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Q9VU84

- DBNL_DROME

UniProt

Q9VU84 - DBNL_DROME

Protein

Drebrin-like protein

Gene

Abp1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin By similarity. Does not seem to be involved in actin-based lamella protrusion during cell migration.By similarity1 Publication

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. actin filament binding Source: FlyBase
    3. phosphatidylinositol-3,4,5-trisphosphate binding Source: FlyBase
    4. phosphatidylinositol-4,5-bisphosphate binding Source: FlyBase
    5. phosphatidylserine binding Source: FlyBase

    GO - Biological processi

    1. chaeta development Source: FlyBase

    Keywords - Ligandi

    Actin-binding

    Enzyme and pathway databases

    SignaLinkiQ9VU84.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Drebrin-like protein
    Alternative name(s):
    Actin binding protein 1
    Gene namesi
    Name:Abp1
    ORF Names:CG10083
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0036372. Abp1.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 531531Drebrin-like proteinPRO_0000270188Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei242 – 2421Phosphoserine1 Publication
    Modified residuei328 – 3281Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9VU84.
    PRIDEiQ9VU84.

    Expressioni

    Gene expression databases

    BgeeiQ9VU84.

    Interactioni

    Protein-protein interaction databases

    BioGridi64863. 1 interaction.
    MINTiMINT-1645145.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VU84.
    SMRiQ9VU84. Positions 1-138, 472-529.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 133132ADF-HPROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 53160SH3PROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili177 – 22044Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi321 – 35838Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABP1 family.Curated
    Contains 1 ADF-H domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiNOG265859.
    GeneTreeiENSGT00530000062953.
    InParanoidiQ9VU84.
    OMAiFQDTGPQ.
    OrthoDBiEOG7X3QR9.
    PhylomeDBiQ9VU84.

    Family and domain databases

    Gene3Di3.40.20.10. 1 hit.
    InterProiIPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00241. Cofilin_ADF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00102. ADF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    PROSITEiPS51263. ADF_H. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VU84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVSFEKNRA QIVAAWKDVL DDKSDTNWSL FGYEGQTNEL KVVATGDGGV    50
    DELNEDLNSG KIMYAFVRIE DPKTGLNKYL LINWQGEGAP VLRKGTCANH 100
    IRDVSNLLSG AHLTINARNE DDIDLDRLLK KLSTVSSAYS FKEPRGAMEE 150
    QKAPVGTNYT RVIPTKELNA SVMQDFWKKE EAEEKLRQEA EKESKRLELQ 200
    KLEQEQRSRE EKEHKEREKL VISTTKLQPA HVPIKTSPQP LSPEKTAPGF 250
    ANNLTDAERM RQARNQEARE LIGSRVGAAK AMFTKHTSEG QLQSKLNTQP 300
    PAKPARNSIA QRINVFNQNQ PQDAPVPSPP RAASPAKPLP VEAPEPVVPA 350
    PAIAPAAPVA AEVVSTIAEV EESQPVDDLP LAHESEQFST IKRSPHSKSN 400
    SLQSQSPDET TSSNETDTAV SQEQEEEVRT KVSVTVQQSQ SVKSSGMSTL 450
    ERNALTDLVN EDDFICQETL GDLGQRARAL YDYQAADETE ITFDPGDVIT 500
    HIDQIDEGWW QGLGPDGTYG LFPANYVEII N 531
    Length:531
    Mass (Da):58,729
    Last modified:May 1, 2000 - v1
    Checksum:iA1CAAFA251F151C7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49805.1.
    AY119287 mRNA. Translation: AAM51147.1.
    BT021389 mRNA. Translation: AAX33537.1.
    RefSeqiNP_648657.1. NM_140400.2.
    UniGeneiDm.13622.

    Genome annotation databases

    EnsemblMetazoaiFBtr0075819; FBpp0075561; FBgn0036372.
    GeneIDi39520.
    KEGGidme:Dmel_CG10083.
    UCSCiCG10083-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49805.1 .
    AY119287 mRNA. Translation: AAM51147.1 .
    BT021389 mRNA. Translation: AAX33537.1 .
    RefSeqi NP_648657.1. NM_140400.2.
    UniGenei Dm.13622.

    3D structure databases

    ProteinModelPortali Q9VU84.
    SMRi Q9VU84. Positions 1-138, 472-529.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 64863. 1 interaction.
    MINTi MINT-1645145.

    Proteomic databases

    PaxDbi Q9VU84.
    PRIDEi Q9VU84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0075819 ; FBpp0075561 ; FBgn0036372 .
    GeneIDi 39520.
    KEGGi dme:Dmel_CG10083.
    UCSCi CG10083-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0036372. Abp1.

    Phylogenomic databases

    eggNOGi NOG265859.
    GeneTreei ENSGT00530000062953.
    InParanoidi Q9VU84.
    OMAi FQDTGPQ.
    OrthoDBi EOG7X3QR9.
    PhylomeDBi Q9VU84.

    Enzyme and pathway databases

    SignaLinki Q9VU84.

    Miscellaneous databases

    GenomeRNAii 39520.
    NextBioi 814077.
    PROi Q9VU84.

    Gene expression databases

    Bgeei Q9VU84.

    Family and domain databases

    Gene3Di 3.40.20.10. 1 hit.
    InterProi IPR002108. ADF-H.
    IPR029006. ADF-H/Gelsolin-like_dom.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00241. Cofilin_ADF. 1 hit.
    PF14604. SH3_9. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00102. ADF. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    PROSITEi PS51263. ADF_H. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    4. "Flying through the Drosophila cytoskeletal genome."
      Goldstein L.S., Gunawardena S.
      J. Cell Biol. 150:F63-F68(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    5. "Molecular requirements for actin-based lamella formation in Drosophila S2 cells."
      Rogers S.L., Wiedemann U., Stuurman N., Vale R.D.
      J. Cell Biol. 162:1079-1088(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
      Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
      Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
      Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
      J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Embryo.

    Entry informationi

    Entry nameiDBNL_DROME
    AccessioniPrimary (citable) accession number: Q9VU84
    Secondary accession number(s): Q8MRS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3