Q9VV74 (Q9VV74_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
LD23602p EMBL AAL13758.1

Submitted name:
Survival motor neuron EMBL AAF49446.1
Submitted name:
Survival motor neuron protein SMN EMBL AAG17893.1

Gene names

Name:	Smn FlyBase FBgn0036641 EMBL AAL13758.1
ORF Names:	CG16725 FlyBase FBgn0036641, Dmel_CG16725 EMBL AAF49446.1

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 1VU3 PDB 1VU2 PDB 4F77 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neuromuscular junction development Inferred from mutant phenotype PubMed 18791638. Source: FlyBase skeletal muscle thin filament assembly Inferred from mutant phenotype PubMed 17353360. Source: FlyBase spliceosomal snRNP assembly Inferred from mutant phenotype PubMed 17353360PubMed 22813737. Source: FlyBase terminal cell fate specification, open tracheal system Inferred from mutant phenotype PubMed 23029159. Source: FlyBase
Cellular_component	Cajal body Inferred from direct assay PubMed 16533947PubMed 17595295PubMed 18791638PubMed 18923150. Source: FlyBase Z disc Inferred from direct assay PubMed 17353360. Source: FlyBase cytoplasmic U snRNP body Inferred from direct assay PubMed 17595295. Source: FlyBase neuromuscular junction Inferred from direct assay PubMed 18791638. Source: FlyBase
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		2	EBI-185315,EBI-185315
Rpp20	Q2MGL3	3	EBI-185315,EBI-1151669
SNRPN	P63162	2	EBI-185315,EBI-712493	From a different organism.

Sequences

	Sequence		Length	Mass (Da)
	Q9VV74 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9F00D85A3E9614C7	FASTA	226	24,622
	10 20 30 40 50 60 MSDETNAAVW DDSLLVKTYD ESVGLAREAL ARRLADSTNK REEENAAAAE EEAGEISATG 70 80 90 100 110 120 GATSPEPVSF KVGDYARATY VDGVDYEGAV VSINEEKGTC VLRYLGYENE QEVLLVDLLP 130 140 150 160 170 180 SWGKRVRREQ FLIAKKDEDE QLSRPKASAG SHSKTPKSSR RSRISGGLVM PPMPPVPPMI 190 200 210 220 VGQGDGAEQD FVAMLTAWYM SGYYTGLYQG KKEASTTSGK KKTPKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Disruption of SMN function by ectopic expression of the human SMN gene in Drosophila." Miguel-Aliaga I., Chan Y.B., Davies K.E., van den Heuvel M. FEBS Lett. 486:99-102(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J. , Pacleb J., Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S. Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley EMBL AAL13758.1.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[5]	"Structural Basis of Assembly Chaperone- Mediated snRNP Formation." Grimm C., Chari A., Pelz J.P., Kuper J., Kisker C., Diederichs K., Stark H., Schindelin H., Fischer U. Mol. Cell 49:692-703(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 1-122.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE014296 Genomic DNA. Translation: AAF49446.1.
AF296281 mRNA. Translation: AAG17893.1.
AY058529 mRNA. Translation: AAL13758.1.

RefSeq

NP_001261954.1. NM_001275025.1.
NP_524112.1. NM_079388.4.

UniGene

Dm.2679.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VU2	X-ray	3.10	1/E/M/U/c/k/s	1-122	[»]
1VU3	X-ray	3.10	E/M/U/c/k/s	1-122	[»]
4F77	X-ray	3.10	1/E/M/U/c/k/s	1-122	[»]

HSSP

HSSP built from PDB template 1MHN based on UniProtKB Q16637.

SMR

Q9VV74. Positions 68-121.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-18223N.

IntAct

Q9VV74. 8 interactions.

MINT

MINT-750365.

STRING

7227.FBpp0075153.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0075395; FBpp0075153; FBgn0036641.
FBtr0329921; FBpp0302954; FBgn0036641.

GeneID

39844.

KEGG

dme:Dmel_CG16725.

UCSC

CG16725-RA. d. melanogaster.

Organism-specific databases

CTD

39844.

FlyBase

FBgn0036641. Smn.

Phylogenomic databases

eggNOG

NOG296671.

GeneTree

ENSGT00560000077236.

InParanoid

Q9VV74.

KO

K13129.

OMA

SAMLMSW.

OrthoDB

EOG473N7S.

Family and domain databases

InterPro

IPR010304. Survival_motor_neuron.
IPR002999. Tudor.
[Graphical view]

Pfam

PF06003. SMN. 1 hit.
[Graphical view]

SMART

SM00333. TUDOR. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

39844.

NextBio

815685.

Entry information

Entry name

Q9VV74_DROME

Accession

Primary (citable) accession number: Q9VV74

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)