Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable insulin-like peptide 3

Gene

Ilp3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin receptor binding Source: UniProtKB

GO - Biological processi

  • female mating behavior Source: FlyBase
  • insulin receptor signaling pathway Source: UniProtKB
  • locomotor rhythm Source: FlyBase
  • sleep Source: FlyBase
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9VT52.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable insulin-like peptide 3
Short name:
dILP3
Alternative name(s):
Insulin-related peptide 3
Cleaved into the following 2 chains:
Gene namesi
Name:Ilp3
ORF Names:CG14167
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0044050. Ilp3.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001619330 – 120Probable insulin-like peptide 3Add BLAST91
PeptideiPRO_000001619430 – 48Probable insulin-like peptide 3 B chainSequence analysisAdd BLAST19
PropeptideiPRO_000001619551 – 89Connecting peptideSequence analysisAdd BLAST39
PeptideiPRO_000001619692 – 120Probable insulin-like peptide 3 A chainSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 101Interchain (between B and A chains)By similarity
Disulfide bondi46 ↔ 114Interchain (between B and A chains)By similarity
Disulfide bondi100 ↔ 105By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9VT52.
PRIDEiQ9VT52.

Expressioni

Tissue specificityi

Expressed at a high level in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells.1 Publication

Developmental stagei

Expressed in the larva, but not in the embryo.1 Publication

Gene expression databases

BgeeiFBgn0044050.
ExpressionAtlasiQ9VT52. baseline.
GenevisibleiQ9VT52. DM.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

  • insulin receptor binding Source: UniProtKB

Protein-protein interaction databases

STRINGi7227.FBpp0076102.

Structurei

3D structure databases

ProteinModelPortaliQ9VT52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KAYJ. Eukaryota.
ENOG411155G. LUCA.
InParanoidiQ9VT52.
KOiK04526.
OMAiLCVYGFN.
OrthoDBiEOG091G0H56.
PhylomeDBiQ9VT52.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VT52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIEMRCQDR RILLPSLLLL ILMIGGVQAT MKLCGRKLPE TLSKLCVYGF
60 70 80 90 100
NAMTKRTLDP VNFNQIDGFE DRSLLERLLS DSSVQMLKTR RLRDGVFDEC
110 120
CLKSCTMDEV LRYCAAKPRT
Length:120
Mass (Da):13,708
Last modified:June 7, 2004 - v2
Checksum:iFA834C8BAE1CE31B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50203.2.
RefSeqiNP_648360.2. NM_140103.3.
UniGeneiDm.27102.

Genome annotation databases

EnsemblMetazoaiFBtr0076373; FBpp0076102; FBgn0044050.
GeneIDi39151.
KEGGidme:Dmel_CG14167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA. Translation: AAF50203.2.
RefSeqiNP_648360.2. NM_140103.3.
UniGeneiDm.27102.

3D structure databases

ProteinModelPortaliQ9VT52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0076102.

Proteomic databases

PaxDbiQ9VT52.
PRIDEiQ9VT52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076373; FBpp0076102; FBgn0044050.
GeneIDi39151.
KEGGidme:Dmel_CG14167.

Organism-specific databases

CTDi39151.
FlyBaseiFBgn0044050. Ilp3.

Phylogenomic databases

eggNOGiENOG410KAYJ. Eukaryota.
ENOG411155G. LUCA.
InParanoidiQ9VT52.
KOiK04526.
OMAiLCVYGFN.
OrthoDBiEOG091G0H56.
PhylomeDBiQ9VT52.

Enzyme and pathway databases

SignaLinkiQ9VT52.

Miscellaneous databases

GenomeRNAii39151.
PROiQ9VT52.

Gene expression databases

BgeeiFBgn0044050.
ExpressionAtlasiQ9VT52. baseline.
GenevisibleiQ9VT52. DM.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINSL3_DROME
AccessioniPrimary (citable) accession number: Q9VT52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.