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Q9VTJ4 (FUCO_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative alpha-L-fucosidase

EC=3.2.1.51
Alternative name(s):
Alpha-L-fucoside fucohydrolase
Gene names
Name:Fuca
ORF Names:CG6128
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins By similarity. UniProtKB P04066

Catalytic activity

An alpha-L-fucoside + H2O = L-fucose + an alcohol.

Sequence similarities

Belongs to the glycosyl hydrolase 29 family.

Caution

Lacks the cysteine thought to be important for catalysis. It is replaced by Ala-288.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 494469Putative alpha-L-fucosidase
PRO_0000010318

Amino acid modifications

Glycosylation1131N-linked (GlcNAc...) Potential
Glycosylation3771N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9VTJ4 [UniParc].

Last modified October 1, 2002. Version 2.
Checksum: 96E0B3C893E45F56

FASTA49457,723
        10         20         30         40         50         60 
MAISAWMPLL VALIVVWISA AEVDAQVPGP RTRYQPNWAS LDQRPLPQWY DDAKVGIFLH 

        70         80         90        100        110        120 
YGVYSVPSFG SEWFWTNWKN LRNPEYVQFM QRNYKPDFTY QEFASQFTAE LFNATKWALL 

       130        140        150        160        170        180 
FKDSGARYVV LTSKHHDGFT LWPSKNSYGW NSMDVGPKRD IVKELAAAIR KESDLRFGLY 

       190        200        210        220        230        240 
YSLFEWFNPL WTDDKLHLLM QQHFVERKVR PEQMELVQQY LPEIIWSDGD WEAPAKYWRS 

       250        260        270        280        290        300 
EEFIAWLYND SPVRDTVVTN DRWGFGTACM HGDFYNCADR FNPGVLQAHK WENAFTLDRT 

       310        320        330        340        350        360 
SWGQRFDVSL SDFMTSKEVI KEIITTVSCN GNVLINVGPT KFGTILPIFE ERLRDMGRWL 

       370        380        390        400        410        420 
KFNGEGIYGS VPWIYQNDTI NGNVWYTRQK EASNGKITIY AFVLEYPYDT NELDIYPLGK 

       430        440        450        460        470        480 
DINIFRNVML TGIDMGTGGD ILNEQSTEVV MLGMEDTKIK WNADHNRLHI VFPPKNHIDK 

       490 
RGLDYAWTFK ITIT 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[2]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[3]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[4]"Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism."
Roos C., Kolmer M., Mattila P., Renkonen R.
J. Biol. Chem. 277:3168-3175(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: HOMOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014296 Genomic DNA. Translation: AAF50054.2.
AE014296 Genomic DNA. Translation: AAO41255.1.
AY119638 mRNA. Translation: AAM50292.1.
RefSeqNP_648472.1. NM_140215.3.
UniGeneDm.7762.

3D structure databases

ProteinModelPortalQ9VTJ4.
SMRQ9VTJ4. Positions 33-494.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-19942N.

Protein family/group databases

CAZyGH29. Glycoside Hydrolase Family 29.

Proteomic databases

PRIDEQ9VTJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0100588; FBpp0100046; FBgn0036169.
GeneID3772574.
KEGGdme:Dmel_CG6128.
UCSCCG6128-RA. d. melanogaster.

Organism-specific databases

CTD3772574.
FlyBaseFBgn0036169. Fuca.

Phylogenomic databases

eggNOGCOG3669.
GeneTreeENSGT00440000035378.
InParanoidQ9VTJ4.
KOK01206.
OMAQFTAEFF.
OrthoDBEOG7DC249.
PhylomeDBQ9VTJ4.

Gene expression databases

BgeeQ9VTJ4.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR016286. FUC_metazoa-typ.
IPR000933. Glyco_hydro_29.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR10030. PTHR10030. 1 hit.
PfamPF01120. Alpha_L_fucos. 1 hit.
[Graphical view]
PIRSFPIRSF001092. Alpha-L-fucosidase. 1 hit.
PRINTSPR00741. GLHYDRLASE29.
SMARTSM00812. Alpha_L_fucos. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Other

ChiTaRSFuca. drosophila.
GenomeRNAi3772574.
NextBio854234.
PROQ9VTJ4.

Entry information

Entry nameFUCO_DROME
AccessionPrimary (citable) accession number: Q9VTJ4
Secondary accession number(s): A4V1U8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase