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Q9VTI8 (CHRB_DROME) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein charybde
Alternative name(s):
Protein charybdis
Protein regulated in development and DNA damage response 1
Short name=REDD-1
Gene names
Name:chrb
Synonyms:char
ORF Names:CG7533
OrganismDrosophila melanogaster (Fruit fly) [Reference proteome]
Taxonomic identifier7227 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development. Ref.6 Ref.7 Ref.8

Subcellular location

Cytoplasm By similarity.

Developmental stage

Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic development, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells. Ref.8

Induction

Expression is controlled by homeobox transcription factors. At larval stages, induced by starvation, and mildly by hypoxia in midgut but not fat body. Ref.6 Ref.8

Sequence similarities

Belongs to the DDIT4 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Protein charybde
PRO_0000307209

Experimental info

Sequence conflict1541C → G in AAF59840. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9VTI8 [UniParc].

Last modified March 1, 2001. Version 2.
Checksum: CD224D3BFBF315E7

FASTA29932,179
        10         20         30         40         50         60 
MKMEVLSVQN HIQGKFGVNK IKDWQASTAP LEEEEELTAG VNGNTAAGEG ILDVDVVDGH 

        70         80         90        100        110        120 
PASVLHMRQH QALNTRPSAT PPSAGGGGPL AGGGSVGMTT PKQATSPVAA ASFEAPLSGG 

       130        140        150        160        170        180 
SAAAYHHAYM TNVLSSTAQQ HHPLPASPLQ STACARFGAA DNLDDVSASA VRELSQQLQA 

       190        200        210        220        230        240 
QLRDAKRRHL ACTEVTLPND LTQRIAAEII RMSEREPCGE RACTLFIEFE SEPNKVKRIA 

       250        260        270        280        290 
YFKVDPDTVS IFELYLTLRQ DKSGWSSLVP QFIKNLTRSN TINISPDFTL TKKKLYSSE 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of charybde and scylla, two paralogous target genes of Hox and cofactors proteins in Drosophila."
Chauvet S., Maurel-Zaffran C., Miassod R., Jullien N., Pradel J., Aragnol D.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The genome sequence of Drosophila melanogaster."
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. expand/collapse author list , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Berkeley.
[3]"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review."
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. expand/collapse author list , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: Berkeley.
[4]"A Drosophila full-length cDNA resource."
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Berkeley.
Tissue: Embryo.
[5]"REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species."
Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K., Oliner J.D., McKeon F., Haber D.A.
Mol. Cell 10:995-1005(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]"The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila."
Reiling J.H., Hafen E.
Genes Dev. 18:2879-2892(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[7]"The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway."
Corradetti M.N., Inoki K., Guan K.-L.
J. Biol. Chem. 280:9769-9772(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila."
Scuderi A., Simin K., Kazuko S.G., Metherall J.E., Letsou A.
Dev. Biol. 291:110-122(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF221109 mRNA. Translation: AAF59840.1.
AE014296 Genomic DNA. Translation: AAF50060.2.
AY060367 mRNA. Translation: AAL25406.1.
RefSeqNP_001261711.1. NM_001274782.1.
NP_648470.2. NM_140213.4.
UniGeneDm.20385.

3D structure databases

ProteinModelPortalQ9VTI8.
SMRQ9VTI8. Positions 164-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid64656. 2 interactions.
IntActQ9VTI8. 1 interaction.
MINTMINT-912909.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0076093; FBpp0099774; FBgn0036165.
FBtr0331841; FBpp0304225; FBgn0036165.
GeneID39284.
KEGGdme:Dmel_CG7533.

Organism-specific databases

CTD39284.
FlyBaseFBgn0036165. chrb.

Phylogenomic databases

eggNOGNOG71738.
GeneTreeENSGT00530000063652.
InParanoidQ9VTI8.
OMACGERACT.
OrthoDBEOG7P2XTF.
PhylomeDBQ9VTI8.

Gene expression databases

BgeeQ9VTI8.

Family and domain databases

InterProIPR012918. RTP801-like.
[Graphical view]
PANTHERPTHR12478. PTHR12478. 1 hit.
PfamPF07809. RTP801_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSchrb. drosophila.
GenomeRNAi39284.
NextBio812898.

Entry information

Entry nameCHRB_DROME
AccessionPrimary (citable) accession number: Q9VTI8
Secondary accession number(s): Q9NHN5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase