##gff-version 3 Q9VV74 UniProtKB Chain 1 226 . . . ID=PRO_0000424374;Note=Survival motor neuron protein Q9VV74 UniProtKB Domain 69 128 . . . Note=Tudor;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q9VV74 UniProtKB Region 35 68 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VV74 UniProtKB Region 137 172 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9VV74 UniProtKB Region 159 226 . . . Note=Required for homodimerization;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11113446;Dbxref=PMID:11113446 Q9VV74 UniProtKB Mutagenesis 20 20 . . . Note=Does not affect homodimer formation. D->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22813737;Dbxref=PMID:22813737 Q9VV74 UniProtKB Mutagenesis 70 70 . . . Note=Does not affect homodimer formation. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22813737;Dbxref=PMID:22813737 Q9VV74 UniProtKB Mutagenesis 201 201 . . . Note=In allele Smn-B%3B homozygous lethal at late larval stages and abolishes homodimerization. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12783845;Dbxref=PMID:12783845 Q9VV74 UniProtKB Mutagenesis 202 202 . . . Note=In allele Smn-73Ao%3B homozygous lethal at late larval stages and abolishes homodimerization. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12783845;Dbxref=PMID:12783845 Q9VV74 UniProtKB Mutagenesis 203 203 . . . Note=Weakly inhibits homodimer formation. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22813737;Dbxref=PMID:22813737 Q9VV74 UniProtKB Mutagenesis 205 205 . . . Note=Rescues larval viability and locomotion defects and only partially restores U5 and U12 snRNA levels in the null mutant. Weakly inhibits homodimer formation. Does not affect protein stability. T->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22813737;Dbxref=PMID:22813737 Q9VV74 UniProtKB Mutagenesis 206 206 . . . Note=Inhibits homodimer formation. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22813737;Dbxref=PMID:22813737 Q9VV74 UniProtKB Helix 15 23 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4V98