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Q9VTJ4

- FUCO_DROME

UniProt

Q9VTJ4 - FUCO_DROME

Protein

Putative alpha-L-fucosidase

Gene

Fuca

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.By similarity

    Catalytic activityi

    An alpha-L-fucoside + H2O = L-fucose + an alcohol.

    GO - Molecular functioni

    1. alpha-L-fucosidase activity Source: UniProtKB
    2. fucose binding Source: FlyBase

    GO - Biological processi

    1. defense response to bacterium Source: FlyBase
    2. fucose metabolic process Source: InterPro
    3. glycosaminoglycan catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH29. Glycoside Hydrolase Family 29.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative alpha-L-fucosidase (EC:3.2.1.51)
    Alternative name(s):
    Alpha-L-fucoside fucohydrolase
    Gene namesi
    Name:Fuca
    ORF Names:CG6128
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0036169. Fuca.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. lysosome Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 494469Putative alpha-L-fucosidasePRO_0000010318Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi377 – 3771N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9VTJ4.

    Expressioni

    Gene expression databases

    BgeeiQ9VTJ4.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-19942N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VTJ4.
    SMRiQ9VTJ4. Positions 32-494.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 29 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3669.
    GeneTreeiENSGT00440000035378.
    InParanoidiQ9VTJ4.
    KOiK01206.
    OMAiVGSICKH.
    OrthoDBiEOG7DC249.
    PhylomeDBiQ9VTJ4.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10030. PTHR10030. 1 hit.
    PfamiPF01120. Alpha_L_fucos. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSiPR00741. GLHYDRLASE29.
    SMARTiSM00812. Alpha_L_fucos. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9VTJ4-1 [UniParc]FASTAAdd to Basket

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    MAISAWMPLL VALIVVWISA AEVDAQVPGP RTRYQPNWAS LDQRPLPQWY    50
    DDAKVGIFLH YGVYSVPSFG SEWFWTNWKN LRNPEYVQFM QRNYKPDFTY 100
    QEFASQFTAE LFNATKWALL FKDSGARYVV LTSKHHDGFT LWPSKNSYGW 150
    NSMDVGPKRD IVKELAAAIR KESDLRFGLY YSLFEWFNPL WTDDKLHLLM 200
    QQHFVERKVR PEQMELVQQY LPEIIWSDGD WEAPAKYWRS EEFIAWLYND 250
    SPVRDTVVTN DRWGFGTACM HGDFYNCADR FNPGVLQAHK WENAFTLDRT 300
    SWGQRFDVSL SDFMTSKEVI KEIITTVSCN GNVLINVGPT KFGTILPIFE 350
    ERLRDMGRWL KFNGEGIYGS VPWIYQNDTI NGNVWYTRQK EASNGKITIY 400
    AFVLEYPYDT NELDIYPLGK DINIFRNVML TGIDMGTGGD ILNEQSTEVV 450
    MLGMEDTKIK WNADHNRLHI VFPPKNHIDK RGLDYAWTFK ITIT 494
    Length:494
    Mass (Da):57,723
    Last modified:October 1, 2002 - v2
    Checksum:i96E0B3C893E45F56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAO41255.1.
    AY119638 mRNA. Translation: AAM50292.1.
    RefSeqiNP_648472.1. NM_140215.3.
    UniGeneiDm.7762.

    Genome annotation databases

    EnsemblMetazoaiFBtr0100588; FBpp0100046; FBgn0036169.
    GeneIDi3772574.
    KEGGidme:Dmel_CG6128.
    UCSCiCG6128-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014296 Genomic DNA. Translation: AAO41255.1 .
    AY119638 mRNA. Translation: AAM50292.1 .
    RefSeqi NP_648472.1. NM_140215.3.
    UniGenei Dm.7762.

    3D structure databases

    ProteinModelPortali Q9VTJ4.
    SMRi Q9VTJ4. Positions 32-494.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-19942N.

    Protein family/group databases

    CAZyi GH29. Glycoside Hydrolase Family 29.

    Proteomic databases

    PRIDEi Q9VTJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0100588 ; FBpp0100046 ; FBgn0036169 .
    GeneIDi 3772574.
    KEGGi dme:Dmel_CG6128.
    UCSCi CG6128-RA. d. melanogaster.

    Organism-specific databases

    CTDi 3772574.
    FlyBasei FBgn0036169. Fuca.

    Phylogenomic databases

    eggNOGi COG3669.
    GeneTreei ENSGT00440000035378.
    InParanoidi Q9VTJ4.
    KOi K01206.
    OMAi VGSICKH.
    OrthoDBi EOG7DC249.
    PhylomeDBi Q9VTJ4.

    Miscellaneous databases

    ChiTaRSi Fuca. drosophila.
    GenomeRNAii 3772574.
    NextBioi 854234.
    PROi Q9VTJ4.

    Gene expression databases

    Bgeei Q9VTJ4.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR016286. FUC_metazoa-typ.
    IPR000933. Glyco_hydro_29.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10030. PTHR10030. 1 hit.
    Pfami PF01120. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001092. Alpha-L-fucosidase. 1 hit.
    PRINTSi PR00741. GLHYDRLASE29.
    SMARTi SM00812. Alpha_L_fucos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    2. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    4. "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism."
      Roos C., Kolmer M., Mattila P., Renkonen R.
      J. Biol. Chem. 277:3168-3175(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: HOMOLOGY.

    Entry informationi

    Entry nameiFUCO_DROME
    AccessioniPrimary (citable) accession number: Q9VTJ4
    Secondary accession number(s): A4V1U8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Caution

    Lacks the cysteine thought to be important for catalysis. It is replaced by Ala-288.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3