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Q9VTI8

- CHRB_DROME

UniProt

Q9VTI8 - CHRB_DROME

Protein

Protein charybde

Gene

chrb

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development.3 Publications

    GO - Biological processi

    1. apoptotic process Source: UniProtKB
    2. cell death Source: FlyBase
    3. head involution Source: UniProtKB
    4. negative regulation of growth Source: FlyBase
    5. negative regulation of signal transduction Source: InterPro
    6. regulation of TOR signaling Source: UniProtKB
    7. response to oxidative stress Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein charybde
    Alternative name(s):
    Protein charybdis
    Protein regulated in development and DNA damage response 1
    Short name:
    REDD-1
    Gene namesi
    Name:chrb
    Synonyms:char
    ORF Names:CG7533
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 3L

    Organism-specific databases

    FlyBaseiFBgn0036165. chrb.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 299299Protein charybdePRO_0000307209Add
    BLAST

    Expressioni

    Developmental stagei

    Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic development, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells.1 Publication

    Inductioni

    Expression is controlled by homeobox transcription factors. At larval stages, induced by starvation, and mildly by hypoxia in midgut but not fat body.2 Publications

    Gene expression databases

    BgeeiQ9VTI8.

    Interactioni

    Protein-protein interaction databases

    BioGridi64656. 2 interactions.
    IntActiQ9VTI8. 1 interaction.
    MINTiMINT-912909.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9VTI8.
    SMRiQ9VTI8. Positions 164-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DDIT4 family.Curated

    Phylogenomic databases

    eggNOGiNOG71738.
    GeneTreeiENSGT00530000063652.
    InParanoidiQ9VTI8.
    OMAiCGERACT.
    OrthoDBiEOG7P2XTF.
    PhylomeDBiQ9VTI8.

    Family and domain databases

    InterProiIPR012918. RTP801-like.
    [Graphical view]
    PANTHERiPTHR12478. PTHR12478. 1 hit.
    PfamiPF07809. RTP801_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9VTI8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKMEVLSVQN HIQGKFGVNK IKDWQASTAP LEEEEELTAG VNGNTAAGEG    50
    ILDVDVVDGH PASVLHMRQH QALNTRPSAT PPSAGGGGPL AGGGSVGMTT 100
    PKQATSPVAA ASFEAPLSGG SAAAYHHAYM TNVLSSTAQQ HHPLPASPLQ 150
    STACARFGAA DNLDDVSASA VRELSQQLQA QLRDAKRRHL ACTEVTLPND 200
    LTQRIAAEII RMSEREPCGE RACTLFIEFE SEPNKVKRIA YFKVDPDTVS 250
    IFELYLTLRQ DKSGWSSLVP QFIKNLTRSN TINISPDFTL TKKKLYSSE 299
    Length:299
    Mass (Da):32,179
    Last modified:March 1, 2001 - v2
    Checksum:iCD224D3BFBF315E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti154 – 1541C → G in AAF59840. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF221109 mRNA. Translation: AAF59840.1.
    AE014296 Genomic DNA. Translation: AAF50060.2.
    AY060367 mRNA. Translation: AAL25406.1.
    RefSeqiNP_001261711.1. NM_001274782.1.
    NP_648470.2. NM_140213.4.
    UniGeneiDm.20385.

    Genome annotation databases

    EnsemblMetazoaiFBtr0076093; FBpp0099774; FBgn0036165.
    FBtr0331841; FBpp0304225; FBgn0036165.
    GeneIDi39284.
    KEGGidme:Dmel_CG7533.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF221109 mRNA. Translation: AAF59840.1 .
    AE014296 Genomic DNA. Translation: AAF50060.2 .
    AY060367 mRNA. Translation: AAL25406.1 .
    RefSeqi NP_001261711.1. NM_001274782.1.
    NP_648470.2. NM_140213.4.
    UniGenei Dm.20385.

    3D structure databases

    ProteinModelPortali Q9VTI8.
    SMRi Q9VTI8. Positions 164-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 64656. 2 interactions.
    IntActi Q9VTI8. 1 interaction.
    MINTi MINT-912909.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0076093 ; FBpp0099774 ; FBgn0036165 .
    FBtr0331841 ; FBpp0304225 ; FBgn0036165 .
    GeneIDi 39284.
    KEGGi dme:Dmel_CG7533.

    Organism-specific databases

    CTDi 39284.
    FlyBasei FBgn0036165. chrb.

    Phylogenomic databases

    eggNOGi NOG71738.
    GeneTreei ENSGT00530000063652.
    InParanoidi Q9VTI8.
    OMAi CGERACT.
    OrthoDBi EOG7P2XTF.
    PhylomeDBi Q9VTI8.

    Miscellaneous databases

    ChiTaRSi chrb. drosophila.
    GenomeRNAii 39284.
    NextBioi 812898.

    Gene expression databases

    Bgeei Q9VTI8.

    Family and domain databases

    InterProi IPR012918. RTP801-like.
    [Graphical view ]
    PANTHERi PTHR12478. PTHR12478. 1 hit.
    Pfami PF07809. RTP801_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of charybde and scylla, two paralogous target genes of Hox and cofactors proteins in Drosophila."
      Chauvet S., Maurel-Zaffran C., Miassod R., Jullien N., Pradel J., Aragnol D.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    3. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Berkeley.
      Tissue: Embryo.
    5. "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species."
      Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K., Oliner J.D., McKeon F., Haber D.A.
      Mol. Cell 10:995-1005(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    6. "The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila."
      Reiling J.H., Hafen E.
      Genes Dev. 18:2879-2892(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    7. "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway."
      Corradetti M.N., Inoki K., Guan K.-L.
      J. Biol. Chem. 280:9769-9772(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila."
      Scuderi A., Simin K., Kazuko S.G., Metherall J.E., Letsou A.
      Dev. Biol. 291:110-122(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCHRB_DROME
    AccessioniPrimary (citable) accession number: Q9VTI8
    Secondary accession number(s): Q9NHN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3