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Protein

Probable DNA mismatch repair protein Msh6

Gene

Msh6

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in post-replicative DNA-mismatch repair.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi958 – 9658ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: FlyBase
  • maintenance of DNA repeat elements Source: GO_Central
  • meiotic mismatch repair Source: FlyBase
  • negative regulation of DNA recombination Source: GO_Central
  • postreplication repair Source: FlyBase
  • reciprocal meiotic recombination Source: GO_Central
  • response to UV Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA mismatch repair protein Msh6
Gene namesi
Name:Msh6
ORF Names:CG7003
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036486. Msh6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11901190Probable DNA mismatch repair protein Msh6PRO_0000115209Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei7 – 71Phosphothreonine1 Publication
Modified residuei8 – 81Phosphoserine1 Publication
Modified residuei12 – 121Phosphothreonine1 Publication
Modified residuei14 – 141Phosphothreonine1 Publication
Modified residuei16 – 161Phosphothreonine1 Publication
Modified residuei22 – 221Phosphoserine1 Publication
Modified residuei24 – 241Phosphoserine1 Publication
Modified residuei33 – 331Phosphothreonine1 Publication
Modified residuei95 – 951Phosphoserine1 Publication
Modified residuei97 – 971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VUM0.
PRIDEiQ9VUM0.

PTM databases

iPTMnetiQ9VUM0.

Expressioni

Gene expression databases

BgeeiFBgn0036486.
GenevisibleiQ9VUM0. DM.

Interactioni

Subunit structurei

Heterodimer of Msh2/Spel and Msh6.By similarity

Protein-protein interaction databases

BioGridi64976. 1 interaction.
DIPiDIP-23712N.
IntActiQ9VUM0. 4 interactions.
MINTiMINT-323400.
STRINGi7227.FBpp0075399.

Structurei

3D structure databases

ProteinModelPortaliQ9VUM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.Curated

Phylogenomic databases

eggNOGiKOG0217. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000075024.
InParanoidiQ9VUM0.
KOiK08737.
OMAiALKDCMR.
OrthoDBiEOG091G018J.
PhylomeDBiQ9VUM0.

