Q9VUQ5 (AGO2_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein argonaute-2

Gene names

Name:	AGO2
ORF Names:	CG7439

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1214 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger. Ref.6
Subunit structure	Interacts with Fmr1 to form a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are mRpL5, mRpL11, Rm62 and Dcr-1. Interacts with Dcr-1 to form components of the RISC. Interacts with cricket paralysis virus protein 1A; this interaction may block the RISC activity. Ref.6 Ref.7 Ref.8
Domain	PAZ domain provides a major contribution for nucleic acid recognition. PAZ binds oligonucleotides of different lengths and has a strong preference for single-stranded nucleic acids (ssRNA or SSDNA) or RNA duplexes with single-stranded 3' overhangs. Can bind the characteristic two-base 3' overhangs of siRNAs, indicating that it may contribute to the specific and productive incorporation of siRNAs and miRNAs into the RNAi pathway.
Sequence similarities	Belongs to the argonaute family. Ago subfamily. Contains 1 PAZ domain. Contains 1 Piwi domain.
Sequence caution	The sequence AAM11104.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Host-virus interaction RNA-mediated gene silencing
Coding sequence diversity	Alternative splicing
Ligand	RNA-binding
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	defense response to virus Inferred from mutant phenotype PubMed 16556799PubMed 20978209. Source: FlyBase dsRNA transport Inferred from mutant phenotype PubMed 16862146. Source: FlyBase heterochromatin organization involved in chromatin silencing Inferred from mutant phenotype PubMed 19948966. Source: FlyBase negative regulation of viral genome replication Inferred from mutant phenotype PubMed 19632183. Source: FlyBase pole cell formation Inferred from mutant phenotype PubMed 16024657. Source: FlyBase production of siRNA involved in RNA interference Inferred from direct assay Ref.6. Source: UniProtKB salivary gland cell autophagic cell death Inferred from expression pattern PubMed 12593804. Source: FlyBase segment polarity determination Inferred from genetic interaction PubMed 16934003. Source: FlyBase siRNA loading onto RISC involved in RNA interference Inferred from direct assay PubMed 17123955. Source: FlyBase syncytial nuclear migration Inferred from mutant phenotype PubMed 16024657. Source: FlyBase targeting of mRNA for destruction involved in RNA interference Traceable author statement PubMed 12011447. Source: FlyBase virus-host interaction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	RISC-loading complex Inferred from direct assay PubMed 17123955. Source: FlyBase RNA-induced silencing complex Inferred from direct assay Ref.6PubMed 17123955PubMed 19661431. Source: FlyBase cytoplasm Inferred from direct assay PubMed 19252745. Source: FlyBase
Molecular_function	endoribonuclease activity Inferred from direct assay PubMed 16271385. Source: FlyBase siRNA binding Inferred from direct assay Ref.10PubMed 16271385PubMed 18463636. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Fmr1	Q9NFU0	4	EBI-442476,EBI-422631

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform B Ref.1 (identifier: Q9VUQ5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform C Ref.1 (identifier: Q9VUQ5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MGKKDK → MHFPITTPE

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1214

1214

Protein argonaute-2

PRO_0000194071

Regions

Domain

608 – 717

110

PAZ

Domain

885 – 1186

302

Piwi

Compositional bias

19 – 391

373

Gln/Gly-rich

Natural variations

Alternative sequence

1 – 6

6

MGKKDK → MHFPITTPE in isoform C.

VSP_050781

Natural variant

714

1

S → R in strain: 186. Ref.4

Natural variant

740

1

S → P in strain: 130. Ref.4

Natural variant

783

1

S → N in strain: 138, 140 and 196. Ref.4 Ref.5

Natural variant

835

1

T → A in strain: 128, 130, 138, 140, 141, 186, 187 and 196. Ref.4 Ref.5

Natural variant

854

1

S → T in strain: 128, 130, 138, 140, 141, 186, 187 and 196. Ref.4 Ref.5

Natural variant

866

1

D → E in strain: 128, 130, 141, 186 and 187. Ref.4

Experimental info

Sequence conflict

201

1

G → D in AAO39550. Ref.3

Secondary structure

1

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1214

Helix Strand Turn

Details...

