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Protein

Protein charybde

Gene

chrb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development.3 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB
  • cell death Source: FlyBase
  • head involution Source: UniProtKB
  • negative regulation of growth Source: FlyBase
  • negative regulation of signal transduction Source: InterPro
  • regulation of TOR signaling Source: UniProtKB
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-DME-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein charybde
Alternative name(s):
Protein charybdis
Protein regulated in development and DNA damage response 1
Short name:
REDD-1
Gene namesi
Name:chrb
Synonyms:char
ORF Names:CG7533
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036165. chrb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003072091 – 299Protein charybdeAdd BLAST299

Proteomic databases

PaxDbiQ9VTI8.
PRIDEiQ9VTI8.

Expressioni

Developmental stagei

Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic development, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells.1 Publication

Inductioni

Expression is controlled by homeobox transcription factors. At larval stages, induced by starvation, and mildly by hypoxia in midgut but not fat body.2 Publications

Gene expression databases

BgeeiFBgn0036165.
ExpressionAtlasiQ9VTI8. baseline.
GenevisibleiQ9VTI8. DM.

Interactioni

Protein-protein interaction databases

BioGridi64656. 3 interactors.
IntActiQ9VTI8. 6 interactors.
MINTiMINT-912909.
STRINGi7227.FBpp0304225.

Structurei

3D structure databases

ProteinModelPortaliQ9VTI8.
SMRiQ9VTI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DDIT4 family.Curated

Phylogenomic databases

eggNOGiENOG410J0CV. Eukaryota.
ENOG4111V50. LUCA.
GeneTreeiENSGT00530000063652.
InParanoidiQ9VTI8.
OMAiEREPCGE.
OrthoDBiEOG091G0LVJ.
PhylomeDBiQ9VTI8.

Family and domain databases

InterProiIPR012918. RTP801-like.
[Graphical view]
PANTHERiPTHR12478. PTHR12478. 1 hit.
PfamiPF07809. RTP801_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VTI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMEVLSVQN HIQGKFGVNK IKDWQASTAP LEEEEELTAG VNGNTAAGEG
60 70 80 90 100
ILDVDVVDGH PASVLHMRQH QALNTRPSAT PPSAGGGGPL AGGGSVGMTT
110 120 130 140 150
PKQATSPVAA ASFEAPLSGG SAAAYHHAYM TNVLSSTAQQ HHPLPASPLQ
160 170 180 190 200
STACARFGAA DNLDDVSASA VRELSQQLQA QLRDAKRRHL ACTEVTLPND
210 220 230 240 250
LTQRIAAEII RMSEREPCGE RACTLFIEFE SEPNKVKRIA YFKVDPDTVS
260 270 280 290
IFELYLTLRQ DKSGWSSLVP QFIKNLTRSN TINISPDFTL TKKKLYSSE
Length:299
Mass (Da):32,179
Last modified:March 1, 2001 - v2
Checksum:iCD224D3BFBF315E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154C → G in AAF59840 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221109 mRNA. Translation: AAF59840.1.
AE014296 Genomic DNA. Translation: AAF50060.2.
AY060367 mRNA. Translation: AAL25406.1.
RefSeqiNP_648470.2. NM_140213.5.
UniGeneiDm.20385.

Genome annotation databases

EnsemblMetazoaiFBtr0076093; FBpp0099774; FBgn0036165.
GeneIDi39284.
KEGGidme:Dmel_CG7533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221109 mRNA. Translation: AAF59840.1.
AE014296 Genomic DNA. Translation: AAF50060.2.
AY060367 mRNA. Translation: AAL25406.1.
RefSeqiNP_648470.2. NM_140213.5.
UniGeneiDm.20385.

3D structure databases

ProteinModelPortaliQ9VTI8.
SMRiQ9VTI8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64656. 3 interactors.
IntActiQ9VTI8. 6 interactors.
MINTiMINT-912909.
STRINGi7227.FBpp0304225.

Proteomic databases

PaxDbiQ9VTI8.
PRIDEiQ9VTI8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076093; FBpp0099774; FBgn0036165.
GeneIDi39284.
KEGGidme:Dmel_CG7533.

Organism-specific databases

CTDi39284.
FlyBaseiFBgn0036165. chrb.

Phylogenomic databases

eggNOGiENOG410J0CV. Eukaryota.
ENOG4111V50. LUCA.
GeneTreeiENSGT00530000063652.
InParanoidiQ9VTI8.
OMAiEREPCGE.
OrthoDBiEOG091G0LVJ.
PhylomeDBiQ9VTI8.

Enzyme and pathway databases

ReactomeiR-DME-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

ChiTaRSichrb. fly.
GenomeRNAii39284.
PROiQ9VTI8.

Gene expression databases

BgeeiFBgn0036165.
ExpressionAtlasiQ9VTI8. baseline.
GenevisibleiQ9VTI8. DM.

Family and domain databases

InterProiIPR012918. RTP801-like.
[Graphical view]
PANTHERiPTHR12478. PTHR12478. 1 hit.
PfamiPF07809. RTP801_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHRB_DROME
AccessioniPrimary (citable) accession number: Q9VTI8
Secondary accession number(s): Q9NHN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.