Q9VTU1 (APG12_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy protein 12-like
Short name=APG12-like

Gene names

Name:	Atg12
ORF Names:	CG10861

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	111 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for autophagy. Ref.4
Subunit structure	Conjugated to autophagy protein 5-like By similarity.
Subcellular location	Cytoplasm By similarity.
Post-translational modification	Conjugation of the G-112 to the K-132 of Autophagy protein 5-like is a covalent modification that is essential for autophagy By similarity.

Ontologies

Keywords
Biological process	Autophagy Ubl conjugation pathway
Cellular component	Cytoplasm
PTM	Isopeptide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	autophagic vacuole assembly Inferred from electronic annotation. Source: InterPro salivary gland cell autophagic cell death Inferred from expression pattern. Source: FlyBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 111	111	Autophagy protein 12-like		PRO_0000064632
Amino acid modifications
	Cross-link	111		Glycyl lysine isopeptide (Gly-Lys) (interchain with K-132 in APG5) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9VTU1 [UniParc]. Last modified July 7, 2009. Version 3. Checksum: 6FA2EBDA01BC1377	FASTA	111	12,348
	10 20 30 40 50 60 MAETPESQAA LSTSSSTPAD KDGSKICILL NATGNVPIIK KRTWTVDPNK TVGWIQTFIH 70 80 90 100 110 KFLKLDASEQ IFLYVNQTFA PAPDQIIKNL YECHGTNGKL VLYYCKNQAW G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley.
[4]	"Role and regulation of starvation-induced autophagy in the Drosophila fat body." Scott R.C., Schuldiner O., Neufeld T.P. Dev. Cell 7:167-178(2004) [PubMed: 15296714] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAF49955.4. BT022374 mRNA. Translation: AAY54790.1. BT022397 mRNA. Translation: AAY54813.1.
RefSeq	NP_648551.3. NM_140294.3.
UniGene	Dm.27131.
3D structure databases
ProteinModelPortal	Q9VTU1.
SMR	Q9VTU1. Positions 24-110.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9VTU1.
Proteomic databases
PRIDE	Q9VTU1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0300011; FBpp0289288; FBgn0036255.
GeneID	39383.
KEGG	dme:Dmel_CG10861.
NMPDR	fig|7227.3.peg.9500.
Organism-specific databases
CTD	9140.
FlyBase	FBgn0036255. Atg12.
Phylogenomic databases
eggNOG	inNOG11451.
GeneTree	EMGT00050000018114.
InParanoid	Q9VTU1.
OrthoDB	EOG4T1G40.
PhylomeDB	Q9VTU1.
Gene expression databases
Bgee	Q9VTU1.
GermOnline	CG10861. Drosophila melanogaster.
Family and domain databases
InterPro	IPR007242. Autophagy-rel_prot_12. [Graphical view]
KO	K08336.
PANTHER	PTHR13385. APG12. 1 hit.
Pfam	PF04110. APG12. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	813372.

Entry information

Entry name

APG12_DROME

Accession

Primary (citable) accession number: Q9VTU1
Secondary accession number(s): Q4V6A9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	July 7, 2009
Last modified:	January 25, 2012
This is version 73 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project