic DNA. Translation: CAD89147.1.
AJ556583 Genomic DNA. Translation: CAD89148.1.
AJ556584 Genomic DNA. Translation: CAD89149.1.
AJ556585 Genomic DNA. Translation: CAD89150.1.
AE014296 Genomic DNA. Translation: AAF49421.1.
RefSeqiNP_648916.1. NM_140659.3.
UniGeneiDm.24013.

3D structure databases

ProteinModelPortaliQ9VV96.
SMRiQ9VV96. Positions 40-182.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ9VV96.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075320; FBpp0075079; FBgn0043577.
GeneIDi39869.
KEGGidme:Dmel_CG9697.
UCSCiCG9697-RA. d. melanogaster.

Organism-specific databases

CTDi39869.
FlyBaseiFBgn0043577. PGRP-SB2.

Phylogenomic databases

eggNOGiNOG241935.
GeneTreeiENSGT00390000016833.
InParanoidiQ9VV96.
KOiK01446.
OrthoDBiEOG757CZ5.
PhylomeDBiQ9VV96.

Miscellaneous databases

GenomeRNAii39869.
NextBioi815800.

Gene expression databases

BgeeiQ9VV96.
ExpressionAtlasiQ9VV96. differential.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR017331. Peptidoglycan_recognition.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF037945. PGRPs. 1 hit.
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The evolution of parasite recognition genes in the innate immune system: purifying selection on Drosophila melanogaster peptidoglycan recognition proteins."
    Jiggins F.M., Hurst G.D.D.
    J. Mol. Evol. 57:598-605(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: DI7, Draveil, KY024, KY038, Loua, Monty5, P.bourg, S30, Tahiti, Texas and ZW141.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster."
    Werner T., Liu G., Kang D., Ekengren S., Steiner H., Hultmark D.
    Proc. Natl. Acad. Sci. U.S.A. 97:13772-13777(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiPGSB2_DROME
AccessioniPrimary (citable) accession number: Q9VV96
Secondary accession number(s): Q70PX1, Q70PX3, Q70PX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.