Q9VTH4 (SCLLA_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 70.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein scylla Alternative name(s): Protein regulated in development and DNA damage response 2 Short name=REDD-2 | ||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Reference proteome] | ||||
| Taxonomic identifier | 7227 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › ![]() |
Protein attributes
| Sequence length | 280 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Inhibits cell growth by regulating the Tor pathway upstream of the Tsc1-Tsc2 complex and downstream of Akt1. Acts as cell death activator during head development. Ref.7 Ref.8 Ref.9 |
| Subcellular location | Cytoplasm By similarity. |
| Developmental stage | Expression peaks 2-8 hours after egg laying. Expressed in the dorsal domains of gastrulation stage embryos. During mid-embryonic developmental stages, expressed in the central nervous system, the three thoracic segments and the cardiac precursor cells. Ref.9 |
| Induction | Expression is controlled by homeobox transcription factors. At larval stages, induced by starvation, and by hypoxia in midgut and fat body. Ref.7 Ref.9 |
| Sequence similarities | Belongs to the DDIT4 family. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform A (identifier: Q9VTH4-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform B (identifier: Q9VTH4-2) The sequence of this isoform differs from the canonical sequence as follows: 1-39: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 280 | 280 | Protein scylla | PRO_0000307211 | |||||
Natural variations | |||||||||
| Alternative sequence | 1 – 39 | 39 | Missing in isoform B. | VSP_028636 | |||||
Experimental info | |||||||||
| Sequence conflict | 21 | 1 | K → E in AAV36860. Ref.4 | ||||||
| Sequence conflict | 203 | 1 | S → P in AAF59841. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of charybde and scylla, two paralogous target genes of Hox and cofactors proteins in Drosophila." Chauvet S., Maurel-Zaffran C., Miassod R., Jullien N., Pradel J., Aragnol D. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). |
| [2] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [3] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING (ISOFORMS A AND B). Strain: Berkeley. |
| [4] | "A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B). Strain: Berkeley. Tissue: Embryo. |
| [5] | Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Strain: Berkeley. |
| [6] | "REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species." Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K., Oliner J.D., McKeon F., Haber D.A. Mol. Cell 10:995-1005(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION. |
| [7] | "The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila." Reiling J.H., Hafen E. Genes Dev. 18:2879-2892(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION. |
| [8] | "The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway." Corradetti M.N., Inoki K., Guan K.-L. J. Biol. Chem. 280:9769-9772(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION. |
| [9] | "scylla and charybde, homologues of the human apoptotic gene RTP801, are required for head involution in Drosophila." Scuderi A., Simin K., Kazuko S.G., Metherall J.E., Letsou A. Dev. Biol. 291:110-122(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION, DEVELOPMENTAL STAGE. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF221110 mRNA. Translation: AAF59841.1. AE014296 Genomic DNA. Translation: AAF50074.1. AE014296 Genomic DNA. Translation: AAS65038.1. AY075382 mRNA. Translation: AAL68220.1. BT015975 mRNA. Translation: AAV36860.1. BT057991 mRNA. Translation: ACM16701.1. |
| RefSeq | NP_648456.2. NM_140199.3. |
| UniGene | Dm.6574. |
3D structure databases | |
| ProteinModelPortal | Q9VTH4. |
| SMR | Q9VTH4. Positions 154-251. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-976501. |
| STRING | 7227.FBpp0075899. |
Proteomic databases | |
| PRIDE | Q9VTH4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0076168; FBpp0075899; FBgn0041094. |
| GeneID | 39270. |
| KEGG | dme:Dmel_CG7590. |
| UCSC | CG7590-RA. d. melanogaster. |
Organism-specific databases | |
| CTD | 39270. |
| FlyBase | FBgn0041094. scyl. |
Phylogenomic databases | |
| eggNOG | NOG71738. |
| GeneTree | ENSGT00530000063652. |
| InParanoid | Q9VTH4. |
| OMA | ISPEYTI. |
| OrthoDB | EOG4FJ6RK. |
| PhylomeDB | Q9VTH4. |
Gene expression databases | |
| Bgee | Q9VTH4. |
Family and domain databases | |
| InterPro | IPR012918. RTP801-like. [Graphical view] |
| PANTHER | PTHR12478. PTHR12478. 1 hit. |
| Pfam | PF07809. RTP801_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | scyl. drosophila. |
| GenomeRNAi | 39270. |
| NextBio | 812820. |
Entry information
| Entry name | SCLLA_DROME | ||||||||
| Accession | Primary (citable) accession number: Q9VTH4 Secondary accession number(s): B9EQR6 Q9NHN4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with
