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Q9VU84

- DBNL_DROME

UniProt

Q9VU84 - DBNL_DROME

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Protein
Drebrin-like protein
Gene
Abp1, CG10083
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin By similarity. Does not seem to be involved in actin-based lamella protrusion during cell migration.1 Publication

GO - Molecular functioni

  1. actin binding Source: UniProtKB
  2. actin filament binding Source: FlyBase
  3. phosphatidylinositol-3,4,5-trisphosphate binding Source: FlyBase
  4. phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase
  5. phosphatidylserine binding Source: FlyBase

GO - Biological processi

  1. chaeta development Source: FlyBase
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiQ9VU84.

Names & Taxonomyi

Protein namesi
Recommended name:
Drebrin-like protein
Alternative name(s):
Actin binding protein 1
Gene namesi
Name:Abp1
ORF Names:CG10083
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036372. Abp1.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Drebrin-like protein
PRO_0000270188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421Phosphoserine1 Publication
Modified residuei328 – 3281Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9VU84.
PRIDEiQ9VU84.

Expressioni

Gene expression databases

BgeeiQ9VU84.

Interactioni

Protein-protein interaction databases

BioGridi64863. 1 interaction.
MINTiMINT-1645145.

Structurei

3D structure databases

ProteinModelPortaliQ9VU84.
SMRiQ9VU84. Positions 1-138, 472-529.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 133132ADF-H
Add
BLAST
Domaini472 – 53160SH3
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili177 – 22044 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi321 – 35838Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the ABP1 family.
Contains 1 ADF-H domain.
Contains 1 SH3 domain.

Keywords - Domaini

Coiled coil, Repeat, SH3 domain

Phylogenomic databases

eggNOGiNOG265859.
GeneTreeiENSGT00530000062953.
InParanoidiQ9VU84.
OMAiFQDTGPQ.
OrthoDBiEOG7X3QR9.
PhylomeDBiQ9VU84.

Family and domain databases

Gene3Di3.40.20.10. 1 hit.
InterProiIPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00241. Cofilin_ADF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00102. ADF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
PROSITEiPS51263. ADF_H. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VU84-1 [UniParc]FASTAAdd to Basket

« Hide

MAVSFEKNRA QIVAAWKDVL DDKSDTNWSL FGYEGQTNEL KVVATGDGGV    50
DELNEDLNSG KIMYAFVRIE DPKTGLNKYL LINWQGEGAP VLRKGTCANH 100
IRDVSNLLSG AHLTINARNE DDIDLDRLLK KLSTVSSAYS FKEPRGAMEE 150
QKAPVGTNYT RVIPTKELNA SVMQDFWKKE EAEEKLRQEA EKESKRLELQ 200
KLEQEQRSRE EKEHKEREKL VISTTKLQPA HVPIKTSPQP LSPEKTAPGF 250
ANNLTDAERM RQARNQEARE LIGSRVGAAK AMFTKHTSEG QLQSKLNTQP 300
PAKPARNSIA QRINVFNQNQ PQDAPVPSPP RAASPAKPLP VEAPEPVVPA 350
PAIAPAAPVA AEVVSTIAEV EESQPVDDLP LAHESEQFST IKRSPHSKSN 400
SLQSQSPDET TSSNETDTAV SQEQEEEVRT KVSVTVQQSQ SVKSSGMSTL 450
ERNALTDLVN EDDFICQETL GDLGQRARAL YDYQAADETE ITFDPGDVIT 500
HIDQIDEGWW QGLGPDGTYG LFPANYVEII N 531
Length:531
Mass (Da):58,729
Last modified:May 1, 2000 - v1
Checksum:iA1CAAFA251F151C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF49805.1.
AY119287 mRNA. Translation: AAM51147.1.
BT021389 mRNA. Translation: AAX33537.1.
RefSeqiNP_648657.1. NM_140400.2.
UniGeneiDm.13622.

Genome annotation databases

EnsemblMetazoaiFBtr0075819; FBpp0075561; FBgn0036372.
GeneIDi39520.
KEGGidme:Dmel_CG10083.
UCSCiCG10083-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014296 Genomic DNA. Translation: AAF49805.1 .
AY119287 mRNA. Translation: AAM51147.1 .
BT021389 mRNA. Translation: AAX33537.1 .
RefSeqi NP_648657.1. NM_140400.2.
UniGenei Dm.13622.

3D structure databases

ProteinModelPortali Q9VU84.
SMRi Q9VU84. Positions 1-138, 472-529.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 64863. 1 interaction.
MINTi MINT-1645145.

Proteomic databases

PaxDbi Q9VU84.
PRIDEi Q9VU84.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0075819 ; FBpp0075561 ; FBgn0036372 .
GeneIDi 39520.
KEGGi dme:Dmel_CG10083.
UCSCi CG10083-RA. d. melanogaster.

Organism-specific databases

FlyBasei FBgn0036372. Abp1.

Phylogenomic databases

eggNOGi NOG265859.
GeneTreei ENSGT00530000062953.
InParanoidi Q9VU84.
OMAi FQDTGPQ.
OrthoDBi EOG7X3QR9.
PhylomeDBi Q9VU84.

Enzyme and pathway databases

SignaLinki Q9VU84.

Miscellaneous databases

GenomeRNAii 39520.
NextBioi 814077.
PROi Q9VU84.

Gene expression databases

Bgeei Q9VU84.

Family and domain databases

Gene3Di 3.40.20.10. 1 hit.
InterProi IPR002108. ADF-H.
IPR029006. ADF-H/Gelsolin-like_dom.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00241. Cofilin_ADF. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00102. ADF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
PROSITEi PS51263. ADF_H. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Flying through the Drosophila cytoskeletal genome."
    Goldstein L.S., Gunawardena S.
    J. Cell Biol. 150:F63-F68(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  5. "Molecular requirements for actin-based lamella formation in Drosophila S2 cells."
    Rogers S.L., Wiedemann U., Stuurman N., Vale R.D.
    J. Cell Biol. 162:1079-1088(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
    Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
    Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiDBNL_DROME
AccessioniPrimary (citable) accession number: Q9VU84
Secondary accession number(s): Q8MRS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi