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Protein

Probable insulin-like peptide 3

Gene

Ilp3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • hormone activity Source: InterPro
  • insulin receptor binding Source: UniProtKB

GO - Biological processi

  • cell surface receptor signaling pathway Source: Reactome
  • entry into reproductive diapause Source: FlyBase
  • female mating behavior Source: FlyBase
  • insulin receptor signaling pathway Source: FlyBase
  • locomotor rhythm Source: FlyBase
  • phosphatidylinositol phosphorylation Source: Reactome
  • positive regulation of TOR signaling Source: FlyBase
  • response to carbohydrate Source: FlyBase
  • sleep Source: FlyBase

Enzyme and pathway databases

ReactomeiR-DME-110478 Insulin signaling pathway
SignaLinkiQ9VT52

Names & Taxonomyi

Protein namesi
Recommended name:
Probable insulin-like peptide 3
Short name:
dILP3
Alternative name(s):
Insulin-related peptide 3
Cleaved into the following 2 chains:
Gene namesi
Name:Ilp3
ORF Names:CG14167
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0044050 Ilp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000001619330 – 120Probable insulin-like peptide 3Add BLAST91
PeptideiPRO_000001619430 – 48Probable insulin-like peptide 3 B chainSequence analysisAdd BLAST19
PropeptideiPRO_000001619551 – 89Connecting peptideSequence analysisAdd BLAST39
PeptideiPRO_000001619692 – 120Probable insulin-like peptide 3 A chainSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 101Interchain (between B and A chains)By similarity
Disulfide bondi46 ↔ 114Interchain (between B and A chains)By similarity
Disulfide bondi100 ↔ 105By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiQ9VT52
PRIDEiQ9VT52

Expressioni

Tissue specificityi

Expressed at a high level in seven cells of each larval brain hemisphere that may correspond to neurosecretory cells.1 Publication

Developmental stagei

Expressed in the larva, but not in the embryo.1 Publication

Gene expression databases

BgeeiFBgn0044050
ExpressionAtlasiQ9VT52 differential
GenevisibleiQ9VT52 DM

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

  • hormone activity Source: InterPro
  • insulin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi64539, 2 interactors
STRINGi7227.FBpp0076102

Structurei

3D structure databases

ProteinModelPortaliQ9VT52
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410KAYJ Eukaryota
ENOG411155G LUCA
InParanoidiQ9VT52
KOiK04526
OMAiQATMKLC
OrthoDBiEOG091G0H56
PhylomeDBiQ9VT52

Family and domain databases

InterProiView protein in InterPro
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9VT52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIEMRCQDR RILLPSLLLL ILMIGGVQAT MKLCGRKLPE TLSKLCVYGF
60 70 80 90 100
NAMTKRTLDP VNFNQIDGFE DRSLLERLLS DSSVQMLKTR RLRDGVFDEC
110 120
CLKSCTMDEV LRYCAAKPRT
Length:120
Mass (Da):13,708
Last modified:June 7, 2004 - v2
Checksum:iFA834C8BAE1CE31B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF50203.2
RefSeqiNP_648360.2, NM_140103.3
UniGeneiDm.27102

Genome annotation databases

EnsemblMetazoaiFBtr0076373; FBpp0076102; FBgn0044050
GeneIDi39151
KEGGidme:Dmel_CG14167

Similar proteinsi

Entry informationi

Entry nameiINSL3_DROME
AccessioniPrimary (citable) accession number: Q9VT52
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 7, 2004
Last modified: April 25, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health