Beta strand

601 – 603

3

Helix

604 – 611

8

Beta strand

618 – 621

4

Helix

623 – 625

3

Helix

627 – 634

8

Beta strand

638 – 641

4

Helix

645 – 647

3

Beta strand

652 – 655

4

Beta strand

658 – 663

6

Turn

664 – 666

3

Beta strand

668 – 677

10

Helix

678 – 683

6

Turn

684 – 686

3

Beta strand

692 – 698

7

Beta strand

705 – 708

4

Helix

710 – 712

3

Beta strand

713 – 716

4

Turn

717 – 719

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform B [UniParc]. Last modified August 16, 2004. Version 3. Checksum: 0DC73AF09CC33F73	FASTA	1,214	136,850
	10 20 30 40 50 60 MGKKDKNKKG GQDSAAAPQP QQQQKQQQQR QQQPQQLQQP QQLQQPQQLQ QPQQQQQQQP 70 80 90 100 110 120 HQQQQQSSRQ QPSTSSGGSR ASGFQQGGQQ QKSQDAEGWT AQKKQGKQQV QGWTKQGQQG 130 140 150 160 170 180 GHQQGRQGQD GGYQQRPPGQ QQGGHQQGRQ GQEGGYQQRP PGQQQGGHQQ GRQGQEGGYQ 190 200 210 220 230 240 QRPSGQQQGG HQQGRQGQEG GYQQRPPGQQ QGGHQQGRQG QEGGYQQRPS GQQQGGHQQG 250 260 270 280 290 300 RQGQEGGYQQ RPPGQQQGGH QQGRQGQEGG YQQRPPGQQQ GGHEQGRQGQ EGGYQQRPSG 310 320 330 340 350 360 QQQGGHQQGR QGQEGGYQQR PSGQQQGGHQ QGRQGQEGGY QQRPSGQQQG GHQQGRQGQE 370 380 390 400 410 420 GGYQQRPPGQ QPNQTQSQGQ YQSRGPPQQQ QAAPLPLPPQ PAGSIKRGTI GKPGQVGINY 430 440 450 460 470 480 LDLDLSKMPS VAYHYDVKIM PERPKKFYRQ AFEQFRVDQL GGAVLAYDGK ASCYSVDKLP 490 500 510 520 530 540 LNSQNPEVTV TDRNGRTLRY TIEIKETGDS TIDLKSLTTY MNDRIFDKPM RAMQCVEVVL 550 560 570 580 590 600 ASPCHNKAIR VGRSFFKMSD PNNRHELDDG YEALVGLYQA FMLGDRPFLN VDISHKSFPI 610 620 630 640 650 660 SMPMIEYLER FSLKAKINNT TNLDYSRRFL EPFLRGINVV YTPPQSFQSA PRVYRVNGLS 670 680 690 700 710 720 RAPASSETFE HDGKKVTIAS YFHSRNYPLK FPQLHCLNVG SSIKSILLPI ELCSIEEGQA 730 740 750 760 770 780 LNRKDGATQV ANMIKYAATS TNVRKRKIMN LLQYFQHNLD PTISRFGIRI ANDFIVVSTR 790 800 810 820 830 840 VLSPPQVEYH SKRFTMVKNG SWRMDGMKFL EPKPKAHKCA VLYCDPRSGR KMNYTQLNDF 850 860 870 880 890 900 GNLIISQGKA VNISLDSDVT YRPFTDDERS LDTIFADLKR SQHDLAIVII PQFRISYDTI 910 920 930 940 950 960 KQKAELQHGI LTQCIKQFTV ERKCNNQTIG NILLKINSKL NGINHKIKDD PRLPMMKNTM 970 980 990 1000 1010 1020 YIGADVTHPS PDQREIPSVV GVAASHDPYG ASYNMQYRLQ RGALEEIEDM FSITLEHLRV 1030 1040 1050 1060 1070 1080 YKEYRNAYPD HIIYYRDGVS DGQFPKIKNE ELRCIKQACD KVGCKPKICC VIVVKRHHTR 1090 1100 1110 1120 1130 1140 FFPSGDVTTS NKFNNVDPGT VVDRTIVHPN EMQFFMVSHQ AIQGTAKPTR YNVIENTGNL 1150 1160 1170 1180 1190 1200 DIDLLQQLTY NLCHMFPRCN RSVSYPAPAY LAHLVAARGR VYLTGTNRFL DLKKEYAKRT 1210 IVPEFMKKNP MYFV
	Isoform C [UniParc]. Checksum: 7C794ABF4D993EAF	FASTA	1,217	137,216
	10 20 30 40 50 60 MHFPITTPEN KKGGQDSAAA PQPQQQQKQQ QQRQQQPQQL QQPQQLQQPQ QLQQPQQQQQ 70 80 90 100 110 120 QQPHQQQQQS SRQQPSTSSG GSRASGFQQG GQQQKSQDAE GWTAQKKQGK QQVQGWTKQG 130 140 150 160 170 180 QQGGHQQGRQ GQDGGYQQRP PGQQQGGHQQ GRQGQEGGYQ QRPPGQQQGG HQQGRQGQEG 190 200 210 220 230 240 GYQQRPSGQQ QGGHQQGRQG QEGGYQQRPP GQQQGGHQQG RQGQEGGYQQ RPSGQQQGGH 250 260 270 280 290 300 QQGRQGQEGG YQQRPPGQQQ GGHQQGRQGQ EGGYQQRPPG QQQGGHEQGR QGQEGGYQQR 310 320 330 340 350 360 PSGQQQGGHQ QGRQGQEGGY QQRPSGQQQG GHQQGRQGQE GGYQQRPSGQ QQGGHQQGRQ 370 380 390 400 410 420 GQEGGYQQRP PGQQPNQTQS QGQYQSRGPP QQQQAAPLPL PPQPAGSIKR GTIGKPGQVG 430 440 450 460 470 480 INYLDLDLSK MPSVAYHYDV KIMPERPKKF YRQAFEQFRV DQLGGAVLAY DGKASCYSVD 490 500 510 520 530 540 KLPLNSQNPE VTVTDRNGRT LRYTIEIKET GDSTIDLKSL TTYMNDRIFD KPMRAMQCVE 550 560 570 580 590 600 VVLASPCHNK AIRVGRSFFK MSDPNNRHEL DDGYEALVGL YQAFMLGDRP FLNVDISHKS 610 620 630 640 650 660 FPISMPMIEY LERFSLKAKI NNTTNLDYSR RFLEPFLRGI NVVYTPPQSF QSAPRVYRVN 670 680 690 700 710 720 GLSRAPASSE TFEHDGKKVT IASYFHSRNY PLKFPQLHCL NVGSSIKSIL LPIELCSIEE 730 740 750 760 770 780 GQALNRKDGA TQVANMIKYA ATSTNVRKRK IMNLLQYFQH NLDPTISRFG IRIANDFIVV 790 800 810 820 830 840 STRVLSPPQV EYHSKRFTMV KNGSWRMDGM KFLEPKPKAH KCAVLYCDPR SGRKMNYTQL 850 860 870 880 890 900 NDFGNLIISQ GKAVNISLDS DVTYRPFTDD ERSLDTIFAD LKRSQHDLAI VIIPQFRISY 910 920 930 940 950 960 DTIKQKAELQ HGILTQCIKQ FTVERKCNNQ TIGNILLKIN SKLNGINHKI KDDPRLPMMK 970 980 990 1000 1010 1020 NTMYIGADVT HPSPDQREIP SVVGVAASHD PYGASYNMQY RLQRGALEEI EDMFSITLEH 1030 1040 1050 1060 1070 1080 LRVYKEYRNA YPDHIIYYRD GVSDGQFPKI KNEELRCIKQ ACDKVGCKPK ICCVIVVKRH 1090 1100 1110 1120 1130 1140 HTRFFPSGDV TTSNKFNNVD PGTVVDRTIV HPNEMQFFMV SHQAIQGTAK PTRYNVIENT 1150 1160 1170 1180 1190 1200 GNLDIDLLQQ LTYNLCHMFP RCNRSVSYPA PAYLAHLVAA RGRVYLTGTN RFLDLKKEYA 1210 KRTIVPEFMK KNPMYFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[3]	Stapleton M., Brokstein P., Hong L., Agbayani A., Booth B., Carlson J.W., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G. , Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS B AND C). Strain: Berkeley. Tissue: Embryo.
[4]	"Natural selection drives extremely rapid evolution in antiviral RNAi genes." Obbard D.J., Jiggins F.M., Halligan D.L., Little T.J. Curr. Biol. 16:580-585(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 376-1214, VARIANTS ARG-714; PRO-740; ASN-783; ALA-835; THR-854 AND GLU-866. Strain: 128, 130, 138, 140, 141, 186, 187 and 196.
[5]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 449-1214, VARIANTS ASN-783; ALA-835 AND THR-854. Strain: Berkeley. Tissue: Ovary.
[6]	"Argonaute2, a link between genetic and biochemical analyses of RNAi." Hammond S.M., Boettcher S., Caudy A.A., Kobayashi R., Hannon G.J. Science 293:1146-1150(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 506-515; 525-531; 554-557; 617-627; 662-674; 809-815 AND 1181-1188 (ISOFORM B), FUNCTION, INTERACTION WITH DCR-1.
[7]	"A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins." Ishizuka A., Siomi M.C., Siomi H. Genes Dev. 16:2497-2508(2002) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FMR1.
[8]	"Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila." Nayak A., Berry B., Tassetto M., Kunitomi M., Acevedo A., Deng C., Krutchinsky A., Gross J., Antoniewski C., Andino R. Nat. Struct. Mol. Biol. 17:547-554(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CRICKET PARALYSIS VIRUS PROTEIN 1A.
[9]	"The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes." Song J.J., Liu J., Tolia N.H., Schneiderman J., Smith S.K., Martienssen R.A., Hannon G.J., Joshua-Tor L. Nat. Struct. Biol. 10:1026-1032(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 591-726.
[10]	"Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain." Lingel A., Simon B., Izaurralde E., Sattler M. Nature 426:465-469(2003) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 602-740.
[11]	"Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain." Lingel A., Simon B., Izaurralde E., Sattler M. Nat. Struct. Mol. Biol. 11:576-577(2004) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 605-720.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE014296 Genomic DNA. Translation: AAF49619.2.
AE014296 Genomic DNA. Translation: AAF49620.2.
BT003546 mRNA. Translation: AAO39550.1.
BT099682 mRNA. Translation: ACV44468.1.
DQ228766 Genomic DNA. Translation: ABB54719.1.
DQ228767 Genomic DNA. Translation: ABB54720.1.
DQ228768 Genomic DNA. Translation: ABB54721.1.
DQ228769 Genomic DNA. Translation: ABB54722.1.
DQ228770 Genomic DNA. Translation: ABB54723.1.
DQ228771 Genomic DNA. Translation: ABB54724.1.
DQ228772 Genomic DNA. Translation: ABB54725.1.
DQ228773 Genomic DNA. Translation: ABB54726.1.
AY094751 mRNA. Translation: AAM11104.1. Different initiation.

