Q9VV74 (Q9VV74_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LD23602p EMBL AAL13758.1

Submitted name:
Survival motor neuron EMBL AAF49446.1
Submitted name:
Survival motor neuron protein SMN EMBL AAG17893.1

Gene names

Name:	Smn EMBL AAF49446.1 FlyBase FBgn0036641
ORF Names:	CG16725 FlyBase FBgn0036641, Dmel_CG16725 EMBL AAF49446.1

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	neuromuscular junction development Inferred from mutant phenotype. Source: FlyBase skeletal muscle thin filament assembly Inferred from mutant phenotype. Source: FlyBase spliceosomal snRNP assembly Inferred from mutant phenotype. Source: FlyBase
Cellular component	Cajal body Inferred from direct assay. Source: FlyBase Z disc Inferred from direct assay. Source: FlyBase cytoplasmic U snRNP body Inferred from direct assay. Source: FlyBase neuromuscular junction Inferred from direct assay. Source: FlyBase
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro alpha-actinin binding Inferred from physical interaction. Source: FlyBase identical protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VV74 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9F00D85A3E9614C7	FASTA	226	24,622
	10 20 30 40 50 60 MSDETNAAVW DDSLLVKTYD ESVGLAREAL ARRLADSTNK REEENAAAAE EEAGEISATG 70 80 90 100 110 120 GATSPEPVSF KVGDYARATY VDGVDYEGAV VSINEEKGTC VLRYLGYENE QEVLLVDLLP 130 140 150 160 170 180 SWGKRVRREQ FLIAKKDEDE QLSRPKASAG SHSKTPKSSR RSRISGGLVM PPMPPVPPMI 190 200 210 220 VGQGDGAEQD FVAMLTAWYM SGYYTGLYQG KKEASTTSGK KKTPKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila." Miguel-Aliaga I., Chan Y.B., Davies K.E., van den Heuvel M. FEBS Lett. 486:99-102(2000) [PubMed: 11113446] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL13758.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAF49446.1. AF296281 mRNA. Translation: AAG17893.1. AY058529 mRNA. Translation: AAL13758.1.
RefSeq	NP_524112.1. NM_079388.2.
UniGene	Dm.2679.
3D structure databases
HSSP	HSSP built from PDB template 1MHN based on UniProtKB Q16637.
ProteinModelPortal	Q9VV74.
SMR	Q9VV74. Positions 67-124.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-18223N.
IntAct	Q9VV74. 10 interactions.
MINT	MINT-750365.
STRING	Q9VV74.
Proteomic databases
PRIDE	Q9VV74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0075395; FBpp0075153; FBgn0036641.
GeneID	39844.
KEGG	dme:Dmel_CG16725.
NMPDR	fig|7227.3.peg.10169.
UCSC	CG16725-RA. d. melanogaster.
Organism-specific databases
CTD	39844.
FlyBase	FBgn0036641. Smn.
Phylogenomic databases
eggNOG	inNOG11503.
GeneTree	EMGT00050000009603.
InParanoid	Q9VV74.
OMA	SAMLMSW.
OrthoDB	EOG473N7S.
PhylomeDB	Q9VV74.
Gene expression databases
ArrayExpress	Q9VV74.
Bgee	Q9VV74.
Family and domain databases
InterPro	IPR010304. Survival_motor_neuron. IPR002999. Tudor. [Graphical view]
KO	K13129.
Pfam	PF06003. SMN. 1 hit. [Graphical view]
SMART	SM00333. TUDOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	815685.

Entry information

Entry name

Q9VV74_DROME

Accession

Primary (citable) accession number: Q9VV74

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)