Unreviewed, UniProtKB/TrEMBL Q9VUX3 (Q9VUX3_DROME)

Names and origin

Protein names

Submitted name:
    Notum, isoform A EMBL AAF49550.3
Submitted name:
    Notum protein EMBL CAD29885.1
    Wingful EMBL AAL85497.1

Gene names

Name:	Notum EMBL AAF49550.3 FlyBase FBgn0044028
Synonyms:	wf EMBL AAL85497.1
ORF Names:	CG13076 FlyBase FBgn0044028, Dmel_CG13076 EMBL AAF49550.3

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	GPI anchor release Inferred from mutant phenotype. Source: FlyBase negative regulation of Wnt receptor signaling pathway Ref.4 Non-traceable author statement. Source: FlyBase proteoglycan metabolic process Ref.4 Non-traceable author statement. Source: FlyBase regulation of compound eye pigmentation Inferred from mutant phenotype. Source: FlyBase wing disc dorsal/ventral pattern formation Inferred from genetic interaction. Source: FlyBase
Cellular component	extracellular space Ref.3 Inferred from direct assay. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9VUX3-1 [UniParc]. Last modified July 5, 2004. Version 3. Checksum: 0230294B1E754D94	FASTA	671	76,937
	10 20 30 40 50 60 MAVEQIDKMA AKAGEATNKW IKPQQPLLTL LLLLATFSQL PAVCSSSILD AASLQEKDPL 70 80 90 100 110 120 RDTSMNMIQR NYMVMHSASG SGDHSRSLKR ANLANTSITC NDGSHAGFYL RKHPSSKKWI 130 140 150 160 170 180 VLLEGGWHCF DVRSCRSRWM RLRHLMTSSQ WPETRDVGGI LSPHPEENPY WHNANHVLIP 190 200 210 220 230 240 YCSSDSWSGT RTEPDTSDRE NSWRFMGALI LRQVIAELIP VGLGRVPGGE LMLVGSSAGG 250 260 270 280 290 300 MGVMLNLDRI RDFLVNEKKL QITVRGVSDS GWFLDREPYT PAAVASNEAV RQGWKLWQGL 310 320 330 340 350 360 LPEECTKSYP TEPWRCYYGY RLYPTLKTPL FVFQWLFDEA QMRVDNVGAP VTPQQWNYIH 370 380 390 400 410 420 EMGGALRSSL DNVSAVFAPS CIGHGVLFKR DWVNIKIDDI SLPSALRCWE HSTRSRRHDK 430 440 450 460 470 480 LKRSTEPSTA VSHPEHANNQ RHQRHRQRLQ RQKHNNVAQS GGQQRKHNHL SKEEREERKR 490 500 510 520 530 540 LRQEQRQRRK QRRRQQQQKK ANGGQEHRNK KDNSPKSSNG NDQRKQRRRQ QLTAEERQEQ 550 560 570 580 590 600 RKRRRKAQQQ QMKMQREQPA AGVFLEASAP QKTRSSNNAS AGTKSKKRHR VPRVPEKCGL 610 620 630 640 650 660 RLLERCSWPQ CNHSCPTLTN PMTGEEMRFL ELLTAFGLDI EAVAAALGVD MHTLNNMERT 670 ELVNMLTQQA N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Wingful, an extracellular feedback inhibitor of Wingless." Gerlitz O., Basler K. Genes Dev. 16:1055-1059(2002) [PubMed: 12000788] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient." Giraldez A.J., Copley R.R., Cohen S.M. Dev. Cell 2:667-676(2002) [PubMed: 12015973] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Regulation of the wingless morphogen gradient by Torero:a novel secreted enzyme that modifies proteoglycans." Giraldez A.J. Thesis (2002), Department of Molecular Biology, Universidad de Madrid, Madrid, Spain Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014296 Genomic DNA. Translation: AAF49550.3. AY078993 mRNA. Translation: AAL85497.1. AJ457833 mRNA. Translation: CAD29885.1.
RefSeq	NP_730096.2.
UniGene	Dm.12824
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	FBgn0044028. Drosophila melanogaster. [Contig view]
GeneID	39751.
NMPDR	fig|7227.3.peg.10036.
Organism-specific databases
FlyBase	FBgn0044028. Notum.
Gene expression databases
ArrayExpress	Q9VUX3.
Family and domain databases
InterPro	IPR004963. Pec_acetylest. [Graphical view]
Pfam	PF03283. PAE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	815196.

Entry information

Entry name

Q9VUX3_DROME

Accession

Primary (citable) accession number: Q9VUX3
Secondary accession number(s): Q8T385

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	July 5, 2004
Last modified:	June 16, 2009
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)