Family and domain databases

Gene3Di3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VUM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKLNTSVG GTPTNTLLNY FSKSPAFDKK KLTPSVKTDP DASKSEKENL
60 70 80 90 100
QNQQPKVKDG KKEASKPAAK RKLPISDDEP ASGQRKRKRI VQPESDSEPE
110 120 130 140 150
MEVTKSEDDF SDCASDYEPD ENEASDDSVS SGAEEVSPSE NDMSVDSPTP
160 170 180 190 200
KKSRKKSKIL NNNNNNEPSS KKVKLESTIQ LAEGATFQEK LKNLQSNAKQ
210 220 230 240 250
DASYDDIVTN TSNLDEPVVW PHQKLEFLQP DKIKDKEGRR PDHPDYDKST
260 270 280 290 300
LHVPEKFLNG LSPGVRQWWV LKSDNYDCVL FFKVGKFYEL YHMDADVGVN
310 320 330 340 350
ELGFTYMRGE FAHSGFPEIS FDKMSTILVD RGFKVARVEQ TETPDMMTER
360 370 380 390 400
CKRIKATKFD KVVAREICQI TNRGTQVFGS QCKIGPNHQP NYMLAIVEKD
410 420 430 440 450
EGTCSRYGVC FIDTSIGDFH LGEFEDDKNC SRLLTLVSHH MPVLFLNEKS
460 470 480 490 500
ALSQRTQQIV RTVLGGILKE PVPGNGKHAC SAEKTLKLLA ERYYAGPGSD
510 520 530 540 550
DNWPLVLRTM QSDMDHLGLT PNDNYKLALK ALGQCIFFIH KCKLEPKVLP
560 570 580 590 600
MARYQLYVPP DQLADAKPAV ASTLRRSHMV LDATTLSNLR IIGEEHSLLS
610 620 630 640 650
TLDHCCTKFG KRLLHHWLCA PSCDVSVIKE RQDAIGELIR MPTELQEVRA
660 670 680 690 700
LLAPMPDFER NLAQIHLFGN KQIKQMDHPD SRAILFEEKL YNKQKLQGFM
710 720 730 740 750
AVLKGFNDLT KLPTMFHQCK TTLLKRITQL PESGGSFPDL SKELQYFATA
760 770 780 790 800
FDHDAAAKTG VIAPQAGMDA EYDAAMDSIG EVEKRLKTYL VEQERHFGCR
810 820 830 840 850
ITYFGSDKKR YQLDVPESHA SKANKSYTLE GQTKGKKPSR RYTTAETRAL
860 870 880 890 900
LKDMQHAEDT RNMVLKDLAR RLFEKFSNHY DQWKQCIDCV ANLDVLGSLA
910 920 930 940 950
EYAGQQMVIC VPELVSDADQ PFIQLEEGYH PCANASTYIP NGLELGTASE
960 970 980 990 1000
APLSLLTGPN MGGKSTLMRE VGLLVIMAQI GAHIPAASCR LSLVDRIFTR
1010 1020 1030 1040 1050
LGAQDDILAG HSTFLVELNE TSLILKHATC HSLVLLDELG RGTATYDGTA
1060 1070 1080 1090 1100
IAASVVNFLA NLKCRTLFST HYHNLIDFFH NDKRITLGHM ACMVENEDNA
1110 1120 1130 1140 1150
DPTQETVTFL YKYTAGACPK SYGFNAAKLA GMPQGIIKRA YELSKKVEAI
1160 1170 1180 1190
ALQRKITAKI VAATAGNEDT KKEKINALKD LLKQLKMCQV
Length:1,190
Mass (Da):133,136
Last modified:February 21, 2001 - v2
Checksum:i1A416CE869EA5996
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49656.2.
BT050543 mRNA. Translation: ACJ13250.1.
RefSeqiNP_648755.1. NM_140498.2.
UniGeneiDm.966.

Genome annotation databases

EnsemblMetazoaiFBtr0075646; FBpp0075399; FBgn0036486.
GeneIDi39654.
KEGGidme:Dmel_CG7003.
UCSCiCG7003-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49656.2.
BT050543 mRNA. Translation: ACJ13250.1.
RefSeqiNP_648755.1. NM_140498.2.
UniGeneiDm.966.

3D structure databases

ProteinModelPortaliQ9VUM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64976. 1 interaction.
DIPiDIP-23712N.
IntActiQ9VUM0. 4 interactions.
MINTiMINT-323400.
STRINGi7227.FBpp0075399.

PTM databases

iPTMnetiQ9VUM0.

Proteomic databases

PaxDbiQ9VUM0.
PRIDEiQ9VUM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075646; FBpp0075399; FBgn0036486.
GeneIDi39654.
KEGGidme:Dmel_CG7003.
UCSCiCG7003-RA. d. melanogaster.

Organism-specific databases

CTDi2956.
FlyBaseiFBgn0036486. Msh6.

Phylogenomic databases

eggNOGiKOG0217. Eukaryota.
COG0249. LUCA.
GeneTreeiENSGT00550000075024.
InParanoidiQ9VUM0.
KOiK08737.
OMAiALKDCMR.
OrthoDBiEOG091G018J.
PhylomeDBiQ9VUM0.

Enzyme and pathway databases

ReactomeiR-DME-5358565. Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).

Miscellaneous databases

GenomeRNAii39654.
PROiQ9VUM0.

Gene expression databases

BgeeiFBgn0036486.
GenevisibleiQ9VUM0. DM.

Family and domain databases

Gene3Di3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSH6_DROME
AccessioniPrimary (citable) accession number: Q9VUM0
Secondary accession number(s): B6IDV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.