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Q9VTV9 (Q9VTV9_DROME) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515
Gene names
Name:Pbgs EMBL AAF49936.1 FlyBase FBgn0036271
ORF Names:CG10335 FlyBase FBgn0036271 EMBL AAL48669.1, Dmel_CG10335 EMBL AAF49936.1
OrganismDrosophila melanogaster (Fruit fly)
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515

Subunit structure

Homooctamer By similarity. RuleBase RU000515

Sequence similarities

Belongs to the ALADH family. RuleBase RU004161

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1951Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Active site2481Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
Metal binding1201Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
Metal binding1221Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
Metal binding1291Zinc 2 By similarity PIRSR PIRSR001415-4
Metal binding1301Zinc 1; catalytic By similarity PIRSR PIRSR001415-4
Metal binding2191Zinc 2 By similarity PIRSR PIRSR001415-4
Binding site2051Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2171Substrate 1 By similarity PIRSR PIRSR001415-2
Binding site2751Substrate 2 By similarity PIRSR PIRSR001415-2
Binding site3141Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

Sequence LengthMass (Da)Tools
Q9VTV9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 2DE187AE5F5EF39A

FASTA32735,934
        10         20         30         40         50         60 
MERKLHSGMH HATLRQLQES GCEIAPHNLM YPVFIVSNDD DVQPIASMPG ISRFGLNRLK 

        70         80         90        100        110        120 
EHLEPLVAKG LSSVLLFGVV DPDMKDEQAS NADSAKNPVV LALPKLREWF PDLLIACDVC 

       130        140        150        160        170        180 
ICPYSSHGHC GLLGETGLEN GPSIKRIAEI AVAYAKAGAH IVAPSDMMDN RVKAIKQALI 

       190        200        210        220        230        240 
DAQMNSVSLL AYSAKFTSNF YGPFREAAQS APKFGDRRCY QLPSGSRSLA MRAIQRDVAE 

       250        260        270        280        290        300 
GADMLMVKPG MPYLDILRST KDSYPYHTLY VYQVSGEFAM LYHAAKAGAF DLKDAVLEAM 

       310        320 
KGFRRAGADC IITYYTPFLL DIIGKVK

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley.
[3]Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R., Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A. expand/collapse author list , Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S., Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.
Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Berkeley EMBL AAL48669.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014296 Genomic DNA. Translation: AAF49936.1.
AY071047 mRNA. Translation: AAL48669.1.
RefSeqNP_648564.1. NM_140307.2.
UniGeneDm.6144.

3D structure databases

HSSPHSSP built from PDB template 1E51 based on UniProtKB P13716.
ProteinModelPortalQ9VTV9.
SMRQ9VTV9. Positions 5-320.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9VTV9. 2 interactions.
MINTMINT-1562429.
STRINGQ9VTV9.

Proteomic databases

PRIDEQ9VTV9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0076011; FBpp0075743; FBgn0036271.
GeneID39402.
KEGGdme:Dmel_CG10335.
NMPDRfig|7227.3.peg.9523.

Organism-specific databases

CTD39402.
FlyBaseFBgn0036271. Pbgs.

Phylogenomic databases

eggNOGinNOG07757.
GeneTreeEMGT00050000016887.
InParanoidQ9VTV9.
OMAGAHCVAP.
OrthoDBEOG4HX3GR.
PhylomeDBQ9VTV9.

Gene expression databases

ArrayExpressQ9VTV9.
BgeeQ9VTV9.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR001731. Porphobilinogen_synth.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01698.
PANTHERPTHR11458. AlaD_dehydratase. 1 hit.
PfamPF00490. ALAD. 1 hit.
[Graphical view]
PIRSFPIRSF001415. Porphbilin_synth. 1 hit.
PRINTSPR00144. DALDHYDRTASE.
SMARTSM01004. ALAD. 1 hit.
[Graphical view]
PROSITEPS00169. D_ALA_DEHYDRATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio813463.

Entry information

Entry nameQ9VTV9_DROME
AccessionPrimary (citable) accession number: Q9VTV9
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info