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Q9VU84 (DBNL_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Drebrin-like protein
Alternative name(s):
Actin binding protein 1
Gene names
Name:Abp1
ORF Names:CG10083
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length531 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G-actin By similarity. Does not seem to be involved in actin-based lamella protrusion during cell migration. Ref.5

Subcellular location

Cytoplasmcytoskeleton By similarity.

Sequence similarities

Belongs to the ABP1 family.

Contains 1 ADF-H domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 531531Drebrin-like protein
PRO_0000270188

Regions

Domain2 – 133132ADF-H
Domain472 – 53160SH3
Coiled coil177 – 22044 Potential
Compositional bias321 – 35838Pro-rich

Amino acid modifications

Modified residue2421Phosphoserine Ref.7
Modified residue3281Phosphoserine Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9VU84 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: A1CAAFA251F151C7

FASTA53158,729
        10         20         30         40         50         60 
MAVSFEKNRA QIVAAWKDVL DDKSDTNWSL FGYEGQTNEL KVVATGDGGV DELNEDLNSG 

        70         80         90        100        110        120 
KIMYAFVRIE DPKTGLNKYL LINWQGEGAP VLRKGTCANH IRDVSNLLSG AHLTINARNE 

       130        140        150        160        170        180 
DDIDLDRLLK KLSTVSSAYS FKEPRGAMEE QKAPVGTNYT RVIPTKELNA SVMQDFWKKE 

       190        200        210        220        230        240 
EAEEKLRQEA EKESKRLELQ KLEQEQRSRE EKEHKEREKL VISTTKLQPA HVPIKTSPQP 

       250        260        270        280        290        300 
LSPEKTAPGF ANNLTDAERM RQARNQEARE LIGSRVGAAK AMFTKHTSEG QLQSKLNTQP 

       310        320        330        340        350        360 
PAKPARNSIA QRINVFNQNQ PQDAPVPSPP RAASPAKPLP VEAPEPVVPA PAIAPAAPVA 

       370        380        390        400        410        420 
AEVVSTIAEV EESQPVDDLP LAHESEQFST IKRSPHSKSN SLQSQSPDET TSSNETDTAV 

       430        440        450        460        470        480 
SQEQEEEVRT KVSVTVQQSQ SVKSSGMSTL ERNALTDLVN EDDFICQETL GDLGQRARAL 

       490        500        510        520        530 
YDYQAADETE ITFDPGDVIT HIDQIDEGWW QGLGPDGTYG LFPANYVEII N 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]"Flying through the Drosophila cytoskeletal genome."
Goldstein L.S., Gunawardena S.
J. Cell Biol. 150:F63-F68(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]"Molecular requirements for actin-based lamella formation in Drosophila S2 cells."
Rogers S.L., Wiedemann U., Stuurman N., Vale R.D.
J. Cell Biol. 162:1079-1088(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, IDENTIFICATION BY MASS SPECTROMETRY.
[7]"Phosphoproteome analysis of Drosophila melanogaster embryos."
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014296 Genomic DNA. Translation: AAF49805.1.
AY119287 mRNA. Translation: AAM51147.1.
BT021389 mRNA. Translation: AAX33537.1.
RefSeqNP_648657.1. NM_140400.2.
UniGeneDm.13622.

3D structure databases

ProteinModelPortalQ9VU84.
SMRQ9VU84. Positions 1-138, 472-529.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid64863. 1 interaction.
MINTMINT-1645145.

Proteomic databases

PaxDbQ9VU84.
PRIDEQ9VU84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0075819; FBpp0075561; FBgn0036372.
GeneID39520.
KEGGdme:Dmel_CG10083.
UCSCCG10083-RA. d. melanogaster.

Organism-specific databases

FlyBaseFBgn0036372. Abp1.

Phylogenomic databases

eggNOGNOG265859.
GeneTreeENSGT00530000062953.
InParanoidQ9VU84.
OMAFQDTGPQ.
OrthoDBEOG7X3QR9.
PhylomeDBQ9VU84.

Enzyme and pathway databases

SignaLinkQ9VU84.

Gene expression databases

BgeeQ9VU84.

Family and domain databases

InterProIPR002108. ADF-H.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00241. Cofilin_ADF. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00102. ADF. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 2 hits.
PROSITEPS51263. ADF_H. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi39520.
NextBio814077.
PROQ9VU84.

Entry information

Entry nameDBNL_DROME
AccessionPrimary (citable) accession number: Q9VU84
Secondary accession number(s): Q8MRS9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase