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Q9VTJ4

- FUCO_DROME

UniProt

Q9VTJ4 - FUCO_DROME

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Protein

Putative alpha-L-fucosidase

Gene

Fuca

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

Catalytic activityi

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

GO - Molecular functioni

  1. alpha-L-fucosidase activity Source: UniProtKB
  2. fucose binding Source: FlyBase

GO - Biological processi

  1. defense response to bacterium Source: FlyBase
  2. fucose metabolic process Source: InterPro
  3. glycosaminoglycan catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH29. Glycoside Hydrolase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative alpha-L-fucosidase (EC:3.2.1.51)
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene namesi
Name:Fuca
ORF Names:CG6128
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036169. Fuca.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. lysosome Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 494469Putative alpha-L-fucosidasePRO_0000010318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9VTJ4.

Expressioni

Gene expression databases

BgeeiQ9VTJ4.

Interactioni

Protein-protein interaction databases

DIPiDIP-19942N.

Structurei

3D structure databases

ProteinModelPortaliQ9VTJ4.
SMRiQ9VTJ4. Positions 43-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 29 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3669.
GeneTreeiENSGT00440000035378.
InParanoidiQ9VTJ4.
KOiK01206.
OMAiVGSICKH.
OrthoDBiEOG7DC249.
PhylomeDBiQ9VTJ4.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10030. PTHR10030. 1 hit.
PfamiPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSiPR00741. GLHYDRLASE29.
SMARTiSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VTJ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAISAWMPLL VALIVVWISA AEVDAQVPGP RTRYQPNWAS LDQRPLPQWY
60 70 80 90 100
DDAKVGIFLH YGVYSVPSFG SEWFWTNWKN LRNPEYVQFM QRNYKPDFTY
110 120 130 140 150
QEFASQFTAE LFNATKWALL FKDSGARYVV LTSKHHDGFT LWPSKNSYGW
160 170 180 190 200
NSMDVGPKRD IVKELAAAIR KESDLRFGLY YSLFEWFNPL WTDDKLHLLM
210 220 230 240 250
QQHFVERKVR PEQMELVQQY LPEIIWSDGD WEAPAKYWRS EEFIAWLYND
260 270 280 290 300
SPVRDTVVTN DRWGFGTACM HGDFYNCADR FNPGVLQAHK WENAFTLDRT
310 320 330 340 350
SWGQRFDVSL SDFMTSKEVI KEIITTVSCN GNVLINVGPT KFGTILPIFE
360 370 380 390 400
ERLRDMGRWL KFNGEGIYGS VPWIYQNDTI NGNVWYTRQK EASNGKITIY
410 420 430 440 450
AFVLEYPYDT NELDIYPLGK DINIFRNVML TGIDMGTGGD ILNEQSTEVV
460 470 480 490
MLGMEDTKIK WNADHNRLHI VFPPKNHIDK RGLDYAWTFK ITIT
Length:494
Mass (Da):57,723
Last modified:October 1, 2002 - v2
Checksum:i96E0B3C893E45F56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAO41255.1.
AY119638 mRNA. Translation: AAM50292.1.
RefSeqiNP_648472.1. NM_140215.3.
UniGeneiDm.7762.

Genome annotation databases

EnsemblMetazoaiFBtr0100588; FBpp0100046; FBgn0036169.
GeneIDi3772574.
KEGGidme:Dmel_CG6128.
UCSCiCG6128-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAO41255.1 .
AY119638 mRNA. Translation: AAM50292.1 .
RefSeqi NP_648472.1. NM_140215.3.
UniGenei Dm.7762.

3D structure databases

ProteinModelPortali Q9VTJ4.
SMRi Q9VTJ4. Positions 43-447.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-19942N.

Protein family/group databases

CAZyi GH29. Glycoside Hydrolase Family 29.

Proteomic databases

PRIDEi Q9VTJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0100588 ; FBpp0100046 ; FBgn0036169 .
GeneIDi 3772574.
KEGGi dme:Dmel_CG6128.
UCSCi CG6128-RA. d. melanogaster.

Organism-specific databases

CTDi 3772574.
FlyBasei FBgn0036169. Fuca.

Phylogenomic databases

eggNOGi COG3669.
GeneTreei ENSGT00440000035378.
InParanoidi Q9VTJ4.
KOi K01206.
OMAi VGSICKH.
OrthoDBi EOG7DC249.
PhylomeDBi Q9VTJ4.

Miscellaneous databases

ChiTaRSi Fuca. fly.
GenomeRNAii 3772574.
NextBioi 854234.
PROi Q9VTJ4.

Gene expression databases

Bgeei Q9VTJ4.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10030. PTHR10030. 1 hit.
Pfami PF01120. Alpha_L_fucos. 1 hit.
[Graphical view ]
PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSi PR00741. GLHYDRLASE29.
SMARTi SM00812. Alpha_L_fucos. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  4. "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism."
    Roos C., Kolmer M., Mattila P., Renkonen R.
    J. Biol. Chem. 277:3168-3175(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMOLOGY.

Entry informationi

Entry nameiFUCO_DROME
AccessioniPrimary (citable) accession number: Q9VTJ4
Secondary accession number(s): A4V1U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

Lacks the cysteine thought to be important for catalysis. It is replaced by Ala-288.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3