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Q9VTZ6

- PMM_DROME

UniProt

Q9VTZ6 - PMM_DROME

Protein

Probable phosphomannomutase

Gene

CG10688

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

    Catalytic activityi

    Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei16 – 161NucleophileBy similarity
    Active sitei18 – 181Proton donor/acceptorSequence Analysis
    Binding sitei25 – 251SubstrateBy similarity
    Binding sitei129 – 1291SubstrateBy similarity
    Binding sitei140 – 1401SubstrateBy similarity
    Binding sitei147 – 1471SubstrateBy similarity
    Binding sitei185 – 1851SubstrateBy similarity
    Binding sitei187 – 1871SubstrateBy similarity

    GO - Molecular functioni

    1. phosphomannomutase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular response to hypoxia Source: FlyBase
    2. GDP-mannose biosynthetic process Source: UniProtKB-UniPathway
    3. mannose biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    ReactomeiREACT_180316. Synthesis of GDP-mannose.
    UniPathwayiUPA00126; UER00424.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phosphomannomutase (EC:5.4.2.8)
    Short name:
    PMM
    Gene namesi
    ORF Names:CG10688
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0036300. CG10688.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Probable phosphomannomutasePRO_0000199699Add
    BLAST

    Proteomic databases

    PaxDbiQ9VTZ6.
    PRIDEiQ9VTZ6.

    Expressioni

    Gene expression databases

    BgeeiQ9VTZ6.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    BioGridi64785. 1 interaction.
    STRINGi7227.FBpp0075693.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VTZ6.
    SMRiQ9VTZ6. Positions 12-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic PMM family.Curated

    Phylogenomic databases

    eggNOGiCOG0561.
    GeneTreeiENSGT00390000002918.
    InParanoidiQ9VTZ6.
    KOiK17497.
    OMAiTYCLQHV.
    OrthoDBiEOG773XH0.
    PhylomeDBiQ9VTZ6.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    InterProiIPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view]
    PANTHERiPTHR10466. PTHR10466. 1 hit.
    PfamiPF03332. PMM. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9VTZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTAALKRDE ILLLFDVDGT LTMPRSVVTP EFEEFFYSRV KPRATIGIVG    50
    GSDLEKMFEQ LNGRKILNEF DFIFPENGLV QIEGGKEVGK QNIIMHLGEE 100
    TVKRFINFVL RYLSELDVPI KRGTFIEFRN GMMNVCPIGR QCTREERNMF 150
    AEYDIEHKVR EKMIKDLKQE FADVDLTYSI GGQISFDVFP HGWDKTYCLR 200
    HIEAHYKFKE IHFFGDKTEP GGNDYEIYSD PRTISHRVYT PKDTQRILTE 250
    ILEL 254
    Length:254
    Mass (Da):29,667
    Last modified:May 1, 2000 - v1
    Checksum:i716E05E7BB2438BB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49899.1.
    BT009926 mRNA. Translation: AAQ22395.1.
    RefSeqiNP_648589.1. NM_140332.2.
    UniGeneiDm.23285.

    Genome annotation databases

    EnsemblMetazoaiFBtr0075961; FBpp0075693; FBgn0036300.
    GeneIDi39436.
    KEGGidme:Dmel_CG10688.
    UCSCiCG10688-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAF49899.1 .
    BT009926 mRNA. Translation: AAQ22395.1 .
    RefSeqi NP_648589.1. NM_140332.2.
    UniGenei Dm.23285.

    3D structure databases

    ProteinModelPortali Q9VTZ6.
    SMRi Q9VTZ6. Positions 12-247.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 64785. 1 interaction.
    STRINGi 7227.FBpp0075693.

    Proteomic databases

    PaxDbi Q9VTZ6.
    PRIDEi Q9VTZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0075961 ; FBpp0075693 ; FBgn0036300 .
    GeneIDi 39436.
    KEGGi dme:Dmel_CG10688.
    UCSCi CG10688-RA. d. melanogaster.

    Organism-specific databases

    FlyBasei FBgn0036300. CG10688.

    Phylogenomic databases

    eggNOGi COG0561.
    GeneTreei ENSGT00390000002918.
    InParanoidi Q9VTZ6.
    KOi K17497.
    OMAi TYCLQHV.
    OrthoDBi EOG773XH0.
    PhylomeDBi Q9VTZ6.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00424 .
    Reactomei REACT_180316. Synthesis of GDP-mannose.

    Miscellaneous databases

    GenomeRNAii 39436.
    NextBioi 813625.

    Gene expression databases

    Bgeei Q9VTZ6.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    InterProi IPR023214. HAD-like_dom.
    IPR006379. HAD-SF_hydro_IIB.
    IPR005002. PMM.
    [Graphical view ]
    PANTHERi PTHR10466. PTHR10466. 1 hit.
    Pfami PF03332. PMM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR01484. HAD-SF-IIB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.

    Entry informationi

    Entry nameiPMM_DROME
    AccessioniPrimary (citable) accession number: Q9VTZ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3