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Protein

Palmitoyltransferase

Gene

app

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferaseUniRule annotationImported, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
PalmitoyltransferaseUniRule annotation (EC:2.3.1.225UniRule annotation)
Gene namesi
Name:appImported
Synonyms:CR32097Imported, Dmel\CG42318Imported
ORF Names:CG17144Imported, CG42318Imported, CG5620Imported, Dmel_CG42318Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0260941. app.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 63HelicalUniRule annotationAdd BLAST20
Transmembranei75 – 92HelicalUniRule annotationAdd BLAST18
Transmembranei191 – 218HelicalUniRule annotationAdd BLAST28
Transmembranei230 – 254HelicalUniRule annotationAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiFBgn0260941.
ExpressionAtlasiQ9VTV6. differential.

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0290276.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini145 – 270zf-DHHCInterPro annotationAdd BLAST126

Domaini

The DHHC domain is required for palmitoyltransferase activity.UniRule annotation

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
OMAiMRRQSTQ.
OrthoDBiEOG091G0BOW.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9VTV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLLCCCCCS NMAPNQRVTR KWELFAGRNK FYCDGLLMSA PHTGVFYLTC
60 70 80 90 100
ILITGTSALF FAFDCPFLAD SINPAIPIVG AVLYFFTMSS LLRTTFTDPG
110 120 130 140 150
VIPRASNDEA AYIEKQIEVP NSLNSPTYRP PPRTKEVLVK GQTVKLKYCF
160 170 180 190 200
TCKIFRPPRA SHCSLCDNCV DRFDHHCPWV GNCVGKRNYR FFYLFLVSLA
210 220 230 240 250
FLAVFIFSCS VTHLVLLMKK EHEVFNVIKA APFTVIVVFI CFFSIWSVIG
260 270 280 290 300
LAGFHTYLTT SDQTTNEDLK GSFSSKGGPR TQNPYSRGNI CLNCCHILCG
310 320 330 340 350
PMTPSLIDRR GIATDEFIQQ MQHQSSPRHA LSDVLSASHM VTTSQPMMGG
360 370 380 390 400
LGGGGIGGAG GGISIGGAEL KPRFYDESNP SSSTLEGNGG AINGHGNGHG
410 420 430 440 450
NGFDHPPPSY DLVQNGKSRK HHQQRCSLQT LLPASAQQQF KASKHKHKQL
460 470 480 490 500
KQHLVAAELQ QHEGGPGPGP NSPSLLRSPA TSSSYRLNLK RSLHLPLTPS
510 520 530 540 550
YDDVRHSPLP LLHHHVHAQQ TTAIGTVAAA AAAVASGASG TNTGTGTGTG
560 570 580 590 600
GSSSSATTTA PTSVSVSLAT APPPLAPRRP STLQLQASGA ISASNSTLTT
610 620 630 640 650
IHTTAPQAPA PTDFKYYSPQ RSTDSNLMRN YPFPKAARGM RRQSTMSVDS
660 670 680 690 700
QKVNIAGYQP LPMRKPYKHQ EVMFELKSPT NRLTIRECDF GGGGEPCDDD
710 720 730 740 750
QSIKDSQIFR VSKRNLYMNH RSPWKERDRY SNLYEYSFNI DLNSIIEDAA

GSDSS
Length:755
Mass (Da):82,257
Last modified:November 30, 2010 - v3
Checksum:i927EE14506DBA2C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49939.3.
AE014296 Genomic DNA. Translation: AAS65016.2.
RefSeqiNP_648561.2. NM_140304.7.
NP_996065.2. NM_206343.5.
UniGeneiDm.5785.

Genome annotation databases

EnsemblMetazoaiFBtr0301054; FBpp0290276; FBgn0260941.
FBtr0301055; FBpp0290277; FBgn0260941.
GeneIDi39399.
UCSCiCG42318-RB. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF49939.3.
AE014296 Genomic DNA. Translation: AAS65016.2.
RefSeqiNP_648561.2. NM_140304.7.
NP_996065.2. NM_206343.5.
UniGeneiDm.5785.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0290276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0301054; FBpp0290276; FBgn0260941.
FBtr0301055; FBpp0290277; FBgn0260941.
GeneIDi39399.
UCSCiCG42318-RB. d. melanogaster.

Organism-specific databases

CTDi351.
FlyBaseiFBgn0260941. app.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00550000074293.
OMAiMRRQSTQ.
OrthoDBiEOG091G0BOW.

Miscellaneous databases

ChiTaRSiapp. fly.
GenomeRNAii39399.

Gene expression databases

BgeeiFBgn0260941.
ExpressionAtlasiQ9VTV6. differential.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9VTV6_DROME
AccessioniPrimary (citable) accession number: Q9VTV6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: November 30, 2010
Last modified: April 12, 2017
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.