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Q9VTI8

- CHRB_DROME

UniProt

Q9VTI8 - CHRB_DROME

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Protein
Protein charybde
Gene
chrb, char, CG7533
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development.3 Publications

GO - Biological processi

  1. apoptotic process Source: UniProtKB
  2. cell death Source: FlyBase
  3. head involution Source: UniProtKB
  4. negative regulation of growth Source: FlyBase
  5. negative regulation of signal transduction Source: InterPro
  6. regulation of TOR signaling Source: UniProtKB
  7. response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein charybde
Alternative name(s):
Protein charybdis
Protein regulated in development and DNA damage response 1
Short name:
REDD-1
Gene namesi
Name:chrb
Synonyms:char
ORF Names:CG7533
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0036165. chrb.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 299299Protein charybde
PRO_0000307209Add
BLAST

Expressioni

Developmental stagei

Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic development, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells.1 Publication

Inductioni

Expression is controlled by homeobox transcription factors. At larval stages, induced by starvation, and mildly by hypoxia in midgut but not fat body.2 Publications

Gene expression databases

BgeeiQ9VTI8.

Interactioni

Protein-protein interaction databases

BioGridi64656. 2 interactions.
IntActiQ9VTI8. 1 interaction.
MINTiMINT-912909.

Structurei

3D structure databases

ProteinModelPortaliQ9VTI8.
SMRiQ9VTI8. Positions 164-296.

Family & Domainsi

Sequence similaritiesi

Belongs to the DDIT4 family.

Phylogenomic databases

eggNOGiNOG71738.
GeneTreeiENSGT00530000063652.
InParanoidiQ9VTI8.
OMAiCGERACT.
OrthoDBiEOG7P2XTF.
PhylomeDBiQ9VTI8.

Family and domain databases

InterProiIPR012918. RTP801-like.
[Graphical view]
PANTHERiPTHR12478. PTHR12478. 1 hit.
PfamiPF07809. RTP801_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9VTI8-1 [UniParc]FASTAAdd to Basket

« Hide

MKMEVLSVQN HIQGKFGVNK IKDWQASTAP LEEEEELTAG VNGNTAAGEG    50
ILDVDVVDGH PASVLHMRQH QALNTRPSAT PPSAGGGGPL AGGGSVGMTT 100
PKQATSPVAA ASFEAPLSGG SAAAYHHAYM TNVLSSTAQQ HHPLPASPLQ 150
STACARFGAA DNLDDVSASA VRELSQQLQA QLRDAKRRHL ACTEVTLPND 200
LTQRIAAEII RMSEREPCGE RACTLFIEFE SEPNKVKRIA YFKVDPDTVS 250
IFELYLTLRQ DKSGWSSLVP QFIKNLTRSN TINISPDFTL TKKKLYSSE 299
Length:299
Mass (Da):32,179
Last modified:March 1, 2001 - v2
Checksum:iCD224D3BFBF315E7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541C → G in AAF59840. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF221109 mRNA. Translation: AAF59840.1.
AE014296 Genomic DNA. Translation: AAF50060.2.
AY060367 mRNA. Translation: AAL25406.1.
RefSeqiNP_001261711.1. NM_001274782.1.
NP_648470.2. NM_140213.4.
UniGeneiDm.20385.

Genome annotation databases

EnsemblMetazoaiFBtr0076093; FBpp0099774; FBgn0036165.
FBtr0331841; FBpp0304225; FBgn0036165.
GeneIDi39284.
KEGGidme:Dmel_CG7533.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF221109 mRNA. Translation: AAF59840.1 .
AE014296 Genomic DNA. Translation: AAF50060.2 .
AY060367 mRNA. Translation: AAL25406.1 .
RefSeqi NP_001261711.1. NM_001274782.1.
NP_648470.2. NM_140213.4.
UniGenei Dm.20385.

3D structure databases

ProteinModelPortali Q9VTI8.
SMRi Q9VTI8. Positions 164-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 64656. 2 interactions.
IntActi Q9VTI8. 1 interaction.
MINTi MINT-912909.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0076093 ; FBpp0099774 ; FBgn0036165 .
FBtr0331841 ; FBpp0304225 ; FBgn0036165 .
GeneIDi 39284.
KEGGi dme:Dmel_CG7533.

Organism-specific databases

CTDi 39284.
FlyBasei FBgn0036165. chrb.

Phylogenomic databases

eggNOGi NOG71738.
GeneTreei ENSGT00530000063652.
InParanoidi Q9VTI8.
OMAi CGERACT.
OrthoDBi EOG7P2XTF.
PhylomeDBi Q9VTI8.

Miscellaneous databases

ChiTaRSi chrb. drosophila.
GenomeRNAii 39284.
NextBioi 812898.

Gene expression databases

Bgeei Q9VTI8.

Family and domain databases

InterProi IPR012918. RTP801-like.
[Graphical view ]
PANTHERi PTHR12478. PTHR12478. 1 hit.
Pfami PF07809. RTP801_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of charybde and scylla, two paralogous target genes of Hox and cofactors proteins in Drosophila."
    Chauvet S., Maurel-Zaffran C., Miassod R., Jullien N., Pradel J., Aragnol D.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  5. "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species."
    Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K., Oliner J.D., McKeon F., Haber D.A.
    Mol. Cell 10:995-1005(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  6. "The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila."
    Reiling J.H., Hafen E.
    Genes Dev. 18:2879-2892(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  7. "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway."
    Corradetti M.N., Inoki K., Guan K.-L.
    J. Biol. Chem. 280:9769-9772(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila."
    Scuderi A., Simin K., Kazuko S.G., Metherall J.E., Letsou A.
    Dev. Biol. 291:110-122(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCHRB_DROME
AccessioniPrimary (citable) accession number: Q9VTI8
Secondary accession number(s): Q9NHN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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