Q9VUY4 (Q9VUY4_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CG5414 EMBL AAF49539.2
EC=6.1.1.5 EMBL AAF49539.2

Gene names

ORF Names:

CG5414 EMBL AAF49539.2 FlyBase FBgn0036569, Dmel_CG5414 EMBL AAF49539.2

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	941 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. RuleBase RU003489

Ontologies

Keywords
Biological process	Protein biosynthesis RuleBase RU003489
Ligand	ATP-binding RuleBase RU003489 Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase RuleBase RU003489 Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	isoleucyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW isoleucine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VUY4 [UniParc]. Last modified November 30, 2010. Version 2. Checksum: 2C762504EEB1D9FD	FASTA	941	107,570
	10 20 30 40 50 60 MLRIFYFRVG NRLYSMKAAK KDAKKYTDTI NLPKTKFPNR LTAAKREEQE RLVLENKIAV 70 80 90 100 110 120 SYAYQEQRLA EKGKPTFVLH DGPPYANGQL HMGHAVNKIL KDITLRQRVA HGQRVNYIPG 130 140 150 160 170 180 WDCHGLPIEL KATSTAPGQS AQEIRQKSRA FAWEAIKSQK EEFSSWGILA NWQKDNIYMT 190 200 210 220 230 240 FQPEFIVNQL EMFYNLYEKG LVYRDLKPVY WSPSSRTALA EAELEYDANH ISPSVYVRFA 250 260 270 280 290 300 LNPSSFDVKD KQIYALVWTT TPWTLPSNQA ICYNASLEYV IVRLSDRNQD ELYLMASALM 310 320 330 340 350 360 ADFEANTQLK CEIVQHLSGE LLSKLSYNHP IDKEQSNLPF FDASHVQDSK GTGLVHTAPA 370 380 390 400 410 420 HGPEDFLVSL TQKIPVKCFV NEEGTYTKEA PDFLRGKSVL DQGNSLVLDR IAEDVVHSSK 430 440 450 460 470 480 LEHSYPIDWR TKKPVIIRAS EQWFINTEKL KTPAADALEQ VEIYPRANAE ASKKALLTQL 490 500 510 520 530 540 QKRPYWCISR QRAWGVPIPV LYSRESGKVV LNSALIEHLC NLLRKEGSID FWWVKSVEEL 550 560 570 580 590 600 VPEHLLRELH HEAKDLVKGT DILDIWFDSG STWSAVLGKD KIADLYLEGY DQFTGWFQSS 610 620 630 640 650 660 LLMSIAAREC APYKALFVHG FTVDEKGYKM SKSLGNVISP KQITKKYGTD ALRWWVASHG 670 680 690 700 710 720 TQHMSITVSD KLLQQAAENL CKIRGTMRYL KGVIGEKQSG EKLIRTSDKS YLNRYLLSQL 730 740 750 760 770 780 VEFESEVEKL YQAYEYNRVV ACVQNFIANQ VSAVYVHLIK DRLYCGDDHE LLAIRQTLTH 790 800 810 820 830 840 CYQQLCKSLW PIVPFLVEES WSYYDTTGGA FHEQIVQTNP EWQDTKATEV INAAFDVKRL 850 860 870 880 890 900 INQQAGDVNT WHLAVTIKGK ERSQLDLLRE LHSPLGESVS NSELCEILQV GSVTLLQSHN 910 920 930 940 SDLDIALSKL QISLCPRCRR YGLEDEQKTC QRCSDVMEAK N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAF49539.2.
RefSeq	NP_648837.2. NM_140580.2.
UniGene	Dm.15254.
3D structure databases
ProteinModelPortal	Q9VUY4.
SMR	Q9VUY4. Positions 25-939.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9VUY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0302328; FBpp0291534; FBgn0036569.
GeneID	39762.
KEGG	dme:Dmel_CG5414.
UCSC	CG5414-RA. d. melanogaster.
Organism-specific databases
FlyBase	FBgn0036569. CG5414.
Phylogenomic databases
GeneTree	EMGT00050000004675.
OrthoDB	EOG40VT4H.
PhylomeDB	Q9VUY4.
Gene expression databases
Bgee	Q9VUY4.
Family and domain databases
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR002300. aa-tRNA-synth_Ia. IPR002301. Ile-tRNA-synt. IPR023585. Ile-tRNA-synt_type1. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. IPR013155. V/L/I-tRNA-synth_anticodon-bd. IPR009008. Val/Leu/Ile-tRNA-synth_edit. [Graphical view]
Gene3D	G3DSA:3.90.740.10. G3DSA:3.90.740.10. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K01870.
PANTHER	PTHR11946:SF9. Ile-tRNA-synt_Ia. 1 hit.
Pfam	PF08264. Anticodon_1. 1 hit. PF00133. tRNA-synt_1. 1 hit. [Graphical view]
PRINTS	PR00984. TRNASYNTHILE.
SUPFAM	SSF47323. tRNAsyn_1a_bind. 1 hit. SSF50677. ValRS_IleRS_edit. 1 hit.
TIGRFAMs	TIGR00392. IleS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9VUY4_DROME

Accession

Primary (citable) accession number: Q9VUY4

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	November 30, 2010
Last modified:	January 25, 2012
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)