RefSeq

NP_648775.1. NM_140518.3.
NP_730054.1. NM_168626.3.

UniGene

Dm.9677.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1R6Z	X-ray	2.80	A/P/Z	591-726	[»]
1T2R	NMR	-	A	605-720	[»]
1T2S	NMR	-	A	605-720	[»]
1VYN	NMR	-	A	605-740	[»]
3MJ0	X-ray	2.31	A	601-723	[»]

ProteinModelPortal

Q9VUQ5.

SMR

Q9VUQ5. Positions 398-1183.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-41570N.

IntAct

Q9VUQ5. 6 interactions.

MINT

MINT-248245.

Proteomic databases

PaxDb

Q9VUQ5.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblMetazoa

FBtr0075559; FBpp0075312; FBgn0087035.

GeneID

39683.

KEGG

dme:Dmel_CG7439.

Organism-specific databases

CTD

27161.

FlyBase

FBgn0087035. AGO2.

Phylogenomic databases

eggNOG

NOG279895.

GeneTree

ENSGT00640000091312.

InParanoid

Q9VUQ5.

KO

K11593.

OMA

QGRQGQE.

OrthoDB

EOG47D7X0.

Gene expression databases

Bgee

Q9VUQ5.

GermOnline

CG7439. Drosophila melanogaster.

Family and domain databases

InterPro

IPR014811. DUF1785.
IPR003100. PAZ.
IPR003165. Piwi.
IPR012337. RNaseH-like_dom.
[Graphical view]

Pfam

PF08699. DUF1785. 1 hit.
PF02170. PAZ. 1 hit.
PF02171. Piwi. 1 hit.
[Graphical view]

SMART

SM00950. Piwi. 1 hit.
[Graphical view]

SUPFAM

SSF101690. PAZ. 1 hit.
SSF53098. RNaseH_fold. 1 hit.

PROSITE

PS50821. PAZ. 1 hit.
PS50822. PIWI. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9VUQ5.

GenomeRNAi

39683.

NextBio

814859.

Entry information

Entry name

AGO2_DROME

Accession

Primary (citable) accession number: Q9VUQ5
Secondary accession number(s): C7LAD2 , Q2Q3Y0, Q2Q3Y1, Q2Q3Y3, Q2Q3Y4, Q2Q3Y5, Q86P07, Q8T3N2, Q9VUQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	August 16, 2004
Last modified:	May 1, 2013
This is version 97 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project