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Protein

Probable phosphomannomutase

Gene

CG10688

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Mannose-6-phosphate isomerase (CG8417)
  2. Probable phosphomannomutase (CG10688)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei16NucleophileBy similarity1
Active sitei18Proton donor/acceptorSequence analysis1
Binding sitei25SubstrateBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei140SubstrateBy similarity1
Binding sitei147SubstrateBy similarity1
Binding sitei185SubstrateBy similarity1
Binding sitei187SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular response to hypoxia Source: FlyBase
  • GDP-mannose biosynthetic process Source: GO_Central
  • mannose metabolic process Source: GO_Central
  • negative regulation of synaptic growth at neuromuscular junction Source: FlyBase
  • positive regulation of Wnt signaling pathway Source: FlyBase
  • protein N-linked glycosylation Source: FlyBase
  • protein targeting to ER Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

ReactomeiR-DME-446205. Synthesis of GDP-mannose.
UniPathwayiUPA00126; UER00424.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphomannomutase (EC:5.4.2.8)
Short name:
PMM
Gene namesi
ORF Names:CG10688
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036300. CG10688.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001996991 – 254Probable phosphomannomutaseAdd BLAST254

Proteomic databases

PaxDbiQ9VTZ6.
PRIDEiQ9VTZ6.

Expressioni

Gene expression databases

BgeeiFBgn0036300.
GenevisibleiQ9VTZ6. DM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi64785. 1 interactor.
STRINGi7227.FBpp0075693.

Structurei

3D structure databases

ProteinModelPortaliQ9VTZ6.
SMRiQ9VTZ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic PMM family.Curated

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
GeneTreeiENSGT00390000002918.
InParanoidiQ9VTZ6.
KOiK17497.
OMAiEFRNGMM.
OrthoDBiEOG091G0J2S.
PhylomeDBiQ9VTZ6.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VTZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTAALKRDE ILLLFDVDGT LTMPRSVVTP EFEEFFYSRV KPRATIGIVG
60 70 80 90 100
GSDLEKMFEQ LNGRKILNEF DFIFPENGLV QIEGGKEVGK QNIIMHLGEE
110 120 130 140 150
TVKRFINFVL RYLSELDVPI KRGTFIEFRN GMMNVCPIGR QCTREERNMF
160 170 180 190 200
AEYDIEHKVR EKMIKDLKQE FADVDLTYSI GGQISFDVFP HGWDKTYCLR
210 220 230 240 250
HIEAHYKFKE IHFFGDKTEP GGNDYEIYSD PRTISHRVYT PKDTQRILTE

ILEL
Length:254
Mass (Da):29,667
Last modified:May 1, 2000 - v1
Checksum:i716E05E7BB2438BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49899.1.
BT009926 mRNA. Translation: AAQ22395.1.
RefSeqiNP_648589.1. NM_140332.2.
UniGeneiDm.23285.

Genome annotation databases

EnsemblMetazoaiFBtr0075961; FBpp0075693; FBgn0036300.
GeneIDi39436.
KEGGidme:Dmel_CG10688.
UCSCiCG10688-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49899.1.
BT009926 mRNA. Translation: AAQ22395.1.
RefSeqiNP_648589.1. NM_140332.2.
UniGeneiDm.23285.

3D structure databases

ProteinModelPortaliQ9VTZ6.
SMRiQ9VTZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64785. 1 interactor.
STRINGi7227.FBpp0075693.

Proteomic databases

PaxDbiQ9VTZ6.
PRIDEiQ9VTZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0075961; FBpp0075693; FBgn0036300.
GeneIDi39436.
KEGGidme:Dmel_CG10688.
UCSCiCG10688-RA. d. melanogaster.

Organism-specific databases

FlyBaseiFBgn0036300. CG10688.

Phylogenomic databases

eggNOGiKOG3189. Eukaryota.
COG0561. LUCA.
GeneTreeiENSGT00390000002918.
InParanoidiQ9VTZ6.
KOiK17497.
OMAiEFRNGMM.
OrthoDBiEOG091G0J2S.
PhylomeDBiQ9VTZ6.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00424.
ReactomeiR-DME-446205. Synthesis of GDP-mannose.

Miscellaneous databases

GenomeRNAii39436.
PROiQ9VTZ6.

Gene expression databases

BgeeiFBgn0036300.
GenevisibleiQ9VTZ6. DM.

Family and domain databases

Gene3Di3.40.50.1000. 2 hits.
InterProiIPR023214. HAD-like_dom.
IPR006379. HAD-SF_hydro_IIB.
IPR005002. PMM.
[Graphical view]
PANTHERiPTHR10466. PTHR10466. 1 hit.
PfamiPF03332. PMM. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01484. HAD-SF-IIB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMM_DROME
AccessioniPrimary (citable) accession number: Q9VTZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.