Q9VT50 (INSL1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable insulin-like peptide 1
Short name=dILP1

Alternative name(s):
Insulin-related peptide 1

Cleaved into the following 2 chains:

1. Probable insulin-like peptide 1 A chain
2. Probable insulin-like peptide 1 B chain

Gene names

Name:	Ilp1
ORF Names:	CG14173

Organism

Drosophila melanogaster (Fruit fly)

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure	Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the insulin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Cleavage on pair of basic residues Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	insulin receptor signaling pathway Inferred from sequence or structural similarity Ref.3. Source: UniProtKB
Cellular component	extracellular region Traceable author statement. Source: Reactome
Molecular function	hormone activity Inferred from electronic annotation. Source: InterPro insulin receptor binding Inferred from sequence or structural similarity Ref.3. Source: UniProtKB transmembrane receptor protein tyrosine kinase activity Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 29	29	Potential
	Chain	30 – 154	125	Probable insulin-like peptide 1		PRO_0000016185
	Peptide	30 – 69	40	Probable insulin-like peptide 1 B chain Potential		PRO_0000016186
	Propeptide	73 – 122	50	Connecting peptide Potential		PRO_0000016187
	Peptide	125 – 154	30	Probable insulin-like peptide 1 A chain Potential		PRO_0000016188
Amino acid modifications
	Disulfide bond	49 ↔ 138		Interchain (between B and A chains) By similarity
	Disulfide bond	61 ↔ 151		Interchain (between B and A chains) By similarity
	Disulfide bond	137 ↔ 142		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9VT50 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 65E78F17EDC12041	FASTA	154	16,851
	10 20 30 40 50 60 MFSQHNGAAV HGLRLQSLLI AAMLTAAMAM VTPTGSGHQL LPPGNHKLCG PALSDAMDVV 70 80 90 100 110 120 CPHGFNTLPR KRESLLGNSD DDEDTEQEVQ DDSSMWQTLD GAGYSFSPLL TNLYGSEVLI 130 140 150 KMRRHRRHLT GGVYDECCVK TCSYLELAIY CLPK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley.
[3]	"An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control." Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., Hafen E. Curr. Biol. 11:213-221(2001) [PubMed: 11250149] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014296 Genomic DNA. Translation: AAF50205.1.
RefSeq	NP_648359.1. NM_140102.1.
UniGene	Dm.27101.
3D structure databases
ProteinModelPortal	Q9VT50.
SMR	Q9VT50. Positions 44-154.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9VT50.
Proteomic databases
PRIDE	Q9VT50.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0076328; FBpp0076057; FBgn0044051.
GeneID	39149.
KEGG	dme:Dmel_CG14173.
NMPDR	fig|7227.3.peg.9153.
Organism-specific databases
CTD	39149.
FlyBase	FBgn0044051. Ilp1.
Phylogenomic databases
GeneTree	EMGT00050000016171.
InParanoid	Q9VT50.
OMA	KLCGPAL.
OrthoDB	EOG4T76KR.
PhylomeDB	Q9VT50.
Enzyme and pathway databases
Reactome	REACT_115106. Signal Transduction. REACT_6313. Insulin receptor mediated signaling.
Gene expression databases
GermOnline	CG14173. Drosophila melanogaster.
Family and domain databases
InterPro	IPR016179. Insulin-like. IPR022353. Insulin_CS. IPR022352. Insulin_family. [Graphical view]
Gene3D	G3DSA:1.10.100.10. Ins/IGF/relaxin. 2 hits.
Pfam	PF00049. Insulin. 1 hit. [Graphical view]
PRINTS	PR00276. INSULINFAMLY.
SMART	SM00078. IlGF. 1 hit. [Graphical view]
SUPFAM	SSF56994. Insulin-like. 1 hit.
PROSITE	PS00262. INSULIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	812191.

Entry information

Entry name

INSL1_DROME

Accession

Primary (citable) accession number: Q9VT50

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project