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Protein
Submitted name:

Autophagy-related 1, isoform A

Gene

Atg1

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • protein kinase activity Source: FlyBase
  • protein serine/threonine kinase activity Source: FlyBase
  • ubiquitin-like protein binding Source: FlyBase

GO - Biological processi

  • autophagy Source: FlyBase
  • axo-dendritic transport Source: FlyBase
  • cellular response to oxidative stress Source: FlyBase
  • cellular response to starvation Source: FlyBase
  • glycophagy Source: FlyBase
  • larval midgut cell programmed cell death Source: FlyBase
  • larval midgut histolysis Source: FlyBase
  • macroautophagy Source: FlyBase
  • modulation of synaptic transmission Source: FlyBase
  • negative regulation of phosphatidylinositol 3-kinase signaling Source: FlyBase
  • negative regulation of TOR signaling Source: FlyBase
  • nurse cell apoptotic process Source: FlyBase
  • positive regulation of autophagy Source: FlyBase
  • positive regulation of glycogen catabolic process Source: FlyBase
  • positive regulation of nurse cell apoptotic process Source: FlyBase
  • protein autophosphorylation Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of autophagy Source: FlyBase
  • regulation of cell growth Source: FlyBase
  • regulation of glucose metabolic process Source: FlyBase
  • regulation of terminal button organization Source: FlyBase
  • response to oxidative stress Source: FlyBase
  • synapse organization Source: FlyBase
  • synaptic growth at neuromuscular junction Source: FlyBase

Keywordsi

Molecular functionTransferaseImported

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.

Names & Taxonomyi

Protein namesi
Submitted name:
Autophagy-related 1, isoform AImported (EC:2.7.11.-Imported)
Submitted name:
LP23904pImported
Gene namesi
Name:Atg1Imported
Synonyms:anon-WO0118547.287Imported, ATG1Imported, atg1Imported, dATG1Imported, dAtg1Imported, DK-4Imported, DmATG1Imported, Dmel\CG10967Imported, l(3)00305Imported, ULK1Imported, UNC 51-likeImported, Unc-51Imported, unc-51Imported, Unc51Imported, unc51Imported
ORF Names:CG10967Imported, Dmel_CG10967Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0260945. Atg1.

Subcellular locationi

GO - Cellular componenti

  • ATG1/ULK1 kinase complex Source: FlyBase
  • neuron projection Source: GOC

Expressioni

Gene expression databases

BgeeiFBgn0260945.

Interactioni

GO - Molecular functioni

  • ubiquitin-like protein binding Source: FlyBase

Protein-protein interaction databases

IntActiQ9VU14. 2 interactors.
MINTiMINT-962144.
STRINGi7227.FBpp0289788.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 274Protein kinaseInterPro annotationAdd BLAST266

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili302 – 333Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0595. Eukaryota.
ENOG410XR01. LUCA.
GeneTreeiENSGT00870000136410.
OrthoDBiEOG091G0P85.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR022708. Ser/Thr_kinase_C.
IPR015943. WD40/YVTN_repeat-like_dom.
PfamiView protein in Pfam
PF12063. DUF3543. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VU14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVGEYEYS SKDMLGHGAF AVVYKGRHRK KHMPVAIKCI TKKGQLKTQN
60 70 80 90 100
LLGKEIKILK ELTELHHENV VALLDCKESQ DCVSLVMEYC NGGDLADYLS
110 120 130 140 150
VKGTLSEDTV RLFLVQLAGA MKALYTKGIV HRDLKPQNIL LSHNYGKTLP
160 170 180 190 200
APSKITLKIA DFGFARFLNE GAMAATLCGS PMYMAPEVIM SLQYDSKADL
210 220 230 240 250
WSLGTIVYQC LTGKAPFYAQ TPNELKSYYE QNANLAPKIP SGVSPDLRDL
260 270 280 290 300
LLCLLRRNSK DRISYESFFV HRFLQGKKAA VSPVDMPPLG GTPPAKAKSP
310 320 330 340 350
LQQQLEQELK LVKLAEQQQK EREEQEAQED ENTVSVVANP AICATITNVG
360 370 380 390 400
VLCDSENNSG SCSSHEDSDD FVLVPKNLPE DQRQGLAQVQ AQPASGGQRP
410 420 430 440 450
QQQQNQSSPP RPSSLPISEP KPVPAPARRQ VARPGPLTVA TLGGQQIPRS
460 470 480 490 500
QPISVKQPRP DQRKSSVSSD INSISPPAVQ FAIGTPPTRM RSASGGSLSE
510 520 530 540 550
TPPPHAPSTW QVSPGHSQSP LRRSGNSSPV LPSAALTKLP TLGSPTMLVA
560 570 580 590 600
PGSLGSIGSA GSGSENNNQH HMLGPRAFTL PELGATGGLH SLLDTGAGGG
610 620 630 640 650
GEPHAFQAPE LSEETLMDRE HNETLSKLNF VLALTDCIQE VADSRCAPLS
660 670 680 690 700
TFMVAGSQSA AQAASADAQQ IPPHAPEHCK RAERLVLLVR GLQLLSSGMN
710 720 730 740 750
LASQQLSNGQ LKPSSNVKNA LLTMNAKYRS MLFESKRLNG SGLLQKANAF
760 770 780 790 800
NITADKILYD YALDMCQAAA LDELLKNTKN CFERYNTAHI LLHSLVQKCN
810 820 830
HPQDKMMLNK YRDAVEKRLS ILQQHGYIYM TDENA
Length:835
Mass (Da):90,646
Last modified:May 1, 2000 - v1
Checksum:i82ED8ADAE06DEF9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49878.1.
BT021340 mRNA. Translation: AAX33488.1.
RefSeqiNP_648601.1. NM_140344.3.
UniGeneiDm.11426.

Genome annotation databases

EnsemblMetazoaiFBtr0075945; FBpp0075677; FBgn0260945.
GeneIDi39454.
UCSCiCG10967-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49878.1.
BT021340 mRNA. Translation: AAX33488.1.
RefSeqiNP_648601.1. NM_140344.3.
UniGeneiDm.11426.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9VU14. 2 interactors.
MINTiMINT-962144.
STRINGi7227.FBpp0289788.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075945; FBpp0075677; FBgn0260945.
GeneIDi39454.
UCSCiCG10967-RA. d. melanogaster.

Organism-specific databases

CTDi39454.
FlyBaseiFBgn0260945. Atg1.

Phylogenomic databases

eggNOGiKOG0595. Eukaryota.
ENOG410XR01. LUCA.
GeneTreeiENSGT00870000136410.
OrthoDBiEOG091G0P85.

Enzyme and pathway databases

ReactomeiR-DME-1632852. Macroautophagy.

Miscellaneous databases

GenomeRNAii39454.

Gene expression databases

BgeeiFBgn0260945.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR022708. Ser/Thr_kinase_C.
IPR015943. WD40/YVTN_repeat-like_dom.
PfamiView protein in Pfam
PF12063. DUF3543. 1 hit.
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VU14_DROME
AccessioniPrimary (citable) accession number: Q9VU14
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 10, 2017
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.