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Protein

39S ribosomal protein L39, mitochondrial

Gene

mRpL39

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • gene silencing by RNA Source: UniProtKB-KW
  • mitochondrial genome maintenance Source: GO_Central
  • mitochondrial translation Source: FlyBase
  • regulation of translation Source: UniProtKB-KW
  • translation Source: FlyBase
  • tRNA aminoacylation for protein translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

RNA-mediated gene silencing, Translation regulation

Enzyme and pathway databases

ReactomeiR-DME-5389840. Mitochondrial translation elongation.
R-DME-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L39, mitochondrial
Short name:
MRP-L39
Alternative name(s):
MRP-L5
Gene namesi
Name:mRpL39
Synonyms:mRpL5
ORF Names:CG17166
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036462. mRpL39.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000876861 – 33339S ribosomal protein L39, mitochondrialAdd BLAST333

Proteomic databases

PaxDbiQ9VUJ0.
PRIDEiQ9VUJ0.

Expressioni

Gene expression databases

BgeeiFBgn0036462.
ExpressionAtlasiQ9VUJ0. baseline.
GenevisibleiQ9VUJ0. DM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). Interacts with Fmr1 to form a ribonucleoprotein (RNP) complex involved in translation regulation, other members of the complex are mRpL11, AGO2, Rm62 and Dcr-1.By similarity1 Publication

Protein-protein interaction databases

BioGridi64951. 4 interactors.
DIPiDIP-20391N.
IntActiQ9VUJ0. 1 interactor.
MINTiMINT-747485.
STRINGi7227.FBpp0075425.

Structurei

3D structure databases

ProteinModelPortaliQ9VUJ0.
SMRiQ9VUJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L39 family.Curated

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
InParanoidiQ9VUJ0.
KOiK17420.
OMAiPYNCAMH.
OrthoDBiEOG091G0CTH.
PhylomeDBiQ9VUJ0.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR012675. Beta-grasp_dom.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
[Graphical view]
SUPFAMiSSF55186. SSF55186. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VUJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAATKLHKT SWCALRQLQQ YRTKANFSGS SASLAKRNDL FNQEQRRQRD
60 70 80 90 100
AVGRIDKIEV RYLGLPEDVT LVMNGNISTP FNCAQHLSEG HCKRSALALI
110 120 130 140 150
DGSVPWDMHR PLQESCTLQL LNFHVSEPHV VNKAFWRTCS FMLGAALNRA
160 170 180 190 200
FKPEANLQLH SFPGPNIKSG SFVHDIVLQT QNWEPGKEEM RALSAEMVKL
210 220 230 240 250
AAQDLRIERL DVQQDLAQEM FKDSKYKSEQ LPSISQQTNG RVTLYRLGDH
260 270 280 290 300
IDISRGPMVA STSFLGKCVI SAAHKVAEEG PSGAFYRIQG VALPSGFQLN
310 320 330
HVAFGVLEER SKKPSPARLP NEPFEEQQQL QLS
Length:333
Mass (Da):37,324
Last modified:January 27, 2003 - v2
Checksum:i27C6515156D35D70
GO

Sequence cautioni

The sequence AAL49047 differs from that shown. Reason: Frameshift at position 282.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49686.2.
AY071425 mRNA. Translation: AAL49047.1. Frameshift.
RefSeqiNP_524075.2. NM_079351.4.
UniGeneiDm.2748.

Genome annotation databases

EnsemblMetazoaiFBtr0075672; FBpp0075425; FBgn0036462.
GeneIDi39627.
KEGGidme:Dmel_CG17166.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49686.2.
AY071425 mRNA. Translation: AAL49047.1. Frameshift.
RefSeqiNP_524075.2. NM_079351.4.
UniGeneiDm.2748.

3D structure databases

ProteinModelPortaliQ9VUJ0.
SMRiQ9VUJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64951. 4 interactors.
DIPiDIP-20391N.
IntActiQ9VUJ0. 1 interactor.
MINTiMINT-747485.
STRINGi7227.FBpp0075425.

Proteomic databases

PaxDbiQ9VUJ0.
PRIDEiQ9VUJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075672; FBpp0075425; FBgn0036462.
GeneIDi39627.
KEGGidme:Dmel_CG17166.

Organism-specific databases

CTDi54148.
FlyBaseiFBgn0036462. mRpL39.

Phylogenomic databases

eggNOGiKOG1637. Eukaryota.
COG0441. LUCA.
GeneTreeiENSGT00390000002149.
InParanoidiQ9VUJ0.
KOiK17420.
OMAiPYNCAMH.
OrthoDBiEOG091G0CTH.
PhylomeDBiQ9VUJ0.

Enzyme and pathway databases

ReactomeiR-DME-5389840. Mitochondrial translation elongation.
R-DME-5419276. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii39627.
PROiQ9VUJ0.

Gene expression databases

BgeeiFBgn0036462.
ExpressionAtlasiQ9VUJ0. baseline.
GenevisibleiQ9VUJ0. DM.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR012675. Beta-grasp_dom.
IPR018163. Thr/Ala-tRNA-synth_IIc_edit.
[Graphical view]
SUPFAMiSSF55186. SSF55186. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRM39_DROME
AccessioniPrimary (citable) accession number: Q9VUJ0
Secondary accession number(s): Q8SYN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 27, 2003
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.